Diabetes mellitus is being recognized as a serious global health problem and frequently associated with cirrhosis of liver. The cross-sectional comparative study was conducted among 83 diabetic cirrhotic patients admitted in Gastrointestinal Hepatobilliary and Pancreatic Disorders Department of Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic disorders and 83 non-diabetic cirrhotic patients admitted in Gastroenterology and Hepatology Department of Bangabandhu Sheikh Mujibar Medical University, Dhaka to assess the relationship between cirrhosis of liver and diabetes mellitus. The study was carried out during the period of January to June, 2010 and data were collected through face to face interview and reviewing medical documents by using a semi-structured questionnaire and checklist. Male, Muslims and illiterate were predominant in both diabetic and non-diabetic cirrhotic patients. It was found that non-viral cirrhosis was much higher in older age group (51-60years) than in younger age group (41-50years) in comparison to viral cirrhosis and this difference was found statistically significant [÷ 2 (3) =20.97, p<0.001]. Association of non-viral cirrhosis was found with hyperglycemia [÷ 2 (1) =15.65, p<0.001], poor glycaemic control [÷ 2 (1) = 9.86, p<0.01] and longer duration of diabetes [÷ 2 (2) =9.51, p<0.01]. Non-viral cirrhosis was significantly higher (28.3%) among the diabetic patients than the non-diabetic patients who suffered more (28.3%) from viral [÷ 2 (1) =41.36, p<.001]. The study recommends for glycemic control by leading disciplined life and taking apposite therapy for prevention of non-viral cirrhosis among diabetic patients. DOI: http://dx.doi.org/10.3329/imcj.v6i2.14734 Ibrahim Med. Coll. J. 2012; 6(2): 59-63
{"title":"Cirrhosis of Liver and Diabetes Mellitus","authors":"Smita Debsarma, Z. Islam","doi":"10.3329/IMCJ.V6I2.14734","DOIUrl":"https://doi.org/10.3329/IMCJ.V6I2.14734","url":null,"abstract":"Diabetes mellitus is being recognized as a serious global health problem and frequently associated with cirrhosis of liver. The cross-sectional comparative study was conducted among 83 diabetic cirrhotic patients admitted in Gastrointestinal Hepatobilliary and Pancreatic Disorders Department of Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic disorders and 83 non-diabetic cirrhotic patients admitted in Gastroenterology and Hepatology Department of Bangabandhu Sheikh Mujibar Medical University, Dhaka to assess the relationship between cirrhosis of liver and diabetes mellitus. The study was carried out during the period of January to June, 2010 and data were collected through face to face interview and reviewing medical documents by using a semi-structured questionnaire and checklist. Male, Muslims and illiterate were predominant in both diabetic and non-diabetic cirrhotic patients. It was found that non-viral cirrhosis was much higher in older age group (51-60years) than in younger age group (41-50years) in comparison to viral cirrhosis and this difference was found statistically significant [÷ 2 (3) =20.97, p<0.001]. Association of non-viral cirrhosis was found with hyperglycemia [÷ 2 (1) =15.65, p<0.001], poor glycaemic control [÷ 2 (1) = 9.86, p<0.01] and longer duration of diabetes [÷ 2 (2) =9.51, p<0.01]. Non-viral cirrhosis was significantly higher (28.3%) among the diabetic patients than the non-diabetic patients who suffered more (28.3%) from viral [÷ 2 (1) =41.36, p<.001]. The study recommends for glycemic control by leading disciplined life and taking apposite therapy for prevention of non-viral cirrhosis among diabetic patients. DOI: http://dx.doi.org/10.3329/imcj.v6i2.14734 Ibrahim Med. Coll. J. 2012; 6(2): 59-63","PeriodicalId":226732,"journal":{"name":"Ibrahim Medical College Journal","volume":"406 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131956181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ferdousi, M. Sharif, Hijbul Bahar, As Mohiuiddin, A. Hossain, S. G. Banu
