Pub Date : 2022-03-10DOI: 10.1080/1539445X.2022.2049307
Subhajit Kundu, Debarati Mitra
ABSTRACT Ionic liquids have the potential to play a significant role in mitigating the critical challenge of refractory sulfur removal from diesel. In the present investigation, a mixture of imidazolium, pyrazolium and triazolium acetate -based ionic liquids has been immobilized on silica gel using sol-gel technology at ambient temperature (25°C), yielding a novel adsorbent. The sol-gel processing route has been elucidated by Dynamic Light Scattering (DLS) and rheology study. The fabricated adsorbent has been characterized by Fourier Transfer Infra-red (FTIR) spectroscopy, X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). The results reveal that the ionic liquids have been immobilized in the silica gel support. This adsorbent has been successfully applied to remove heterocyclic sulfur compounds from model diesel containing thiophene and dibenzothiophene. The highest desulfurization efficiencies achieved for thiophene and dibenzothiophene removal are 98.31 and 99.29% respectively, using an adsorbent with 15% ionic liquid loading, model diesel: adsorbent ratio of 1:0.075, an adsorption time of 60 minutes at 25°C. The system under investigation followed the Langmuir isotherm model and the adsorption performance best fitted with the Ho’s pseudo second-order kinetics.
{"title":"Immobilization of acetate based ionic liquids on silica gel to fabricate a prospective desulfurizing adsorbent","authors":"Subhajit Kundu, Debarati Mitra","doi":"10.1080/1539445X.2022.2049307","DOIUrl":"https://doi.org/10.1080/1539445X.2022.2049307","url":null,"abstract":"ABSTRACT Ionic liquids have the potential to play a significant role in mitigating the critical challenge of refractory sulfur removal from diesel. In the present investigation, a mixture of imidazolium, pyrazolium and triazolium acetate -based ionic liquids has been immobilized on silica gel using sol-gel technology at ambient temperature (25°C), yielding a novel adsorbent. The sol-gel processing route has been elucidated by Dynamic Light Scattering (DLS) and rheology study. The fabricated adsorbent has been characterized by Fourier Transfer Infra-red (FTIR) spectroscopy, X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). The results reveal that the ionic liquids have been immobilized in the silica gel support. This adsorbent has been successfully applied to remove heterocyclic sulfur compounds from model diesel containing thiophene and dibenzothiophene. The highest desulfurization efficiencies achieved for thiophene and dibenzothiophene removal are 98.31 and 99.29% respectively, using an adsorbent with 15% ionic liquid loading, model diesel: adsorbent ratio of 1:0.075, an adsorption time of 60 minutes at 25°C. The system under investigation followed the Langmuir isotherm model and the adsorption performance best fitted with the Ho’s pseudo second-order kinetics.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"344 - 357"},"PeriodicalIF":1.2,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45374582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT A series of amphiphilic rodlike α-cyanostilbene mesogens bearing an α-cyanostilbene core, with one/three lipophilic and flexible alkyl chains at one end and a polar oligooxyethylene (EO) at the opposite end, have been synthesized and investigated by polarized optical microscopy (POM), differential scanning calorimetry (DSC), X-ray scattering, scanning electron microscope (SEM), UV-vis spectroscopy and photoluminescence as well as CV measurements. These compounds can self-assemble into photoresponsive liquid crystalline phases and possess AIEE characteristics, mechanofluorochromic properties and Fe3+ recognition properties. The conductivity of the lithium cation complex was also measured to be 2.6 × 10−7 S m−1. Such compounds can be considered as a kind of multifunctional materials.
