Pub Date : 2024-01-10DOI: 10.22625/2072-6732-2023-15-4-25-34
A. A. Ruleva, S. Kharit
Premature newborns are most vulnerable to the severe infectious diseases. The timeliness of vaccination in this group of children is extremely important. Historically, however, vaccination coverage for premature newborns has been significantly reduced due to unjustified contraindications. This is due to the fear of developing post-vaccination complications and the opinion that the immune response to vaccines in preterm newborns is reduced. In addition, in our country, there are no approved federal clinical guidelines for the vaccination of premature newborns, which determines the lack of a unified approach among medical workers and raises doubts among parents.The article presents a review of Russian and foreign literature data, highlighting the state of the problem of timeliness and completeness of vaccination coverage of premature newborns. Features of the immunity of a child born prematurely and the possibility of an adequate response to vaccine antigens in various degrees of prematurity. According to the list of the National Immunization Schedule, scientific and practical data on the safety and efficacy of vaccines registered in Russia, the benefits of complying with approved schedule and the positive non-specific effects of individual vaccines are given. Data on the specific prevention of RS-virus infection are presented. It has been shown that conditions that can develop after vaccination and are characteristic of prematurity are not directly related to the vaccine and that premature newborns is able to develop a sufficient immune response. Accordingly, children born prematurely should be immunized in accordance with the passport age with the stabilization of the child’s condition and adequate weight gain.
{"title":"Vaccination of premature newborns","authors":"A. A. Ruleva, S. Kharit","doi":"10.22625/2072-6732-2023-15-4-25-34","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-4-25-34","url":null,"abstract":"Premature newborns are most vulnerable to the severe infectious diseases. The timeliness of vaccination in this group of children is extremely important. Historically, however, vaccination coverage for premature newborns has been significantly reduced due to unjustified contraindications. This is due to the fear of developing post-vaccination complications and the opinion that the immune response to vaccines in preterm newborns is reduced. In addition, in our country, there are no approved federal clinical guidelines for the vaccination of premature newborns, which determines the lack of a unified approach among medical workers and raises doubts among parents.The article presents a review of Russian and foreign literature data, highlighting the state of the problem of timeliness and completeness of vaccination coverage of premature newborns. Features of the immunity of a child born prematurely and the possibility of an adequate response to vaccine antigens in various degrees of prematurity. According to the list of the National Immunization Schedule, scientific and practical data on the safety and efficacy of vaccines registered in Russia, the benefits of complying with approved schedule and the positive non-specific effects of individual vaccines are given. Data on the specific prevention of RS-virus infection are presented. It has been shown that conditions that can develop after vaccination and are characteristic of prematurity are not directly related to the vaccine and that premature newborns is able to develop a sufficient immune response. Accordingly, children born prematurely should be immunized in accordance with the passport age with the stabilization of the child’s condition and adequate weight gain.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"67 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-10DOI: 10.22625/2072-6732-2023-15-4-5-13
A. Vilnits, Y. Lobzin, N. V. Skripchenko, L. Mazankova, O. I. Klimova, A. Rtishchev, I. Osmanov, K. Markova, N. H. Tkhakushinova, G. P. Martinova, A. U. Sabitov, R. K. Babik, I. Y. Izvekova, V. V. Krasnov, E. V. Sidorenkova, O. V. Borisova, N. M. Bochkareva, O. Samodova, V. Sokolovskaya, A. A. Girina, A. Kurganskaya, E. M. Simovanyan, M. A. Kim, O. Rychkova, L. V. Khanipova, S. Grigorev
The heavy burden of meningococcal infection is associated not only with life-threatening complications in the acute period and high mortality in invasive forms of the disease, but also with severe consequences in survivors, who are not recorded in our country.The aim of study: to analyze clinical manifestations, complications of the acute period and outcomes of invasive forms of meningococcal disease in children in various regions of the Russian Federation.Materials and methods: an analysis of data from 1327 inpatient medical records of children with an invasive meningococcal infection from 14 regional centers of the Russian Federation for 2012-2021 was carried out (28.3% of cases of the disease in children in the represented federal districts).Results: it was found that young children predominated among the patients – the median was 27.4 (10.7-70.4) months. Complications of the acute period, often combined, were observed in 47.6% of cases. The development of septic shock was noted in 30.4%, Waterhouse-Friderichsen syndrome in 6.6%, carditis in 2.9%, cerebral edema in 15.7%, arthritis in 1.4% of cases; the formation of hydrocephalus, subdural effusion, sensorineural hearing loss in 1.8%, 0.6%, 1% of children, respectively. The presence of soft tissue necrosis requiring surgical intervention was noted in 3.5% of cases. Mortality rate was 10.1%. At the time of discharge from the hospital, 30% of children had complications associated with meningococcal infection: organ dysfunction/ failure in 13.2% of patients (severe in 1.3%), cerebral insufficiency in 19.6%; severe psycho-neurological deficits, sensorineural hearing loss, problems associated with the need for orthopedic/surgical interventions accounted for 0.7%, 0.6% and 0.8%, respectively.Conclusion. Considering the epidemiological features of meningococcal infection – the risk of a sharp increase in morbidity in short periods of time, the life-threatening nature of the disease itself, it is necessary to remain alert to these risks and take all possible measures to prevent the disease using all available means, the most effective of which is vaccine prevention.