A 42-year-old female patient presented with loss of vision and proptosis of her right eye. Computerized tomography (CT) scan revealed hyperostotic lesion involving the right sphenoid ridge, anterior clinoid process and roof and lateral wall of orbit with mass effect on the intraorbital contents. CT findings were suggestive of intra-osseous meningioma arising from right sphenoid bone. Later, MRI of the brain and orbit and histopathology of the lesion confirmed the case as an intra-osseous meningioma of the sphenoid bone. Though meningioma of tuberculum sella and primary calvarial meningioma were reported earlier, intraosseous meningioma of the sphenoid bone is rare. DOI: http://dx.doi.org/10.3329/imcj.v6i2.14737 Ibrahim Med. Coll. J. 2012; 6(2): 73-75
{"title":"A Rare Case of Intra-Osseous Meningioma of the Sphenoid Bone - A Case Report","authors":"M. Ferdousi, M. Sharif, Hijbul Bahar, As Mohiuiddin, A. Hossain, S. G. Banu","doi":"10.3329/IMCJ.V6I2.14737","DOIUrl":"https://doi.org/10.3329/IMCJ.V6I2.14737","url":null,"abstract":"A 42-year-old female patient presented with loss of vision and proptosis of her right eye. Computerized tomography (CT) scan revealed hyperostotic lesion involving the right sphenoid ridge, anterior clinoid process and roof and lateral wall of orbit with mass effect on the intraorbital contents. CT findings were suggestive of intra-osseous meningioma arising from right sphenoid bone. Later, MRI of the brain and orbit and histopathology of the lesion confirmed the case as an intra-osseous meningioma of the sphenoid bone. Though meningioma of tuberculum sella and primary calvarial meningioma were reported earlier, intraosseous meningioma of the sphenoid bone is rare. DOI: http://dx.doi.org/10.3329/imcj.v6i2.14737 Ibrahim Med. Coll. J. 2012; 6(2): 73-75","PeriodicalId":226732,"journal":{"name":"Ibrahim Medical College Journal","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127183582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We present a case of Cushing’s syndrome and virilization in a 15 year old girl which was suspected to be due to an adrenal carcinoma. She presented with features of virilization in addition to those of hypercortisilism. Her high androgen levels especially dehydroepiandrosterone sulfate (DHEAS) were also in favor of an adrenal carcinoma. An unenhanced computerized tomography (CT) scan showed a mass (size: 5.3 cm) in the right adrenal gland with a soft tissue intensity of more than 10 HU which was suggestive of adrenal carcinoma. But, histopathology of the resected mass revealed a benign adrenocortical adenoma. DOI: http://dx.doi.org/10.3329/imcj.v6i2.14736 Ibrahim Med. Coll. J. 2012; 6(2): 70-72
{"title":"VIRILIZATION IN A GIRL WITH ADRENOCORTICAL ADENOMA: A CASE REPORT","authors":"T. Haq, S. Ashrafuzzaman, Latif Za","doi":"10.3329/IMCJ.V6I2.14736","DOIUrl":"https://doi.org/10.3329/IMCJ.V6I2.14736","url":null,"abstract":"We present a case of Cushing’s syndrome and virilization in a 15 year old girl which was suspected to be due to an adrenal carcinoma. She presented with features of virilization in addition to those of hypercortisilism. Her high androgen levels especially dehydroepiandrosterone sulfate (DHEAS) were also in favor of an adrenal carcinoma. An unenhanced computerized tomography (CT) scan showed a mass (size: 5.3 cm) in the right adrenal gland with a soft tissue intensity of more than 10 HU which was suggestive of adrenal carcinoma. But, histopathology of the resected mass revealed a benign adrenocortical adenoma. DOI: http://dx.doi.org/10.3329/imcj.v6i2.14736 Ibrahim Med. Coll. J. 2012; 6(2): 70-72","PeriodicalId":226732,"journal":{"name":"Ibrahim Medical College Journal","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121180140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A case of post-vaccination myelitis following administration of chick embryo cell rabies vaccine in a 20 year-old young lady is described. The case presented with paraplegia five days after receiving the third dose (on 12th day) of the vaccine for rabies. Myelitis was confirmed by signal changes on magnetic resonance imaging (MRI). She improved considerably on steroids treatment. This is the first case of myelitis following rabies chick embryo cell vaccination in Bangladesh. DOI: http://dx.doi.org/10.3329/imcj.v6i2.14738 Ibrahim Med. Coll. J. 2012; 6(2): 76-77
