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Melioidosis – case reports and review of cases recorded among Bangladeshi population from 1988-2014 类鼻疽病——1988-2014年孟加拉国人口中记录的病例报告和病例审查
Pub Date : 2015-04-15 DOI: 10.3329/IMCJ.V8I1.22985
L. Barai, Md. Shariful Alam Jilani, J Ashraful Haq
Melioidosis, caused by Burkholderia pseudomallei, is a potentially fatal infectious disease. Early and correct diagnosis is important, as mortality in untreated melioidosis is high. The first case of melioidosis from Bangladesh was reported in 1988. Since then a few cases have been reported from Bangladesh. We report here four culture confirmed cases of melioidosis diagnosed in BIRDEM Genaral Hospital during May 2009 to April 2010.The detail demographic data, clinical features and outcome are discussed. We have also reviewed all the melioidosis cases among Bangladeshi population recorded from 1988 to 2014. Ibrahim Med. Coll. J. 2014; 8(1): 25-31
类鼻疽是一种潜在的致命传染病,由假杆菌伯克霍尔德菌引起。早期和正确的诊断很重要,因为未经治疗的类鼻疽病死亡率很高。1988年孟加拉国报告了第一例类鼻疽病。从那时起,孟加拉国报告了一些病例。我们在此报告2009年5月至2010年4月在BIRDEM总医院确诊的4例类鼻疽病培养确诊病例。详细的人口统计资料,临床特点和结果进行了讨论。我们还回顾了1988年至2014年孟加拉国人口中记录的所有类鼻疽病例。易卜拉欣·迈德,上校。j . 2014;8 (1): 25-31
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引用次数: 15
Subclinical Hypothyroidism & Infertility: A Review 亚临床甲状腺功能减退与不孕症:综述
Pub Date : 2015-04-15 DOI: 10.3329/IMCJ.V8I1.22984
Hs Ferdous, F. Afsana, N. Qureshi, R. Rouf, I. Noor, Aatif Parvez, A. Mir
Subclinical hypothyroidism (SCH) may be of greater clinical importance in women with “unexplained” infertility, especially when the luteal phase is inadequate, and such patients should be investigated for thyroid dysfunction in detail. To date, studies investigating the association between SCH and infertility are still based on the high serum thyroid stimulating hormone (TSH) levels while some older studies are based on the presence of an abnormal serum TSH after a thyrotropin releasing hormone (TRH) stimulation test. The recommendation in the current guidelines to treat subclinical hypothyroidism is based on minimal evidence and it is thought that with treatment the potential benefits outweigh the potential risks. Thyroxine-replacement therapy should be started in patients with SCH caused by conditions which are at high risk of progression to overt hypothyroidism. Ibrahim Med. Coll. J. 2014; 8(1): 17-24
亚临床甲状腺功能减退症(SCH)可能在“不明原因”不孕的女性中具有更大的临床重要性,特别是当黄体期不足时,这类患者应详细检查甲状腺功能障碍。迄今为止,调查SCH与不孕之间关系的研究仍然基于高血清促甲状腺激素(TSH)水平,而一些较早的研究是基于促甲状腺激素释放激素(TRH)刺激试验后血清TSH异常的存在。目前指南中关于治疗亚临床甲状腺功能减退的建议是基于很少的证据,并且认为治疗的潜在益处大于潜在风险。甲状腺素替代治疗应该开始于由病情发展为显性甲状腺功能减退的高风险引起的SCH患者。易卜拉欣·迈德,上校。j . 2014;8 (1): 17-24
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引用次数: 0
Effect of edible mushroom (Pleurotus ostreatus) on type-2 diabetics 食用菌平菇对2型糖尿病的治疗作用
Pub Date : 2015-04-15 DOI: 10.3329/IMCJ.V8I1.22982
M. Sayeed, A. Banu, K. Khatun, P. Khanam, T. Begum, H. Mahtab, J. Haq
