Pub Date : 2024-06-13DOI: 10.18295/squmj.6.2024.031
A. Wasim, Shihab S Al Maawali, Abdulrahman S AlJabri, F. Al Amrani, Faraz Ahmad, Ahmed Mansi, Amna Al Futaisi
Objective: This study aimed to evaluate the etiology, management, and outcomes of convulsive status epilepticus (CSE) in children highlighting the factors that affect patient outcome. Methods: In a retrospective study spanning 2020 to 2023, 93 children with convulsive status epilepticus (CSE) treated at Sultan Qaboos University Hospital's emergency department (ED), High Dependency (HD), and intensive care unit (ICU) were analyzed. The Modified Rankin Scale at discharge determined CSE outcome. Results: Study of 93 children (mean age 4.84 years ± 3.64), predominantly Omani (92.47%). Acute 14 symptomatic (37.7%) and febrile tatus (31.2%) were primary causes. Diazepam used in 67.44% 15 cases as first-line treatment, with median seizure duration of 45 minutes. Successful control achieved in 16 76.34% within 60 minutes. Return to baseline in 55.9%, 5.38% mortality, and 38.7% disability. Etiology and 17 duration significantly impacted outcomes (p < 0.05). Conclusion: Acute symptomatic is the most common etiology of CSE, and a longer duration is associated with higher mortality and neurological disability. Therefore, managing CSE promptly and appropriately is crucial. Furthermore, identifying and treating the underlying cause is essential to reduce the duration of CSE and improve the outcome. Keywords: Etiology, Outcome, Convulsive Status Epilepticus, Modified Rankin Scale
{"title":"Aetiology and Outcome of Childhood Convulsive Status Epilepticus","authors":"A. Wasim, Shihab S Al Maawali, Abdulrahman S AlJabri, F. Al Amrani, Faraz Ahmad, Ahmed Mansi, Amna Al Futaisi","doi":"10.18295/squmj.6.2024.031","DOIUrl":"https://doi.org/10.18295/squmj.6.2024.031","url":null,"abstract":"Objective: This study aimed to evaluate the etiology, management, and outcomes of convulsive status epilepticus (CSE) in children highlighting the factors that affect patient outcome. Methods: In a retrospective study spanning 2020 to 2023, 93 children with convulsive status epilepticus (CSE) treated at Sultan Qaboos University Hospital's emergency department (ED), High Dependency (HD), and intensive care unit (ICU) were analyzed. The Modified Rankin Scale at discharge determined CSE outcome. Results: Study of 93 children (mean age 4.84 years ± 3.64), predominantly Omani (92.47%). Acute 14 symptomatic (37.7%) and febrile tatus (31.2%) were primary causes. Diazepam used in 67.44% 15 cases as first-line treatment, with median seizure duration of 45 minutes. Successful control achieved in 16 76.34% within 60 minutes. Return to baseline in 55.9%, 5.38% mortality, and 38.7% disability. Etiology and 17 duration significantly impacted outcomes (p < 0.05). Conclusion: Acute symptomatic is the most common etiology of CSE, and a longer duration is associated with higher mortality and neurological disability. Therefore, managing CSE promptly and appropriately is crucial. Furthermore, identifying and treating the underlying cause is essential to reduce the duration of CSE and improve the outcome. \u0000Keywords: Etiology, Outcome, Convulsive Status Epilepticus, Modified Rankin Scale","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141345425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-13DOI: 10.18295/squmj.6.2024.042
Idris A. Adedeji, Abdulrahim Abdullahi, Abdulmohsen S Alharbi, Fatimah Abusrair, Mohamed Alshehri
Disseminated Herpes Simplex Virus (HSV) is a known fatal condition in neonate and immunocompromised patients. However, very few cases have been reported in immunocompetent host. We report a one year old child who was previously healthy, presented with febrile illness associated with decrease conscious level. Child has been found to have marked elevated liver enzymes. Ultimately diagnosed with disseminated. HSV (encephalitis/ hepatitis) based on Cerebrospinal fluid (CSF) polymerase chain reaction (PCR) finding of HSV as well as positive HSV Immunoglobulin M (IgM) serology. She received acyclovir course and follow up for 1 year showed excellent developmental outcome. Keywords: HSV, Encephalitis, Hepatitis.