{"title":"POST VACCINATION MYELITIS IN A YOUNG WOMAN FOLLOWING ADMINISTRATION OF RABIES CHICK EMBRYO CELL VACCINE - A CASE REPORT","authors":"S. Ikhtaire, M. Faiz","doi":"10.3329/IMCJ.V6I2.14738","DOIUrl":"https://doi.org/10.3329/IMCJ.V6I2.14738","url":null,"abstract":"A case of post-vaccination myelitis following administration of chick embryo cell rabies vaccine in a 20 year-old young lady is described. The case presented with paraplegia five days after receiving the third dose (on 12th day) of the vaccine for rabies. Myelitis was confirmed by signal changes on magnetic resonance imaging (MRI). She improved considerably on steroids treatment. This is the first case of myelitis following rabies chick embryo cell vaccination in Bangladesh. DOI: http://dx.doi.org/10.3329/imcj.v6i2.14738 Ibrahim Med. Coll. J. 2012; 6(2): 76-77","PeriodicalId":226732,"journal":{"name":"Ibrahim Medical College Journal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126141424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nosocomial or hospital acquired infection is a major cause of morbidity and mortality of patients attending the healthcare facilities all over the world. The issue of infection associated with medical practice probably dates back to over two thousand years when the medical healer started to practice surgical procedures.1 In the last two hundred years it has emerged as a matter of great concern with the rapid advancement of medical science. In the 1800s as many as 80% of all operations ended in infection. 2 For a long time medics refused to acknowledge the fact that infection could be afflicted by the healer during treatment until in mid 19th century, when Ignaz Philip Semmelweis in Vienna demonstrated the relationship between hand washing with chlorinated water and reduction of puerperal sepsis. He successfully demonstrated a dramatic reduction in the incidence of puerperal sepsis from over 8% to 2.3 % only by insisting on stringent hand washing with a solution of chlorinated water.2 The importance of controlling hospital infection was finally recognized by the work of Joseph Lister in mid sixties of 19th century by publication of his landmark paper ‘On the Antiseptic Principle in the Practice of Surgery’ in the British Medical Journal. He recognized the role of microbes and the use of carbolic acid, an antiseptic solution, in controlling surgical wound infections. These observations provided the basis for control of hospital acquired infections and thereby the importance of infection control was conceptualized. However, the introduction of penicillin in 1941 brought a negative blow to infection control practices in hospitals on a false perception that ‘penicillin the magic bullet’ would readily alleviate this problem. As a result, there was rapid decline in interest in hospital infection control activities. But this euphoria did not last long because of the outbreak of large staphylococcal pandemics in the 1950s which resulted in renewed interest on infection control programs in hospitals.3
院内或医院获得性感染是全世界在医疗机构就诊的患者发病和死亡的主要原因。与医疗实践有关的感染问题可能可以追溯到两千多年前，当时医生开始实践外科手术在过去的两百年里，随着医学科学的迅速发展，它已经成为一个备受关注的问题。在19世纪，多达80%的手术以感染告终。在很长一段时间里，医生们都拒绝承认治疗者在治疗过程中可能会感染这一事实，直到19世纪中叶，维也纳的伊格纳兹·菲利普·塞梅尔韦斯(Ignaz Philip Semmelweis)证明了用氯化水洗手与减少产褥期败血症之间的关系。他成功地证明了仅通过坚持用氯化水溶液严格洗手，就能将产褥期败血症的发生率从8%大幅降低到2.3%控制医院感染的重要性最终被约瑟夫·李斯特在19世纪60年代中期的工作所认识到，他在英国医学杂志上发表了具有里程碑意义的论文《外科手术中的消毒原则》。他认识到微生物的作用和使用石炭酸(一种防腐溶液)来控制手术伤口感染。这些观察结果为医院获得性感染的控制提供了依据，从而认识到感染控制的重要性。然而，1941年青霉素的引入给医院的感染控制实践带来了负面打击，因为人们错误地认为“青霉素是灵丹妙药”会轻易缓解这个问题。结果，人们对医院感染控制活动的兴趣迅速下降。但这种兴奋并没有持续多久，因为20世纪50年代葡萄球菌大流行的爆发，重新引起了人们对医院感染控制项目的兴趣
