{"title":"The BMJ appeal 2025-26: Breaking the cycle of sexual violence in the Democratic Republic of the Congo demands action.","authors":" ","doi":"10.1136/bmj.s38","DOIUrl":"https://doi.org/10.1136/bmj.s38","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"397 1","pages":"s38"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bowel cancer: Tumour samples stored since the 1950s could shed light on rising cases in younger adults.","authors":"Jacqui Wise","doi":"10.1136/bmj.s45","DOIUrl":"https://doi.org/10.1136/bmj.s45","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"29 1","pages":"s45"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mounjaro: Experts issue warning over black market jabs, with fifth of areas still lacking NHS access.","authors":"Elisabeth Mahase","doi":"10.1136/bmj.s48","DOIUrl":"https://doi.org/10.1136/bmj.s48","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"57 1","pages":"s48"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The BMJ appeal 2025-26: How innovation is supporting those who need it most.","authors":"Anne Gulland","doi":"10.1136/bmj.r2673","DOIUrl":"https://doi.org/10.1136/bmj.r2673","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"264 1","pages":"r2673"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ovarian cancer: Age based blood test thresholds proposed to improve diagnosis.","authors":"Jacqui Wise","doi":"10.1136/bmj.s23","DOIUrl":"https://doi.org/10.1136/bmj.s23","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"29 1","pages":"s23"},"PeriodicalIF":0.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OBJECTIVETo investigate whether oral ivermectin or topical 5% permethrin can clinically cure scabies in index cases and in members of their households.DESIGNMulticentre, assessor blinded, cluster randomised clinical trial.SETTING28 French hospitals, 19 January 2016 to 16 December 2021.PARTICIPANTSIndex cases; adults and children weighing >15 kg with scabies, confirmed by dermoscopy.INTERVENTIONSIndex cases were randomly assigned to the ivermectin group or permethrin group (1:1 ratio). Each member of the cluster, defined as the household of each index case, received the same treatment as the index case, except for children weighing <15 kg who were prescribed topical 5% permethrin. All participants received oral ivermectin 200 µg/kg or 5% permethrin cream on day 0 and day 10. Permethrin cream was applied to the whole body, from head to toe.MAIN OUTCOME MEASURESThe primary outcome was clinical cure of the cluster on day 28 (ie, disappearance of clinical signs and symptoms of scabies for all cluster members). Secondary outcomes were index case and individual level analyses and safety. Dermatologists were used as assessors and were masked to the treatment.RESULTS507 participants in 142 households (clusters) were treated with ivermectin and 568 participants in 147 households received permethrin. Cluster level cure rates were 71.8% versus 88.5% (-16.7 percentage point difference, 95% confidence interval (CI) -26.3 to -7.1) for ivermectin versus permethrin. Secondary outcome percentage point differences also showed the inferiority of ivermectin compared with 5% permethrin for index cases (76.6% v 91.5%; percentage point difference -14.9, 95% CI -23.6 to -6.2) and participants (85.3% v 94.2%; -9.2 percentage point difference, -14.9 to -3.5). Intraclass correlation coefficients were higher for permethrin than ivermectin for all clusters (0.68, 95% CI 0.61 to 0.75 v 0.46, 0.37 to 0.56) and for cluster size >1 (0.67, 0.60 to 0.74 v 0.47, 0.37 to 0.56). Cutaneous adverse events were found in 11.9% and 15.6% of participants treated with ivermectin and permethrin, respectively.CONCLUSIONSThe results of this cluster randomised trial of classic scabies, confirmed by dermoscopy, did not show the non-inferiority of oral ivermectin compared with 5% permethrin cream, given on days 0 and 10, in achieving clinical cure of scabies on day 28 in index cases and their household members. Conversely, the trial showed the statistical superiority of 5% permethrin cream.TRIAL REGISTRATIONNCT02407782.
