Karen C. Goehring, B. Marriage, J. Oliver, J. Wilder, E. Barrett, R. Buck
BACKGROUND Evidence suggests that human milk oligosaccharides (HMOs) provide multiple benefits to infants, including prebiotic effects, gut maturation, antimicrobial activities, and immune modulation. Clinical intervention studies with HMOs are required to confirm these benefits in infants. OBJECTIVE Our objective was to investigate the effects of feeding formulas supplemented with the HMO 2'-fucosyllactose (2'-FL) on biomarkers of immune function in healthy term infants. METHODS We performed a substudy nested within a randomized, double-blind, controlled growth and tolerance study in healthy singleton infants (birth weight ≥2490 g) who were enrolled by 5 d of life and exclusively formula-fed (n = 317) or breastfed (n = 107) from enrollment to 4 mo of age. Formula-fed infants were randomly assigned to receive 1 of 3 formulas, all containing 2.4 g total oligosaccharides/L [control: galacto-oligosaccharides (GOS) only; experimental formulas: GOS + 0.2 or 1.0 g 2'-FL/L], and compared with a breastfed reference group. For this substudy, blood samples were drawn from infants at 6 wk of age (n = 31-42/group). Peripheral blood mononuclear cells (PBMCs) were isolated for cellular phenotyping and stimulated ex vivo with phytohemagglutinin for proliferation and cell cycle progression or respiratory syncytial virus (RSV). Cytokine concentrations were measured in plasma and in ex vivo-stimulated culture supernatants. RESULTS Breastfed infants and infants fed either of the experimental formulas with 2'-FL were not different but had 29-83% lower concentrations of plasma inflammatory cytokines than did infants fed the control formula [interleukin (IL) receptor antagonist (IL-1ra), IL-1α, IL-1β, IL-6, and tumor necrosis factor α (TNF-α)] (P ≤ 0.05). In ex vivo RSV-stimulated PBMC cultures, breastfed infants were not different than either of the groups fed formula with 2'-FL, but they had lower concentrations of TNF-α (31%) and interferon γ (IFN-γ 54%) (P ≤ 0.05) and tended to have lower IL-1ra (25%) and IL-6 (38%) (unadjusted P ≤ 0.05) and IL-1β (30%) (unadjusted P = 0.06) than did infants fed the control formula. CONCLUSIONS Our data indicate that infants fed formula supplemented with 2'-FL exhibit lower plasma and ex vivo inflammatory cytokine profiles, similar to those of a breastfed reference group. This trial was registered at clinicaltrials.gov as NCT01808105.
{"title":"Similar to Those Who Are Breastfed, Infants Fed a Formula Containing 2'-Fucosyllactose Have Lower Inflammatory Cytokines in a Randomized Controlled Trial.","authors":"Karen C. Goehring, B. Marriage, J. Oliver, J. Wilder, E. Barrett, R. Buck","doi":"10.3945/JN.116.236919","DOIUrl":"https://doi.org/10.3945/JN.116.236919","url":null,"abstract":"BACKGROUND\u0000Evidence suggests that human milk oligosaccharides (HMOs) provide multiple benefits to infants, including prebiotic effects, gut maturation, antimicrobial activities, and immune modulation. Clinical intervention studies with HMOs are required to confirm these benefits in infants.\u0000\u0000\u0000OBJECTIVE\u0000Our objective was to investigate the effects of feeding formulas supplemented with the HMO 2'-fucosyllactose (2'-FL) on biomarkers of immune function in healthy term infants.\u0000\u0000\u0000METHODS\u0000We performed a substudy nested within a randomized, double-blind, controlled growth and tolerance study in healthy singleton infants (birth weight ≥2490 g) who were enrolled by 5 d of life and exclusively formula-fed (n = 317) or breastfed (n = 107) from enrollment to 4 mo of age. Formula-fed infants were randomly assigned to receive 1 of 3 formulas, all containing 2.4 g total oligosaccharides/L [control: galacto-oligosaccharides (GOS) only; experimental formulas: GOS + 0.2 or 1.0 g 2'-FL/L], and compared with a breastfed reference group. For this substudy, blood samples were drawn from infants at 6 wk of age (n = 31-42/group). Peripheral blood mononuclear cells (PBMCs) were isolated for cellular phenotyping and stimulated ex vivo with phytohemagglutinin for proliferation and cell cycle progression or respiratory syncytial virus (RSV). Cytokine concentrations were measured in plasma and in ex vivo-stimulated culture supernatants.