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Children’s right to oral health—day to day, right from the start 儿童的口腔健康权--每天,从一开始
Pub Date : 2025-01-15 DOI: 10.1136/bmj.r54
Jenny C Harris
At a time when access to NHS dentistry has reached crisis point, it is good to see oral health featured in The BMJ .1 The authors rightly raise awareness of the crucial importance of upholding children’s right to oral health at a population level and on a global scale. I affirm their advocacy for upstream public health approaches. It bears repeating …
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引用次数: 0
Adult social care reform cannot afford to wait 成人社会护理改革刻不容缓
Pub Date : 2025-01-15 DOI: 10.1136/bmj.r63
Jon Glasby, Clenton Farquharson, Catherine Needham, Kate Hamblin
Overhaul of policy and funding is needed now The UK government has announced its approach for social care—establishing yet another commission.1 In its 2024 election manifesto Labour pledged to create a “national care service” (without explaining what this means), tackle low pay for care workers, and “build consensus for the longer term reform needed.”2 Meanwhile, social care is in crisis. Analysis suggests that age adjusted spending per person will be at least 5% lower in 2024-25 than in 2009-10, and that an additional £8.3bn a year could be needed by 2032-33 to keep up with rising demand.3 Age UK estimates that two million people aged ≥65 have unmet needs for care and support,4 and analysis by Healthwatch suggests that up to 1.5 million disabled adults of working age could be eligible for social care support but are not receiving it.5 There are 131 000 staff vacancies,6 and some 81% of councils are due to overspend their adult social care budget in the current financial year. More than one third have had to make in-year budget savings, in addition to the almost £1bn of savings planned for 2024-25.7 The government has proposed an independent commission, chaired by …
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引用次数: 0
UK needs national strategy to tackle alcohol related harms
Pub Date : 2025-01-15 DOI: 10.1136/bmj.r38
Julia M A Sinclair, Melinda King, Steven Masson, Ian Gilmore
Sustained funding is needed for screening and care, but industry must also shoulder costs Alcohol is widely available and drunk by around 80% of adults in the UK. No safe level of alcohol consumption has been established,1 and the physical and mental health harms increase (at different rates) with the amount consumed.2 Alcohol is well recognised as a leading preventable cause of cancer.3 The health and social harms of alcohol are higher in socially disadvantaged groups4 despite lower rates of use than in more advantaged groups. This “alcohol harm paradox” means that alcohol consumption has the greatest detrimental effect on the most vulnerable in society and is a significant contributor to health inequalities and premature death.567 The challenges faced during the covid-19 pandemic89 resulted in an increase in the number of people drinking alcohol at increased and higher risk levels.1011 Deaths from alcohol specific causes in England also rose by 42.2% between 2019 and 2023, the highest number on record, most of them from alcohol related liver disease.1213 Successive …
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引用次数: 0
Medical and political paternalism and the end of life
Pub Date : 2025-01-15 DOI: 10.1136/bmj.r34
Charlotte Augst
The BMJ widely discussed the assisted dying bill that is currently at the committee stage in the UK parliament.1 Having worked for many years now for a health system that gives people more agency and dignity, I thought I had already come across all the arguments of medical paternalism. But I was wrong. What I wasn’t prepared for in the discussion about the assisted dying bill was that the current state of palliative care would be used as an argument for why we shouldn’t have agency. …
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引用次数: 0
Immunotherapies for sepsis and the impact of study design
Pub Date : 2025-01-15 DOI: 10.1136/bmj.r48
John H Powers, Charles Natanson