{"title":"Control of Hospital Acquired Infection in Bangladesh - An Endeavor to be Strengthened","authors":"J. Haq","doi":"10.3329/IMCJ.V6I2.14726","DOIUrl":"https://doi.org/10.3329/IMCJ.V6I2.14726","url":null,"abstract":"Nosocomial or hospital acquired infection is a major cause of morbidity and mortality of patients attending the healthcare facilities all over the world. The issue of infection associated with medical practice probably dates back to over two thousand years when the medical healer started to practice surgical procedures.1 In the last two hundred years it has emerged as a matter of great concern with the rapid advancement of medical science. In the 1800s as many as 80% of all operations ended in infection. 2 For a long time medics refused to acknowledge the fact that infection could be afflicted by the healer during treatment until in mid 19th century, when Ignaz Philip Semmelweis in Vienna demonstrated the relationship between hand washing with chlorinated water and reduction of puerperal sepsis. He successfully demonstrated a dramatic reduction in the incidence of puerperal sepsis from over 8% to 2.3 % only by insisting on stringent hand washing with a solution of chlorinated water.2 The importance of controlling hospital infection was finally recognized by the work of Joseph Lister in mid sixties of 19th century by publication of his landmark paper ‘On the Antiseptic Principle in the Practice of Surgery’ in the British Medical Journal. He recognized the role of microbes and the use of carbolic acid, an antiseptic solution, in controlling surgical wound infections. These observations provided the basis for control of hospital acquired infections and thereby the importance of infection control was conceptualized. However, the introduction of penicillin in 1941 brought a negative blow to infection control practices in hospitals on a false perception that ‘penicillin the magic bullet’ would readily alleviate this problem. As a result, there was rapid decline in interest in hospital infection control activities. But this euphoria did not last long because of the outbreak of large staphylococcal pandemics in the 1950s which resulted in renewed interest on infection control programs in hospitals.3","PeriodicalId":226732,"journal":{"name":"Ibrahim Medical College Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132544727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Sultana, Zinat Nasrin, Mahfuzar Rahman, Nayeema Rahman, A. K. Ahmedullah
Mediastinal lipoma (ML) is a rare entity. Though the mediastinum is the most common site of intrathoracic lipoma, ML constitutes less than 1% of all mediastinal tumours. ML frequently presents on incidental radiographic finding, CT scan is considered the investigation of choice. CT features of lipoma are quite characteristic. They are clinically significant because: (1) Despite their benign nature, these tumours tend to reach an enormous size and can cause compression of lungs and mediastinal structures; (2) It may not always be possible to differentiate a ML from a liposarcoma by CT or MRI alone. DOI: http://dx.doi.org/10.3329/imcj.v6i1.14725 Ibrahim Med. Coll. J. 2012; 6(1): 37-38
摘要纵隔脂肪瘤是一种罕见的肿瘤。纵隔是胸内脂肪瘤最常见的部位，但ML在所有纵隔肿瘤中所占比例不到1%。ML经常出现在偶然的x线检查中，CT扫描被认为是检查的选择。脂肪瘤的CT表现很有特征性。它们具有重要的临床意义，因为:(1)尽管它们是良性的，但这些肿瘤往往会达到巨大的体积，并可能导致肺部和纵隔结构的压迫;(2)仅通过CT或MRI可能并不总是能够区分ML和脂肪肉瘤。DOI: http://dx.doi.org/10.3329/imcj.v6i1.14725 Ibrahim Med. col。j . 2012;6 (1): 37-38
{"title":"RECURRENT MEDIASTINAL LIPOMA: A CASE REPORT","authors":"J. Sultana, Zinat Nasrin, Mahfuzar Rahman, Nayeema Rahman, A. K. Ahmedullah","doi":"10.3329/IMCJ.V6I1.14725","DOIUrl":"https://doi.org/10.3329/IMCJ.V6I1.14725","url":null,"abstract":"Mediastinal lipoma (ML) is a rare entity. Though the mediastinum is the most common site of intrathoracic lipoma, ML constitutes less than 1% of all mediastinal tumours. ML frequently presents on incidental radiographic finding, CT scan is considered the investigation of choice. CT features of lipoma are quite characteristic. They are clinically significant because: (1) Despite their benign nature, these tumours tend to reach an enormous size and can cause compression of lungs and mediastinal structures; (2) It may not always be possible to differentiate a ML from a liposarcoma by CT or MRI alone. DOI: http://dx.doi.org/10.3329/imcj.v6i1.14725 Ibrahim Med. Coll. J. 2012; 6(1): 37-38","PeriodicalId":226732,"journal":{"name":"Ibrahim Medical College Journal","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127499583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study