\u0000\u0000\u0000RESULTS\u0000Breastfed infants and infants fed either of the experimental formulas with 2'-FL were not different but had 29-83% lower concentrations of plasma inflammatory cytokines than did infants fed the control formula [interleukin (IL) receptor antagonist (IL-1ra), IL-1α, IL-1β, IL-6, and tumor necrosis factor α (TNF-α)] (P ≤ 0.05). In ex vivo RSV-stimulated PBMC cultures, breastfed infants were not different than either of the groups fed formula with 2'-FL, but they had lower concentrations of TNF-α (31%) and interferon γ (IFN-γ 54%) (P ≤ 0.05) and tended to have lower IL-1ra (25%) and IL-6 (38%) (unadjusted P ≤ 0.05) and IL-1β (30%) (unadjusted P = 0.06) than did infants fed the control formula.\u0000\u0000\u0000CONCLUSIONS\u0000Our data indicate that infants fed formula supplemented with 2'-FL exhibit lower plasma and ex vivo inflammatory cytokine profiles, similar to those of a breastfed reference group. This trial was registered at clinicaltrials.gov as NCT01808105.","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80718220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cuiling Xu, V. Fang, Ranawaka A.P.M Perera, Andrea May-Sin Kam, S. Ng, Y. Chan, Kwok-Hung Chan, Dennis K M Ip, J. Peiris, B. Cowling
BACKGROUND Some studies have hypothesized that vitamin D may have a role to play in protection against influenza virus infections and illnesses, and that seasonal fluctuation in serum 25-hydroxyvitamin D [25(OH)D] may affect seasonal patterns of influenza virus infections. OBJECTIVE We aimed to investigate whether serum 25(OH)D concentrations were associated with the incidence of influenza virus infections and illnesses in children and adults in Hong Kong. METHODS In 2009-2010, 3030 children and adults of all ages from 796 households in Hong Kong were followed up to identify acute respiratory illnesses. Sera from 2694 participants were collected at baseline and after ∼1 mo, 6 mo, and 12 mo. Influenza virus infections were confirmed by reverse transcriptase-polymerase chain reaction performed on nasal and throat swab samples collected during illness episodes. Serologic evidence of influenza virus infection was measured by hemagglutination inhibition assays in unvaccinated participants. The serum 25(OH)D concentrations were measured after collection of all specimens. Each individual's baseline serum 25(OH)D concentration on 1 January 2010 was predicted by a random-effects linear regression model. RESULTS We found that, in children and adults who had not received a seasonal influenza vaccine, baseline serum 25(OH)D concentrations (<50 nmol/L compared with ≥50 nmol/L) were not statistically significantly associated with serologic evidence of influenza A(H1N1)pdm09 (RR, 1.18; 95% CI: 0.85, 1.65) or seasonal influenza virus infections [including A(H3N2) and B virus] (RR, 1.13; 95% CI: 0.86, 1.49). In all participants, baseline serum 25(OH)D concentrations were not statistically significantly associated with polymerase chain reaction-confirmed influenza virus infection (RR, 1.15; 95% CI: 0.73, 1.83) and influenza-like illness (RR, 1.18; 95% CI: 0.98, 1.43). CONCLUSIONS These findings indicate that lower serum vitamin D concentrations may not contribute to the seasonality of influenza and are not associated with an increased risk of influenza virus infections in persons of all ages in Hong Kong.
