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The East and Central African Journal of Pharmaceutical Sciences最新文献

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Brine shrimp lethality of a glutarimide alkaloid from Croton sylvaticus Hochst 海参戊二酰亚胺生物碱对卤虾的致死性研究
Pub Date : 2006-09-06 DOI: 10.4314/ECAJPS.V8I1.9716
M. Kapingu, Z. Mbwambo, M. Moshi, Jj Magadula
No Abstract. The East and Central African Journal of Pharmaceutical Sciences Vol. 8(1) 2005: 3-5
没有抽象的。东非和中非医药科学杂志Vol. 8(1) 2005: 3-5
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引用次数: 5
Anthelminthic activity of Withania somnifera . L. Dunal water extract in sheep 牡丹的虫栖活性。绵羊杜纳尔水提取物
Pub Date : 2006-09-06 DOI: 10.4314/ECAJPS.V8I1.9717
J. O. Miaron, Pg Wahome, Im Mapenay
No Abstract. The East and Central African Journal of Pharmaceutical Sciences Vol 8(1) 2005: 6-9
没有抽象的。东非和中非医药科学杂志Vol 8(1) 2005: 6-9
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引用次数: 2
Human poisoning with plants in Kenya 肯尼亚人因植物中毒
Pub Date : 2006-09-06 DOI: 10.4314/ECAJPS.V8I1.9718
C. Maitai, N. Mungai
No Abstract. The East and Central African Journal of Pharmaceutical Sciences Vol. 8(1) 2005:10-13
没有抽象的。东非和中非医药科学杂志Vol. 8(1) 2005:10-13
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引用次数: 1
Formulation and evaluation of tenoxicam gels for tropical use 热带用替诺昔康凝胶的配方及评价
Pub Date : 2006-09-06 DOI: 10.4314/ECAJPS.V8I1.9719
S. M. Maru, F. Manvi
No Abstract. The East and Central African Journal of Pharmaceutical Sciences Vol. 8(1) 2005: 14-19
没有抽象的。东非和中非医药科学杂志Vol. 8(1) 2005: 14-19
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引用次数: 0
Adherence to antiretroviral drugs in North-Central zone of Nigeria 尼日利亚中北部地区抗逆转录病毒药物的依从性
Pub Date : 2006-07-21 DOI: 10.4314/ECAJPS.V7I3.9713
M. Mohammed, R. Sarki
A cross-sectional study of 110 patients attending State House Clinic, Abuja were assessed for compliance in time and dose of anti-retroviral drugs for one month. One hundred and five of the patients complied to taking the drugs (taking complience >95%) and compliance to the dosage was also good (98.1%). However, the mean timing compliance was not good (73.1%). Forgetfulness (7.0%) and travelling out of town (4.3%) were the commonest reasons for missing a dose. Forgetfulness (20%), non-availability of food (25.5%) and stigmatization of carrying drugs around (3.6%) were the commonest reasons for altering the dosing time. It was concluded that the timing compliance was low and that may affect the success of the program. Patients should be encouraged to take the right dose at the right time. Keywords : adherence, antiretroviral drugs, taking compliance, timing compliance, dosing compliance The East and Central African Journal of Pharmaceutical Sciences Vol. 7(3) 2004: 52-55
对在阿布贾州议会诊所就诊的110名患者进行了一项横断面研究,评估了一个月抗逆转录病毒药物的时间和剂量依从性。105例患者遵医服药(服药依从性>95%),用药依从性也较好(98.1%)。然而,平均时间依从性不佳(73.1%)。健忘(7.0%)和出城旅行(4.3%)是错过一剂药的最常见原因。健忘(20%)、没有食物(25.5%)和对携带药物感到羞耻(3.6%)是改变给药时间的最常见原因。得出的结论是,时间依从性很低,这可能会影响计划的成功。应鼓励患者在适当的时间服用适当的剂量。关键词:依从性,抗逆转录病毒药物,服用依从性,定时依从性,剂量依从性东非和中非医药科学杂志Vol. 7(3) 2004: 52-55