Enrolling the right number and type of patient is crucial Sepsis is a life threatening syndrome initiated by microorganisms.1 Severe and often lethal injuries (eg, shock, multiorgan failure, and metabolic derangements) are the manifestation of the syndrome, with systemic inflammatory cascade activation and circulating mediators thought to cause host injury. Scores of trials evaluating host-immune modifiers, many of which were the initial ventures of a new biotech industry 30 years ago, did not improve patient outcomes in sepsis.2 Undaunted by this history, investigators in the linked trial(doi:10.1136/bmj-2024-082583) evaluated another immune therapy, thymosin-α-1, in patients with sepsis, enrolling 1106 participants at 22 sites in China.3 The trial compared thymosin-α-1 with placebo plus usual care in a blinded randomised trial evaluating all cause mortality at 28 days. The results showed 24% mortality with thymosin versus 23% in the control group (hazard ratio 0.99, 95% confidence interval 0.77 to 1.77), which indicate no improvement with thymosin. Several positive aspects of the trial’s design include a superiority hypothesis with direct patient-outcomes of all cause mortality using inferential statistics, rather than non-inferiority hypotheses on surrogate endpoints using descriptive statistics commonly used in infection …
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引用次数: 0
Keep it in the ground: climate change could prompt the reemergence of zombie pathogens
Pub Date : 2025-01-14 DOI: 10.1136/bmj.r46
Kris A Murray
We must resolve how thawing of permafrost as a result of climate change could resurface pathogens with the potential to infect humans, writes Kris A Murray There is nothing permanent about permafrost. Models suggest that between 24% and 70% of existing permafrost will thaw by 2100 owing to climate change.1 This is a frightening prospect—permafrost covers almost a quarter of the northern hemisphere and a few areas elsewhere. The thaw is changing the form and function of these frozen ecosystems,2 by releasing much that has been firmly underfoot or safely stored away in ice, including carbon dioxide and methane that will contribute to further global warming; subsiding ground that is destabilising arctic infrastructure; and revealing mummified wildlife, livestock, and people and their pathogens within. A frequently headlining risk from permafrost thaw is the emergence of long frozen microbes often called zombie viruses, although bacteria, fungi, and other potential pathogens also lie beneath. Together, they are feared for their potential to resurrect and become infectious again, potentially even sparking another pandemic.3 Yet opinions …
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引用次数: 0
Intra-arterial tenecteplase after successful endovascular recanalisation in patients with acute posterior circulation arterial occlusion (ATTENTION-IA): multicentre randomised controlled trial
Pub Date : 2025-01-14 DOI: 10.1136/bmj-2024-080489
Wei Hu, Chunrong Tao, Li Wang, Zhongjun Chen, Di Li, Wenhuo Chen, Tingyu Yi, Lihua Xu, Chuanqing Yu, Tao Wang, Xiaoxi Yao, Tao Cui, Guangxiong Yuan, Junfeng Su, Li Chen, Zhiming Zhou, Zhengfei Ma, Junjun Wang, Benxiao Wang, Hongxing Han, Hao Wang, Jie Chen, Peiyang Zhou, Zhihua Cao, Youquan Ren, Xueli Cai, Huaizhang Shi, Guang Zhang, Liping Yu, Xingyun Yuan, Jinglun Li, Guoyong Zeng, Chuyuan Ni, Tong Li, Yingchun Wu, Yuwen Li, Kai Li, Yong Liu, Yao Wang, Yu Jin, Hanwen Liu, Jianshang Wen, Jun Sun, Yuyou Zhu, Rui Li, Chao Zhang, Tianlong Liu, Jianlong Song, Li Wang, Juan Cheng, Adnan I Qureshi, Thanh N Nguyen, Jeffrey L Saver, Raul G Nogueira, Xinfeng Liu
Objective To assess whether intra-arterial tenecteplase administered after successful endovascular recanalisation improves outcomes in patients with acute arterial occlusion of the posterior circulation. Design Multicentre randomised controlled trial. Setting 31 hospitals in China, 24 January 2023 to 24 August 2023. Participants 208 patients with successful recanalisation (grade 2b50-3 on the extended thrombolysis in cerebral infarction scale) of an occlusion in the V4 segment of the vertebral artery; proximal, middle, or distal segment of the basilar artery; or P1 segment of the posterior cerebral artery: 104 were randomly allocated to receive tenecteplase and 104 to receive standard care. Interventions Intra-arterial tenecteplase (0.0625 mg/kg, maximum dose 6.25 mg) administered proximal to the residual thrombus (if still present) or distal to the origin of the main pontine perforator branches