{"title":"Serum 25-Hydroxyvitamin D Was Not Associated with Influenza Virus Infection in Children and Adults in Hong Kong, 2009-2010.","authors":"Cuiling Xu, V. Fang, Ranawaka A.P.M Perera, Andrea May-Sin Kam, S. Ng, Y. Chan, Kwok-Hung Chan, Dennis K M Ip, J. Peiris, B. Cowling","doi":"10.3945/JN.116.234856","DOIUrl":"https://doi.org/10.3945/JN.116.234856","url":null,"abstract":"BACKGROUND\u0000Some studies have hypothesized that vitamin D may have a role to play in protection against influenza virus infections and illnesses, and that seasonal fluctuation in serum 25-hydroxyvitamin D [25(OH)D] may affect seasonal patterns of influenza virus infections.\u0000\u0000\u0000OBJECTIVE\u0000We aimed to investigate whether serum 25(OH)D concentrations were associated with the incidence of influenza virus infections and illnesses in children and adults in Hong Kong.\u0000\u0000\u0000METHODS\u0000In 2009-2010, 3030 children and adults of all ages from 796 households in Hong Kong were followed up to identify acute respiratory illnesses. Sera from 2694 participants were collected at baseline and after ∼1 mo, 6 mo, and 12 mo. Influenza virus infections were confirmed by reverse transcriptase-polymerase chain reaction performed on nasal and throat swab samples collected during illness episodes. Serologic evidence of influenza virus infection was measured by hemagglutination inhibition assays in unvaccinated participants. The serum 25(OH)D concentrations were measured after collection of all specimens. Each individual's baseline serum 25(OH)D concentration on 1 January 2010 was predicted by a random-effects linear regression model.\u0000\u0000\u0000RESULTS\u0000We found that, in children and adults who had not received a seasonal influenza vaccine, baseline serum 25(OH)D concentrations (<50 nmol/L compared with ≥50 nmol/L) were not statistically significantly associated with serologic evidence of influenza A(H1N1)pdm09 (RR, 1.18; 95% CI: 0.85, 1.65) or seasonal influenza virus infections [including A(H3N2) and B virus] (RR, 1.13; 95% CI: 0.86, 1.49). In all participants, baseline serum 25(OH)D concentrations were not statistically significantly associated with polymerase chain reaction-confirmed influenza virus infection (RR, 1.15; 95% CI: 0.73, 1.83) and influenza-like illness (RR, 1.18; 95% CI: 0.98, 1.43).\u0000\u0000\u0000CONCLUSIONS\u0000These findings indicate that lower serum vitamin D concentrations may not contribute to the seasonality of influenza and are not associated with an increased risk of influenza virus infections in persons of all ages in Hong Kong.","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74519232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ziaei, Anisur Rahman, R. Raqib, B. Lönnerdal, E. Ekström
Background: The effects of prenatal food and micronutrient supplementation on maternal micronutrient status are not well known. Objective: We compared the efficacy and effectiveness of 3 different micronutrient supplements on maternal micronutrient status when combined with food supplementation. Methods: In the MINIMat (Maternal and Infant Nutrition Intervention, Matlab) trial in Bangladesh, 4436 pregnant women were randomly assigned to daily intake of 3 types of micronutrient capsules: 30 mg Fe and 400 μg folic acid (Fe30F), 60 mg Fe and 400 μg folic acid (Fe60F), or multiple micronutrient supplements (MMNs) combined with early (week 9 of pregnancy) or usual (week 20 of pregnancy) food supplementation in a 2 by 3 factorial design. Plasma concentrations of vitamin B-12, folate, ferritin, and zinc were analyzed before the start of micronutrient supplementation (week 14) and at week 30 of pregnancy in 641 randomly selected women. An electronic monitoring device was used to measure the number of capsules taken. The effectiveness of food and micronutrient regimens as well as efficacy per capsule in maternal micronutrient status were analyzed by ANOVA and general linear models. Results: At week 30 of pregnancy, women in the MMN group had higher geometric mean concentrations of vitamin B-12 than women in the Fe60F group (119 compared with 101 pmol/L, respectively); no other differences in effectiveness of micronutrient and food regimens were observed. A dose-response relation between the number of capsules taken and concentrations of folate and ferritin was observed for all micronutrient supplements. Fe30F had lower efficacy per capsule in increasing ferritin concentrations within the first tertile of capsule intake than did Fe60F and MMNs. Because ferritin reached a plateau for all types of micronutrient supplements, there was no difference between the regimens in their effectiveness. Conclusion: Compared with Fe60F, MMNs produced higher maternal vitamin B-12 and similar ferritin and folate concentrations in Bangladeshi women. The MINIMat trial was registered at isrctn.org as ISRCTN16581394.