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引用次数: 13
Formulation of a topical sun protection cream for people with albinism 针对白化病患者的局部防晒霜配方
Pub Date : 2006-07-21 DOI: 10.4314/ECAJPS.V7I3.9715
Moipone L Moloisane, W. Liebenberg, A. P. Lötter, M. M. Villiers
The aim of this investigation was to design and develop a sun protection product for people with albinism that is affordable, applicable to their specific skin condition, and provide them with the maximum sun protection possible. To achieve the required Sun Protection Factor value of > 20, simple creams were combined with very fine inorganic oxides (zinc oxide and titanium dioxide) and organic sunscreen filters (2-ethylhexyl cinnamate and octyl methoxycinnamate). These combinations also ensured high UV A /UV B protection ratios. The physical stability and change in Sun Protection Factor were for products stored for 8 weeks at 25°C (60% RH) and 45°C (75% RH) were also determined. Hypoallergenic and physically stable product(s) were formulated with SPF values between 20 to 30 and UV A /UV B ratios above 0.8 by combining simple cream formulations with fine particle inorganic oxides and organic UV protection agents. This approach offered an opportunity to formulate broad-spectrum sunscreen products that met the needs of albinos. Keywords : sun protection cream, sun protection factor, albinism The East and Central African Journal of Pharmaceutical Sciences Vol. 7(3) 2006: 60-64
这项调查的目的是为白化病患者设计和开发一种价格合理、适用于他们特定皮肤状况的防晒产品,并为他们提供最大程度的防晒。为了达到所需的防晒系数值> 20,简单的面霜与非常精细的无机氧化物(氧化锌和二氧化钛)和有机防晒过滤器(2-乙基己基肉桂酸酯和辛基甲氧基肉桂酸酯)结合在一起。这些组合还确保了高UV A /UV B防护比率。测定产品在25°C (60% RH)和45°C (75% RH)条件下保存8周的物理稳定性和防晒系数的变化。通过将简单的乳霜配方与细颗粒无机氧化物和有机紫外线防护剂相结合,配制出具有低过敏性和物理稳定性的产品,SPF值在20至30之间,UV A /UV B比值在0.8以上。这种方法为制定满足白化病患者需求的广谱防晒产品提供了机会。关键词:防晒霜,防晒因子,白化病[j] .东非和中非医药科学杂志Vol. 7(3) 2006: 60-64
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引用次数: 0
Direct compression properties of microcrystalline cellulose and its silicified product 微晶纤维素及其硅化产物的直接压缩性能
Pub Date : 2006-07-21 DOI: 10.4314/ECAJPS.V7I3.9714
J. Alfa, Michael A. Odeniyi, K. T. Jaiyeoba
The influence of silicified microcrystalline cellulose (SMCC) on the flow, compaction and tableting properties of metronidazole powder was investigated. The study compared medium grades of both SMCC and standard microcrystalline cellulose (MCC) as direct compressible excipients. The bulk densities, Hausner quotient (H f ), compressibility index (CI) and angle of repose of the formulations were evaluated. Compacts of the metronidazole containing different concentrations of SMCC or MCC (10-30% w/w) were made at compression forces of 20 to 30 KN and evaluated for their physical characteristics. The flow behaviour of the drug was improved in the presence of SMCC. Formulations containing 25% w/w SMCC had lower CI and H f values than those made with 30% w/w MCC. The crushing