was undertaken to estimate the risk factors age, gender, race, obesity (BMI), glycemic status (prediabetes, diabetes), exercise and psychosocial factors (sleep, sadness) related to coronary artery disease (CAD). The data set for this study is the National Health Interview Survey (NHIS), which is a large scale, cross sectional, voluntary, household interview survey maintaining data on health status, health care access and progress towards achieving the national health objectives in the USA. A total of 26,965 (male/female =55.8/ 44.2%) subjects were included in the study. Of them, 79.9% were less than 65 years of age. Regarding obesity, overweight, obese and morbid obese were 34.8, 17.3 and 11.0%, respectively. Sadness of any degree was reported in 28%. Sleep duration was found 9h/d in 9.7%. Heart disease was reported in 4.9%. About 10% were reported to have diabetes and 4.1% prediabetes. 40% of the respondents’ maintained exercise once per week and only 12.8% maintained 10 or more times per week. Logistic regression estimated that compared with the non-diabetics, the subjects with prediabetes (OR 3.27, 95% CI, 2.32-4.59) and diabetes (OR 6.44 95% CI, 5.21-7.96) had excess risk of CAD, more significant in the younger subjects ( 65y). The risk of CAD was found significant in both prediabetes (OR 2.47, 95% CI, 1.44-4.23) and diabetes (OR 3.03, 95% CI, 2.16-4.24) as compared with nondiabetic group who slept >9h a day. The subjects with prediabetes or diabetes had excess risk for CAD compared with the non-diabetic subjects, which was more marked in the younger people. Again, compared with the non-diabetic people, the subjects with prediabetes or diabetes, having less sleep or excess sleep, had excess risk for CAD. Further study may confirm our findings. DOI: http://dx.doi.org/10.3329/imcj.v6i2.14727 Ibrahim Med. Coll. J. 2012; 6(2): 39-45
{"title":"Hyperclycemia, Young Age, Altered Sleep Habits: The Three Shifting Paradigms of Coronary Artery Disease Risk Stratification","authors":"Irtiza Hasan, T. Rashid, I. Tasnim, M. M. Rhaman","doi":"10.3329/IMCJ.V6I2.14727","DOIUrl":"https://doi.org/10.3329/IMCJ.V6I2.14727","url":null,"abstract":"The study was undertaken to estimate the risk factors age, gender, race, obesity (BMI), glycemic status (prediabetes, diabetes), exercise and psychosocial factors (sleep, sadness) related to coronary artery disease (CAD). The data set for this study is the National Health Interview Survey (NHIS), which is a large scale, cross sectional, voluntary, household interview survey maintaining data on health status, health care access and progress towards achieving the national health objectives in the USA. A total of 26,965 (male/female =55.8/ 44.2%) subjects were included in the study. Of them, 79.9% were less than 65 years of age. Regarding obesity, overweight, obese and morbid obese were 34.8, 17.3 and 11.0%, respectively. Sadness of any degree was reported in 28%. Sleep duration was found 9h/d in 9.7%. Heart disease was reported in 4.9%. About 10% were reported to have diabetes and 4.1% prediabetes. 40% of the respondents’ maintained exercise once per week and only 12.8% maintained 10 or more times per week. Logistic regression estimated that compared with the non-diabetics, the subjects with prediabetes (OR 3.27, 95% CI, 2.32-4.59) and diabetes (OR 6.44 95% CI, 5.21-7.96) had excess risk of CAD, more significant in the younger subjects ( 65y). The risk of CAD was found significant in both prediabetes (OR 2.47, 95% CI, 1.44-4.23) and diabetes (OR 3.03, 95% CI, 2.16-4.24) as compared with nondiabetic group who slept >9h a day. The subjects with prediabetes or diabetes had excess risk for CAD compared with the non-diabetic subjects, which was more marked in the younger people. Again, compared with the non-diabetic people, the subjects with prediabetes or diabetes, having less sleep or excess sleep, had excess risk for CAD. Further study may confirm our findings. DOI: http://dx.doi.org/10.3329/imcj.v6i2.14727 Ibrahim Med. Coll. J. 2012; 6(2): 39-45","PeriodicalId":226732,"journal":{"name":"Ibrahim Medical