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Prevalence and factors associated with suicidal behaviors in a cross-sectional sample of Nigerian young adults 尼日利亚年轻人自杀行为的流行率和相关因素
Pub Date : 2021-07-01 DOI: 10.4103/TPSY.TPSY_24_21
Opakunle Tolulope, Opakunle Olubukola, A. Olutayo
Objective: In this study, we intended to assess the prevalence of suicidal behaviors and their associated factors among Nigerian young adults. Methods: This is a cross-sectional descriptive study involving 1171 Nigerian young adults from the six geopolitical regions of Nigeria. They completed a study-specific sociodemographic questionnaire, Suicidal Behaviors Questionnaire-Revised Scale, Satisfaction with Life Scale, 10-item Drug Abuse Screening Test, Hospital Anxiety and Depression Scale, and Rosenberg Self-Esteem Scale. Results: The mean age ± standard deviation of the respondents was 24.92 ± 2.42 years. The lifetime suicidal ideation, plan, and attempt were 9.6%, 5.7%, and 2.6%, respectively. Of them, 7.1% had the 12-month suicidal ideation, and 4.8% were at risk of suicide attempt. Totally, 9.6% of the respondents had high suicide risk. The symptoms of depression and anxiety were present in 13.5% and 23.1% of the respondents, respectively. Suicidal behaviors among Nigerian young adults were significantly associated with dissatisfaction with life (p < 0.05), anxiety (p < 0.001), drug abuse (p < 0.001), and low self-esteem (p < 0.01). Conclusion: Suicidal behaviors were relatively high among Nigerian young adults, and were associated with dissatisfaction with life, anxiety, psychoactive substance use, and low self-esteem.
目的:在本研究中,我们旨在评估尼日利亚年轻人自杀行为的患病率及其相关因素。方法:这是一项横断面描述性研究,涉及来自尼日利亚六个地缘政治地区的1171名尼日利亚年轻人。他们完成了一份社会人口学调查问卷、自杀行为问卷修正量表、生活满意度量表、10项药物滥用筛选测试、医院焦虑和抑郁量表以及罗森博格自尊量表。结果:被调查者的平均年龄±标准差为24.92±2.42岁。终生自杀意念、计划和企图分别为9.6%、5.7%和2.6%。其中7.1%有12个月的自杀意念,4.8%有自杀倾向。总共有9.6%的受访者有高自杀风险。有抑郁和焦虑症状的受访者分别占13.5%和23.1%。尼日利亚年轻人自杀行为与生活不满意(p < 0.05)、焦虑(p < 0.001)、药物滥用(p < 0.001)和自卑(p < 0.01)显著相关。结论:自杀行为在尼日利亚年轻人中相对较高,并与生活不满意、焦虑、精神活性物质使用和低自尊有关。
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引用次数: 1
Paliperidone-induced dose-dependent sialorrhea treated with biperiden: A case report 利培酮治疗剂量依赖性唾液漏1例
Pub Date : 2021-07-01 DOI: 10.4103/TPSY.TPSY_29_21
Ji Lin, Pei Wu
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引用次数: 2
Isobaric tags for relative and absolute quantitation in identifying proteins for clozapine treatment response in patients with schizophrenia: A preliminary study 用于鉴定精神分裂症患者氯氮平治疗反应蛋白的相对和绝对定量等压标签:一项初步研究
Pub Date : 2021-07-01 DOI: 10.4103/TPSY.TPSY_27_21
Chin-Chuen Lin, H. Su, J. Shiea, Tiao-Lai Huang
Objective: Schizophrenia is a mental disorder characterized by reduced social engagement, abnormal emotional expression, and a lack of motivation. Isobaric tags for relative and absolute quantitation (iTRAQ) are a novel proteomic technique. In this study, we intended to identify potential biomarkers for predicting clozapine treatment response using iTRAQ. Methods: We identified patients with schizophrenia that responded to a four-week treatment with clozapine. Patient's peripheral blood mononuclear cells (PBMC) were collected before and after treatment. iTRAQ-based proteomics analysis was done to identify differentially expressed proteins in PBMC before and after treatment. STRING analysis map was built, and a target protein was selected. Western blot validation was then done. Results: In 10 identified clozapine treatment-responsive patients, we screened 2,735 proteins. Nine downregulated proteins and 11 upregulated proteins were differentially expressed by 1.5-fold after clozapine treatment. STRING network analysis revealed a series of apolipoproteins, and only apolipoprotein A4 (APOA-IV) was selected for validation. Western blot validations showed that protein levels of APOA-IV were significantly most downregulated in the patient after clozapine treatment (p = 0.05). Conclusion: In this study, we integrated clinical observation data, bioinformational protein interaction analysis, and iTRAQ labeling to study proteomics in patients with schizophrenia successfully treated with clozapine. We suggest that APOA-IV protein can be a biomarker for predicting clozapine treatment response in patients with schizophrenia. But these results in this study need a larger sample size to be validated.