over 15 seconds, or endovascular treatment only (control group). Main outcome measures The primary outcome was freedom from disability (modified Rankin scale score 0 or 1) at 90 days after randomisation. Primary safety outcomes included symptomatic intracranial haemorrhage within 36 hours and all cause mortality at 90 days. All efficacy and safety analyses were conducted by intention to treat and adjusted for age, pre-stroke modified Rankin scale score, time from onset of moderate to severe stroke (National Institutes of Health stroke scale score ≥6) to randomisation, hypertension, and baseline stroke severity. Results At 90 days, 36 patients (34.6%) in the tenecteplase group and 27 (26.0%) in the control group had a modified Rankin scale score of 0 or 1 (adjusted risk ratio 1.36, 95% confidence interval 0.92 to 2.02; P=0.12). Mortality at 90 days was similar between the tenecteplase and control groups: 29 (27.9%) v 28 (26.9%), adjusted risk ratio 1.13, 0.73 to 1.74. Symptomatic intracranial haemorrhage within 36 hours occurred in eight patients (8.3%) in the tenecteplase group and three (3.1%) in the control group (adjusted risk ratio 3.09, 0.78 to 12.20). Conclusions In patients with acute ischaemic stroke due to acute posterior large or proximal vessel occlusion, intra-arterial tenecteplase administered after successful recanalisation was not associated with a statistically significant reduction in combined disability and mortality at 90 days. Trial registration ClinicalTrials.gov [NCT05684172.][1] Data collected for the study, including deidentified individual participant data and a data dictionary defining each field in the set, can be made available to researchers on reasonable request and after signing appropriate data sharing agreements. Data access requests should be sent to the corresponding author. Such requests must be approved by the respective ethics boards and appropriate data custodians. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT05684172.&atom=%2Fbmj%2F388%2Fbmj-2024-080489.atom
目的 评估在血管内再通术成功后使用动脉内替奈替普酶是否能改善后循环急性动脉闭塞患者的预后。设计 多中心随机对照试验。地点 中国31家医院,2023年1月24日至2023年8月24日。参与者 208 名椎动脉 V4 段;基底动脉近端、中段或远端;或大脑后动脉 P1 段闭塞再通成功(脑梗塞扩大溶栓量表 2b50-3 级)的患者:104 人随机分配接受替奈普酶治疗,104 人接受标准治疗。干预措施 在残余血栓近端(如果仍然存在)或主要桥脑穿孔支起源远端注射动脉内替尼采普酶(0.0625 毫克/千克,最大剂量 6.25 毫克),持续 15 秒,或仅进行血管内治疗(对照组)。主要结果测量 主要结果是随机分组后90天内无残疾(改良Rankin量表评分0或1)。主要安全性结果包括36小时内的无症状颅内出血和90天时的全因死亡率。所有疗效和安全性分析均采用意向治疗,并对年龄、卒中前修改后的Rankin量表评分、中重度卒中发病(美国国立卫生研究院卒中量表评分≥6分)至随机化的时间、高血压和基线卒中严重程度进行了调整。结果 90 天时,替奈普酶组有 36 名患者(34.6%)和对照组有 27 名患者(26.0%)的修改后兰金量表评分为 0 或 1(调整后风险比为 1.36,95% 置信区间为 0.92 至 2.02;P=0.12)。替奈替普酶组和对照组的90天死亡率相似:29(27.9%)v 28(26.9%),调整后风险比为1.13,0.73至1.74。在 36 小时内出现症状性颅内出血的患者中,替奈替普酶组有 8 人(8.3%),对照组有 3 人(3.1%)(调整后风险比为 3.09,0.78 至 12.20)。结论 对于因急性后方大血管或近端血管闭塞导致的急性缺血性脑卒中患者,在成功再通后进行动脉内替尼epase治疗与90天后合并致残率和死亡率的显著降低无统计学关系。试验注册 ClinicalTrials.gov [NCT05684172.][1] 为该研究收集的数据,包括去身份化的受试者个人数据和定义数据集中每个字段的数据字典,可应研究人员的合理要求并在签署适当的数据共享协议后提供给研究人员。数据访问请求应发送给通讯作者。此类请求必须获得相关伦理委员会和适当数据保管人的批准。[1]:/lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT05684172.&atom=%2Fbmj%2F388%2Fbmj-2024-080489.atom
{"title":"Intra-arterial tenecteplase after successful endovascular recanalisation in patients with acute posterior circulation arterial occlusion (ATTENTION-IA): multicentre randomised controlled trial","authors":"Wei Hu, Chunrong Tao, Li Wang, Zhongjun Chen, Di Li, Wenhuo Chen, Tingyu Yi, Lihua Xu, Chuanqing Yu, Tao Wang, Xiaoxi Yao, Tao Cui, Guangxiong Yuan, Junfeng Su, Li Chen, Zhiming Zhou, Zhengfei Ma, Junjun Wang, Benxiao Wang, Hongxing Han, Hao Wang, Jie Chen, Peiyang Zhou, Zhihua Cao, Youquan Ren, Xueli Cai, Huaizhang Shi, Guang Zhang, Liping Yu, Xingyun Yuan, Jinglun Li, Guoyong Zeng, Chuyuan Ni, Tong Li, Yingchun Wu, Yuwen Li, Kai Li, Yong Liu, Yao Wang, Yu Jin, Hanwen Liu, Jianshang Wen, Jun Sun, Yuyou Zhu, Rui Li, Chao Zhang, Tianlong Liu, Jianlong Song, Li Wang, Juan Cheng, Adnan I Qureshi, Thanh N Nguyen, Jeffrey L Saver, Raul G Nogueira, Xinfeng Liu","doi":"10.1136/bmj-2024-080489","DOIUrl":"https://doi.org/10.1136/bmj-2024-080489","url":null,"abstract":"Objective To assess whether intra-arterial tenecteplase administered after successful endovascular recanalisation improves outcomes in patients with acute arterial occlusion of the posterior circulation. Design Multicentre randomised controlled trial. Setting 31 hospitals