摘要合成了一系列具有α-氰基二苯乙烯核的两亲性棒状α-氰基二苯乙烯介晶，一端有三条亲脂性和柔性的烷基链，另一端有极性低聚氧乙烯（EO），并用偏光显微镜（POM）、差示扫描量热法（DSC）、X射线散射、扫描电子显微镜（SEM），紫外可见光谱和光致发光以及CV测量。这些化合物可以自组装成光响应液晶相，并具有AIEE特性、机械荧光变色特性和Fe3+识别特性。锂-阳离子复合物的电导率也测得为2.6×10−7 S m−1。这些化合物可以被认为是一种多功能材料。
{"title":"Amphiphilic α-cyanostilbene mesogens with oligooxyethylene polar tails: syntheses and properties","authors":"Tengyu Ma, Hongmei Zhao, Qing Chang, Xinhao Liu, Xiaohong Cheng","doi":"10.1080/1539445X.2022.2028828","DOIUrl":"https://doi.org/10.1080/1539445X.2022.2028828","url":null,"abstract":"ABSTRACT A series of amphiphilic rodlike α-cyanostilbene mesogens bearing an α-cyanostilbene core, with one/three lipophilic and flexible alkyl chains at one end and a polar oligooxyethylene (EO) at the opposite end, have been synthesized and investigated by polarized optical microscopy (POM), differential scanning calorimetry (DSC), X-ray scattering, scanning electron microscope (SEM), UV-vis spectroscopy and photoluminescence as well as CV measurements. These compounds can self-assemble into photoresponsive liquid crystalline phases and possess AIEE characteristics, mechanofluorochromic properties and Fe3+ recognition properties. The conductivity of the lithium cation complex was also measured to be 2.6 × 10−7 S m−1. Such compounds can be considered as a kind of multifunctional materials.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"299 - 309"},"PeriodicalIF":1.2,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48164966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-22DOI: 10.1080/1539445X.2022.2041033
Jalababu Ramani, M. Alle, Garima Sharma, K. Reddy, Y. Park, K. K. Rao, Jin-Chul Kim
ABSTRACT In this study, modified natural polymeric-based pH-responsive hydrogels (GNAHs) were formulated using guar gum-grafted-poly(N-acryloyl phenyl alanine), 2-hydroxy ethyl acrylate, and 2-acrylamido-2-methyl-1-propane sulfonic acid. GNAH hydrogels were synthesized using a single-step radical polymerization reaction using N,N’-methylenebisacrylamide as a crosslinker and potassium persulfate as an initiator. The GNAH was used for the controlled release of Imatinib mesylate (IMS), an anticancer drug. The FTIR spectroscopy confirmed the IMS loading as well as grafting reaction between GG-g-PNPA and PHEA-co-PAMPS. This was further confirmed by XRD and DSC studies. The IMS also reduced the negative surface charge of the GNAH hydrogel. The microscopic images showed that the GNAH hydrogels have porous and canal structures with IMS molecules entrapped within the pores. The mode of drug release mechanism was assessed by applying various kinetic equations (non-Fickian diffusion mechanism, Higuchi square root and Korsmeyer–Peppas kinetic models) that showed pH-dependent drug release of hydrogels exhibiting an excellent controlled-release pattern for IMS for more than 48 h. Based on the drug release behavior of the as-synthesized amino acid-functionalized hydrogel, it can be suggested that GNAH hydrogels could also be used as a potential pH-responsive anticancer drug delivery system for other anticancer drugs.
{"title":"Guar gum-g-poly(N-acryloyl-L-phenyl alanine) based pH responsive smart hydrogels for in-vitro anticancer drug delivery","authors":"Jalababu Ramani, M. Alle, Garima Sharma, K. Reddy, Y. Park, K. K. Rao, Jin-Chul Kim","doi":"10.1080/1539445X.2022.2041033","DOIUrl":"https://doi.org/10.1080/1539445X.2022.2041033","url":null,"abstract":"ABSTRACT In this study, modified natural polymeric-based pH-responsive hydrogels (GNAHs) were formulated using guar gum-grafted-poly(N-acryloyl phenyl alanine), 2-hydroxy ethyl acrylate, and 2-acrylamido-2-methyl-1-propane sulfonic acid. GNAH hydrogels were synthesized using a single-step radical polymerization reaction using N,N’-methylenebisacrylamide as a crosslinker and potassium persulfate as an initiator. The GNAH was used for the controlled release of Imatinib mesylate (IMS), an anticancer drug. The FTIR spectroscopy confirmed the IMS loading as well as grafting reaction between GG-g-PNPA and PHEA-co-PAMPS. This was further confirmed by XRD and DSC studies. The IMS also reduced the negative surface charge of the GNAH hydrogel. The microscopic images showed that the GNAH hydrogels have porous and canal structures with IMS molecules entrapped within the pores. The mode of drug release mechanism was assessed by applying various kinetic equations (non-Fickian diffusion mechanism, Higuchi square root and Korsmeyer–Peppas kinetic models) that showed pH-dependent drug release of hydrogels exhibiting an excellent controlled-release pattern for IMS for more than 48 h. Based on the drug release behavior of the as-synthesized amino acid-functionalized hydrogel, it can be suggested that GNAH hydrogels could also be used as a potential pH-responsive anticancer drug delivery system for other anticancer drugs.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"329 - 343"},"PeriodicalIF":1.2,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44497485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-02DOI: 10.1080/1539445X.2022.2032152
Ryo Miyashita, R. Kumai, H. Goto
ABSTRACT In this paper, a stable twist grain boundary A (TGBA*) and blue phase liquid crystal (LC) blend is prepared by mixing an achiral-imine-type compound with cholesteryl pelargonate and 4-cyano-4’-pentylbiphenyl (nematic LC). The LC blend has five LC phases, which contain the TGBA* phase at room temperature and the blue phase as frustrated LC.