College Journal","volume":"531 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132388123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acinetobacter species are aerobic Gram variable coccobacilli that are now emerging as an important nosocomial pathogen. Infections caused by them are difficult to control due to multidrug resistance. The purpose of this study was to detect virulence factors namely gelatinase production, biofilm formation and antibiotic susceptibility of Acinetobacter species. Two hundred fifty six clinical samples collected from Bangabandhu Sheikh Mujib medical University (BSMMU) and from burn unit of Dhaka Medical College Hospital were included in the study. Gelatinase production was seen on Luria Bertani agar media containing gelatin (30 gm/l) and biofilm formation was detected in microtiter plate assay. Out of 256 clinical samples, 52 (20.3%) were Acinetobacter species . Out of 52 Acinetobacter isolates, none were gelatinase producer but 39 (75%) were found biofilm producers. Acinetobacter isolates were 100% resistant to ceftazidime, cefotaxime cefuroxime and ceftriaxone. High level of resistance was also recorded for amoxicillin (98.1%), aztreonam (98.1%), gentamicin (90.4%), ciprofloxacin (73.1%), amikacin (57.6%), netilmicin (53.8%) and imipenem (44.2%). Susceptibility to colistin was maximum (96.2%). The present study demonstrated a high propensity of biofilm formation by the clinical isolates of Acinetobacter species and most of the Acinetobacter were multidrug resistant. DOI: http://dx.doi.org/10.3329/imcj.v6i1.14722 Ibrahim Med. Coll. J. 2012; 6(1): 27-30
不动杆菌是一种需氧革兰氏变球芽杆菌，目前已成为一种重要的医院病原体。由于耐多药，它们引起的感染难以控制。本研究的目的是检测不动杆菌的毒力因素，即明胶酶的产生、生物膜的形成和抗生素的敏感性。从孟加拉班班杜谢赫穆吉布医科大学(BSMMU)和达卡医学院附属医院烧伤科采集的256份临床样本被纳入研究。在含有明胶(30 gm/l)的Luria Bertani琼脂培养基上观察到明胶酶的产生，并用微滴板法检测生物膜的形成。256份临床样本中，52份(20.3%)为不动杆菌。在52株不动杆菌分离株中，没有一株产生明胶酶，但发现有39株(75%)产生生物膜。分离的不动杆菌对头孢他啶、头孢噻肟、头孢呋辛和头孢曲松耐药100%。阿莫西林(98.1%)、氨曲南(98.1%)、庆大霉素(90.4%)、环丙沙星(73.1%)、阿米卡星(57.6%)、那替米星(53.8%)、亚胺培南(44.2%)耐药程度较高。对粘菌素的敏感性最高(96.2%)。本研究表明临床分离的不动杆菌种类具有高度的生物膜形成倾向，并且大多数不动杆菌具有多重耐药性。DOI: http://dx.doi.org/10.3329/imcj.v6i1.14722 Ibrahim Med. col。j . 2012;6 (1):
{"title":"Virulence Factors and Antibiotic Susceptibility Pattern of Acinetobacter Species in a Tertiary Care Hospital in Bangladesh","authors":"Azizun Nahar, S. Anwar, A. Saleh, R. Miah","doi":"10.3329/IMCJ.V6I1.14722","DOIUrl":"https://doi.org/10.3329/IMCJ.V6I1.14722","url":null,"abstract":"Acinetobacter species are aerobic Gram variable coccobacilli that are now emerging as an important nosocomial pathogen. Infections caused by them are difficult to control due to multidrug resistance. The purpose of this study was to detect virulence factors namely gelatinase production, biofilm formation and antibiotic susceptibility of Acinetobacter species. Two hundred fifty six clinical samples collected from Bangabandhu Sheikh Mujib medical University (BSMMU) and from burn unit of Dhaka Medical College Hospital were included in the study. Gelatinase production was seen on Luria Bertani agar media containing gelatin (30 gm/l) and biofilm formation was detected in microtiter plate assay. Out of 256 clinical samples, 52 (20.3%) were Acinetobacter species . Out of 52 Acinetobacter isolates, none were gelatinase producer but 39 (75%) were found biofilm producers. Acinetobacter isolates were 100% resistant to ceftazidime, cefotaxime cefuroxime and ceftriaxone. High level of resistance was also recorded for amoxicillin (98.1%), aztreonam (98.1%), gentamicin (90.4%), ciprofloxacin (73.1%), amikacin (57.6%), netilmicin (53.8%) and imipenem (44.2%). Susceptibility to colistin was maximum (96.2%). The present study demonstrated a high propensity of biofilm formation by the clinical isolates of Acinetobacter species and most of the Acinetobacter were multidrug resistant. DOI: http://dx.doi.org/10.3329/imcj.v6i1.14722 Ibrahim Med. Coll. J. 2012; 6(1): 27-30","PeriodicalId":226732,"journal":{"name":"Ibrahim Medical College Journal","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129776373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A definitive and accurate