目的:精神分裂症是一种以社交活动减少、情绪表达异常和缺乏动力为特征的精神障碍。等压标签相对和绝对定量(iTRAQ)是一种新的蛋白质组学技术。在这项研究中,我们打算用iTRAQ确定预测氯氮平治疗反应的潜在生物标志物。方法:我们确定了对氯氮平治疗有反应的精神分裂症患者。治疗前后采集患者外周血单个核细胞(PBMC)。基于itraq的蛋白质组学分析鉴定治疗前后PBMC中差异表达的蛋白。构建STRING分析图谱,选择目标蛋白。然后进行Western blot验证。结果:在10例氯氮平治疗应答的患者中,我们筛选了2735个蛋白。氯氮平治疗后,9个下调蛋白和11个上调蛋白的差异表达量为1.5倍。STRING网络分析显示了一系列载脂蛋白,仅选择载脂蛋白A4 (APOA-IV)进行验证。Western blot检测结果显示,经氯氮平治疗后,APOA-IV蛋白水平明显下调(p = 0.05)。结论:本研究结合临床观察数据、生物信息蛋白相互作用分析和iTRAQ标记,研究氯氮平治疗成功的精神分裂症患者的蛋白质组学。我们认为APOA-IV蛋白可以作为预测精神分裂症患者氯氮平治疗反应的生物标志物。但本研究的这些结果需要更大的样本量来验证。
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引用次数: 0
Chen's reply on “A comment on risk of teenage pregnancy among adolescents with borderline personality disorder” 陈女士对“关于边缘型人格障碍青少年怀孕风险的评析”的回复
Pub Date : 2021-07-01 DOI: 10.4103/TPSY.TPSY_32_21
Mu-Hong Chen
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引用次数: 0
Cognitive deficits correlated with increased latency of event-related potentials in drug-free patients with generalized anxiety disorder 无药物的广泛性焦虑障碍患者的认知缺陷与事件相关电位潜伏期增加相关
Pub Date : 2021-07-01 DOI: 10.4103/TPSY.TPSY_28_21
Shuo-En Hsu, Lan-Ting Lee, H. Tsai, M. Chi, K. Chen, I. Lee, P. Chen, Yen Kuang Yang
Objective: Few studies have identified a relationship between cognitive deficits and altered event-related potentials (ERPs), which measure the synchronous activity of neurons in response to a stimulus in patients with generalized anxiety disorder (GAD). In this study, we intended to explore the relation between cognitive function and ERP in patients with GAD. Methods: Fourteen drug-free participants with GAD and 14 healthy controls were recruited. ERPs were measured, and neuropsychological tests were administered. We compared the differences of the data between two groups of the study participants. Results: Poor performances of full IQ and the numbers of the categories completed on the Wisconsin Card Sorting Test were found significantly correlated with increased frontal lobe latency in the patients with GAD (Spearman's ρ = −0.70, p < 0.05; Spearman's ρ = −0.85, p < 0.01), respectively, but not in the controls. Conclusion: As ERPs represent an index of information speed, we propose that patients with GAD could exhibit deficits in tasks requiring mental speed.