{"title":"Disseminated Herpes Simplex Virus-1 in Previously Healthy Child Without Skin Rash","authors":"Idris A. Adedeji, Abdulrahim Abdullahi, Abdulmohsen S Alharbi, Fatimah Abusrair, Mohamed Alshehri","doi":"10.18295/squmj.6.2024.042","DOIUrl":"https://doi.org/10.18295/squmj.6.2024.042","url":null,"abstract":"Disseminated Herpes Simplex Virus (HSV) is a known fatal condition in neonate and immunocompromised patients. However, very few cases have been reported in immunocompetent host. We report a one year old child who was previously healthy, presented with febrile illness associated with decrease conscious level. Child has been found to have marked elevated liver enzymes. Ultimately diagnosed with disseminated. HSV (encephalitis/ hepatitis) based on Cerebrospinal fluid (CSF) polymerase chain reaction (PCR) finding of HSV as well as positive HSV Immunoglobulin M (IgM) serology. She received acyclovir course and follow up for 1 year showed excellent developmental outcome. \u0000Keywords: HSV, Encephalitis, Hepatitis.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141345471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-13DOI: 10.18295/squmj.6.2024.033
Noor N Junejo, N. AbuDraz, Shahid Aquil, Joseph K Mathew, Ghalib Al Badaai, M. Al-Marhoon, K. M. Siddiqui
Objectives: Renal Cell Carcinoma (RCC) is one of the foremost urological malignancies. In Oman, an age-standardized incidence rate of 2.5 per 100,000 per year is reported. There is a trend towards early detection and use of minimally invasive technology for the treatment of RCC. Aim of our study was to report the changing trend in clinical presentation and RCC management, including to compare the outcomes of laparoscopic versus open nephrectomy in Oman. Methods: After ethical committee’s approval, the bio-data for adult patients and peri-operative details were collected, who were diagnosed with RCC between 2011 and 2022. We analyze the variables, both continuous and categorical by Chi-square analysis. The p-value <0.05 was set as a level of significance. Results: Fifty-six patients underwent surgical treatment of RCC. Among them, 34 patients underwent laparoscopic nephrectomy (LN) and 22 open nephrectomy (ON). The mean age in the LN group was 53.82 years ± 13.44, and 56.2 years ± 15 (p-value 0.535) in ON group. Forty-seven patients were of Omani descent and 9 patients were expatiates. The mean tumor size was 6.25 ± 3.16 and 9.2 ± 5.20 cm for the LN and ON groups, respectively. More than 55% cases were incidentally diagnosed. Over the years there has been a trend towards LN. Conclusion: In our study, we found a trend towards early diagnosis with majority of cancers discovered incidentally. We also recognized that laparoscopic approach is more commonly employed in the surgical management with acceptable morbidity. These trends are in congruence with the global literature. Keywords: nephrectomy, laparoscopic, open, renal cell carcinoma
{"title":"Surgical Management of Renal Cell Carcinoma","authors":"Noor N Junejo, N. AbuDraz, Shahid Aquil, Joseph K Mathew, Ghalib Al Badaai, M. Al-Marhoon, K. M. Siddiqui","doi":"10.18295/squmj.6.2024.033","DOIUrl":"https://doi.org/10.18295/squmj.6.2024.033","url":null,"abstract":"Objectives: Renal Cell Carcinoma (RCC) is one of the foremost urological malignancies. In Oman, an age-standardized incidence rate of 2.5 per 100,000 per year is reported. There is a trend towards early detection and use of minimally invasive technology for the treatment of RCC. Aim of our study was to report the changing trend in clinical presentation and RCC management, including to compare the outcomes of laparoscopic versus open nephrectomy in Oman. Methods: After ethical committee’s approval, the bio-data for adult patients and peri-operative details were collected, who were diagnosed with RCC between 2011 and 2022. We analyze the variables, both continuous and categorical by Chi-square analysis. The p-value <0.05 was set as a level of significance. Results: Fifty-six patients underwent surgical treatment of RCC. Among them, 34 patients underwent laparoscopic nephrectomy (LN) and 22 open nephrectomy (ON). The mean age in the LN group was 53.82 years ± 13.44, and 56.2 years ± 15 (p-value 0.535) in ON group. Forty-seven patients were of Omani descent and 9 patients were expatiates. The mean tumor size was 6.25 ± 3.16 and 9.2 ± 5.20 cm for the LN and ON groups, respectively. More than 55% cases were incidentally diagnosed. Over the years there has been a trend towards LN. Conclusion: In our study, we found a trend towards early diagnosis with majority of cancers discovered incidentally. We also recognized that laparoscopic approach is more commonly employed in the surgical management with acceptable morbidity. These trends are in congruence with the global literature. \u0000Keywords: nephrectomy, laparoscopic, open, renal cell carcinoma","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141346248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Albumin