{"title":"Plastic surgeon who tried to kill colleague is struck off.","authors":"Clare Dyer","doi":"10.1136/bmj.s538","DOIUrl":"https://doi.org/10.1136/bmj.s538","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"86 1","pages":"s538"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What doctors need to know about meningitis B now.","authors":"Emma Wilkinson","doi":"10.1136/bmj.s537","DOIUrl":"https://doi.org/10.1136/bmj.s537","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"8 1","pages":"s537"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josef Isung,Lorena Fernández de la Cruz,David Mataix-Cols
{"title":"Innovation in treating obsessive-compulsive disorder will not solve the care gap.","authors":"Josef Isung,Lorena Fernández de la Cruz,David Mataix-Cols","doi":"10.1136/bmj.s472","DOIUrl":"https://doi.org/10.1136/bmj.s472","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"11 1","pages":"s472"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Special educational needs reforms are a good start to resolving the crisis in schools-but where is the focus on health?","authors":"Ruth Gilbert","doi":"10.1136/bmj.s539","DOIUrl":"https://doi.org/10.1136/bmj.s539","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"11 1","pages":"s539"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The US must never support research and policies that inflict harm on Black communities.","authors":"Jeannette M Wade","doi":"10.1136/bmj.s524","DOIUrl":"https://doi.org/10.1136/bmj.s524","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"57 1","pages":"s524"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A sole treatment for hip arthritis . . . and other research.","authors":"Tom Nolan","doi":"10.1136/bmj.s452","DOIUrl":"https://doi.org/10.1136/bmj.s452","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"57 1","pages":"s452"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katie Scandrett,Alice J Sitch,Jonathan Barratt,Elizabeth A Brettell,Paul Cockwell,R Neil Dalton,Jonathan James Deeks,Gillian Eaglestone,Philip A Kalra,Kamlesh Khunti,Fiona C Loud,Ryan Ottridge,Tracy Pellatt-Higgins,Aisling Potter,Ceri Rowe,Claire C Sharpe,Bethany Shinkins,Alison Smith,Paul E Stevens,Andrew J Sutton,Maarten W Taal,Edmund J Lamb
OBJECTIVESTo provide evidence on the longitudinal accuracy of glomerular filtration rate (GFR) estimating equations that include creatinine and cystatin C to monitor patients with moderate chronic kidney disease.DESIGNProspective, longitudinal, cohort study.SETTINGPrimary, secondary, and tertiary care across six centres in England, 1 April 2014 to 31 December 2017.PARTICIPANTS1229 adults (≥18 years) with moderate chronic kidney disease (creatinine estimated GFR of 30-59 mL/min/1.73 m2 for at least three successive months before recruitment).MAIN OUTCOME MEASURESAbility of estimating equations to monitor GFR over three years, with slope deviations from reference measured GFR (iohexol clearance) within ±3 mL/min/1.73 m2/year indicating agreement. Ability of GFR estimating equations to detect disease progression (ie, a reduction in measured GFR of ≥25% with a reduction in disease category).RESULTSAfter three years, 875 participants had measured and estimated GFR data recorded at the start and end of the study and comprised the study cohort. Median measured GFR decreased from 48.1 mL/min/1.73 m2 at baseline to 43.6 mL/min/1.73 m2 at three years. GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and European Kidney Function Consortium (EKFC) estimating equations. Median change in measured GFR exceeded median change in estimated GFR for all equations. All equations achieved agreement with change in measured GFR in >72.5% of participants. Dual biomarker equations showed better agreement with change in measured GFR (CKD-EPIcreatinine-cystatin 78.6% of individuals, 95% confidence interval 75.8% to 81.3%; CKD-EPI(2021)creatinine-cystatin 78.1%, 75.2% to 80.8%; and EKFCcreatinine-cystatin 80.2%, 77.4% to 82.8%) than CKD-EPIcreatinine (73.1%, 70.1% to 76.1%) (all P<0.001). Progression of kidney disease was seen in 139 (15.9%) individuals. All GFR equations had poor sensitivity (<54.1%) but good specificity (>90.4%) for identifying progression of chronic kidney disease.CONCLUSIONSUnderestimation of the reduction in GFR by estimated GFR requires further investigation. Equations that included both creatinine and cystatin C more accurately monitored change in measured GFR than equations based on one biomarker. Increased use of combined biomarker equations in clinical practice could improve disease monitoring and potentially clinical care.STUDY REGISTRATIONISRCTN registry ISRCTN42955626.