目的探讨伊维菌素口服或5%氯菊酯外用对指示病例及家庭成员疥疮的临床疗效。设计多中心、评估者盲法、聚类随机临床试验。28家法国医院，2016年1月19日至2021年12月16日。PARTICIPANTSIndex案件;成人和儿童体重150公斤，疥疮，经皮肤镜检查证实。干预指数随机分为伊维菌素组和氯菊酯组（比例为1:1）。聚类的每个成员（定义为每个指标病例的家庭）接受与指标病例相同的处理，但体重为1的儿童除外（0.67,0.60至0.74 v 0.47, 0.37至0.56）。在伊维菌素和氯菊酯治疗的参与者中，分别有11.9%和15.6%的人发现皮肤不良事件。结论经皮肤镜检查证实的经典疥疮整群随机试验结果显示，口服伊维菌素与5%氯菊酯乳膏在第0天和第10天对指示病例及其家庭成员的疥疮实现临床治愈的效果没有明显的非低效性。相反，试验显示5%氯菊酯乳膏具有统计学优势。REGISTRATIONNCT02407782审判。
{"title":"Oral ivermectin versus 5% permethrin cream to treat children and adults with classic scabies: multicentre, assessor blinded, cluster randomised clinical trial.","authors":"Franck Boralevi,Guillaume Simon,Charlotte Bernigaud,Jennifer Brun,Elisa Goujon,Jean-Luc Perrot,Alice Phan,Anne-Laure Hérissé,Annabel Maruani,Clélia Vanhaecke,Emmanuelle Couty,Claire Abasq-Thomas,Marine Fournet,Stéphanie Mallet,Emilie Brenaut,Thomas Hubiche,Xavier Balguerie,Frédéric Caux,Nathalie Beneton,Anne-Sophie Dutkiewicz,Henri Adamski,Hélène Aubert,Emmanuelle Bourrat,Caroline Couzan,Alexia Eyraud,Raphaël Janela-Lapert,Aurélie Marti,Juliette Miquel,Muriel Richard,Sébastien Barbarot,Bertille Bonniaud,Cécile Chabbert,Frédérique Delion,Monica Dinulescu,Tu-Anh Duong,Maxime Etienne,Gaëlle Hirsch,Camille Isnard,Flavien Huet,Emmanuelle Le Bidre,Sophie Leducq,Adeline Legrand,Sandrine Monestier,Fanny Morice-Picard,Julien Seneschal,Aurore Capelli,Caroline Lacoste,Christine Labrèze,Giulio Miraglia,Giao Do-Pham,Bruno Giraudeau,Olivier Chosidow","doi":"10.1136/bmj-2025-086277","DOIUrl":"https://doi.org/10.1136/bmj-2025-086277","url":null,"abstract":"OBJECTIVETo investigate whether oral ivermectin or topical 5% permethrin can clinically cure scabies in index cases and in members of their households.DESIGNMulticentre, assessor blinded, cluster randomised clinical trial.SETTING28 French hospitals, 19 January 2016 to 16 December 2021.PARTICIPANTSIndex cases; adults and children weighing >15 kg with scabies, confirmed by dermoscopy.INTERVENTIONSIndex cases were randomly assigned to the ivermectin group or permethrin group (1:1 ratio). Each member of the cluster, defined as the household of each index case, received the same treatment as the index case, except for children weighing <15 kg who were prescribed topical 5% permethrin. All participants received oral ivermectin 200 µg/kg or 5% permethrin cream on day 0 and day 10. Permethrin cream was applied to the whole body, from head to toe.MAIN OUTCOME MEASURESThe primary outcome was clinical cure of the cluster on day 28 (ie, disappearance of clinical signs and symptoms of scabies for all cluster members). Secondary outcomes were index case and individual level analyses and safety. Dermatologists were used as assessors and were masked to the treatment.RESULTS507 participants in 142 households (clusters) were treated with ivermectin and 568 participants in 147 households received permethrin. Cluster level cure rates were 71.8% versus 88.5% (-16.7 percentage point difference, 95% confidence interval (CI) -26.3 to -7.1) for ivermectin versus permethrin. Secondary outcome percentage point differences also showed the inferiority of ivermectin compared with 5% permethrin for index cases (76.6% v 91.5%; percentage point difference -14.9, 95% CI -23.6 to -6.2) and participants (85.3% v 94.2%; -9.2 percentage point difference, -14.9 to -3.5). Intraclass correlation coefficients were higher for permethrin than ivermectin for all clusters (0.68, 95% CI 0.61 to 0.75 v 0.46, 0.37 to 0.56) and for cluster size >1 (0.67, 0.60 to 0.74 v 0.47, 0.37 to 0.56). Cutaneous adverse events were found in 11.9% and 15.6% of participants treated with ivermectin and permethrin, respectively.CONCLUSIONSThe results of this cluster randomised trial of classic scabies, confirmed by dermoscopy, did not show the non-inferiority of oral ivermectin compared with 5% permethrin cream, given on days 0 and 10, in achieving clinical cure of scabies on day 28 in index cases and their household members. Conversely, the trial showed the statistical superiority of 5% permethrin cream.TRIAL REGISTRATIONNCT02407782.","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"5 1","pages":"e086277"},"PeriodicalIF":0.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trump and RFK Jr are dismantling public health-aided and abetted by powerful doctors.","authors":"Gavin Yamey,Jonathan Shaffer","doi":"10.1136/bmj.s19","DOIUrl":"https://doi.org/10.1136/bmj.s19","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"15 1","pages":"s19"},"PeriodicalIF":0.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multiple password frustration: can the NHS solve its logging-in problem?","authors":"Chris Stokel-Walker","doi":"10.1136/bmj.r2471","DOIUrl":"https://doi.org/10.1136/bmj.r2471","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"30 1","pages":"r2471"},"PeriodicalIF":0.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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