Sustainable Chemistry and Pharmacy最新文献_第4页

Green and sustainable ultrasound–microwave hybrid system for intensified and efficient quercetin extraction from Pinus koraiensis seed scales 绿色可持续超声微波杂交系统强化高效提取红松种皮槲皮素的研究

IF 5.8 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy

Pub Date : 2025-12-04 DOI: 10.1016/j.scp.2025.102284

Zhanjun Li , Yunwei Liu , Mingru Kong , Zheng Qin , Qi Shen , Mengze Wang

The primary objective of this study was to achieve high-efficiency, sustainable method for extracting quercetin from Pinus koraiensis seed scales using a green chitosan–Cu–Fe catalyzed ultrasound–microwave continuous system. Key factors were screened and optimized, with the following optimal conditions: a liquid material ratio of 10:1 mL/g for both ultrasonic and microwave treatments, ultrasonic 10 min, 90 W, 40 °C; microwave irradiation at 303 W for 8.19 min; and exogenous chitosan–Cu–Fe at 0.6 %, achieving an actual yield of 3.13 mg/g. The optimal process was compared with conventional Soxhlet extraction, used as a benchmark to evaluate the new method's efficiency. Kinetic analysis showed equilibrium at 12.5 and 50 min, with yields of 3.33 and 3.23 mg/g, respectively, while prolonged high-temperature exposure extraction caused partial degradation of the extract. Life cycle assessment and inductively coupled plasma mass spectrometry confirmed the superior stability and environmental sustainability of the optimal process. Mechanistic evaluation indicated that the extraction followed a second-order kinetics model; with the second-stage activation energy (87.56 kJ/mol) primarily governed by extraction, indicating that regulating the temperature enhances efficiency and reduces losses. Ultrasonic cavitation and microwave heating enhance extraction efficiency, while chitosan–Cu–Fe improves stability by increasing active sites and facilitating electron transfer. The process offers environmental and sustainability benefits, providing insights into the valorization of forest residues.

本研究的主要目的是建立绿色壳聚糖- cu - fe催化超声-微波连续提取红松籽皮中槲皮素的高效、可持续的方法。对关键因素进行筛选和优化，最佳条件为：超声和微波处理的液料比均为10:1 mL/g，超声10 min，功率90 W，温度40℃；303 W微波辐照8.19 min；外源壳聚糖- cu - fe用量为0.6%，实际产率为3.13 mg/g。将优化工艺与传统索氏提取工艺进行比较，并以此为基准评价新方法的有效性。动力学分析表明，在12.5 min和50 min达到平衡，产率分别为3.33和3.23 mg/g，而长时间高温暴露提取导致提取物部分降解。生命周期评价和电感耦合等离子体质谱分析证实了优化工艺优越的稳定性和环境可持续性。机理评价表明，萃取过程符合二级动力学模型；第二阶段活化能（87.56 kJ/mol）主要受萃取控制，说明调节温度可以提高效率，减少损失。超声空化和微波加热提高了萃取效率，壳聚糖- cu - fe通过增加活性位点和促进电子转移来提高萃取稳定性。这一过程提供了环境和可持续性的好处，为森林残留物的价值增值提供了见解。

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引用次数: 0

Green and efficient extraction of Artemisia integrifolia leaves essential oil via ultrasound coupled with microwave-assisted deep eutectic solvent 超声波-微波助溶深度共晶萃取绿色高效提取黄花蒿叶精油

