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The Effect of Different Storage Condition on Leukocytes in Human Breast Milk 不同储存条件对母乳中白细胞的影响
Q3 Medicine Pub Date : 2023-12-20 DOI: 10.18295/squmj.12.2023.084
Diah K Putri, Rahimi Syaidah, A. A. Jusuf
Objectives: Breast milk is the best baby food because it contains a complete nutritional composition and contains important factors for the baby's immune system, including leukocytes. Store breast milk to guarantee the baby receives it while the mother works. This study aims to determine the effect of morphology, number cells and the population of breast milk leukocytes on various ways of storing breast milk based on differences in temperature and storage duration. Methods: We used transitional breast milk samples from 7 breastfeeding mothers. A total of 50 ml was then divided into 4 tubes of 12.5 ml each and treated based on temperature, storage time, and method of thawing frozen breast milk based on the recommendations of the CDC for breast milk storage. Then the breast milk cells were isolated to calculate the cell number and leukocyte population. After that, breast milk cells were stained with Hematoxylin and Eosin (HE) to analyze the number and morphology of leukocytes. Results: The results showed a significant decrease in the total number, population in breast milk. Besides that, there were also changes in the morphology of breast milk leukocytes after storage. Conclusion: This study indicate that CDC storage recommendations have no effect on the quantity of the CD45+ leukocyte population; though, there is a decreased the total number of leukocytes as well as alterations in their microscopic morphology. However, additional research is still required to determine whether these modifications also influence the function of these cells. Keywords: Breast milk; leukocytes; storage; population; morphology.
目的:母乳是最好的婴儿食品,因为它含有完整的营养成分,并含有婴儿免疫系统的重要因子,包括白细胞。储存母乳可保证婴儿在母亲工作时也能吃到母乳。本研究旨在根据温度和储存时间的不同,确定母乳白细胞的形态、细胞数和数量对各种母乳储存方式的影响。研究方法我们使用了 7 位母乳喂养母亲的过渡性母乳样本。然后将总计 50 毫升的母乳分成 4 管,每管 12.5 毫升,并根据美国疾病预防控制中心对母乳储存的建议,按照温度、储存时间和解冻冷冻母乳的方法进行处理。然后分离母乳细胞,计算细胞数和白细胞数。然后,用苏木精和伊红(HE)对母乳细胞进行染色,分析白细胞的数量和形态。结果显示结果显示,母乳中的白细胞总数和数量明显减少。此外,母乳中白细胞的形态在储存后也发生了变化。结论这项研究表明,疾病预防控制中心的贮藏建议对 CD45+ 白细胞群的数量没有影响;但白细胞的总数量减少了,其显微形态也发生了变化。然而,要确定这些改变是否也会影响这些细胞的功能,还需要进行更多的研究。关键词:母乳;白细胞母乳;白细胞;储存;数量;形态。
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引用次数: 0
A Newly Detected Left Ventricular Mass Following A Complex Intracardiac Repair. 复杂的心内修复术后新发现的左心室肿块
Q3 Medicine Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.069
Madan M Maddali, Avinash Chauhan, Pranav S Kandachar, Abdulla Al-Farqani, Hamood N Al Kindi

Appearance of unexpected masses in the chambers of the heart during cardiac surgery can be intriguing. We report the case of a mass in the left ventricle that appeared at the time of separation from cardiopulmonary bypass in a child after a complex intracardiac repair. The child presented for surgery to a tertiary care hospital in Muscat, Oman, in 2022. Prior to the surgical repair the mass was not appreciated by echocardiography. An intraventricular baffle was used to divert left ventricular blood flow towards the outflow tract, after which an intraventricular "mass" was observed. Intraoperative transoesophageal echocardiography identified the mass as a portion of the interventricular septum that was located between the inlet and outlet ventricular septal defects.