{"title":"Meningococcal infection in children in the period 2012–2021. Main results of a retrospective multicenter study, issues of the day","authors":"A. Vilnits, Y. Lobzin, N. V. Skripchenko, L. Mazankova, O. I. Klimova, A. Rtishchev, I. Osmanov, K. Markova, N. H. Tkhakushinova, G. P. Martinova, A. U. Sabitov, R. K. Babik, I. Y. Izvekova, V. V. Krasnov, E. V. Sidorenkova, O. V. Borisova, N. M. Bochkareva, O. Samodova, V. Sokolovskaya, A. A. Girina, A. Kurganskaya, E. M. Simovanyan, M. A. Kim, O. Rychkova, L. V. Khanipova, S. Grigorev","doi":"10.22625/2072-6732-2023-15-4-5-13","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-4-5-13","url":null,"abstract":"The heavy burden of meningococcal infection is associated not only with life-threatening complications in the acute period and high mortality in invasive forms of the disease, but also with severe consequences in survivors, who are not recorded in our country.The aim of study: to analyze clinical manifestations, complications of the acute period and outcomes of invasive forms of meningococcal disease in children in various regions of the Russian Federation.Materials and methods: an analysis of data from 1327 inpatient medical records of children with an invasive meningococcal infection from 14 regional centers of the Russian Federation for 2012-2021 was carried out (28.3% of cases of the disease in children in the represented federal districts).Results: it was found that young children predominated among the patients – the median was 27.4 (10.7-70.4) months. Complications of the acute period, often combined, were observed in 47.6% of cases. The development of septic shock was noted in 30.4%, Waterhouse-Friderichsen syndrome in 6.6%, carditis in 2.9%, cerebral edema in 15.7%, arthritis in 1.4% of cases; the formation of hydrocephalus, subdural effusion, sensorineural hearing loss in 1.8%, 0.6%, 1% of children, respectively. The presence of soft tissue necrosis requiring surgical intervention was noted in 3.5% of cases. Mortality rate was 10.1%. At the time of discharge from the hospital, 30% of children had complications associated with meningococcal infection: organ dysfunction/ failure in 13.2% of patients (severe in 1.3%), cerebral insufficiency in 19.6%; severe psycho-neurological deficits, sensorineural hearing loss, problems associated with the need for orthopedic/surgical interventions accounted for 0.7%, 0.6% and 0.8%, respectively.Conclusion. Considering the epidemiological features of meningococcal infection – the risk of a sharp increase in morbidity in short periods of time, the life-threatening nature of the disease itself, it is necessary to remain alert to these risks and take all possible measures to prevent the disease using all available means, the most effective of which is vaccine prevention.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"57 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-10DOI: 10.22625/2072-6732-2023-15-4-42-53
I. Babachenko
The purpose of the article is a systematic review of studies conducted in recent decades in children and adults, with an emphasis on domestic works, on the use of inosine pranobex preparations, in the treatment of infectious diseases. The clinical and immunological effectiveness of inosine pranobex in the treatment and prevention of relapses in patients with recurrent respiratory viral infections against the background of persistent herpesviruses types 4-6 has been demonstrated. Using the example of multicenter comparative as well as placebo-controlled studies, not only the effectiveness, but also the safety of long-term courses of therapy is shown. A promising direction is the use of inosine pranobex in the treatment of COVID-19 and post-Covid conditions, taking into account its immunomodulatory effect without the risk of increasing the “cytokine storm”, as well as studies of the direct antiviral effect on the SARS-CoV-2 virus in vitro.