IF 5.8 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy

Pub Date : 2025-12-03 DOI: 10.1016/j.scp.2025.102272

Qingfen Zhang , Zhiqiang He , Chao Ding , Qi Lu , Zhijian Zhang

This study reports a green and efficient strategy for extracting oxygenated terpenoid-rich essential oil from Artemisia integrifolia leaves (AEO) using an ultrasound coupled with microwave-assisted deep eutectic solvent (DES) extraction (UDME). Ultrasound pretreatment disrupts plant cell wall structures, enabling enhanced DES penetration and subsequent microwave-assisted mass transfer. The UDME technique achieves an essential oil yield of 5.29 ± 0.13 mg/g, demonstrating a 31.92 % improvement over conventional hydrodistillation (4.01 ± 0.11 mg/g). Notably, UDME reduces energy consumption and CO₂ emissions compared to traditional methods. Spectroscopic analysis (FTIR and GC-MS) revealed that UDME extracted essential oil contains 67.80 % oxygenated terpenoids, with significant increases in artemisia alcohol (+7.81 %), artemisia ketone (+5.25 %), and eucalyptol (+4.93 %) relative to hydrodistillation. Molecular dynamics (MD) simulations complemented the study by elucidating the dissolution mechanism of artemisia alcohol in a betaine-lactate DES, which is driven by strong electrostatic interactions. Furthermore, radial distribution function (RDF) analysis verified that hydrogen bonding, particularly from lactic acid, serves as the dominant mechanism facilitating efficient dissolution. These compositional advantages correlate with superior bioactivities: AEO exhibits IC₅₀ values of 0.4930 mg/mL (DPPH) and 0.5196 mg/mL (ABTS⁺) for antioxidant capacity, and a minimum inhibitory concentration (MIC) of 0.20 mg/mL against Listeria monocytogenes. Therefore, the UDME method has proved to be both environmentally friendly and efficient in extracting premium essential oil from leaves of A. integrifolia.

本研究采用超声-微波辅助深度共晶溶剂（DES）萃取（UDME）技术，建立了一种绿色高效提取青蒿叶（AEO）富氧萜类精油的方法。超声预处理破坏植物细胞壁结构，增强DES穿透和随后的微波辅助传质。UDME技术的精油得率为5.29±0.13 mg/g，比传统的加氢蒸馏（4.01±0.11 mg/g）提高了31.92%。值得注意的是，与传统方法相比，UDME减少了能源消耗和二氧化碳排放。光谱分析（FTIR和GC-MS）显示，UDME提取精油中含氧萜类化合物67.80%，其中青蒿醇（+ 7.81%）、青蒿酮（+ 5.25%）和桉油醇（+ 4.93%）含量显著高于加氢蒸馏。分子动力学（MD）模拟通过阐明青蒿醇在甜菜碱乳酸DES中的溶解机制来补充研究，该机制是由强静电相互作用驱动的。此外，径向分布函数（RDF）分析证实，氢键，特别是来自乳酸的氢键，是促进高效溶解的主要机制。这些优势与优越的生物活性相关：AEO抗氧化能力的IC50值为0.4930 mg/mL （DPPH）和0.5196 mg/mL (ABTS+)，对单核增生李斯特菌的最低抑制浓度（MIC）为0.20 mg/mL。因此，UDME法是一种既环保又高效的提取金合藤叶精油的方法。

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引用次数: 0

Corrigendum to “Multi-drug extraction using octanol supported rotating cellulose paper disc (RPD) device from complex biological matrices: Fabrication and application in forensic case work” [Sustain. Chem. Pharm. 41 (2024) 101724] “使用辛醇支持的旋转纤维素纸盘（RPD）装置从复杂生物基质中提取多种药物：制造和在法医案件工作中的应用”的勘误表。化学。医药，41 (2024)101724]

IF 5.8 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy

Pub Date : 2025-12-01 DOI: 10.1016/j.scp.2025.102177

Bharti Jain , Rajeev Jain , Sukhminder Kaur , S.K. Manirul Haque , Shweta Sharma , Mohammad M. Ghoneim , Lateefa A. Al-Khateeb

引用次数: 0

Hydrogen-rich syngas production from agro-food waste: catalytic steam gasification of olive pomace and grape marc using Ni and CaO catalysts 利用农业食品废弃物生产富氢合成气：用Ni和CaO催化剂催化橄榄渣和葡萄渣蒸汽气化