{"title":"Preparation of a stable twist grain boundary A (TGBA*) phase and blue phase liquid crystal with ternary system blend","authors":"Ryo Miyashita, R. Kumai, H. Goto","doi":"10.1080/1539445X.2022.2032152","DOIUrl":"https://doi.org/10.1080/1539445X.2022.2032152","url":null,"abstract":"ABSTRACT In this paper, a stable twist grain boundary A (TGBA*) and blue phase liquid crystal (LC) blend is prepared by mixing an achiral-imine-type compound with cholesteryl pelargonate and 4-cyano-4’-pentylbiphenyl (nematic LC). The LC blend has five LC phases, which contain the TGBA* phase at room temperature and the blue phase as frustrated LC.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"322 - 328"},"PeriodicalIF":1.2,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43279830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-22DOI: 10.1080/1539445X.2022.2028832
Larisa Popescu-Lipan, Anda Les, M. Grigoraș, G. Ababei, I. Motrescu, G. Bulai, F. Brînză, D. Creanga, M. Bălășoiu
ABSTRACT The preparation of antioxidant-coated magnetic nanoparticles (MNPs) has been studied to improve their biocompatibility, i.e. reducing negative side effects. The theoretical study was focused on the interaction of gallic acid (GA) with ionic iron at the surface of nanoparticles that increased reactivity and favors the uniform dispersion in water of magnetic nanoparticles and the interaction with other molecules of biomedical interest. Experimentally, we worked with an optimal method of coating the MNP with GA at 80°C which led to fine granulation highlighted by TEM, preservation of good crystallinity, proven by XRD as well as magnetic properties suitable for biomedical applications based on magnetically targeted guidance. The study of nanotoxicity was focused on the fate of MNPs eliminated in the biosphere, so the influence on photosynthesis in seedlings in early ontogenetic stages was sought. The small variation, with a positive trend, of the efficiency of photosynthesis was correlated with the balancing of the toxic effects, of ROS generation catalyzed by iron ions from the MNP surface by means of the antioxidant character of GA.