在心脏手术过程中,心脏腔内意外出现的肿块可能会令人感到好奇。我们报告了一例左心室肿块的病例,该肿块出现在一名接受复杂心内修复手术的患儿脱离心肺旁路时。该患儿于 2022 年到阿曼马斯喀特的一家三级医院接受手术治疗。手术修复前,超声心动图检查未发现肿块。手术中使用了心室内挡板将左心室血流引向流出道,之后观察到了心室内的 "肿块"。术中经食道超声心动图检查发现,肿块是位于入口和出口室间隔缺损之间的部分室间隔。
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引用次数: 0
Propofol and Kearns-Sayre Syndrome: An idiographic approach. 异丙酚与卡恩斯-赛尔综合征:成因分析法
Q3 Medicine Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.080
Madan M Maddali, Thushara D Munasinghe, Is'haq Al Aamri, Ismail A Al-Abri, Samir Al-Adawi

With the focus on an idiographic approach whereby the observations incorporated the various dimensions of individual functioning 'top-down' to 'bottom-up', this case report describes the successful management of a 14-year-old girl with Kearns-Sayre syndrome and Dyggve-Melchior-Clausen disease requiring a transvenous permanent pacemaker implantation for complete heart block. The patient presented to a tertiary care centre in Muscat, Oman, in 2023 seeking consultation. The current idiographic approach appears to have a heuristic value for 2 interrelated reasons. Firstly, it is unlikely that even tertiary care units can accrue such rare presentations and scrutinise them under nomothetic approach. Secondly, by employing the idiographic approach that is capable of examining each case in-depth, the aspiration for good health and well-being may come to the forefront. To the best of the authors' knowledge this is the first published idiographic report in anaesthesia care.

本病例报告重点介绍了对一名患有 Kearns-Sayre 综合征和 Dyggve-Melchior-Clausen 病的 14 岁女孩的成功治疗,该女孩因完全性心脏传导阻滞而需要经静脉植入永久起搏器。患者于 2023 年来到阿曼马斯喀特的一家三级医疗中心就诊。由于两个相互关联的原因,目前的特异性方法似乎具有启发价值。首先,即使是三级医疗单位也不太可能收集到如此罕见的病例,并采用提名法对其进行仔细检查。其次,通过采用能够深入研究每个病例的成因学方法,人们对健康和幸福的渴望可能会凸显出来。据作者所知,这是麻醉护理领域首次发表的特异性报告。
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引用次数: 0
Sudden Cardiac Death in Patients Under 49 Years Including Adolescents: A single-centre study from Oman. 49 岁以下患者(包括青少年)的心脏性猝死:阿曼的一项单中心研究。
Q3 Medicine Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.082
Madan M Maddali, Ahmed S Al Habsi, Mariya J Al Dhamri, Sathish K Jayapal, Hamood N Al Kindi

Objectives: This study aimed to identify the incidence of sudden cardiac death (SCD0 in adult patients under the age of 49 years, including adolescents with an out-of-hospital cardiac arrest that presented to the emergency department of a tertiary care hospital.

Methods: This retrospective cross-sectional study was conducted at the Royal Hospital, Muscat, Oman, between January 2015 and December 2019. All patients with out-of-hospital cardiac arrest were enrolled. The incidence of SCD was evaluated. Information about the patient's demographic data, the site of cardiac arrest, the mode of arrival, the duration of pre-arrest symptoms and if cardiopulmonary resuscitation was performed was gathered. Survival data at 3-year follow-up was obtained.

Results: A total of 117 out of 769 (15%) patients met the criteria for SCD. Male gender was predominant, with a median age of 33 years. In about 79.5% of the patients, cardiac arrest was witnessed. Only 43 patients (36.8%) received cardiopulmonary resuscitation at the arrest site; 21 patients (17.9%) had a shockable rhythm and 96 patients (82.1%) had a non-shockable rhythm. Spontaneous circulation was returned in 15 patients (12.8%). Nine patients (7.7%) were discharged from the hospital and 8 (6.8%) survived at least 36 months.

Conclusion: The study findings indicate the prevalence of SCD among patients who experienced a cardiac arrest outside the hospital. Unfortunately, only a small number of patients were able to survive in the long term. By implementing preemptive screening for individuals and their families, it may be possible to prevent SCD and improve outcomes for those affected.