IF 5.8 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy

Pub Date : 2025-12-01 DOI: 10.1016/j.scp.2025.102270

Aytenew Getaye , Sébastien Vaudreuil , Tijani Bounahmidi , Touria Moudakkar

In this study, an Aspen Plus® catalytic oxygen-steam gasification model was employed to perform a parametric analysis using olive pomace (OP) and grape marc (GM) biowaste, evaluating syngas composition, hydrogen yield, tar formation, and cold gas efficiency. Key parameters such as temperature, equivalence ratio, steam-to-biomass ratio, pressure, biomass feed rate, and catalyst-to-biomass ratio were analyzed to maximize hydrogen output while reducing tar. The model showed good agreement with experimental results reported in the literature, with a maximum error of 5.90 %. The use of Ni as a catalyst resulted in hydrogen yields ranging from 45 to 84.35 g/kg for OP and 48–75.58 g/kg for GM. Similarly, gasification using CaO as a catalyst produced hydrogen yields ranging from 54.14 to 82.15 g/kg for OP and 50–74.12 g/kg for GM. Regardless of the catalyst used, the OP feedstock produced higher hydrogen yields than GM under comparable gasification conditions. Both Ni and CaO catalysts demonstrated notable improvements in the gasification process by significantly reducing tar formation, enhancing cold gas efficiency, increasing hydrogen yield, and lowering the overall carbon footprint. However, when comparing their performance independently of the feedstock type, CaO exhibited superior catalytic activity under most operating conditions, resulting in higher hydrogen production than Ni.

在本研究中，采用Aspen Plus®催化氧蒸汽气化模型对橄榄渣（OP）和葡萄渣（GM）生物废弃物进行参数分析，评估合成气成分、氢气产率、焦油形成和冷气体效率。分析了温度、等效比、蒸汽与生物质比、压力、生物质进料速率和催化剂与生物质比等关键参数，以最大限度地提高氢产量，同时减少焦油。模型与文献报道的实验结果吻合较好，最大误差为5.90%。使用Ni作为催化剂，OP的产氢率为45 - 84.35 g/kg， GM的产氢率为48-75.58 g/kg。同样，使用CaO作为催化剂的气化，OP的产氢率为54.14 - 82.15 g/kg， GM的产氢率为50-74.12 g/kg。无论使用哪种催化剂，在相同的气化条件下，OP原料的产氢率高于GM。Ni和CaO催化剂在气化过程中都表现出显著的改善，显著减少了焦油的形成，提高了冷气效率，增加了氢气产量，降低了总体碳足迹。然而，当将它们的性能独立于原料类型进行比较时，在大多数操作条件下，CaO表现出更好的催化活性，从而产生比Ni更高的氢。

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引用次数: 0

Prediction and characteristic analysis of leaching concentration of manganese particles from calcined electrolytic manganese residue based upon BP neural network 基于BP神经网络的电解锰渣锰粒浸出浓度预测及特征分析

IF 5.8 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy

Pub Date : 2025-12-01 DOI: 10.1016/j.scp.2025.102266

Kefan Chen , Zhaoyi He , Qiong Feng , Penghui Wang

In order to obtain the leaching concentration data of manganese ions from electrolytic manganese residue (EMR) after synergistic calcination quickly and accurately, an artificial neural network (ANN) model with a 5-10-1 topology was designed. The model was optimized using Bat, Grey Wolf, and Particle Swarm Optimization algorithms. The model's input layer parameters include temperature, EMR content, calcium oxide (CaO) content, titanium gypsum (TG) content, and red mud (RM) content. The output layer represented the manganese ion leaching concentration after the calcination of EMR. The dataset consisted of 330 datasets, 230 for training, 50 for validation, and 50 for testing. Various parameters' influence on the leaching concentration of manganese ions was analyzed using the correlation coefficient method. The results showed a strong negative correlation between temperature and the manganese ion leaching concentration. The EMR content was correlated positively with the leaching concentration, while the contents of CaO, TG, and RM were correlated negatively. The PSO-BP neural network model demonstrated the highest accuracy in predicting the manganese ion leaching concentration values, with statistical indicators as follows:R² = 0.9955, MAE = 0.0352, MSE = 0.0022, and RMSE = 0.0466. Principal component analysis (PCA) identified three principal components with eigenvalues greater than 1. A strong correlation was observed among all of the research variables and the principal components. Each condition's influence on the leaching concentration of manganese ions after calcination was ranked in the following order:Temperature > CaO > EMR > RM > TG. The principal component composite score for the EC4 group ratio was the highest, at 1.48, indicating that it is the optimal ratio. The results suggested that PSO-BP neural network model advances the understanding of nonlinear interactions in EMR co-calcination by enabling precise prediction of manganese ion leaching concentrations, which reveals key mechanisms such as additive synergies.