{"title":"Antioxidant molecule useful in the stabilization of nanoparticles in water suspension","authors":"Larisa Popescu-Lipan, Anda Les, M. Grigoraș, G. Ababei, I. Motrescu, G. Bulai, F. Brînză, D. Creanga, M. Bălășoiu","doi":"10.1080/1539445X.2022.2028832","DOIUrl":"https://doi.org/10.1080/1539445X.2022.2028832","url":null,"abstract":"ABSTRACT The preparation of antioxidant-coated magnetic nanoparticles (MNPs) has been studied to improve their biocompatibility, i.e. reducing negative side effects. The theoretical study was focused on the interaction of gallic acid (GA) with ionic iron at the surface of nanoparticles that increased reactivity and favors the uniform dispersion in water of magnetic nanoparticles and the interaction with other molecules of biomedical interest. Experimentally, we worked with an optimal method of coating the MNP with GA at 80°C which led to fine granulation highlighted by TEM, preservation of good crystallinity, proven by XRD as well as magnetic properties suitable for biomedical applications based on magnetically targeted guidance. The study of nanotoxicity was focused on the fate of MNPs eliminated in the biosphere, so the influence on photosynthesis in seedlings in early ontogenetic stages was sought. The small variation, with a positive trend, of the efficiency of photosynthesis was correlated with the balancing of the toxic effects, of ROS generation catalyzed by iron ions from the MNP surface by means of the antioxidant character of GA.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"S76 - S90"},"PeriodicalIF":1.2,"publicationDate":"2022-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45558295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-20DOI: 10.1080/1539445X.2022.2028829
A. Al-Alwani, V. N. Mironyuk, M. V. Pozharov, M. V. Gavrikov, E. Glukhovskoy
ABSTRACT The paper is focused on the study of the dynamic surface properties of mixed monolayers of porphyrin and arachidic acid with various mole fractions at the air–water interface. The choice of porphyrin solid thin film as an object of study is explained by its high potential application in the area of photovoltaics and medicine. The Langmuir monolayers of porphyrin and arachidic acid were formed under different conditions using the Langmuir-Blodgett technique. The increase of subphase temperature led to a decrease in the rigidity of the porphyrin monolayer and leads to accelerating the relaxation process of the monolayer. The chosen surface pressure (4, 5, 15 and 35 mN/m) affected the stability of the floating monolayer. The higher miscibility of the monolayers was obtained at the mole fraction of porphyrin = 0.333. The change in the phase of monolayers surface was reported on the basis of surface potential data. The morphology properties of the mixed systems transferred on silicon substrates by Schaeffer method are studied.
{"title":"Formation and phase behavior of porphyrin/arachidic acid mixed systems and morphology study of Langmuir-Schaefer thin films","authors":"A. Al-Alwani, V. N. Mironyuk, M. V. Pozharov, M. V. Gavrikov, E. Glukhovskoy","doi":"10.1080/1539445X.2022.2028829","DOIUrl":"https://doi.org/10.1080/1539445X.2022.2028829","url":null,"abstract":"ABSTRACT The paper is focused on the study of the dynamic surface properties of mixed monolayers of porphyrin and arachidic acid with various mole fractions at the air–water interface. The choice of porphyrin solid thin film as an object of study is explained by its high potential application in the area of photovoltaics and medicine. The Langmuir monolayers of porphyrin and arachidic acid were formed under different conditions using the Langmuir-Blodgett technique. The increase of subphase temperature led to a decrease in the rigidity of the porphyrin monolayer and leads to accelerating the relaxation process of the monolayer. The chosen surface pressure (4, 5, 15 and 35 mN/m) affected the stability of the floating monolayer. The higher miscibility of the monolayers was obtained at the mole fraction of porphyrin = 0.333. The change in the phase of monolayers surface was reported on the basis of surface potential data. The morphology properties of the mixed systems transferred on silicon substrates by Schaeffer method are studied.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"310 - 321"},"PeriodicalIF":1.2,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48835349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-15DOI: 10.1080/1539445X.2022.2028831
L. Alfhaid
ABSTRACT Mesoporous silica nanoparticles (MSNs) are considered a highly promising candidate for novel the drug delivery systems (DDSs) due to the possibility of controlling their functionalizable pores, their large pore volume, high loading cavities and biocompatibility. MSNs functionalized with stimuli-responsive polymers have been demonstrated to represent a controllable and smart drug delivery application able to release drugs in response to certain stimuli, including pH, temperature, light, enzyme or redox. The surface of the MSNs is coated with stimuli-responsive polymer brushes so as to increase the stability and extend the release period of the loaded drug. This minireview highlights the latest research developments of polymer-brush-grafted MSNs and their potential biomedical applications in this area.