in China, 24 January 2023 to 24 August 2023. Participants 208 patients with successful recanalisation (grade 2b50-3 on the extended thrombolysis in cerebral infarction scale) of an occlusion in the V4 segment of the vertebral artery; proximal, middle, or distal segment of the basilar artery; or P1 segment of the posterior cerebral artery: 104 were randomly allocated to receive tenecteplase and 104 to receive standard care. Interventions Intra-arterial tenecteplase (0.0625 mg/kg, maximum dose 6.25 mg) administered proximal to the residual thrombus (if still present) or distal to the origin of the main pontine perforator branches over 15 seconds, or endovascular treatment only (control group). Main outcome measures The primary outcome was freedom from disability (modified Rankin scale score 0 or 1) at 90 days after randomisation. Primary safety outcomes included symptomatic intracranial haemorrhage within 36 hours and all cause mortality at 90 days. All efficacy and safety analyses were conducted by intention to treat and adjusted for age, pre-stroke modified Rankin scale score, time from onset of moderate to severe stroke (National Institutes of Health stroke scale score ≥6) to randomisation, hypertension, and baseline stroke severity. Results At 90 days, 36 patients (34.6%) in the tenecteplase group and 27 (26.0%) in the control group had a modified Rankin scale score of 0 or 1 (adjusted risk ratio 1.36, 95% confidence interval 0.92 to 2.02; P=0.12). Mortality at 90 days was similar between the tenecteplase and control groups: 29 (27.9%) v 28 (26.9%), adjusted risk ratio 1.13, 0.73 to 1.74. Symptomatic intracranial haemorrhage within 36 hours occurred in eight patients (8.3%) in the tenecteplase group and three (3.1%) in the control group (adjusted risk ratio 3.09, 0.78 to 12.20). Conclusions In patients with acute ischaemic stroke due to acute posterior large or proximal vessel occlusion, intra-arterial tenecteplase administered after successful recanalisation was not associated with a statistically significant reduction in combined disability and mortality at 90 days. Trial registration ClinicalTrials.gov [NCT05684172.][1] Data collected for the study, including deidentified individual participant data and a data dictionary defining each field in the set, can be made available to researchers on reasonable request and after signing appropriate data sharing agreements. Data access requests should be sent to the corresponding author. Such requests must be approved by the respective ethics boards and appropriate data custodians. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT05684172.&atom=%2Fbmj%2F388%2Fbmj-2024-080489.atom","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Halting medical doctor degree apprenticeships is a sensible decision
Pub Date : 2025-01-14 DOI: 10.1136/bmj.r66
Rob Tucker
Medical apprenticeships were scrapped to avoid creating a two tiered system in medical education, writes Rob Tucker The government has reportedly ceased further funding of the controversial doctor apprenticeship programmes.1 The scheme has faced considerable opposition from the medical community and lobbying by the BMA from the start. Proponents initially argued that these programmes would widen access into medicine, but this argument began to fall apart as further details emerged. Medical doctor apprenticeships would not have delivered on the aim of expanding access into medicine, instead we need effective widening participation schemes in medical education. The timelines to deliver the medical apprenticeships were always tight. In 2022, NHS England set out a tender for medical schools to develop a new programme offering the use of the apprenticeship levy funding for the first time to medical degrees. The pilot medical schools were confirmed in January 2023. NHS England then needed to find willing local employment providers, …
罗布-塔克(Rob Tucker)写道:"取消医学学徒制是为了避免在医学教育中形成双轨制。据报道,政府已停止对有争议的医生学徒制项目的进一步资助1 。1 该计划从一开始就遭到了医学界的强烈反对和英国医学会的游说。支持者最初认为,这些计划将拓宽进入医学界的渠道,但随着更多细节的出现,这一论点开始分崩离析。医生学徒制并不能实现扩大从医机会的目标,相反,我们需要有效的医学教育扩大参与计划。医学学徒制的实施时间一直都很紧迫。2022 年,英格兰国家医疗服务体系(NHS)向医学院校招标,以制定一项新计划,首次为医学学位提供学徒征税资金。试点医学院于 2023 年 1 月确定。英格兰国家医疗服务系统随后需要找到有意愿的当地就业提供者,...
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引用次数: 0
Does menstrual cycle syncing really help productivity? 月经周期同步真的有助于提高工作效率吗?