目的:很少有研究确定认知缺陷与事件相关电位(ERPs)改变之间的关系,ERPs测量广泛性焦虑障碍(GAD)患者对刺激反应的神经元同步活动。本研究旨在探讨广泛性焦虑症患者认知功能与ERP的关系。方法:招募14名无药物的广泛性焦虑症患者和14名健康对照者。测量erp,并进行神经心理测试。我们比较了两组研究参与者之间数据的差异。结果:GAD患者的全智商和威斯康辛卡片分类测验的分类数较差与额叶潜伏期增加显著相关(Spearman’s ρ = - 0.70, p < 0.05;Spearman’s ρ = - 0.85, p < 0.01),而对照组无此差异。结论:由于erp是信息速度的一个指标,我们认为广泛性焦虑症患者可能在需要思维速度的任务中表现出缺陷。
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引用次数: 0
A comment on risk of teenage pregnancy among adolescents with borderline personality disorder: A nationwide longitudinal study 边缘型人格障碍青少年怀孕风险的评价:一项全国性的纵向研究
Pub Date : 2021-07-01 DOI: 10.4103/TPSY.TPSY_31_21
Pei-Hsin Kao, Fong-Lin Jang
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引用次数: 0
The Prevalence of Constipation and Its Risk Factors in Patients with Schizophrenia 精神分裂症患者便秘的患病率及其危险因素
Pub Date : 2021-04-01 DOI: 10.4103/tpsy.tpsy_20_21
Chih- Chang, Hsing-Kang Chen
Objective: Constipation is a common symptom in schizophrenia population. Patients treated with antipsychotic drugs are more likely to have constipation. In this study, we intended to identify possible associations and risk factors between schizophrenia patients and constipation. Methods: Patients with schizophrenia (n = 240) were recruited. In this cross-sectional study, we collected information of their socio-demographic and clinical details. Their psychotic symptoms were evaluated using clinical interview with positive and negative syndrome scale (PANSS). Results: In this study, the prevalence of constipation was 59.8%. Odds ratio (OR) (95% confidence interval [CI]) of PANSS average score, 1.018 (1.003–1.034), p < 0.05); OR (95% CI) of using second-generation antipsychotics (SGAs) solely, 3.475 (1.201–10.056), p < 0.05); and OR (95% CI) of using anticholinergic drugs, 1.853 (1.024–3.353), p < 0.05) were significantly associated with constipation. Conclusion: The prevalence of constipation is extremely high in this sample. In those patients who had severe psychotic symptoms, prescription of SGAs or anticholinergic agents, the focus should be on early detection, monitoring the constipation side effect, and early intervention.
目的:便秘是精神分裂症人群的常见症状。服用抗精神病药物的患者更容易出现便秘。在这项研究中,我们试图确定精神分裂症患者和便秘之间可能的关联和危险因素。方法:选取精神分裂症患者240例。在这项横断面研究中,我们收集了他们的社会人口学和临床细节信息。采用阳性和阴性症状量表(PANSS)进行临床访谈。结果:本组患者便秘发生率为59.8%。PANSS平均评分的优势比(OR)(95%可信区间[CI])为1.018 (1.003 ~ 1.034),p < 0.05;单独使用第二代抗精神病药物(SGAs)的OR (95% CI)为3.475 (1.201 ~ 10.056),p < 0.05;使用抗胆碱能药物的OR (95% CI)为1.853 (1.024 ~ 3.353),p < 0.05)与便秘显著相关。结论:该样本中便秘的发生率极高。对于有严重精神病症状的患者,应注意早期发现,监测便秘副作用,早期干预。
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引用次数: 0
Prescription patterns and trends of anxiolytics and hypnotics/sedatives among child and adolescent patients with psychiatric illnesses in a psychiatric center of northern Taiwan 台湾北部某精神科中心儿童及青少年精神疾病患者抗焦虑药及催眠/镇静剂的处方模式及趋势
Pub Date : 2021-04-01 DOI: 10.4103/tpsy.tpsy_18_21
S. Cheng, Hsiao-Ju Sun, H. Chan
Background: The prevalence of prescriptions of anxiolytics and hypnotics/sedatives for child and adolescent patients with psychiatric illnesses is increasing over the world. No studies exist to focus on the prescription trends and patterns of anxiolytics and hypnotics/sedatives for child and adolescent patients in psychiatric hospitals of Taiwan. Methods: In this retrospective study for all outpatients who were equal or younger than 18 years of age in a psychiatric service, we collected related study variables from the study psychiatric services from 2006 to 2015. Reviewing the electronic medical information system, we extracted both patients' demographic or clinical data (such as sex, age, as well as psychiatric diagnoses), and prescriptions of anxiolytics and hynotics/sedatives. Results: During the study period, the proportion of patients received anxiolytics and hypnotics/sedatives was decreased significantly (from 9.16% in 2006 to 5.85% in 2015, p < 0.001). The proportion of patients received anxiolytics was significantly decreased (from 5.34% in 2006 to 4.54% in 2015, p > 0.05), while hypnotics/sedatives was also decreased significantly (from 5.35% to 2.27%, p < 0.001). Logistic regression analysis showed that the use of anxiolytics and hypnotics/sedatives was significantly associated with age (p < 0.001), gender (p < 0.001), patients' status of catastrophic illnesses (p < 0.001), and diseases (p < 0.001). Conclusion: Anxiolytics and hypnotics/sedatives have the rôles in the treatment of child and adolescent patients with psychiatric Illnesses. Clinicians should be aware of the adverse events of these medications and prescribe them carefully for this population. Certainly, we need more well-designed clinical studies to study the safety and efficacy of anxiolytics and hypnotics/sedatives medications for children and adolescents.