The prevalence of non-communicable diseases (NCD) like diabetes, hypertension, dyslipidemia and atherosclerotic cardiovascular diseases (CVD) are on the increase globally and predominantly in the South East Asian Region (SEAR). The increasing NCD and its complications burdened the health cost of Bangladesh. The available literatures suggest that edible mushrooms are effective in controlling metabolic risks like hyperglycemia and hypercholesterolemia. The study addressed the metabolic effects of edible oyster mushroom ( Pleurotus ostreatus ) in diabetic individuals and to assess the undesirable effects of mushroom. A total of 5000 newly registered diabetic women were screened for eligible participants (urban housewives, age 30 – 50y, BMI 22 – 27, FBG 8 – 12 mmol/l; free from complications or systemic illnesses and agreed to adhere to the study for 360 days). The investigations included weight and height for BMI, waist- and hip-girth for WHR, BP, FBG, 2ABF, T-chol, TG, HDL, LDL, ALT and Creatinine starting from the day 0 (baseline) and each subsequent follow-up days: 60, 120, 180, 240, 300 and 360 for comparison between placebo and mushroom groups and also within group (baseline vs. follow up days), individually for placebo and mushroom. The daily intake of mushroom was 200g for the mushroom group and an equivalent calorie of vegetables for the placebo group. Overall, 73 diabetic housewives (mushroom / placebo = 43 /30) volunteered. The mean (with SEM) values of BMI, WHR, BP, FBG, 2ABF, T-chol, TG, HDL, LDL, ALT and Creatinine of the placebo group were compared with the mushroom group. Compared with the placebo, the mushroom group showed significant reductions of FBG (p<0.001), 2ABF (p<0.001), T-chol (p<0.001), TG (p=0.03) and LDL (p<0.001); whereas, no difference was observed for BMI, SBP, DBP, HDL, Hb, creatinine and ALT. The comparison within groups (baseline vs. follow-up) there were significant reduction of these variables in mushroom but not in the placebo group. Mushroom was found to have significant effect in reducing blood glucose, T-chol, TG and LDL. No impaired function was observed for liver, kidney and hemopoeitic tissue in taking mushroom for 360 days of the study period. Ibrahim Med. Coll. J. 2014; 8(1): 6-11
糖尿病、高血压、血脂异常和动脉粥样硬化性心血管疾病等非传染性疾病的患病率在全球呈上升趋势,主要在东南亚区域呈上升趋势。日益增加的非传染性疾病及其并发症加重了孟加拉国的保健费用。现有文献表明,食用菌对控制高血糖、高胆固醇血症等代谢风险具有有效作用。本研究探讨了食用平菇(Pleurotus ostreatus)对糖尿病人的代谢作用,并评估了平菇的不良影响。共有5000名新登记的糖尿病女性被筛选为符合条件的参与者(城市家庭主妇,年龄30 - 50岁,BMI 22 - 27, FBG 8 - 12 mmol/l;无并发症或全身性疾病,并同意坚持研究360天)。调查包括体重和身高的BMI,腰围和臀围的WHR,血压,FBG, 2ABF, T-chol, TG, HDL, LDL, ALT和肌酐从第0天(基线)开始以及随后的每个随访天:安慰剂组和蘑菇组之间的比较,60,120,180,240,300和360,组内(基线与随访天),安慰剂和蘑菇单独。蘑菇组每天摄入200克蘑菇,安慰剂组每天摄入等量卡路里的蔬菜。总共有73名糖尿病家庭主妇(蘑菇/安慰剂= 43 /30)自愿参加。比较安慰剂组与香菇组BMI、WHR、BP、FBG、2ABF、T-chol、TG、HDL、LDL、ALT、肌酐的平均值(SEM)。与安慰剂相比,香菇组的FBG (p<0.001)、2ABF (p<0.001)、T-chol (p<0.001)、TG (p=0.03)和LDL (p<0.001)均显著降低;然而,在BMI、收缩压、舒张压、HDL、Hb、肌酐和ALT方面没有观察到差异。在组内比较(基线与随访)中,蘑菇组显著降低了这些变量,而安慰剂组没有。研究发现,香菇具有显著的降血糖、降t -胆固醇、降TG、降LDL的作用。在360天的研究期间,食用菌未观察到肝、肾和造血组织功能受损。易卜拉欣·迈德,上校。j . 2014;8(1): 6尺11寸