{"title":"Accuracy of glomerular filtration rate estimation based on creatinine and cystatin C for monitoring moderate chronic kidney disease in adults: prospective, longitudinal cohort study.","authors":"Katie Scandrett,Alice J Sitch,Jonathan Barratt,Elizabeth A Brettell,Paul Cockwell,R Neil Dalton,Jonathan James Deeks,Gillian Eaglestone,Philip A Kalra,Kamlesh Khunti,Fiona C Loud,Ryan Ottridge,Tracy Pellatt-Higgins,Aisling Potter,Ceri Rowe,Claire C Sharpe,Bethany Shinkins,Alison Smith,Paul E Stevens,Andrew J Sutton,Maarten W Taal,Edmund J Lamb","doi":"10.1136/bmj-2025-085005","DOIUrl":"https://doi.org/10.1136/bmj-2025-085005","url":null,"abstract":"OBJECTIVESTo provide evidence on the longitudinal accuracy of glomerular filtration rate (GFR) estimating equations that include creatinine and cystatin C to monitor patients with moderate chronic kidney disease.DESIGNProspective, longitudinal, cohort study.SETTINGPrimary, secondary, and tertiary care across six centres in England, 1 April 2014 to 31 December 2017.PARTICIPANTS1229 adults (≥18 years) with moderate chronic kidney disease (creatinine estimated GFR of 30-59 mL/min/1.73 m2 for at least three successive months before recruitment).MAIN OUTCOME MEASURESAbility of estimating equations to monitor GFR over three years, with slope deviations from reference measured GFR (iohexol clearance) within ±3 mL/min/1.73 m2/year indicating agreement. Ability of GFR estimating equations to detect disease progression (ie, a reduction in measured GFR of ≥25% with a reduction in disease category).RESULTSAfter three years, 875 participants had measured and estimated GFR data recorded at the start and end of the study and comprised the study cohort. Median measured GFR decreased from 48.1 mL/min/1.73 m2 at baseline to 43.6 mL/min/1.73 m2 at three years. GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and European Kidney Function Consortium (EKFC) estimating equations. Median change in measured GFR exceeded median change in estimated GFR for all equations. All equations achieved agreement with change in measured GFR in >72.5% of participants. Dual biomarker equations showed better agreement with change in measured GFR (CKD-EPIcreatinine-cystatin 78.6% of individuals, 95% confidence interval 75.8% to 81.3%; CKD-EPI(2021)creatinine-cystatin 78.1%, 75.2% to 80.8%; and EKFCcreatinine-cystatin 80.2%, 77.4% to 82.8%) than CKD-EPIcreatinine (73.1%, 70.1% to 76.1%) (all P<0.001). Progression of kidney disease was seen in 139 (15.9%) individuals. All GFR equations had poor sensitivity (<54.1%) but good specificity (>90.4%) for identifying progression of chronic kidney disease.CONCLUSIONSUnderestimation of the reduction in GFR by estimated GFR requires further investigation. Equations that included both creatinine and cystatin C more accurately monitored change in measured GFR than equations based on one biomarker. Increased use of combined biomarker equations in clinical practice could improve disease monitoring and potentially clinical care.STUDY REGISTRATIONISRCTN registry ISRCTN42955626.","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"240 1","pages":"e085005"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emergency department doctor suspended for \"predatory\" behaviour over examinations of colleagues.","authors":"Clare Dyer","doi":"10.1136/bmj.s541","DOIUrl":"https://doi.org/10.1136/bmj.s541","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"2 1","pages":"s541"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"David Oliver: Unmet care and housing needs are often behind lengthy hospital admissions.","authors":"David Oliver","doi":"10.1136/bmj.s463","DOIUrl":"https://doi.org/10.1136/bmj.s463","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"9 1","pages":"s463"},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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