{"title":"Effectiveness of inosine pranobex in the treatment and prevention of infectious diseases (system review)","authors":"I. Babachenko","doi":"10.22625/2072-6732-2023-15-4-42-53","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-4-42-53","url":null,"abstract":"The purpose of the article is a systematic review of studies conducted in recent decades in children and adults, with an emphasis on domestic works, on the use of inosine pranobex preparations, in the treatment of infectious diseases. The clinical and immunological effectiveness of inosine pranobex in the treatment and prevention of relapses in patients with recurrent respiratory viral infections against the background of persistent herpesviruses types 4-6 has been demonstrated. Using the example of multicenter comparative as well as placebo-controlled studies, not only the effectiveness, but also the safety of long-term courses of therapy is shown. A promising direction is the use of inosine pranobex in the treatment of COVID-19 and post-Covid conditions, taking into account its immunomodulatory effect without the risk of increasing the “cytokine storm”, as well as studies of the direct antiviral effect on the SARS-CoV-2 virus in vitro.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":" 71","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.22625/2072-6732-2023-15-2-139-147
L. Rubis, O. Ekimova, О. S. Safonova, V. Е. Chevskaya
Objective: To identify common and distinctive characteristics of the epidemical process of tick-borne encephalitis and Lyme borreliosis on the example of the Republic of Karelia.Materials and methods. The frequency of infected tick bites, dynamics, intensity, territorial, gender, age and social features of the incidence of tick-borne encephalitis and Lyme borreliosis in 2000–2021 were analyzed according to official statistics, epidemiological examination of foci and laboratory studies. The results of studies of 2379 blood samples of adults who were not ill and not vaccinated against tick-borne encephalitis for the presence of antibodies to the virus were analyzed.Results. The virulence of ticks in 2000–2021 decreased from 23.6 to 1.3%, infection with borrelia at the level of 13.4– 38.4%. The average long-term incidence rates of tick-borne encephalitis and Lyme borreliosis were 6.2 and 6.6 per 100 thousand, the dynamics of incidence had an average pronounced downward trend, correlated with the dynamics of requests for medical care of the population affected by ticks. The main clinical form of tick–borne encephalitis is meningeal (48%). Non-erythemic forms of borreliosis in recent years amounted to 39.1%. Antibodies of class G to tick-borne encephalitis virus were detected in 11.8±0.7% of the examined individuals. The territory of risk of infection with tick-borne encephalitis and Lyme borreliosis is the central and eastern part of the south of the Republic, where I.persulcatus dominates. The proportion of urban residents among patients with both infections is higher, but the incidence of urban and rural populations did not have significant differences. The incidence rates of tick-borne borreliosis in persons aged 40-49, 50-59 and 60 years and older are 1.6-2.2 times higher than those of tick-borne encephalitis, but the difference is not significant. At working age, the percent of men is higher than women, there are no differences among the elderly.Conclusions: Similar and different features of the epidemic process of tick-borne encephalitis and tick-borne borreliosis have been identified, which should be taken to improving the detection of diseases, predicting the situation and planning preventive measures.