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引用次数: 10
Thyroid stimulating hormone resistance syndrome – a case report 促甲状腺激素抵抗综合征1例报告
Pub Date : 2015-04-15 DOI: 10.3329/IMCJ.V8I1.22986
S. Ashrafuzzaman, Latif Za
Resistance to thyrotropin or thyroid stimulating hormone (RTSH) can be defined as decreased responsiveness to thyroid stimulating hormone (TSH) characterized by high TSH with normal but occasionally low T 4 and T 3 usually in absence of goiter or ectopic thyroid. It can be diagnosed when TSH is >30 mIU/L but free T 4 (FT 4 ) is within normal limit. Patient usually presents in euthyroid state with abnormally high TSH but may also present with mild to overt hypothyroidism. The precise prevalence is not known, but 20-30% infants may show transient mild RTSH. In adults it is rare. Here we report a case of RTSH in which a 19 years old young girl presented in euthyroid state with mild goiter. Ibrahim Med. Coll. J. 2014; 8(1): 32-33
对促甲状腺激素或促甲状腺激素(RTSH)的抵抗可以定义为对促甲状腺激素(TSH)的反应性降低,其特征是TSH高,t4和t3正常但偶尔低,通常在没有甲状腺肿或异位甲状腺的情况下。TSH≥30 mIU/L,游离t4 (ft4)在正常范围内即可诊断。患者通常表现为甲状腺功能正常,TSH异常高,但也可能表现为轻度至明显的甲状腺功能减退。确切的患病率尚不清楚,但20-30%的婴儿可能表现为短暂的轻度RTSH。在成人中很少见。在这里,我们报告一个病例的RTSH,其中一个19岁的年轻女孩在甲状腺功能正常的状态,轻度甲状腺肿。易卜拉欣·迈德,上校。j . 2014;8 (1): 32-33
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引用次数: 0
Antimicrobial susceptibility pattern of Enteropathogenic Escherichia coli (EPEC) in paediatric diarrhoeal patients 儿童腹泻患者肠致病性大肠杆菌(EPEC)的抗生素敏感性模式
Pub Date : 2015-04-15 DOI: 10.3329/IMCJ.V8I1.22983
S. Saha, S. T. Jhora, T. Rahman
Enteropathogenic Escherichia coli (EPEC) mediated infantile diarrhoea among children is an important cause of morbidity and mortality in developing countries. The antimicrobial susceptibility pattern of EPEC strains isolated from children under 5 years of age was studied. Stool samples from 272 patients with diarrhoea were collected from two tertiary care hospitals. Out of 272 stool samples, 20 (7.35%) isolates were identified as EPEC on the basis of presence of bfpA gene detected by polymerase chain reaction and antibiotic susceptibility testing was performed on these EPEC strains by Kirby-Bauer disc diffusion method. The antimicrobial susceptibility test revealed that the EPEC isolates were highly resistant to ampicillin (100%), nalidixic acid (95%) and tetracycline (95%) and were sensitive to ceftazidime (95%), cefotaxime (90%), ceftriaxone (95%), imipenem (100%) and levofloxacin (85%). Isolation of EPEC is of great importance since they are responsible for acute diarrhoeal diseases in large number of children under the age of five years. The high antimicrobial resistance observed in our study indicates indiscriminate or improper use of antimicrobials, besides the risks of self-medication. Ibrahim Med. Coll. J. 2014; 8(1): 12-16