研究目的本研究旨在确定 49 岁以下成年患者的心脏性猝死(SCD0)发病率,包括在一家三级医院急诊科就诊的院外心脏骤停青少年患者:这项回顾性横断面研究于 2015 年 1 月至 2019 年 12 月期间在阿曼马斯喀特皇家医院进行。所有院外心脏骤停患者均被纳入研究。对 SCD 的发生率进行了评估。收集了患者的人口统计学数据、心脏骤停部位、到达方式、骤停前症状持续时间以及是否实施了心肺复苏等信息。此外,还获得了随访 3 年的存活数据:结果:在 769 名患者中,共有 117 人(15%)符合 SCD 标准。男性居多,中位年龄为 33 岁。约 79.5% 的患者亲眼目睹了心脏骤停。只有 43 名患者(36.8%)在心跳骤停现场接受了心肺复苏;21 名患者(17.9%)出现可电击心律,96 名患者(82.1%)出现不可电击心律。15 名患者(12.8%)恢复了自主循环。9名患者(7.7%)出院,8名患者(6.8%)存活至少36个月:研究结果表明,在医院外发生心脏骤停的患者中,SCD 的发病率很高。遗憾的是,只有少数患者能够长期存活。通过对个人及其家人进行先期筛查,也许可以预防 SCD 并改善受影响者的预后。
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引用次数: 0
Device Closure of Superior Sinus Venosus Atrial Septal Defects: A single centre experience. 上窦静脉房室隔缺损的设备闭合:单中心经验
Q3 Medicine Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.070
Salim N Al Maskari, Madan M Maddali, Khalid Al Alawi, Sowmiya Raju, Abdulla Al-Farqani

Sinus venosus atrial septal defects present a wide variety of anatomical features and are frequently associated with partial anomalous pulmonary venous drainage of one or more right pulmonary veins. Surgical correction used to be the standard treatment. In recent times, transcatheter correction of superior sinus venosus atrial septal defects has come into vogue. The transcatheter closure of these defects with covered stents at a tertiary care centre in Oman between 2018 and 2023 is reported.

窦性心房中隔缺损的解剖特征多种多样,经常与一条或多条右肺静脉的部分异常肺静脉引流有关。手术矫正曾是标准的治疗方法。近来,经导管矫正上窦静脉房间隔缺损开始流行。据报道,2018 年至 2023 年期间,阿曼的一家三级医疗中心使用有盖支架对这些缺损进行了经导管闭合。
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引用次数: 0
Angiographic Predictors of Viability During Intervention for a ST Elevation Myocardial Infarction. ST 段抬高心肌梗死介入治疗期间血管造影预测存活率。
Q3 Medicine Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.078
Suhaib Al-Maashari, Yasir Al-Malki, Hatim Al Lawati, Adil Al-Riyami, Sunil K Nadar

Objectives: This study aimed to identify angiographic features that would predict myocardial viability after coronary intervention for ST elevation myocardial infarction (STEMI).

Methods: This retrospective study included patients who attended Sultan Qaboos University Hospital, Muscat, Oman, between January and December 2019 with a STEMI.

Results: A total of 72 patients (61 male; mean age = 54.9 ± 12.7 years) were included in the study; 11 patients had evidence of non-viability on echocardiography. There were 13 patients with viable myocardium and 3 with non-viable myocardium who had a myocardial blush grade (MBG) of 2 or lower. Similarly, 10 patients with viability and 1 with non-viable myocardium had thrombolysis in myocardial infarction (TIMI) flow of 2 or lower in the infarct related artery (IRA). However, none of these were statistically significant. The TIMI flow in the IRA at the end of the procedure correlated with the MBG.

Conclusion: There were no clear angiographic features during primary angioplasty that could predict myocardial viability.

研究目的本研究旨在确定可预测ST段抬高型心肌梗死(STEMI)冠状动脉介入治疗后心肌存活率的血管造影特征:这项回顾性研究纳入了2019年1月至12月期间在阿曼马斯喀特苏丹卡布斯大学医院就诊的STEMI患者:研究共纳入 72 名患者(61 名男性;平均年龄 = 54.9 ± 12.7 岁),其中 11 名患者超声心动图显示心肌无活力。有 13 名患者的心肌存活,3 名患者的心肌未存活,其心肌胭脂分级(MBG)为 2 或更低。同样,10 名心肌存活的患者和 1 名心肌未存活的患者心肌梗死溶栓(TIMI)流量在梗死相关动脉(IRA)为 2 或更低。不过,这些数据均无统计学意义。手术结束时,IRA的TIMI血流与MBG相关:结论:在初级血管成形术中,没有明确的血管造影特征可以预测心肌存活能力。
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引用次数: 0
The Evolution of Paediatric Cardiology Service in Oman. 阿曼儿科心脏病学服务的演变。
Q3 Medicine Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.072
Salim N Al Maskari
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引用次数: 0
Mogul in a Baby. 婴儿中的大亨
Q3 Medicine Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.071
Pranav S Kandachar, Nithil A Varughese, Charanjit Kaur, Abdulla M S AlFarqani, Ala Al Lawati
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引用次数: 0
Rupture of Renal Angiomyolipoma Post Fibrinolysis: A rare complication of fibrinolytic therapy. 纤维蛋白溶解术后肾血管肌脂肪瘤破裂:纤维蛋白溶解疗法的罕见并发症。
Q3 Medicine Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.074
Saba Al-Kindi, Mahmood Al-Hajriy, Adil Al-Jabri