is commonly used for various indications. However, conflicting data exists regarding its appropriate use in different clinical cases. In this study we aim to determine the pattern and appropriateness of albumin use among cancer patients treated at a comprehensive cancer center in Jordan. Methods: A retrospective analysis was conducted on adult cancer patients who were prescribed albumin between January 2019 and July 2020, in the outpatient and inpatient settings. Patient- and albumin-related data were collected, which included demographics, prescribing services, indications, and dosing regimens. We conducted thorough research using PubMed, and reviewed the related guidelines, drug information resources and the package insert to evaluate the appropriateness of albumin's indications and dosing regimens. Results: Albumin was prescribed to 1,361 patients during the study period. Each patient received an average of 74.4 ± 89 (SD) grams of albumin for an average of 2.6 ± 1.8 (SD) days. Albumin use was considered appropriate in 69% of the patients. The critical care service had the highest albumin consumption, with 37% of the prescribing being for the indication of septic shock. Inappropriate use was observed among the medical solid tumor service (40.8 % of their prescriptions) and was most commonly prescribed for edema (28%). Conclusion: To our knowledge, this study represents the first to evaluate a large cohort of oncology patients. In about one third of the cases albumin prescribed indications were considered inappropriate. Continuous education on appropriate usage and regular evaluations of guideline implementation is necessary to ensure appropriate utilization. Keywords: Albumins*/therapeutic use, drug utilization review, neoplasms, cancer care facilities, Jordan.
{"title":"Assessment of Albumin Usage Patterns and Appropriateness in a Comprehensive Cancer Centre","authors":"Asma'a Al-Kharabsheh, L. Nazer, Wedad Awad, Ala'a Ghanem, Rand Al-Hadaddin, Batool Bani Amer, Hadeel Thawaibeh, Nour Mustafa, Rula Al-Najjar, Abeer Al-Rabaiah, Saad Jaddoua","doi":"10.18295/squmj.6.2024.029","DOIUrl":"https://doi.org/10.18295/squmj.6.2024.029","url":null,"abstract":"Objectives: Albumin is commonly used for various indications. However, conflicting data exists regarding its appropriate use in different clinical cases. In this study we aim to determine the pattern and appropriateness of albumin use among cancer patients treated at a comprehensive cancer center in Jordan. Methods: A retrospective analysis was conducted on adult cancer patients who were prescribed albumin between January 2019 and July 2020, in the outpatient and inpatient settings. Patient- and albumin-related data were collected, which included demographics, prescribing services, indications, and dosing regimens. We conducted thorough research using PubMed, and reviewed the related guidelines, drug information resources and the package insert to evaluate the appropriateness of albumin's indications and dosing regimens. Results: Albumin was prescribed to 1,361 patients during the study period. Each patient received an average of 74.4 ± 89 (SD) grams of albumin for an average of 2.6 ± 1.8 (SD) days. Albumin use was considered appropriate in 69% of the patients. The critical care service had the highest albumin consumption, with 37% of the prescribing being for the indication of septic shock. Inappropriate use was observed among the medical solid tumor service (40.8 % of their prescriptions) and was most commonly prescribed for edema (28%). Conclusion: To our knowledge, this study represents the first to evaluate a large cohort of oncology patients. In about one third of the cases albumin prescribed indications were considered inappropriate. Continuous education on appropriate usage and regular evaluations of guideline implementation is necessary to ensure appropriate utilization. \u0000Keywords: Albumins*/therapeutic use, drug utilization review, neoplasms, cancer care facilities, Jordan.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141348219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-13DOI: 10.18295/squmj.6.2024.040
Ahmed Soliman, Hanaa Alrashidi, Mohamed A Mohamed, Reem Ghorab, Nihal Al Riyami, Ahmed SA Ashour, Yasmine A Mohammed, Ahmed H Saad
We aimed to compare efficacy of vaginal gel preparations versus placebo in postmenopausal women with sexual dysfunction syndrome. We searched electronic databases from inception to January 2023. We included trials reporting Female Sexual Function Index (FSFI) which compared hormonal (estrogen, oxytocin) and/or non-hormonal (chamomile, fennel) interventions versus placebo. We used Cochrane Risk of Bias assessment tool I to evaluate studies quality. Eight trials (N=672 participants) were included. Total FSFI endpoint score was higher in the vaginal gel preparations group (MD: 6.67; 95% CI: [3.79, 9.55]; p< 0.001) than placebo. Non-hormonal gel preparations had higher FSFI total score (MD: 6.73, 95% CI: [4.7, 8.76], p< 0.001) than hormonal preparations (MD: 2.75, 95% CI: [1.87,3.64], p< 0.001). Non-hormonal interventions increased all FSFI domains. We conclude that Chamomile and fennel vaginal gel preparations could improve overall FSFI six domains score, which reflects on postmenopausal women's sexual activity and satisfaction. Keywords: menopause, psychological sexual dysfunction, estrogen, Chamomile, Meta-analysis