{"title":"Recent advance in functionalized mesoporous silica nanoparticles with stimuli-responsive polymer brush for controlled drug delivery","authors":"L. Alfhaid","doi":"10.1080/1539445X.2022.2028831","DOIUrl":"https://doi.org/10.1080/1539445X.2022.2028831","url":null,"abstract":"ABSTRACT Mesoporous silica nanoparticles (MSNs) are considered a highly promising candidate for novel the drug delivery systems (DDSs) due to the possibility of controlling their functionalizable pores, their large pore volume, high loading cavities and biocompatibility. MSNs functionalized with stimuli-responsive polymers have been demonstrated to represent a controllable and smart drug delivery application able to release drugs in response to certain stimuli, including pH, temperature, light, enzyme or redox. The surface of the MSNs is coated with stimuli-responsive polymer brushes so as to increase the stability and extend the release period of the loaded drug. This minireview highlights the latest research developments of polymer-brush-grafted MSNs and their potential biomedical applications in this area.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"364 - 378"},"PeriodicalIF":1.2,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48920289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.1080/1539445X.2021.2019056
Hediyeh Ebrahimpour, Yousef Toomari, Malihe Pooresmaeil, H. Namazi
ABSTRACT In the current study, it was tried to design and synthesize a new derivative of β-cyclodextrin (β-CD) as a result of reaction with D-maltose (β-CD-M) to compare and investigate its capability as an anticancer drug nanocarrier. The success in the β-CD-M synthesis was validated via common characterization techniques: nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The SEM results indicate that the obtained β-CD-M molecule has a crystalline structure with a size of less than 100 nm. In the following, methotrexate (MTX) and doxorubicin (DOX) as the model of anticancer drugs were separately loaded in β-CD-M and their release profile was obtained. The outcome of the cytotoxic assay against MCF 10A cells indicated that β-CD-M is biocompatible and could be used as a drug carrier. Overall, from the obtained results, the synthesized biocompatible β-CD-M with more drug loading capacity and a controlled release profile in comparison to unmodified β-CD could be proposed as a potential nanocarrier for anticancer drug delivery.
{"title":"Cluster of D-maltose clicked to β-cyclodextrin: preparation and its application as a biocompatible drug delivery nanovehicle","authors":"Hediyeh Ebrahimpour, Yousef Toomari, Malihe Pooresmaeil, H. Namazi","doi":"10.1080/1539445X.2021.2019056","DOIUrl":"https://doi.org/10.1080/1539445X.2021.2019056","url":null,"abstract":"ABSTRACT In the current study, it was tried to design and synthesize a new derivative of β-cyclodextrin (β-CD) as a result of reaction with D-maltose (β-CD-M) to compare and investigate its capability as an anticancer drug nanocarrier. The success in the β-CD-M synthesis was validated via common characterization techniques: nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The SEM results indicate that the obtained β-CD-M molecule has a crystalline structure with a size of less than 100 nm. In the following, methotrexate (MTX) and doxorubicin (DOX) as the model of anticancer drugs were separately loaded in β-CD-M and their release profile was obtained. The outcome of the cytotoxic assay against MCF 10A cells indicated that β-CD-M is biocompatible and could be used as a drug carrier. Overall, from the obtained results, the synthesized biocompatible β-CD-M with more drug loading capacity and a controlled release profile in comparison to unmodified β-CD could be proposed as a potential nanocarrier for anticancer drug delivery.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"288 - 298"},"PeriodicalIF":1.2,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48439684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-19DOI: 10.1080/1539445X.2021.2007128
K. Dubatouka, V. Agabekov
ABSTRACT Liposomes have drawn a lot of interest as pharmaceutical carriers for thrombolytic enzymes. Tissue plasminogen activator (tPA) is a thrombolytic drug used to treat cardiovascular disorders. Clinical efficacy of tPA is limited by its short half-life, hemorrhagic side effects and poor penetration into large blood clots. Using its liposomal form can reduce such effects and improve thrombolytic activity. The aim of this work is to study the effect of the composition of tPA-loaded liposomes on their physicochemical characteristics, such as size, zeta-potential, entrapment efficiency, proteolytic activity and in vitro release. It was found that prepared liposomes were relatively stable, no aggregation was observed during the storage at 4°C. Lipid compositions had a minor influence on the incorporation efficiency and a significant effect on the percentage of tPA released per time as well as its proteolytic activity. Developed liposomal form of tissue plasminogen activator can be used for treatment cardiovascular diseases due to its small size, stability, high entrapment efficiency and slow rate of drug release.