strength of the compacts increased with concentration of the excipients at all the compression forces used. At similar concentrations of SMCC and MCC, compacts of the formulations containing SMCC exhibited higher crushing strengths. SMCC shows great promise as a filler-binder-disintegrant in direct compression of oral tablet formulations from both mechanical and economic viewpoints. Keywords : metronidazole, tablets, direct compression, Silicified Microcrystalline cellulose, microcrystalline cellulose The East and Central African Journal of Pharmaceutical Sciences Vol. 7(3) 2004: 56-59
研究了硅化微晶纤维素(SMCC)对甲硝唑粉末流动、压实和压片性能的影响。该研究比较了中等等级的SMCC和标准微晶纤维素(MCC)作为直接可压缩赋形剂。对配方的容重、豪斯纳商(H f)、压缩指数(CI)和休止角进行了评价。在20 ~ 30 KN的压缩力下,制备了含有不同浓度SMCC或MCC (10 ~ 30% w/w)的甲硝唑压片,并对其物理特性进行了评价。在SMCC的存在下,药物的流动行为得到了改善。含有25% w/w SMCC的配方比含有30% w/w mccc的配方CI和H - f值更低。在所有使用的压缩力下,压实剂的破碎强度随辅料浓度的增加而增加。在SMCC和MCC浓度相同的情况下,含SMCC配方的压块具有更高的抗压强度。从力学和经济的角度来看,SMCC作为一种填料-粘结剂-崩解剂在口服片剂配方的直接压缩中都有很大的前景。关键词:甲硝唑,片剂,直接压缩,硅化微晶纤维素,微晶纤维素。东非和中非医药科学杂志Vol. 7(3) 2004: 56-59
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引用次数: 5
An approach to effective disinfection of salon items [clippers, combs and scissors] 沙龙用品(剪刀、梳子、剪刀)的有效消毒方法
Pub Date : 2006-07-21 DOI: 10.4314/ECAJPS.V7I3.9712
O. Olonitola, P. Olurinola, J. Ehinmidu
Antibacterial susceptibility patterns of some bacteria isolated from selected barbing salons in parts of Northern Nigeria was studied for the purpose of developing a disinfectant system suitable for use in salons. The K-values for selected cells ranged from 0.0072 to 0.0399 (benzalkonium chloride), and from 0.0062 to 0.1338 (propylene glycol) as against a range of 0.0147 to 0.1343 when the two chemicals were combined. The observed D-value range of 64.5 to 99 (benzalkonium chloride), 31.5 to 105 (Propylene glycol) and 21 to 24 (admixture of the two chemicals) were exploited in the development of “SALONSEFE” – a salon disinfectant that was able to eliminate 105 cfu/ ml (of the most resistant bacterial isolated in these studies) completely in 60 seconds. Keywords : salonsafe, antibacterial, disinfectant, salon, K-value, D-value The East and Central African Journal of Pharmaceutical Sciences Vol. 7(3) 2004: 47-51
研究了从尼日利亚北部部分地区选定的倒刺沙龙中分离出的一些细菌的抗菌敏感性模式,目的是开发适合于沙龙使用的消毒系统。所选细胞的k值范围从0.0072到0.0399(苯扎氯铵),从0.0062到0.1338(丙二醇),而当两种化学物质结合在一起时,k值范围为0.0147到0.1343。观察到的d值范围为64.5至99(苯扎氯铵),31.5至105(丙二醇)和21至24(两种化学品的混合物),用于开发“SALONSEFE”——一种沙龙消毒剂,能够在60秒内完全消除105 cfu/ ml(这些研究中分离出的最具耐药性的细菌)。关键词:沙龙安全,抗菌,消毒剂,沙龙,k值,d值。东非和中非医药科学杂志Vol. 7(3) 2004: 47-51
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引用次数: 2
Evidence of male attractants for fruit flies in the leaf extract of Schinus molle 凤尾蛇叶提取物中雄性引诱剂对果蝇的影响
Pub Date : 2006-05-17 DOI: 10.4314/ECAJPS.V7I2.9709
N. Gikonyo, S. Lux