{"title":"Similarities and differences in the characteristics of the epidemical process tick-borne encephalitis and Lyme borreliosis","authors":"L. Rubis, O. Ekimova, О. S. Safonova, V. Е. Chevskaya","doi":"10.22625/2072-6732-2023-15-2-139-147","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-2-139-147","url":null,"abstract":"Objective: To identify common and distinctive characteristics of the epidemical process of tick-borne encephalitis and Lyme borreliosis on the example of the Republic of Karelia.Materials and methods. The frequency of infected tick bites, dynamics, intensity, territorial, gender, age and social features of the incidence of tick-borne encephalitis and Lyme borreliosis in 2000–2021 were analyzed according to official statistics, epidemiological examination of foci and laboratory studies. The results of studies of 2379 blood samples of adults who were not ill and not vaccinated against tick-borne encephalitis for the presence of antibodies to the virus were analyzed.Results. The virulence of ticks in 2000–2021 decreased from 23.6 to 1.3%, infection with borrelia at the level of 13.4– 38.4%. The average long-term incidence rates of tick-borne encephalitis and Lyme borreliosis were 6.2 and 6.6 per 100 thousand, the dynamics of incidence had an average pronounced downward trend, correlated with the dynamics of requests for medical care of the population affected by ticks. The main clinical form of tick–borne encephalitis is meningeal (48%). Non-erythemic forms of borreliosis in recent years amounted to 39.1%. Antibodies of class G to tick-borne encephalitis virus were detected in 11.8±0.7% of the examined individuals. The territory of risk of infection with tick-borne encephalitis and Lyme borreliosis is the central and eastern part of the south of the Republic, where I.persulcatus dominates. The proportion of urban residents among patients with both infections is higher, but the incidence of urban and rural populations did not have significant differences. The incidence rates of tick-borne borreliosis in persons aged 40-49, 50-59 and 60 years and older are 1.6-2.2 times higher than those of tick-borne encephalitis, but the difference is not significant. At working age, the percent of men is higher than women, there are no differences among the elderly.Conclusions: Similar and different features of the epidemic process of tick-borne encephalitis and tick-borne borreliosis have been identified, which should be taken to improving the detection of diseases, predicting the situation and planning preventive measures.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114276792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.22625/2072-6732-2023-15-2-123-131
E. A. Budnikova, O. Kubar, O. V. Iozefovich, S. Kharit
The purpose of the study: to determine the development of vaccination against infections associated with contingents in an epidemic crisis.Materials and methods: the method of a sociological survey of future workers and those vaccinated in different epidemic status periods was used: 2019 – the pre-pandemic period and 2020 – the period of the COVID-19 pandemic. A sociological survey was conducted in 2019 among 212 medical workers (130 doctors and 82 nurses) and among 229 medical workers in 2020 (143 doctors and 86 nurses). Parents were also interviewed using a questionnaire. 100 and 50 respondents took part in the survey, respectively.Results: a large number of pregnant workers – 74.3-88.1% are positive about vaccination. However, 6.8% of therapists and 9.6% of nurses of adult health facilities express a wary attitude, there were no negative reactions, unlike in 2019, when the severity of 2.2% of general practitioners and 4.2% of nurses of adult health facilities was negative. The largest number of respondents of all groups among the reasons for refusing to vaccinate is called “information that vaccinations are dangerous” from 76.6% to 88.9% in 20219, from 74.1% to 93.2% in 2020. Among parents, only 34% had a positive attitude towards vaccination, 12% negatively.Conclusions: It is necessary to take prompt measures to increase adherence to vaccination of the main social groups that have a decisive influence on the attitude and effect of vaccination.
{"title":"The study of the formation processes and signs of the likelihood of vaccination in priority contingents in various epidemic diseases (sociological research)","authors":"E. A. Budnikova, O. Kubar, O. V. Iozefovich, S. Kharit","doi":"10.22625/2072-6732-2023-15-2-123-131","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-2-123-131","url":null,"abstract":"The purpose of the study: to determine the development of vaccination against infections associated with contingents in an epidemic crisis.Materials and methods: the method of a sociological survey of future workers and those vaccinated in different epidemic status periods was used: 2019 – the pre-pandemic period and 2020 – the period of the COVID-19 pandemic. A sociological survey was conducted in 2019 among 212 medical workers (130 doctors and 82 nurses) and among 229 medical workers in 2020 (143 doctors and 86 nurses). Parents were also interviewed using a questionnaire. 100 and 50 respondents took part in the survey, respectively.Results: a large number of pregnant workers – 74.3-88.1% are positive about vaccination. However, 6.8% of therapists and 9.6% of nurses of adult health facilities express a wary attitude, there were no negative reactions, unlike in 2019, when the severity of 2.2% of general practitioners and 4.2% of nurses of adult health facilities was negative. The largest number of respondents of all groups among the reasons for refusing to vaccinate is called “information that vaccinations are dangerous” from 76.6% to 88.9% in 20219, from 74.1% to 93.2% in 2020. Among parents, only 34% had a positive attitude towards vaccination, 12% negatively.Conclusions: It is necessary to take prompt measures to increase adherence to vaccination of the main social groups that have a decisive influence on the attitude and effect of vaccination.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"190 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129224088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.22625/2072-6732-2023-15-2-114-122