背景:在世界范围内,儿童和青少年精神疾病患者使用抗焦虑药和催眠药/镇静剂的情况正在增加。台湾精神病院儿童与青少年患者抗焦虑药与催眠/镇静剂的处方趋势与模式,尚无相关研究。方法:在这项回顾性研究中,我们收集了2006年至2015年研究精神科服务中所有年龄相等或小于18岁的门诊患者的相关研究变量。回顾电子医疗信息系统,我们提取了患者的人口统计或临床数据(如性别、年龄和精神诊断),以及抗焦虑药和催眠药/镇静剂的处方。结果:研究期间,使用抗焦虑药和催眠/镇静药的患者比例明显下降(由2006年的9.16%降至2015年的5.85%,p < 0.001)。使用抗焦虑药的患者比例明显下降(从2006年的5.34%下降到2015年的4.54%,p < 0.05),使用催眠/镇静药的患者比例也明显下降(从5.35%下降到2.27%,p < 0.001)。Logistic回归分析显示,抗焦虑药和催眠/镇静剂的使用与年龄(p < 0.001)、性别(p < 0.001)、患者的灾难性疾病状态(p < 0.001)和疾病(p < 0.001)显著相关。结论:抗焦虑药与催眠/镇静药在儿童和青少年精神疾病患者的治疗中具有rôles的优势。临床医生应该意识到这些药物的不良事件,并为这一人群谨慎地开处方。当然,我们需要更多精心设计的临床研究来研究儿童和青少年抗焦虑药和催眠/镇静药物的安全性和有效性。
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引用次数: 0
The association between depression or stress and internet addiction 抑郁或压力与网瘾之间的联系
Pub Date : 2021-04-01 DOI: 10.4103/tpsy.tpsy_19_21
Akash Vishwakarma, M. Sharma
Objective: In the current study, we intended to examine the association between affective states (depression, stress, and anxiety) and Internet addiction (IA). Methods: The study sample consisted of 291 individuals with the age of 18–40 years. We used an online survey on study participants with the IA Scale (20 items) and the Depression Anxiety Stress Scale-21. Results: The mean age ± standard deviation of the sample was 23.58 ± 4.40 years. The results of stepwise regression analysis indicated that depression (p < 0.001) and stress (p < 0.01) significantly contributed to IA. Anxiety did not significantly contribute to IA. Conclusion: This study showed that depression and stress were related to Internet use. This finding implies the need for early identifying depression and stress for giving an appropriate intervention for the individuals with IA.
目的:本研究旨在探讨情感状态(抑郁、压力和焦虑)与网络成瘾(IA)之间的关系。方法:研究样本为291例,年龄18 ~ 40岁。我们使用IA量表(20项)和抑郁焦虑压力量表-21对研究参与者进行在线调查。结果:样本平均年龄±标准差为23.58±4.40岁。逐步回归分析结果显示,抑郁(p < 0.001)和应激(p < 0.01)对IA有显著影响。焦虑对IA无显著影响。结论:本研究显示抑郁和压力与网络使用有关。这一发现意味着需要早期识别抑郁症和压力,并对IA患者进行适当的干预。
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引用次数: 2
Using lorazepam-assisted interview to help with narrative exposure therapy in posttraumatic stress disorder: A case report 劳拉西泮辅助访谈对创伤后应激障碍叙事暴露疗法的帮助:一例报告
Pub Date : 2021-04-01 DOI: 10.4103/tpsy.tpsy_13_21
Lue-En Lee, Chih-Min Liu
{"title":"Using lorazepam-assisted interview to help with narrative exposure therapy in posttraumatic stress disorder: A case report","authors":"Lue-En Lee, Chih-Min Liu","doi":"10.4103/tpsy.tpsy_13_21","DOIUrl":"https://doi.org/10.4103/tpsy.tpsy_13_21","url":null,"abstract":"","PeriodicalId":22278,"journal":{"name":"Taiwanese Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90164240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Taiwanese Journal of Psychiatry
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