{"title":"Efficacy of Hormonal and Non-hormonal Vaginal Gel Preparations on Female Sexual Satisfaction Index in Postmenopausal Women with Sexual Dysfunction Syndrome","authors":"Ahmed Soliman, Hanaa Alrashidi, Mohamed A Mohamed, Reem Ghorab, Nihal Al Riyami, Ahmed SA Ashour, Yasmine A Mohammed, Ahmed H Saad","doi":"10.18295/squmj.6.2024.040","DOIUrl":"https://doi.org/10.18295/squmj.6.2024.040","url":null,"abstract":"We aimed to compare efficacy of vaginal gel preparations versus placebo in postmenopausal women with sexual dysfunction syndrome. We searched electronic databases from inception to January 2023. We included trials reporting Female Sexual Function Index (FSFI) which compared hormonal (estrogen, oxytocin) and/or non-hormonal (chamomile, fennel) interventions versus placebo. We used Cochrane Risk of Bias assessment tool I to evaluate studies quality. Eight trials (N=672 participants) were included. Total FSFI endpoint score was higher in the vaginal gel preparations group (MD: 6.67; 95% CI: [3.79, 9.55]; p< 0.001) than placebo. Non-hormonal gel preparations had higher FSFI total score (MD: 6.73, 95% CI: [4.7, 8.76], p< 0.001) than hormonal preparations (MD: 2.75, 95% CI: [1.87,3.64], p< 0.001). Non-hormonal interventions increased all FSFI domains. We conclude that Chamomile and fennel vaginal gel preparations could improve overall FSFI six domains score, which reflects on postmenopausal women's sexual activity and satisfaction. \u0000Keywords: menopause, psychological sexual dysfunction, estrogen, Chamomile, Meta-analysis","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141350074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-13DOI: 10.18295/squmj.6.2024.034
M. Joseph, Jansirani Natarajan, Huda Al-Hinai
Objectives: To investigate the association between internet addiction and dietary habits among Omani junior college students. Methods: In this cross-sectional study at Sultan Qaboos University, 377 junior college students were surveyed in November 2020 using demographic data, the Compulsive Internet Use Scale, and a dietary habits questionnaire. Chi-square cross-tabulation analyses explored the relationship between internet addiction and dietary habits. Results: Overall, 59.9% of junior college students were identified as having an internet addiction. Within this group, 62.8% reported reduced meal sizes and 54.4% reported a decrease in appetite. There was a statistically significant difference in both meal size (X2=30.528, p<0.001) and appetite changes (X2=28.731, p<0.001) among student with different levels of internet addiction. These results suggest a possible link between internet addiction and altered dietary habits among this population. Conclusion: This study highlights the need for strategies that encourage healthy living behaviors and raise awareness about the adverse effects of internet addiction. Keywords: Internet addiction disorder; diet; Students; appetite; Oman
{"title":"Association between Internet Addiction and Dietary Habits among Omani Junior College Students","authors":"M. Joseph, Jansirani Natarajan, Huda Al-Hinai","doi":"10.18295/squmj.6.2024.034","DOIUrl":"https://doi.org/10.18295/squmj.6.2024.034","url":null,"abstract":"Objectives: To investigate the association between internet addiction and dietary habits among Omani junior college students. Methods: In this cross-sectional study at Sultan Qaboos University, 377 junior college students were surveyed in November 2020 using demographic data, the Compulsive Internet Use Scale, and a dietary habits questionnaire. Chi-square cross-tabulation analyses explored the relationship between internet addiction and dietary habits. Results: Overall, 59.9% of junior college students were identified as having an internet addiction. Within this group, 62.8% reported reduced meal sizes and 54.4% reported a decrease in appetite. There was a statistically significant difference in both meal size (X2=30.528, p<0.001) and appetite changes (X2=28.731, p<0.001) among student with different levels of internet addiction. These results suggest a possible link between internet addiction and altered dietary habits among this population. Conclusion: This study highlights the need for strategies that encourage healthy living behaviors and raise awareness about the adverse effects of internet addiction. \u0000Keywords: Internet addiction disorder; diet; Students; appetite; Oman","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141347817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-13DOI: 10.18295/squmj.6.2024.037