E. A. Chernozemova, N. V. Mekaeva, L. Arkhipova, I. Fedunyak, E. D. Pshenay-Severin, V. V. Basina, I. Andreeva, E. Esaulenko, M. Pogromskaya
Purpose. To study the features of the clinical course of coronavirus infection (COVID-19) in people living with HIV and risk factors for adverse outcomes.Materials and methods. The study included 523 patients with a confirmed diagnosis of COVID-19 occurring against the background of HIV infection and hospitalized from March 2020 to September 2021 on the basis of the GBUZ “S.P. Botkin KIB” in St. Petersburg. Two groups were formed: 1 – receiving antiretroviral therapy (n=204), 2 – not receiving ART (n=319). A comparative analysis of the results obtained during the examination was carried out using statistical methods: Mann-Whitney (p≤0.05) and the calculation of the relative risk (RR) when comparing the probability of the outcome of the disease depending on the presence of risk factors: respiratory rate ( NPV),% lung damage, levels of CD4 and C-reactive protein (CRP) with a significance level of p≤0.05.Results. Among the patients, persons aged 30 to 49 years predominated. In 50.5% of cases, coronavirus infection proceeded in the form of acute respiratory viral infections, pneumonia was diagnosed in 49.5%, which was subsequently complicated in 22.9% by the development of acute respiratory distress syndrome or sepsis in 2.1%. Severe course of COVID-19 was observed in non-adherent to ART, with CD4 lymphocyte count (≤50 cells/µl), multimorbidity and amounted to 45%.Conclusion. A feature of the course of COVID-19 in patients with HIV/SARS-COV-2 coinfection was a high number of deaths – 21.6%. In the overall structure of causes of death, the maximum share fell on HIV infection – 58.4%, COVID-19 – 24.8%, HIV/ COVID-19 –9.7% coinfection and other causes – 7.1%. Factors associated with the development of severe forms of coronavirus infection caused by SARS-COV-2 in HIV-infected patients who were hospitalized, the combination of which can be used as a predictor of death, have been identified: respiratory rate (RR) > 20 per minute, percentage of involvement lungs> 50%, CD4 lymphocyte level <40 cells/µl, CRP>50 mg/l, presence of three or more concomitant diseases.
{"title":"Features of the clinical course of COVID-19 in people living with HIV","authors":"E. A. Chernozemova, N. V. Mekaeva, L. Arkhipova, I. Fedunyak, E. D. Pshenay-Severin, V. V. Basina, I. Andreeva, E. Esaulenko, M. Pogromskaya","doi":"10.22625/2072-6732-2023-15-2-114-122","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-2-114-122","url":null,"abstract":"Purpose. To study the features of the clinical course of coronavirus infection (COVID-19) in people living with HIV and risk factors for adverse outcomes.Materials and methods. The study included 523 patients with a confirmed diagnosis of COVID-19 occurring against the background of HIV infection and hospitalized from March 2020 to September 2021 on the basis of the GBUZ “S.P. Botkin KIB” in St. Petersburg. Two groups were formed: 1 – receiving antiretroviral therapy (n=204), 2 – not receiving ART (n=319). A comparative analysis of the results obtained during the examination was carried out using statistical methods: Mann-Whitney (p≤0.05) and the calculation of the relative risk (RR) when comparing the probability of the outcome of the disease depending on the presence of risk factors: respiratory rate ( NPV),% lung damage, levels of CD4 and C-reactive protein (CRP) with a significance level of p≤0.05.Results. Among the patients, persons aged 30 to 49 years predominated. In 50.5% of cases, coronavirus infection proceeded in the form of acute respiratory viral infections, pneumonia was diagnosed in 49.5%, which was subsequently complicated in 22.9% by the development of acute respiratory distress syndrome or sepsis in 2.1%. Severe course of COVID-19 was observed in non-adherent to ART, with CD4 lymphocyte count (≤50 cells/µl), multimorbidity and amounted to 45%.Conclusion. A feature of the course of COVID-19 in patients with HIV/SARS-COV-2 coinfection was a high number of deaths – 21.6%. In the overall structure of causes of death, the maximum share fell on HIV infection – 58.4%, COVID-19 – 24.8%, HIV/ COVID-19 –9.7% coinfection and other causes – 7.1%. Factors associated with the development of severe forms of coronavirus infection caused by SARS-COV-2 in HIV-infected patients who were hospitalized, the combination of which can be used as a predictor of death, have been identified: respiratory rate (RR) > 20 per minute, percentage of involvement lungs> 50%, CD4 lymphocyte level <40 cells/µl, CRP>50 mg/l, presence of three or more concomitant diseases.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"235 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121180147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.22625/2072-6732-2023-15-2-74-83