{"title":"A Prenatal Multiple Micronutrient Supplement Produces Higher Maternal Vitamin B-12 Concentrations and Similar Folate, Ferritin, and Zinc Concentrations as the Standard 60-mg Iron Plus 400-μg Folic Acid Supplement in Rural Bangladeshi Women12","authors":"S. Ziaei, Anisur Rahman, R. Raqib, B. Lönnerdal, E. Ekström","doi":"10.3945/jn.116.235994","DOIUrl":"https://doi.org/10.3945/jn.116.235994","url":null,"abstract":"Background: The effects of prenatal food and micronutrient supplementation on maternal micronutrient status are not well known. Objective: We compared the efficacy and effectiveness of 3 different micronutrient supplements on maternal micronutrient status when combined with food supplementation. Methods: In the MINIMat (Maternal and Infant Nutrition Intervention, Matlab) trial in Bangladesh, 4436 pregnant women were randomly assigned to daily intake of 3 types of micronutrient capsules: 30 mg Fe and 400 μg folic acid (Fe30F), 60 mg Fe and 400 μg folic acid (Fe60F), or multiple micronutrient supplements (MMNs) combined with early (week 9 of pregnancy) or usual (week 20 of pregnancy) food supplementation in a 2 by 3 factorial design. Plasma concentrations of vitamin B-12, folate, ferritin, and zinc were analyzed before the start of micronutrient supplementation (week 14) and at week 30 of pregnancy in 641 randomly selected women. An electronic monitoring device was used to measure the number of capsules taken. The effectiveness of food and micronutrient regimens as well as efficacy per capsule in maternal micronutrient status were analyzed by ANOVA and general linear models. Results: At week 30 of pregnancy, women in the MMN group had higher geometric mean concentrations of vitamin B-12 than women in the Fe60F group (119 compared with 101 pmol/L, respectively); no other differences in effectiveness of micronutrient and food regimens were observed. A dose-response relation between the number of capsules taken and concentrations of folate and ferritin was observed for all micronutrient supplements. Fe30F had lower efficacy per capsule in increasing ferritin concentrations within the first tertile of capsule intake than did Fe60F and MMNs. Because ferritin reached a plateau for all types of micronutrient supplements, there was no difference between the regimens in their effectiveness. Conclusion: Compared with Fe60F, MMNs produced higher maternal vitamin B-12 and similar ferritin and folate concentrations in Bangladeshi women. The MINIMat trial was registered at isrctn.org as ISRCTN16581394.","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84837994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-10-13DOI: 10.1093/OXFORDHB/9780199736362.013.0022
J. Ledikwe, Julia A. Ello-Martin, B. Rolls
The rise in obesity rates over the past 30 y has been paralleled by increases in the portion size of many foods and the prevalence of eating away from home. Foods of particular concern are those that have a high energy density (kJ/g). Many well-controlled, laboratory-based studies have found that large portions of energy-dense foods can lead to excess energy intakes. This influence of large portions on energy intake has been supported by data collected in naturalistic settings. Further research is needed to explore strategies that can be used to moderate the effects of portion size on food consumption. One promising strategy is to reduce the energy density of foods, while maintaining food weight or volume, so that consumers can eat satisfying portions while reducing their energy intakes. There is a need for effective educational messages that not only emphasize limiting the consumption of foods high in energy density, but also encourage the consumption of those with a low energy density, such as fruits and vegetables. The delivery of consistent messages will require more cooperation among the food and restaurant industries, policy makers, and scientists. Effective strategies will also require consumers to understand and accept the importance of eating reasonable portions for better health.