肠致病性大肠杆菌(EPEC)介导的儿童腹泻是发展中国家发病率和死亡率的重要原因。研究了5岁以下儿童EPEC菌株的药敏模式。从两所三级医院收集了272名腹泻患者的粪便样本。272份粪便标本中,经聚合酶链反应检测bfpA基因,鉴定为EPEC的20株(7.35%),采用Kirby-Bauer圆盘扩散法对这些EPEC菌株进行药敏试验。药敏试验结果显示,分离株对氨苄西林(100%)、萘啶酸(95%)、四环素(95%)耐药,对头孢他啶(95%)、头孢噻肟(90%)、头孢曲松(95%)、亚胺培南(100%)、左氧氟沙星(85%)敏感。隔离EPEC非常重要,因为它们是造成大量五岁以下儿童急性腹泻病的原因。在我们的研究中观察到的高抗菌素耐药性表明,除了自我用药的风险外,滥用或不当使用抗菌素。易卜拉欣·迈德,上校。j . 2014;8(1): 12日至16日
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引用次数: 0
A case of acute liver failure in dengue hemorrhagic fever 登革出血热急性肝功能衰竭1例
Pub Date : 2014-08-21 DOI: 10.3329/IMCJ.V7I2.20112
R. Biswas, K. A. Hasan
Dengue is an arboviral disease endemic in many parts of the world. The clinical presentation of dengue viral infection ranges from asymptomatic illness to fatal dengue shock syndrome. Although, it is known to cause hepatic involvement, it occasionally results in acute hepatic failure. We report a case of dengue hemorrhagic fever presenting with acute liver failure. The case recovered completely after treatment. DOI: http://dx.doi.org/10.3329/imcj.v7i2.20112 Ibrahim Med. Coll. J. 2013; 7(2): 41-42
登革热是一种在世界许多地区流行的虫媒病毒性疾病。登革热病毒感染的临床表现从无症状疾病到致命的登革休克综合征不等。虽然已知它会累及肝脏,但偶尔也会导致急性肝功能衰竭。我们报告一个病例登革出血热表现为急性肝功能衰竭。该病例经治疗后完全康复。DOI: http://dx.doi.org/10.3329/imcj.v7i2.20112 Ibrahim Med. col。j . 2013;7 (2): 41-42
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引用次数: 1
Peripheral soft tissue Ewing’s sarcoma: a rare case report 外周软组织尤文氏肉瘤1例
Pub Date : 2014-08-21 DOI: 10.3329/IMCJ.V7I2.20113
F. Shegufta, M. Ferdousi, A. Taher
A 22 years male patient presented with gradual left forearm swelling for 6 months. X ray forearm revealed large soft tissue swelling with tiny calcification and mild scalloping at inner aspect of ulna and ultrasonogram (USG) revealed soft tissue mass having calcification and necrotic areas within and spectral Doppler showed arterial type of blood flow with no augmentation. Later computerized tomography (CT) scan showed soft tissue mass with necrotic area and calcification with no bony involvement. Magnetic resonance imaging (MRI) with contrast revealed a large heterogeneously enhancing lobulated mixed intensity lesion in antero-medial compartment of the left forearm involving flexor group of muscles causing displacement of fat plane. MRI and subsequent histopathology of the lesion revealed it as a rare soft tissue Ewing’s sarcoma / primitive neuroectodermal tumor (PNET) in extremity. DOI: http://dx.doi.org/10.3329/imcj.v7i2.20113 Ibrahim Med. Coll. J. 2013; 7(2): 43-46
22岁男性患者表现为左前臂逐渐肿胀6个月。前臂X线示大面积软组织肿胀伴微小钙化,尺骨内侧轻度成扇形,超声示软组织肿块伴钙化坏死,超声多普勒示动脉型血流,无增强。后来的计算机断层扫描(CT)显示软组织肿块坏死区和钙化,没有骨受累。磁共振成像(MRI)显示左前臂前内侧隔室一大块不均匀增强的分叶状混合强度病变,累及屈肌群,导致脂肪平面移位。MRI及病理检查显示为一罕见的四肢软组织尤文氏肉瘤/原始神经外胚层肿瘤。DOI: http://dx.doi.org/10.3329/imcj.v7i2.20113 Ibrahim Med. col。j . 2013;7 (2): 43-46
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引用次数: 0
Laparoscopic evaluation of tubal pathology in cases of infertility 不孕症患者输卵管病理的腹腔镜评估
Pub Date : 2014-08-21 DOI: 10.3329/IMCJ.V7I2.20110
R. Biswas, T. Chowdhury