为了快速准确地获取协同焙烧后电解锰渣中锰离子的浸出浓度数据，设计了5-10-1拓扑的人工神经网络（ANN）模型。采用蝙蝠算法、灰狼算法和粒子群算法对模型进行优化。模型输入层参数包括温度、EMR含量、氧化钙（CaO）含量、钛石膏（TG）含量、赤泥（RM）含量。输出层表示EMR煅烧后锰离子浸出浓度。数据集由330个数据集组成，其中230个用于训练，50个用于验证，50个用于测试。采用相关系数法分析了各参数对锰离子浸出浓度的影响。结果表明，温度与锰离子浸出浓度呈较强的负相关。EMR含量与浸出浓度呈正相关，CaO、TG、RM含量呈负相关。PSO-BP神经网络模型预测锰离子浸出浓度值的准确率最高，统计指标R2 = 0.9955, MAE = 0.0352, MSE = 0.0022, RMSE = 0.0466。主成分分析（PCA）识别出三个特征值大于1的主成分。所有研究变量与主成分之间均存在较强的相关性。各条件对焙烧后锰离子浸出浓度的影响顺序为：温度>； CaO > EMR > RM >； TG。EC4组比例的主成分综合评分最高，为1.48，为最优比例。结果表明，PSO-BP神经网络模型通过精确预测锰离子浸出浓度，提高了对EMR共烧过程中非线性相互作用的理解，揭示了添加剂协同作用等关键机制。

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引用次数: 0

Superior mechanical performance and environmental benefit of internal alkali-latent hydraulic reactivity-sulfate synergistic activated red mud-based low-cement binders 内碱潜水力反应-硫酸盐协同活化赤泥基低水泥粘结剂优越的力学性能和环境效益

IF 5.8 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy

Pub Date : 2025-12-01 DOI: 10.1016/j.scp.2025.102268

Zeyuan Wang, Lingling Wang, Dewen Kong, Daiyu Zhou, Qiwan Zhang

To achieve high-volume utilization of industrial solid wastes in cementitious systems, this study employed red mud (RM) as the primary material, in combination with ground-granulated blast-furnace slag (GGBS) and hemihydrate phosphogypsum (HPG), to progressively replace cement. The evolution of hydration reactions, phase assemblage, and microstructure during the replacement process was systematically investigated, and a technical route of “internal alkali-latent hydraulic reactivity-sulfate synergistic activation” was proposed. The results showed that the binder containing 95 % total solid waste (50 % RM, 25 % GGBS, and 20 % HPG) and 5 % commercial reference cement achieved 28-day flexural and compressive strengths of 6.8 MPa and 32.4 MPa, respectively. Microstructural characterization revealed that RM alone could not substitute cement effectively due to its limited pozzolanic reactivity, while the incorporation of GGBS consumed OH⁻ ions and facilitated the formation of hydration products. In the CRSHPG system, SO₄²⁻ released from HPG hydration reacted with Ca²⁺ and Al³⁺ to generate abundant ettringite (AFt), which formed a load-bearing skeletal framework. Although AFt increased capillary pore volume to some extent, its intergrowth with C-(A)-S-H gel effectively maintained structural integrity and supported long-term strength development. Toxicity leaching tests demonstrated that the system met safety requirements for heavy-metal leaching, though continued attention should be paid to As and Pb concentrations. Life-cycle assessment (LCA) indicated superior environmental performance compared with conventional cement, with an estimated approximately 85 % reduction in CO₂ emissions. This study provides a feasible pathway for the high-volume valorization of multiple industrial solid wastes in sustainable cementitious systems.

为实现工业固体废弃物在胶凝体系中的大批量利用，本研究以赤泥（RM）为主要材料，与磨粒高炉渣（GGBS）和半水磷石膏（HPG）相结合，逐步替代水泥。系统研究了置换过程中水化反应、相组合和微观结构的演变，提出了“内碱-潜水力反应-硫酸盐协同活化”的技术路线。结果表明，含95%固体废物（50% RM、25% GGBS和20% HPG）和5%商业参考水泥的粘结剂，28天的抗折强度和抗压强度分别为6.8 MPa和32.4 MPa。微观结构表征表明，RM由于其有限的火山灰反应活性，不能有效地替代水泥，而GGBS的加入消耗了OH−离子，促进了水化产物的形成。在CRSHPG体系中，HPG水化释放的SO42−与Ca2+和Al3+反应生成丰富的钙矾石（AFt），形成承重骨架框架。虽然AFt在一定程度上增加了毛细孔体积，但它与C-(A)- s - h凝胶的共生有效地保持了结构的完整性，支持了长期的强度发展。毒性浸出试验表明，该系统符合重金属浸出的安全要求，但仍需继续关注砷和铅的浓度。生命周期评估（LCA）表明，与传统水泥相比，该水泥具有优越的环保性能，估计可减少约85%的二氧化碳排放。本研究为多种工业固体废物在可持续胶凝体系中实现高容量增值提供了一条可行途径。