Pub Date : 2025-01-14 DOI: 10.1136/bmj.q2736
Sangeetha Nadarajah
“Cycle syncing”—a trend promoted by wellness influencers who claim that aligning work tasks with the menstrual cycle improves productivity—has drawn scepticism from medical experts. Sangeetha Nadarajah reports Advocates of cycle syncing argue that tailoring work tasks to the different menstrual phases can optimise productivity and performance. Some influencers provide paid coaching, including “cycle based” business coaching and workshops on “cycle syncing for feminine leadership.” Proponents such as the podcast host and chiropractor Mindy Pelz and the author Kate Northrup contend that a woman’s decision making abilities fluctuate throughout the cycle, potentially affecting the effectiveness of her work.1 They suggest that women should leverage these fluctuations to their advantage, postponing certain tasks during phases where they feel less confident in making decisions.1 However, medical experts have pointed out that these claims lack evidence and may perpetuate harmful gender stereotypes. Nanette Santoro, an obstetrician and faculty member in the Division of Reproductive Endocrinology and Infertility at the University of Colorado, warns that these claims disregard the complexity of hormonal fluctuations. “The presumption that all women experience predictable variations in performance due to their menstrual cycle is an oversimplification,” says Santoro. Women may feel impaired if they have an underlying medical condition affected by menstruation, such as heavy bleeding, severe pain, hormonal imbalances, polycystic ovary syndrome, postural orthostatic tachycardia syndrome, premenstrual dysphoric disorder, or menstrual migraines. However, there’s no evidence to support claims that women experience significant cognitive impairment or reduced work performance solely due to hormonal changes associated with their menstrual cycle (boxes 1 and 2). Box 1 ### The menstrual cycle The menstrual cycle consists of four distinct phases, each characterised by hormonal fluctuations and physiological changes. Menstrual hormone fluctuations vary widely from cycle to cycle and day to day. Most women have nearly 450 menstrual cycles over 30-40 years.2 During the menstrual … RETURN TO TEXT
"周期同步"--一种由健康影响者倡导的趋势,声称根据月经周期调整工作任务可以提高工作效率--引起了医学专家的怀疑。Sangeetha Nadarajah 报道:"周期同步 "的倡导者认为,根据不同的月经周期调整工作任务可以优化工作效率和绩效。一些有影响力的人提供有偿辅导,包括 "基于生理周期 "的商业辅导和 "周期同步提升女性领导力 "研讨会。播客主持人、脊椎按摩师明迪-佩尔兹(Mindy Pelz)和作家凯特-诺思鲁普(Kate Northrup)等支持者认为,女性的决策能力会在整个生理周期中波动,可能会影响工作效率。科罗拉多大学生殖内分泌与不孕症分部的产科医生兼教员纳内特-桑托罗警告说,这些说法无视荷尔蒙波动的复杂性。"桑托罗说:"认为所有女性都会因月经周期而出现可预测的表现变化的推断过于简单化了。如果女性患有受月经影响的潜在疾病,如大量出血、剧烈疼痛、荷尔蒙失调、多囊卵巢综合征、体位性正位性心动过速综合征、经前期紧张性障碍或经期偏头痛,那么她们可能会觉得自己的表现受到了影响。然而,并没有证据支持女性仅因与月经周期相关的荷尔蒙变化而导致认知能力严重受损或工作表现下降的说法(方框 1 和 2)。方框 1 ### 月经周期 月经周期由四个不同的阶段组成,每个阶段都有荷尔蒙波动和生理变化。不同周期和不同日子的月经激素波动差异很大。大多数女性在 30-40 年间会经历近 450 个月经周期2。
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引用次数: 0
Partha Kar: The new storm propagated by poor medical workforce planning is now upon us
Pub Date : 2025-01-14 DOI: 10.1136/bmj.r33
Partha Kar
A storm is brewing in the NHS medical workforce. The problem is a lack of jobs for doctors, resulting in questions about competition for jobs between local graduates and international medical graduates (IMGs). An artificial bottleneck has been created by pushing for more medical school places in the NHS long term workforce plan,1 despite not enough jobs being available for those graduating.2 The NHS has also ignored the rising tide of locally employed doctors, mostly IMGs.3 A lack of clear direction for these roles leaves those locally employed doctors without career prospects and increases competition for jobs. Additionally, poor planning around the Professional and Linguistic Assessments Board (PLAB) exams has resulted in a growing number of IMGs being available for jobs.4 PLAB exams run regularly and admit more IMGs into the system, contributing to the bottleneck. This cocktail of problems could threaten the fabric of NHS medical teams. We risk a resurgence of rhetoric, seen previously in heated debates …
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引用次数: 0
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