Infertility is a public health problem in developed and developing countries. Diagnostic laparoscopy is a generally accepted procedure to detect pelvic organ pathologies affecting fertility. This study was undertaken to find out the tubal pathology contributing to primary and secondary infertility by laparoscopic examination. The study was carried out in the department of Gynaecology and Obstetrics, BIRDEM during the period of January 2001 to December 2001. The study group comprised of 100 cases of infertile patients of age between 20 to 40 years. Sixty seven percent patients had primary infertility and 33% patients had secondary infertility. Size and shape of the uterus was normal in 69% cases and bicornuate uterus was found in 2% cases. Out of total cases, 71% and 69% had normal right and left fallopian tubes respectively. Patency of right and left fallopian tube was normal in 90% and 89% cases respectively while 11% and 10% had peritubal adhesions. Laparoscopy examination is an important tool for evaluation of tubal pathology contributing to infertility and might play a major role in infertility management. DOI: http://dx.doi.org/10.3329/imcj.v7i2.20110 Ibrahim Med. Coll. J. 2013; 7(2): 38-40
不孕不育在发达国家和发展中国家都是一个公共卫生问题。诊断性腹腔镜检查是一种普遍接受的检查影响生育的盆腔器官病变的方法。本研究旨在通过腹腔镜检查找出导致原发性和继发性不孕症的输卵管病理。该研究于2001年1月至2001年12月在BIRDEM妇产科进行。研究小组包括100例年龄在20至40岁之间的不孕症患者。67%的患者为原发性不孕症,33%的患者为继发性不孕症。子宫大小形状正常的占69%,双角状子宫占2%。在所有病例中,71%和69%的患者右输卵管和左输卵管正常。90%和89%的患者左右输卵管通畅,11%和10%的患者存在输卵管周围粘连。腹腔镜检查是评估输卵管病理对不孕症影响的重要工具,可能在不孕症的治疗中发挥重要作用。DOI: http://dx.doi.org/10.3329/imcj.v7i2.20110 Ibrahim Med. col。j . 2013;7 (2): 38-40
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引用次数: 2
Effect of Aegle marmelos fruit pulp powder on glycemic status of type 2 diabetic patients 安吉尔蜜瓜果肉粉对2型糖尿病患者血糖状态的影响
Pub Date : 2014-08-21 DOI: 10.3329/IMCJ.V7I2.20109
Mkurshida Aziz, M. Akhter
Plant materials are considered to be attractive potential sources of alternate agents in the prevention and management of type 2 diabetes mellitus (T2DM). Different parts of Aegle marmelos have been claimed to possess anti-glycemic property. The present study was conducted at Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh from July 2010 to June 2011 to determine the anti-glycemic effect of A. marmelos unripe fruit pulp in T2DM patients. The experiment was conducted under a crossover design and the effects were analyzed during the 0-21 as well as 28-49 days with 7 days wash out period. The data were then pooled and the baseline versus endpoint values was also compared. The mean fasting blood glucose (FBG) values did not significantly differ between the two groups at any time points. No significant difference between the baseline and end point values regarding FBG. The effect on blood glucose was not significant in any of the analysis. This study did not reveal any antiglycemic effect of A. marmelos fruit pulp in T2DM patients. DOI: http://dx.doi.org/10.3329/imcj.v7i2.20109 Ibrahim Med. Coll. J. 2013; 7(2): 35-37