{"title":"Preparation and characterization of tissue plasminogen activator-loaded liposomes","authors":"K. Dubatouka, V. Agabekov","doi":"10.1080/1539445X.2021.2007128","DOIUrl":"https://doi.org/10.1080/1539445X.2021.2007128","url":null,"abstract":"ABSTRACT Liposomes have drawn a lot of interest as pharmaceutical carriers for thrombolytic enzymes. Tissue plasminogen activator (tPA) is a thrombolytic drug used to treat cardiovascular disorders. Clinical efficacy of tPA is limited by its short half-life, hemorrhagic side effects and poor penetration into large blood clots. Using its liposomal form can reduce such effects and improve thrombolytic activity. The aim of this work is to study the effect of the composition of tPA-loaded liposomes on their physicochemical characteristics, such as size, zeta-potential, entrapment efficiency, proteolytic activity and in vitro release. It was found that prepared liposomes were relatively stable, no aggregation was observed during the storage at 4°C. Lipid compositions had a minor influence on the incorporation efficiency and a significant effect on the percentage of tPA released per time as well as its proteolytic activity. Developed liposomal form of tissue plasminogen activator can be used for treatment cardiovascular diseases due to its small size, stability, high entrapment efficiency and slow rate of drug release.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"358 - 363"},"PeriodicalIF":1.2,"publicationDate":"2021-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43441888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-19DOI: 10.1080/1539445X.2021.1999270
C. Ianăși, Elena-Mirela Picioruș, Roxana Nicola, Ana-Maria Putz, A. Negrea, M. Ciopec, A. Len, L. Almásy
ABSTRACT Magnetic iron oxide-silica shell nanocomposites (IONP@SiO2) have been prepared in a two-step procedure. IONPs were obtained by coprecipitation of iron salts, and coated by silica in sol-gel method under sonication. Two IONP/silica ratios and two drying methods, heating in oven and supercritical CO2 drying, were used. The samples were analyzed using X-ray diffraction (XRD), infrared spectroscopy, magnetic measurements, small-angle neutron scattering (SANS), nitrogen sorption, and scanning electron microscopy (SEM) coupled with energy-dispersive X-ray analysis (EDX). The iron oxide silica nanocomposites obtained via supercritical drying exhibited higher values of the specific surface area and of saturation magnetization compared to the samples synthesized with the same iron oxide content but obtained after drying at 60 °C. Pd(II) adsorption experiments were performed on the materials prepared by supercritical drying. The maximum adsorption capacity 6.5 mg/g showed that the materials can be used as good and cheap adsorbent for palladium ions from aquatic environment.
{"title":"Synthesis and characterization of magnetic iron oxide – silica nanocomposites used for adsorptive recovery of palladium (II)","authors":"C. Ianăși, Elena-Mirela Picioruș, Roxana Nicola, Ana-Maria Putz, A. Negrea, M. Ciopec, A. Len, L. Almásy","doi":"10.1080/1539445X.2021.1999270","DOIUrl":"https://doi.org/10.1080/1539445X.2021.1999270","url":null,"abstract":"ABSTRACT Magnetic iron oxide-silica shell nanocomposites (IONP@SiO2) have been prepared in a two-step procedure. IONPs were obtained by coprecipitation of iron salts, and coated by silica in sol-gel method under sonication. Two IONP/silica ratios and two drying methods, heating in oven and supercritical CO2 drying, were used. The samples were analyzed using X-ray diffraction (XRD), infrared spectroscopy, magnetic measurements, small-angle neutron scattering (SANS), nitrogen sorption, and scanning electron microscopy (SEM) coupled with energy-dispersive X-ray analysis (EDX). The iron oxide silica nanocomposites obtained via supercritical drying exhibited higher values of the specific surface area and of saturation magnetization compared to the samples synthesized with the same iron oxide content but obtained after drying at 60 °C. Pd(II) adsorption experiments were performed on the materials prepared by supercritical drying. The maximum adsorption capacity 6.5 mg/g showed that the materials can be used as good and cheap adsorbent for palladium ions from aquatic environment.","PeriodicalId":22140,"journal":{"name":"Soft Materials","volume":"20 1","pages":"S68 - S75"},"PeriodicalIF":1.2,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42994136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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