{"title":"Portion sizes and the obesity epidemic.","authors":"J. Ledikwe, Julia A. Ello-Martin, B. Rolls","doi":"10.1093/OXFORDHB/9780199736362.013.0022","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780199736362.013.0022","url":null,"abstract":"The rise in obesity rates over the past 30 y has been paralleled by increases in the portion size of many foods and the prevalence of eating away from home. Foods of particular concern are those that have a high energy density (kJ/g). Many well-controlled, laboratory-based studies have found that large portions of energy-dense foods can lead to excess energy intakes. This influence of large portions on energy intake has been supported by data collected in naturalistic settings. Further research is needed to explore strategies that can be used to moderate the effects of portion size on food consumption. One promising strategy is to reduce the energy density of foods, while maintaining food weight or volume, so that consumers can eat satisfying portions while reducing their energy intakes. There is a need for effective educational messages that not only emphasize limiting the consumption of foods high in energy density, but also encourage the consumption of those with a low energy density, such as fruits and vegetables. The delivery of consistent messages will require more cooperation among the food and restaurant industries, policy makers, and scientists. Effective strategies will also require consumers to understand and accept the importance of eating reasonable portions for better health.","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86722257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Gabelle, S. Roche, C. Geny, F. Portet, J. Touchon, S. Lehmann, G. Meyer, F. Shapiro, H. Vanderstichele, E. Vanmechelen, S. Engelborghs, P. Deyn, L. Shaw, J. Trojanowski, S. Nestor, R. Rupsingh, M. Borrie, M. Smith, J. Wells, R. Bartha, K. Blennow, O. Hansson, L. Minthon, A. Wallin, H. Zetterberg, P. Lewezuk, H. Vandertischele, J. Kornhuber, J. Wiltfang, K. Iqbal, S. Chalbot, I. Grundke‐Iqbal, H. Gertz, M. Berwig, H. Leicht, C. W. Zhu, C. Leibman, R. Townsend, T. Mclaughlin, N. Scarmeas, M. Albert, J. Brandt, D. Blacker, M. Sano, Y. Stern, G. Bravo, M. Dubois, S. Hansel, A. Duguet, P. Robert, A. Deudon, N. Ake, X. Gervais, E. Leone, B. Lavallart, D. Amato, K. Zavitz, R. Green, L. Schneider, E. Swabb, G. A. Kan, I. Carrié, S. Gillette, M. Soto, J. Gardette, C. Przybylski, S. Andrieu, B. Vellas, A. Dangour, E. Allen, D. Elbourne, A. Fletcher, M. Richards, R. Uauy, K. Zavitz, R. Wurtman, O. Peters, D. Lorenz, H. Möller, L. Frölich, I. Heuser, R. Vandenberghe, L. Thurfjell, R. Owenius, D. Brooks, N. Nelisse
{"title":"1st Conference Clinical Trials on Alzheimer’s Disease September 17-18-19, 2008 School of Medecine Montpellier, France","authors":"A. Gabelle, S. Roche, C. Geny, F. Portet, J. Touchon, S. Lehmann, G. Meyer, F. Shapiro, H. Vanderstichele, E. Vanmechelen, S. Engelborghs, P. Deyn, L. Shaw, J. Trojanowski, S. Nestor, R. Rupsingh, M. Borrie, M. Smith, J. Wells, R. Bartha, K. Blennow, O. Hansson, L. Minthon, A. Wallin, H. Zetterberg, P. Lewezuk, H. Vandertischele, J. Kornhuber, J. Wiltfang, K. Iqbal, S. Chalbot, I. Grundke‐Iqbal, H. Gertz, M. Berwig, H. Leicht, C. W. Zhu, C. Leibman, R. Townsend, T. Mclaughlin, N. Scarmeas, M. Albert, J. Brandt, D. Blacker, M. Sano, Y. Stern, G. Bravo, M. Dubois, S. Hansel, A. Duguet, P. Robert, A. Deudon, N. Ake, X. Gervais, E. Leone, B. Lavallart, D. Amato, K. Zavitz, R. Green, L. Schneider, E. Swabb, G. A. Kan, I. Carrié, S. Gillette, M. Soto, J. Gardette, C. Przybylski, S. Andrieu, B. Vellas, A. Dangour, E. Allen, D. Elbourne, A. Fletcher, M. Richards, R. Uauy, K. Zavitz, R. Wurtman, O. Peters, D. Lorenz, H. Möller, L. Frölich, I. Heuser, R. Vandenberghe, L. Thurfjell, R. Owenius, D. Brooks, N. Nelisse","doi":"10.1007/BF02983205","DOIUrl":"https://doi.org/10.1007/BF02983205","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90070872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. B. Vind