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引用次数: 0

Toward greener construction: Advancing self-compacting lightweight mortars with sustainable binders and multiscale performance evaluation 迈向绿色建筑：推进自密实轻质砂浆与可持续粘合剂和多尺度性能评估

IF 5.8 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy

Pub Date : 2025-11-29 DOI: 10.1016/j.scp.2025.102273

Muhammed Ulucan , Ibrahim Cebeci , Musa Yetkin , Kursat Esat Alyamac

This study focuses on exploring the engineering and environmental properties of self-compacting lightweight mortars designed to reduce the environmental outputs of waste materials obtained from buildings demolished by destructive earthquakes, incorporate these waste materials, and minimize carbon emissions. Ten different self-compacting lightweight mortars were prepared using pumice and recycled materials as aggregates, metakaolin and ground granulated blast furnace slag as combination supplementary cementitious materials (SCM). MK15 indicated a 13.9–11.9 % improvement in final age compressive and flexural strengths (180 days). Approximately 40–65 % decrease in flexural and compressive strengths at 600 and 900 °C. In sulphate resistance tests, the lowest decrease in compressive and flexural strength (5.3–5.7 %) was observed in GGBFS10. SCM was found to deliver striking results across five impact categories, identifying the critical importance of cement for greener construction technologies and the effectiveness of design. To this end, this research provides a sustainable approach to reduce earthquake-related waste stock, environmental outputs, and cement consumption by incorporating waste materials into self-compacting concrete and mortar technology, which is widely used in new buildings in Turkey, a country that has been exposed to devastating earthquakes in recent years.

本研究的重点是探索自密实轻质砂浆的工程和环境特性，旨在减少从破坏性地震中拆除的建筑物中获得的废料对环境的影响，将这些废料纳入其中，并最大限度地减少碳排放。以浮石和再生材料为集料，偏高岭土和磨粒高炉矿渣为复合补充胶凝材料，制备了10种不同自密实轻质砂浆。MK15在最终年龄抗压和抗弯强度（180天）方面改善了13.9 - 11.9%。在600和900°C时，弯曲和抗压强度降低约40 - 65%。在抗硫酸盐试验中，GGBFS10的抗压和抗弯强度下降幅度最小（5.3 - 5.7%）。SCM在五个影响类别中产生了惊人的结果，确定了水泥对绿色建筑技术和设计有效性的至关重要性。为此，本研究提供了一种可持续的方法，通过将废物纳入自密实混凝土和砂浆技术，减少与地震有关的废物库存，环境产出和水泥消耗，该技术在土耳其的新建筑中广泛使用，土耳其近年来遭受了毁灭性的地震。

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引用次数: 0

Application of CO2-induced carbonate minerals as novel grouting materials for soil improvement 二氧化碳诱导碳酸盐矿物作为新型土壤改良注浆材料的应用

IF 5.8 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy

Pub Date : 2025-11-29 DOI: 10.1016/j.scp.2025.102274

Hamed A. Keykha , Ottavia Rispoli , Maria Mavroulidou , Hadi Mohamadzadeh Romiani

This study evaluates CO₂-induced carbonate minerals synthesised by direct CO₂ absorption, as novel injectable materials for permeation grouting, aiming to enhance the sustainability of ground improvement techniques. The investigation started with Scanning Electron Microscopy (SEM), and X-ray Diffraction (XRD) analyses that attested the formation of siderite (FeCO₃) and calcite (CaCO₃) carbonate minerals, which precipitated in the soil voids. Sand samples treated with siderite grout achieved the highest Unconfined Compressive Strength (UCS) of 70 kPa at 11 % siderite content; those treated with calcite grout reached 53 kPa at a calcite content of 16 %. Peat, of a 12 kPa UCS, reached a UCS of 36 kPa after grouting with 20 % siderite, and 23 kPa after grouting with 19 % calcite. Life Cycle Assessment (LCA) of carbonate grout mixtures against conventional cement-based grout showed an 85 %–87 % reduction in the global warming potential and improvements in 13–14 out of the 18 environmental impact categories respectively for calcite and siderite grout, with major reductions in fossil and mineral resource scarcity, ground level ozone and fine particle formation. The proposed carbonate-based grouts comply with green chemistry principles and SDGs and have the potential advantage of consuming captured CO₂ from industrial sources. Overall, carbonate minerals synthesised using CO₂ give promise for grouting applications, while providing a potential route for CO₂ utilisation.