植物材料被认为是预防和管理2型糖尿病(T2DM)的替代药物的有吸引力的潜在来源。艾格尔甜瓜的不同部分被认为具有抗血糖的特性。本研究于2010年7月至2011年6月在孟加拉国达卡的孟加拉国糖尿病、内分泌和代谢紊乱研究与康复研究所(BIRDEM)进行,目的是确定蜜瓜未熟果肉对2型糖尿病患者的降糖作用。试验采用交叉设计,分别在0 ~ 21天和28 ~ 49天进行效果分析,其中冲洗期为7 d。然后将数据汇总,并比较基线值和终点值。两组在任何时间点的平均空腹血糖(FBG)值均无显著差异。FBG基线值与终点值无显著差异。在任何分析中,对血糖的影响都不显著。本研究未发现蜜瓜果肉对T2DM患者有任何降糖作用。DOI: http://dx.doi.org/10.3329/imcj.v7i2.20109 Ibrahim Med. col。j . 2013;第35 - 37 (2):7
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引用次数: 0
Association of elevated serum cardiac troponin-I level and complications in acute heart failure cases 急性心力衰竭患者血清肌钙蛋白- 1水平升高与并发症的关系
Pub Date : 2014-08-20 DOI: 10.3329/IMCJ.V7I2.20104
F. Aktar, Selina Ahmed
Acute heart failure is one of the major causes of morbidity and mortality all over the world. Available published data has suggested that patients of acute heart failure with elevated level of serum cardiac troponin-I (cTn-I) have more adverse outcomes than that of acute heart failure with normal cTn-I level. Elevated level of serum cTn-I is a potential risk factor for acute heart failure. This study was carried out in the department of Biochemistry, Dhaka Medical College and National Institute of Cardiovascular Disease (NICVD) during the period from January 2010 to December 2010. In this study, 100 patients with acute heart failure were enrolled. Out of 100 cases, 50 had elevated serum cTn-I (cTn-I ≥ 1.0 ng/ml) and 50 had normal serum cTn-I (cTn-I < 1.0 ng/ml). The adverse outcome of the two groups were recorded and compared. Patients with high and normal serum cTn-I had mean age of 52.40 ± 8.10 years and 54.64 ± 7.26 years respectively while male and female cases were equally distributed. Left ventricular systolic dysfunction (lower ejection fraction) was significantly (p<0.05) higher among cases with elevated cTn-I level compared to those with normal level. The rate of renal failure (raised serum creatinine), impaired liver functions (raised ALT and AST) and abnormal serum electrolytes were significantly higher among the patients with elevated cTn-I compared to those with normal level. The study showed that elevated serum cTn-I level was a good biomarker to indicate adverse complications in acute heart failure cases. DOI: http://dx.doi.org/10.3329/imcj.v7i2.20104 Ibrahim Med. Coll. J. 2013; 7(2): 32-34
急性心力衰竭是全世界发病率和死亡率的主要原因之一。现有已发表的数据表明,血清心肌肌钙蛋白- i (cTn-I)水平升高的急性心力衰竭患者比cTn-I水平正常的急性心力衰竭患者有更多的不良后果。血清ctn - 1水平升高是急性心力衰竭的潜在危险因素。本研究于2010年1月至2010年12月在达卡医学院生物化学系和国家心血管疾病研究所(NICVD)进行。在这项研究中,纳入了100例急性心力衰竭患者。100例患者中,50例血清ctn - 1升高(ctn - 1≥1.0 ng/ml), 50例血清ctn - 1正常(ctn - 1 < 1.0 ng/ml)。记录两组患者的不良反应并进行比较。血清ctn - 1高、正常患者的平均年龄分别为52.40±8.10岁和54.64±7.26岁,男女分布均匀。ctn - 1水平升高组左室收缩功能不全(射血分数降低)明显高于正常组(p<0.05)。ctn - 1升高患者的肾功能衰竭(血清肌酐升高)、肝功能受损(ALT和AST升高)和血清电解质异常的发生率明显高于正常水平的患者。研究表明血清ctn - 1水平升高是提示急性心力衰竭患者不良并发症的良好生物标志物。DOI: http://dx.doi.org/10.3329/imcj.v7i2.20104 Ibrahim Med. col。j . 2013;尺码7 (2):
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引用次数: 0
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Ibrahim Medical College Journal
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