Elham Azmoude, N. J. Shoorab, S. E. Zagami
NONE
无
{"title":"Unbridled Advertising of Female Cosmetic Genitoplasty Procedures in the Absence of Health Policy-making in the World","authors":"Elham Azmoude, N. J. Shoorab, S. E. Zagami","doi":"10.18295/squmj.6.2024.037","DOIUrl":"https://doi.org/10.18295/squmj.6.2024.037","url":null,"abstract":"<jats:p>NONE</jats:p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141347732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-13DOI: 10.18295/squmj.6.2024.028
Fazal Khan, Nausheen Yaqoob, Aida H AlYahyaee, Shoaib A AlZadjali, I. Burney
NONE
无
{"title":"Development of Organoids from Malignant Ascites for Cancer Research in Oman","authors":"Fazal Khan, Nausheen Yaqoob, Aida H AlYahyaee, Shoaib A AlZadjali, I. Burney","doi":"10.18295/squmj.6.2024.028","DOIUrl":"https://doi.org/10.18295/squmj.6.2024.028","url":null,"abstract":"<jats:p>NONE</jats:p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141346871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-13DOI: 10.18295/squmj.6.2024.030
F. Al-Bayaty, A. A. Kamaruddin, Mohd. A. Ismail, Mazen MJ Al-Obaidi
Objective: The objectives of this study were to develop two biodegradable periodontal chips containing Salvadora persica or Benzyl isothiocyanate (BITC) extract and evaluate its clinical effectiveness in managing periodontitis. Methods: Chips were formulated from Salvadora persica, Benzyl isothiocyanate (BITC) and chitosan; twelve patients with periodontal pockets measuring ≥5 mm participated in this study. Overall, 240 periodontal pockets were evaluated. All patients were treated with full mouth scaling and root planning (SRP) at baseline. Periodontal pockets were divided into four groups. One of which is the control group, while group two received plain chitosan chip. Group three received chips containing Salvadora persica extract, and group four received chips containing BITC. Plaque index (PI), bleeding on probing (BOP), periodontal probing pocket (PPD) depth, and clinical attachment levels (CAL) using acrylic stents were recorded at days 0 and 60 only. Results: Data were statistically analysed; Chi-square t-test and an ANOVA were used. Results showed significant improvement in plaque index, bleeding on probing, and reduction in periodontal pocket depth in all four groups (p<0.05). The gain in clinical attachment level was significantly higher (p<0.005) among the group receiving Salvadora persica chips compared to the control and other chip-treated groups. Conclusion: Periodontal chips containing S. persica can be used as adjuncts to treat patients with periodontitis. Keywords: Chitosan; Periodontal chip; Miswak extract; Benzyl isothiocyanate; Periodontitis.
{"title":"Evaluation of Clinical Efficacy of Biodegradable Chip Containing Salvadora persica Extract in Chitosan Base as an Adjunct to Scaling and Root Planning in the Management of Periodontitis","authors":"F. Al-Bayaty, A. A. Kamaruddin, Mohd. A. Ismail, Mazen MJ Al-Obaidi","doi":"10.18295/squmj.6.2024.030","DOIUrl":"https://doi.org/10.18295/squmj.6.2024.030","url":null,"abstract":"Objective: The objectives of this study were to develop two biodegradable periodontal chips containing Salvadora persica or Benzyl isothiocyanate (BITC) extract and evaluate its clinical effectiveness in managing periodontitis. Methods: Chips were formulated from Salvadora persica, Benzyl isothiocyanate (BITC) and chitosan; twelve patients with periodontal pockets measuring ≥5 mm participated in this study. Overall, 240 periodontal pockets were evaluated. All patients were treated with full mouth scaling and root planning (SRP) at baseline. Periodontal pockets were divided into four groups. One of which is the control group, while group two received plain chitosan chip. Group three received chips containing Salvadora persica extract, and group four received chips containing BITC. Plaque index (PI), bleeding on probing (BOP), periodontal probing pocket (PPD) depth, and clinical attachment levels (CAL) using acrylic stents were recorded at days 0 and 60 only. Results: Data were statistically analysed; Chi-square t-test and an ANOVA were used. Results showed significant improvement in plaque index, bleeding on probing, and reduction in periodontal pocket depth in all four groups (p<0.05). The gain in clinical attachment level was significantly higher (p<0.005) among the group receiving Salvadora persica chips compared to the control and other chip-treated groups. Conclusion: Periodontal chips containing S. persica can be used as adjuncts to treat patients with periodontitis. \u0000Keywords: Chitosan; Periodontal chip; Miswak extract; Benzyl isothiocyanate; Periodontitis.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141348805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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