E. Ilyinskikh, E. Filatova, A. V. Semenova, Yu. I. Bulankov, V. N. Nekrasov, Yu. V. Minakova, S. Axyonov, O. Voronkova, K. Samoylov, N. S. Buzhak
Objective: is to assess clinical and laboratory prognostic factors to develop a differential diagnostic model between the monoinfection of tick-borne encephalitis febrile form and the mixed infection of tick-borne encephalitis with Lyme borreliosis non-erythemal form at the onset of the disease.Materials and methods. The clinical examination involving 56 patients with tick-borne encephalitis febrile form (mean age: 46.1±3.1 years) and 27 patients with the mixed infection of tick-borne encephalitis with Lyme borreliosis non-erythemal form (mean age: 47.2±3.2 years) has resulted in the assessment of 65 clinical and laboratory parameters in the first week of the disease including 14 indicators of standard and extended hemogram profiles and 6 blood leukocyte indices. Pearson’s goodness-of-fit test was used for statistical analysis. The predictive values of the parameters were determined by the odds ratio and ROC analysis with AUC. The logistic regression model was developed using STATISTICA 12.0.Results. To make differential diagnosis between mono- and mixed infection at the onset of the disease the following hematological parameters with “average” or “good” predictive values can be used: band neutrophil count (AUC=0.65), the index of leukocytes and erythrocyte sedimentation rate ratio (AUC=0.66), erythrocyte sedimentation rate (AUC=0.70), neutrophil granularity intensity (AUC=0.66), neutrophil reactivity intensity (AUC=0.72) and reactive lymphocytes count (AUC= 0.72). A logistic regression model with a “very good” predictive value (AUC=0.83) is developed which includes the following four predictors: band neutrophil count, erythrocyte sedimentation rate, NEUT-RI and NEUT-GI in peripheral blood.Conclusion. The model is allowed to make a differential diagnosis between the mono- and the mixed infection of tick-borne encephalitis with good sensitivity and specificity values in the first week of disease.
{"title":"Assessment of prognostic factors for differential diagnostics between mono- and mixed infection of the febrile form of tick-borne encephalitis","authors":"E. Ilyinskikh, E. Filatova, A. V. Semenova, Yu. I. Bulankov, V. N. Nekrasov, Yu. V. Minakova, S. Axyonov, O. Voronkova, K. Samoylov, N. S. Buzhak","doi":"10.22625/2072-6732-2023-15-2-74-83","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-2-74-83","url":null,"abstract":"Objective: is to assess clinical and laboratory prognostic factors to develop a differential diagnostic model between the monoinfection of tick-borne encephalitis febrile form and the mixed infection of tick-borne encephalitis with Lyme borreliosis non-erythemal form at the onset of the disease.Materials and methods. The clinical examination involving 56 patients with tick-borne encephalitis febrile form (mean age: 46.1±3.1 years) and 27 patients with the mixed infection of tick-borne encephalitis with Lyme borreliosis non-erythemal form (mean age: 47.2±3.2 years) has resulted in the assessment of 65 clinical and laboratory parameters in the first week of the disease including 14 indicators of standard and extended hemogram profiles and 6 blood leukocyte indices. Pearson’s goodness-of-fit test was used for statistical analysis. The predictive values of the parameters were determined by the odds ratio and ROC analysis with AUC. The logistic regression model was developed using STATISTICA 12.0.Results. To make differential diagnosis between mono- and mixed infection at the onset of the disease the following hematological parameters with “average” or “good” predictive values can be used: band neutrophil count (AUC=0.65), the index of leukocytes and erythrocyte sedimentation rate ratio (AUC=0.66), erythrocyte sedimentation rate (AUC=0.70), neutrophil granularity intensity (AUC=0.66), neutrophil reactivity intensity (AUC=0.72) and reactive lymphocytes count (AUC= 0.72). A logistic regression model with a “very good” predictive value (AUC=0.83) is developed which includes the following four predictors: band neutrophil count, erythrocyte sedimentation rate, NEUT-RI and NEUT-GI in peripheral blood.Conclusion. The model is allowed to make a differential diagnosis between the mono- and the mixed infection of tick-borne encephalitis with good sensitivity and specificity values in the first week of disease.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129469485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.22625/2072-6732-2023-15-2-148-155
L. A. Perminova, J. L. Malakhova, I. B. Ivanov, O. G. Krasnova, A. Ebert, I. G. Skobei, A. V. Tarasov
The article presents the results of the study and analysis of archival documents, on the basis of which the history of the construction of the complex of buildings of the garrison infirmary «York» in Königsberg is recreated, the features of the architectural and planning solutions used in the construction of this medical complex are studied and analyzed. The description of the post-war and modern stages of development of the infectious diseases hospital of the Kaliningrad region, which is located in the preserved buildings of the garrison infirmary «York» in Konigsberg, is given.