本研究对二氧化碳直接吸收合成的二氧化碳诱导碳酸盐矿物作为新型渗透注浆注入材料进行了评价，旨在提高地基改善技术的可持续性。研究开始于扫描电镜（SEM）和x射线衍射（XRD）分析，证实了在土壤空隙中沉淀的菱铁矿（FeCO3）和方解石（CaCO3）碳酸盐矿物的形成。当菱铁矿含量为11%时，经菱铁矿灌浆处理的砂样无侧限抗压强度（UCS）最高，为70 kPa；方解石灌浆处理在方解石含量为16%时达到53 kPa。泥炭的单轴抗压强度为12 kPa， 20%菱铁矿灌浆后单轴抗压强度为36 kPa， 19%方解石灌浆后单轴抗压强度为23 kPa。与常规水泥基浆液相比，碳酸盐浆液的生命周期评估（LCA）显示，碳酸钙浆液的全球变暖潜势降低了85% - 87%，方解石浆液和黄铁矿浆液在18个环境影响类别中分别改善了13-14个，主要减少了化石和矿产资源稀缺、地面臭氧和细颗粒形成。拟议的碳酸盐基灌浆符合绿色化学原则和可持续发展目标，并具有消耗工业来源捕获的二氧化碳的潜在优势。总的来说，用二氧化碳合成的碳酸盐矿物为注浆应用提供了希望，同时为二氧化碳的利用提供了潜在的途径。

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引用次数: 0

A novel synchronous spectrofluorimetric analysis of naproxen and hydroxychloroquine in plasma and pharmaceuticals at nanogram levels: Comparative greenness and sustainability assessment 血浆和药物中纳克水平的萘普生和羟氯喹的新型同步荧光光谱分析：比较绿色和可持续性评估

IF 5.8 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy

Pub Date : 2025-11-28 DOI: 10.1016/j.scp.2025.102271

Zeinab Adel Nasr , Noha Salem Rashed , Eman Abdalla Shalaby , Galal Magdy

A rapid, eco-friendly, and very sensitive synchronous spectrofluorimetric technique was established for the concurrent assay of a binary combination of naproxen (NAP) and hydroxychloroquine (HCQ), for the first time. The technique relies on quantifying the synchronous fluorescence intensities of the two pharmaceuticals in a borate buffer at pH 10 utilizing a fixed wavelength difference (Δλ) of 80.0 nm in water as a green solvent. The simultaneous quantification of both drugs included measuring NAP at 227 nm and HCQ at 325 nm, in the presence of one another without interference. Superb linearity ranges were achieved between 10.0–300.0 ng/mL and 10.0–250.0 ng/mL, for NAP and HCQ, respectively with a correlation coefficient value (r) above 0.999. The findings revealed that the proposed method has very high sensitivity, with detection limits of 2.40 and 1.56 ng/mL for NAP and HCQ, respectively, underscoring its strong bioanalytical application. The proposed methodology was successfully utilized to concurrently quantify the specified pharmaceuticals in their tablets and human plasma samples, attaining elevated recovery percentages and minimal % RSD values. To evaluate the environmental sustainability of the suggested technique, the Analytical Green Star Area (AGSA) and Analytical GREENNESS (AGREE) metrics were utilized. Both tools indicated that the proposed technique is very ecologically sustainable, recommending its use as an eco-friendly alternative for the regular analysis of the examined medications. MA-tool was used to conduct a thorough evaluation of the method's sustainability, practicality, performance, and innovation. The developed methodology was validated in accordance with the ICH Q2 (R2) standards.