diagnosis of tubercular lymphadenitis is important for its proper management. Fine needle aspiration cytology (FNAC) is an easy procedure for collection of material for cytopathological and bacteriological examination. But the detection rate of M. tuberculosis from the aspirated material is low with Ziehl-Neelson (Z-N) stain and even with culture. Polymerase chain reaction (PCR) is a rapid method for diagnosis of tuberculosis from various clinical samples. In the present study, PCR was employed for the detection of mycobacterial DNA sequences in fine needle aspirates of twenty cases of suspected tubercular lymphadenitis and compared with cytomorphological characteristics, Z-N stain and culture. Thermo stable multiplex PCR was used to detect Mycobacterium specific DNA. The rate of PCR positivity for mycobacterial DNA was 70% as compared to 50% and 60% by Z-N stain and culture respectively. Papanicolaou as well as Hematoxylin and Eosin (HE 6(2): 46-49
{"title":"Diagnosis of Tubercular Lymphadenitis by PCR of Fine Needle Aspirates","authors":"M. Parvez, Mohiuddin, Z. Hassan, F. Ahmad, J. Haq","doi":"10.3329/IMCJ.V6I2.14728","DOIUrl":"https://doi.org/10.3329/IMCJ.V6I2.14728","url":null,"abstract":"A definitive and accurate diagnosis of tubercular lymphadenitis is important for its proper management. Fine needle aspiration cytology (FNAC) is an easy procedure for collection of material for cytopathological and bacteriological examination. But the detection rate of M. tuberculosis from the aspirated material is low with Ziehl-Neelson (Z-N) stain and even with culture. Polymerase chain reaction (PCR) is a rapid method for diagnosis of tuberculosis from various clinical samples. In the present study, PCR was employed for the detection of mycobacterial DNA sequences in fine needle aspirates of twenty cases of suspected tubercular lymphadenitis and compared with cytomorphological characteristics, Z-N stain and culture. Thermo stable multiplex PCR was used to detect Mycobacterium specific DNA. The rate of PCR positivity for mycobacterial DNA was 70% as compared to 50% and 60% by Z-N stain and culture respectively. Papanicolaou as well as Hematoxylin and Eosin (HE 6(2): 46-49","PeriodicalId":226732,"journal":{"name":"Ibrahim Medical College Journal","volume":"212 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114344176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This is a case report of a 13 years old indigenous ‘Garo’ girl who presented with purpuric spots and ecchymotic patches all over the body with menorrhagia, mild jaundice, severe anaemia, marked thrombocytopenia, moderate neutrophil leucocytosis and reticulocytosis. Investigations revealed this as a complex case of Haemoglobin E disease with immune thrombocytopenia (ITP) and combined iron, folate and vitamin B 12 DOI: http://dx.doi.org/10.3329/imcj.v6i1.14723 Ibrahim Med. Coll. J. 2012; 6(1): 31-33
这是一个13岁土著“加罗”女孩的病例报告，她表现为全身紫色斑点和淤血斑，月经过多，轻度黄疸，严重贫血，明显的血小板减少，中度中性粒细胞增多和网状细胞增多症。调查显示，这是一个复杂的血红蛋白E病伴免疫性血小板减少症(ITP)和铁、叶酸和维生素b12联合病例DOI: http://dx.doi.org/10.3329/imcj.v6i1.14723 Ibrahim Med. Coll。j . 2012;6(1): 33节
{"title":"A Complex Case of Haemoglobin E Disease with Immune Thrombocytopenia and Combined Iron, Folate and Vit B12 Deficiency","authors":"S. Islam, T. Dipta, G. S. Sultana","doi":"10.3329/IMCJ.V6I1.14723","DOIUrl":"https://doi.org/10.3329/IMCJ.V6I1.14723","url":null,"abstract":"This is a case report of a 13 years old indigenous ‘Garo’ girl who presented with purpuric spots and ecchymotic patches all over the body with menorrhagia, mild jaundice, severe anaemia, marked thrombocytopenia, moderate neutrophil leucocytosis and reticulocytosis. Investigations revealed this as a complex case of Haemoglobin E disease with immune thrombocytopenia (ITP) and combined iron, folate and vitamin B 12 DOI: http://dx.doi.org/10.3329/imcj.v6i1.14723 Ibrahim Med. Coll. J. 2012; 6(1): 31-33","PeriodicalId":226732,"journal":{"name":"Ibrahim Medical College Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114325846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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