{"title":"Garrison hospital «York» Königsberg: history of creation and further development of the infectious hospital of Kaliningrad","authors":"L. A. Perminova, J. L. Malakhova, I. B. Ivanov, O. G. Krasnova, A. Ebert, I. G. Skobei, A. V. Tarasov","doi":"10.22625/2072-6732-2023-15-2-148-155","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-2-148-155","url":null,"abstract":"The article presents the results of the study and analysis of archival documents, on the basis of which the history of the construction of the complex of buildings of the garrison infirmary «York» in Königsberg is recreated, the features of the architectural and planning solutions used in the construction of this medical complex are studied and analyzed. The description of the post-war and modern stages of development of the infectious diseases hospital of the Kaliningrad region, which is located in the preserved buildings of the garrison infirmary «York» in Konigsberg, is given.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115697143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-07DOI: 10.22625/2072-6732-2023-15-2-156-161
K. Zhdanov, O. V. Mal'cev, K. Kozlov, P. I. Miklush, E. V. Peredel’skij, S. N. Sidorchuk, Y. Kravchuk, A. S. Sigidaev, V. Dedkov, A. A. Konushkaliev
Crimean haemorrhagic fever (Crimean-Congo haemorrhagic fever) – an important public health problem due to the wide geographical spread, the ability to cause epidemic outbreaks of disease and high mortality. Evidence that human infection in some cases may occur in direct contact with the patient (bypassing the vector) indicates a high risk of contamination of surrounding people. This article presents a case of severe Crimean haemorrhagic fever in combination with tick-borne borreliosis with different clinical manifestations of the disease with many complications developed due to both direct and indirect effects of virus not only on blood cells, the system of hemostasis and vascular component with the development of hemorrhagic syndrome, but also on many organs and systems of the body. The possibility of long-term persistence of the Crimean haemorrhagic fever virus in the human body against the background of the inhibition of the immune system of the body and the severe course of the disease associated with the development of life-threatening complications, leads to a high risk of death, prolonged restorative treatment and extended hospitalization.
{"title":"A clinical case of severe Crimean hemorrhagic fever with prolonged persistence of the pathogen in combination with tick-borne borreliosis","authors":"K. Zhdanov, O. V. Mal'cev, K. Kozlov, P. I. Miklush, E. V. Peredel’skij, S. N. Sidorchuk, Y. Kravchuk, A. S. Sigidaev, V. Dedkov, A. A. Konushkaliev","doi":"10.22625/2072-6732-2023-15-2-156-161","DOIUrl":"https://doi.org/10.22625/2072-6732-2023-15-2-156-161","url":null,"abstract":"Crimean haemorrhagic fever (Crimean-Congo haemorrhagic fever) – an important public health problem due to the wide geographical spread, the ability to cause epidemic outbreaks of disease and high mortality. Evidence that human infection in some cases may occur in direct contact with the patient (bypassing the vector) indicates a high risk of contamination of surrounding people. This article presents a case of severe Crimean haemorrhagic fever in combination with tick-borne borreliosis with different clinical manifestations of the disease with many complications developed due to both direct and indirect effects of virus not only on blood cells, the system of hemostasis and vascular component with the development of hemorrhagic syndrome, but also on many organs and systems of the body. The possibility of long-term persistence of the Crimean haemorrhagic fever virus in the human body against the background of the inhibition of the immune system of the body and the severe course of the disease associated with the development of life-threatening complications, leads to a high risk of death, prolonged restorative treatment and extended hospitalization.","PeriodicalId":226950,"journal":{"name":"Journal Infectology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130493548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：