首次建立了萘普生（NAP）和羟氯喹（HCQ）双联药同时测定的快速、环保、高灵敏度的同步荧光光谱法。该技术依赖于在pH值为10的硼酸缓冲液中，利用固定波长差（Δλ） 80.0 nm的水作为绿色溶剂，定量测定两种药物的同步荧光强度。两种药物的同时定量包括在227 nm处测量NAP和325 nm处测量HCQ，彼此存在而不干扰。NAP和HCQ分别在10.0 ~ 300.0 ng/mL和10.0 ~ 250.0 ng/mL之间呈良好的线性关系，相关系数(r)均在0.999以上。结果表明，该方法具有很高的灵敏度，对NAP和HCQ的检出限分别为2.40和1.56 ng/mL，具有很强的生物分析应用价值。该方法成功地用于同时定量其片剂和人血浆样品中的指定药物，获得较高的回收率和最小的% RSD值。为了评估所建议技术的环境可持续性，使用了分析绿星面积（AGSA）和分析绿色度（AGREE）指标。这两种工具都表明，所提出的技术在生态上是非常可持续的，建议将其作为一种环保的替代方法，用于定期分析所检查的药物。使用ma工具对该方法的可持续性、实用性、性能和创新性进行了全面评估。所开发的方法按照ICH Q2 （R2）标准进行了验证。

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引用次数: 0

A new hydrogen peroxide-tolerant alkaline protease as a benign element for simultaneous bleaching and felt-proofing of wool 一种新的耐过氧化氢碱性蛋白酶作为羊毛同时漂白和防毡的良性成分

IF 5.8 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy

Pub Date : 2025-11-28 DOI: 10.1016/j.scp.2025.102269

Zheng Hu , Marwa Abou-Taleb , Jianyong Xu , Hui Song , Salwa Mowafi , Hongchen Zheng , Wenqin Bai , Hosam El-Sayed

Woolen products cannot be washed in domestic washing machines due to their tendency to felt during agitation in the wet state. Currently production of machine-washable wool utilizes polluting chemicals, which greatly harm the environment. Herein, an alkaline protease (AP) from soil-derived strains was isolated, characterized, purified, and stabilized. A total of 480 protease-producing strains were screened, and strain SH244 was identified as Bacillus amyloliquefaciens via 16S rDNA sequencing. The alkaline protease SH244-AP was purified using ammonium sulfate precipitation and ion exchange chromatography, achieving a 51.94-fold purification with a 29.8 % yield. The enzyme exhibited optimal activity at 55 °C and pH 10, with enhanced thermal stability in the presence of Ca²⁺. It showed remarkable tolerance to surfactant (e.g., Tween-20, Triton-X100) and H₂O₂. These properties suggest potential applications in textile wet processing, such as felt-proofing of wool. By virtue of its tolerance against H₂O₂, some metal ions, and nonionic detergents, the isolated AP, along with H₂O₂, was used in a water- and energy-saving eco-friendly simultaneous bleaching and felt-proofing of wool. The alteration in the chemical structure of wool was monitored by amino acid analysis, alkali and urea-bisulfite solubility, and base combining capacity of the treated fibers. The effect of bio-treatment of wool with the aforementioned AP on its surface morphology, weight, degree of whiteness, tensile strength and elongation at break was evaluated. The study's results demonstrated that the proposed process can produce machine-washable wool without significant weight and tenacity losses.

羊毛制品不能在家用洗衣机中洗涤，因为它们在潮湿状态下搅拌时容易产生触感。目前，机洗羊毛的生产使用了污染化学品，对环境造成了极大的危害。本文从土壤来源的菌株中分离、表征、纯化和稳定了碱性蛋白酶（AP）。共筛选到480株蛋白酶产菌，通过16S rDNA测序鉴定菌株SH244为解淀粉芽孢杆菌。采用硫酸铵沉淀法和离子交换色谱法对碱性蛋白酶SH244-AP进行纯化，纯化率为29.8%，纯化率为51.94倍。该酶在55°C和pH 10条件下表现出最佳活性，在Ca2+存在下具有增强的热稳定性。它对表面活性剂（如Tween-20、Triton-X100）和H2O2具有显著的耐受性。这些特性表明在纺织品湿法加工方面的潜在应用，如羊毛防毡。由于其对H2O2、一些金属离子和非离子洗涤剂的耐受性，分离的AP与H2O2一起用于节水环保的羊毛同时漂白和防毡。通过氨基酸分析、碱水溶解度、亚硫酸脲溶解度和碱基结合力监测羊毛化学结构的变化。评价了AP生物处理羊毛对羊毛表面形貌、重量、白度、抗拉强度和断裂伸长率的影响。研究结果表明，所提出的工艺可以生产出可机洗的羊毛，而不会有明显的重量和韧性损失。

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