Angiomyolipoma is a common benign solid tumour that accounts for up to 3% of all renal tumours; most of the cases are sporadic. However, it can be part of other diseases. Angiomyolipomas are usually found incidentally through unrelated clinically indicated images but also, they can be diagnosed after complications have occurred. We report the case of retroperitoneal haemorrhage following the rupture of renal angiomyolipoma post-fibrinolysis, we are highlighting such a rare condition, the management options and the follow-up plan. The management of angiomyolipomas ranges from conservative treatment to surgical intervention depending on the patient's condition and the tumour's radiological features. Following-up on patients with angiomyolipomas depends on the symptoms and the tumour size. Till date, there is no reported cases of renal angiomyolipoma rupture post-fibrinolysis therapy as a treatment for myocardial infarction in non-percutaneous intervention capable facility.

血管肌脂肪瘤是一种常见的良性实体瘤,占所有肾肿瘤的 3%;大多数病例为散发性。不过,它也可能是其他疾病的一部分。血管肌脂肪瘤通常是通过与临床无关的图像偶然发现的,但也可能在发生并发症后才被诊断出来。我们报告了一例纤溶后肾血管肌脂肪瘤破裂后腹膜后大出血的病例,重点介绍了这种罕见病症、处理方案和后续计划。血管肌脂肪瘤的治疗方法包括保守治疗和手术治疗,具体取决于患者的病情和肿瘤的放射学特征。血管肌脂肪瘤患者的随访取决于症状和肿瘤大小。迄今为止,在非经皮介入治疗心肌梗死的医疗机构中,还没有关于纤溶疗法后肾血管肌脂肪瘤破裂的病例报道。
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引用次数: 0
The Sinus Venosus Veno-Venous Bridge: Not a septal defect. 静脉窦静脉桥:不是房间隔缺损
Q3 Medicine Pub Date : 2023-12-01 Epub Date: 2023-11-30 DOI: 10.18295/squmj.12.2023.075
Madan M Maddali, Robert H Anderson, Salim N Al Maskari, Faiza Al Kindi, Hamood N Al Kindi

This review provides an update on the morphology of the sinus venosus defect. It was earlier believed that a 'common wall' separated the right pulmonary veins from the superior caval vein. In the sinus venosus defects, this wall was absent. Current evidence shows that the superior rim of the oval fossa, rather than forming a second septum or representing a common wall, is an infolding between the walls of the caval veins and the right pulmonary veins. The sinus venosus defect is caused by the anomalous connection of one or more pulmonary veins to a systemic vein. However, the pulmonary vein(s) retain their left atrial connections, leading to a veno-venous bridge that allows interatrial shunting outside the oval fossa. True atrial septal defects are located within the oval fossa or in the anteo-inferior buttress, while sinus venosus defects, ostium defects and coronary sinus defects are morphologically distinct from them.

这篇综述提供了有关静脉窦缺损形态的最新信息。早先的观点认为,右肺静脉与上腔静脉之间有 "共壁 "分隔。在窦静脉缺损中,这面墙是不存在的。目前的证据显示,卵圆窝上缘不是形成第二道隔膜或代表共壁,而是腔静脉壁和右肺静脉壁之间的折叠。静脉窦缺损是由一条或多条肺静脉与一条全身静脉的异常连接造成的。然而,肺静脉保留了与左心房的连接,从而形成静脉-静脉桥,允许在卵圆窝外进行心房间分流。真正的房间隔缺损位于卵圆窝内或前下托,而窦静脉缺损、房室缺损和冠状窦缺损在形态上与它们截然不同。
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引用次数: 0
期刊
Sultan Qaboos University Medical Journal
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