Attractiveness of odor from leaves of pepper tree ( Schinus molle ) to male Ceratitis rosa and C. capitata was evaluated in a wind-tunnel. Odor from the leaves was as attractive to male C. rosa as Trimedlure and more attractive to C. capitata males. Responses of both male and female C. cosyra, C. rosa and C. capitata when presented with an extract from S. molle leaves were also evaluated. The flies were highly activated and only males were attracted and landed on the treated dispenser. Onset of activation was more rapid for C. rosa and C. capitata than for C. cosyra . Similarly, large numbers of male C. capitata and C. rosa landed on treated dispenser than C. cosyra . Analysis of the S. molle extract by gas chromatography and gas chromatography–mass spectrometry revealed several monoterpenes and sesquiterpenes. Some of the terpenoids or their blend may constitute a male attractant (parapheromone) for C. capitata, C. rosa and possibly other fruit flies attracted to Trimedlure. Keywords : fruit fly, Ceratitis capitata, C. cosyra, C. rosa , parapheromone, Schinus molle , pepper tree East and Central African Journal of Pharmaceutical Sciences Vol. 7 2004: 27-33
用风洞法评价了胡椒树叶片气味对雄性玫瑰角膜炎和头型角膜炎的吸引力。来自叶片的气味对雄性蔷薇的吸引力与三叶草相同,对雄性的吸引力更大。此外,我们还研究了花楸叶提取物对雌雄花楸、rosa和capitata的反应。苍蝇被高度激活,只有雄性苍蝇被吸引并降落在处理过的分配器上。玫瑰和冠状冠状冠的激活开始速度要快于子叶冠。同样地,在处理过的分配器上,有大量的雄性头花和玫瑰花落在处理过的分配器上。通过气相色谱和气相色谱-质谱联用分析,发现了多种单萜类和倍半萜类化合物。某些萜类化合物或它们的混合物可能构成雄性引诱剂(副引诱素),对被三叶草引诱的红腹小锥虫、红腹小锥虫和其他可能的果蝇具有引诱作用。关键词:果蝇,头角性角膜炎,cosyra, C. rosa, parapheromone, Schinus molle, pepper tree东非和中非医药科学杂志Vol. 7 2004: 27-33
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引用次数: 1
Investigation of synthetic spermaceti wax as a potential oral sustained release drug delivery system 合成脑蜡作为一种潜在的口服缓释给药体系的研究
Pub Date : 2006-05-17 DOI: 10.4314/ECAJPS.V7I2.9708
R. Chigwanda, A. Kuudzadombo
The present study was aimed at investigating drug release from spermaceti wax matrices. Materials such as ethylcellulose and methylcellulose were incorporated into the spermaceti wax matrices and release was evaluated. Spermaceti wax can form matrices that release drug in a sustained release fashion. Higuchi or first order release kinetics were found to explain drug release from spermaceti wax, spermaceti wax-ethylcellulose and spermaceti wax-methylcellulose matrices. However, ethylcellulose and methylcellulose enhanced release rate from spermaceti wax matrices. Spermaceti wax matrices can be used to provide drug delivery systems with prolonged action. Release rate from such systems can be regulated by incorporation of materials such as ethylcellulose and methylcellulose. Keywords : carnauba wax, sustained release, particle size, and kinetics East and Central African Journal of Pharmaceutical Sciences Vol. 7 2004: 24-26
本研究旨在研究药物在脑蜡基质中的释放。将乙基纤维素和甲基纤维素等材料掺入鲸蜡基质中,并对其释放度进行了评估。脑蜡可以形成基质,以缓释方式释放药物。发现药物在脑蜡、脑蜡-乙基纤维素和脑蜡-甲基纤维素基质中的释放具有通口或一级释放动力学。然而,乙基纤维素和甲基纤维素提高了鲸蜡基质的释放速度。脑蜡基质可用于提供长效给药系统。这种体系的释放速率可以通过加入乙基纤维素和甲基纤维素等材料来调节。关键词:巴西棕榈蜡,缓释,粒度和动力学东非和中非医药科学杂志Vol. 7 2004: 24-26
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引用次数: 1
期刊
The East and Central African Journal of Pharmaceutical Sciences
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