, H. E. Andersen, P. Schwarz, A. Skalska, A. Sałakowski, M. Dubiel, D. Fedak, T. Grodzicki, C. Annweiler, A. Schott, B. Fantino, G. Berrut, F. Herrmann, O. Beauchet, S. Engels, M. Schroll, C. Popescu, G. Onose, A. Bojan, M. Zutphen, W. Bemelmans, L. Groot, I. Rea, M. Henry, I. S. Young, A. Evans, F. Kee, C. F. Ambien, A. Whitehead, G. Ryzhak, V. Khavinson, L. Kozlov, V. Povoroznyuk, S. Kivelâ, D. Nielsen, W. Nielsen, B. Knold, J. Ryg, N. Nissen, K. Brixen, M. Bjorkman, A. Sorva, R. Tilvis, P. Kannegaard, A. Jung, F. Simonsen, S. Sanders, J. Puustinen, J. Nurminen, M. Lopponen, T. Vahlberg, R. Isoaho, T. Hayashi, K. Ina, H. Nomura, A. Iguchi, L. Tiret, O. Poire, F. Cambien, S. Pautex, G. Notaridis, L. Déramé, G. Zulian, A. Ungar, A. Fedeli, S. Zanieri, S. Pecchioni, M. Belladonna, L. Lambertucci, E. Lotti, G. Pepe, A. Bambi, A. Morrione, G. Masotti, M. Marchionni, F. Mazzella, C. Napoli, D. F. Vitale, L. Viati, G. Longobardi, G. Lucchetti, P. Abete, F. Rengo, P. Lous, G. Gold, K. Lihavainen, S. S
{"title":"Oral and Poster Papers Submitted for Presentation at the 5th Congress of the EUGMS “Geriatric Medicine in a Time of Generational Shift September 3–6, 2008 Copenhagen, Denmark","authors":"A. B. Vind, H. E. Andersen, P. Schwarz, A. Skalska, A. Sałakowski, M. Dubiel, D. Fedak, T. Grodzicki, C. Annweiler, A. Schott, B. Fantino, G. Berrut, F. Herrmann, O. Beauchet, S. Engels, M. Schroll, C. Popescu, G. Onose, A. Bojan, M. Zutphen, W. Bemelmans, L. Groot, I. Rea, M. Henry, I. S. Young, A. Evans, F. Kee, C. F. Ambien, A. Whitehead, G. Ryzhak, V. Khavinson, L. Kozlov, V. Povoroznyuk, S. Kivelâ, D. Nielsen, W. Nielsen, B. Knold, J. Ryg, N. Nissen, K. Brixen, M. Bjorkman, A. Sorva, R. Tilvis, P. Kannegaard, A. Jung, F. Simonsen, S. Sanders, J. Puustinen, J. Nurminen, M. Lopponen, T. Vahlberg, R. Isoaho, T. Hayashi, K. Ina, H. Nomura, A. Iguchi, L. Tiret, O. Poire, F. Cambien, S. Pautex, G. Notaridis, L. Déramé, G. Zulian, A. Ungar, A. Fedeli, S. Zanieri, S. Pecchioni, M. Belladonna, L. Lambertucci, E. Lotti, G. Pepe, A. Bambi, A. Morrione, G. Masotti, M. Marchionni, F. Mazzella, C. Napoli, D. F. Vitale, L. Viati, G. Longobardi, G. Lucchetti, P. Abete, F. Rengo, P. Lous, G. Gold, K. Lihavainen, S. S","doi":"10.1007/BF02983206","DOIUrl":"https://doi.org/10.1007/BF02983206","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77116723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Andrieu, P. Barberger‐Gateau, C. Raffaitin, C. Berr, C. Tzourio, J. Dartigues, H. Gin, L. Fitten, F. Ortiz, L. Fairbanks, G. Bartzokis, P. Lu, J. Ringman, P. Heyn, J. Locher, A. Salvá, E. Fernández, B. Vellas, O. Rest, J. Geleijnse, F. Kok, W. Staveren, A. Beekman, W. Hoefnagels, C. M. Groot, M. Angevaren, G. Aufdemkampe, H. Verhaar, A. Aleman, L. Vannees, S. Arkin, H. Florez, H. Gerstein, P. Sheridan, J. Bosch, R. Goldberg, K. Kaspar, S. Drawert, R. Marcus, J. Kidde, L. Dibble, O. Addison, P. LaStayo, N. Scarmeas, Y. Stern, N. Schupf, J. Luchsinger, J. Sharkey, J. Laditka, S. Laditka, R. Liu, A. Hochhalter, J. Robare, N. Türner, M. Judge, T. Foster, B. Erdős, I. Cudykier, P. Scarpace, L. Weiss, J. Bergstrom, D. Kritz-Silverstein, E. Barrett-Connor, K. Yurko-Mauro, E. Nelson, J. Quinn, F. Sattler, C. Castaneda-Sceppa, E. Binder, E. Schroeder, Y. Wang, S. Bhasin, M. Kawakubo, Y. Stewart, C. Hahn, P. Colletti, R. Roubenoff, K. Yarasheski, S. Azen, Y. Aoki, T. Yamamoto, T. Otuka, C. Blanc-Bisson, I. Bourd
{"title":"3rd IANA (International Academy on Nutrition and Aging) Meeting Nutrition, Exercise & Alzheimer and Clinical Trials on Sarcopenia August 1–2, 2008 Hyatt Regency Tamaya Resort 1300 Tuyuna Trail Santa Ana Pueblo, NM USA","authors":"S. Andrieu, P. Barberger‐Gateau, C. Raffaitin, C. Berr, C. Tzourio, J. Dartigues, H. Gin, L. Fitten, F. Ortiz, L. Fairbanks, G. Bartzokis, P. Lu, J. Ringman, P. Heyn, J. Locher, A. Salvá, E. Fernández, B. Vellas, O. Rest, J. Geleijnse, F. Kok, W. Staveren, A. Beekman, W. Hoefnagels, C. M. Groot, M. Angevaren, G. Aufdemkampe, H. Verhaar, A. Aleman, L. Vannees, S. Arkin, H. Florez, H. Gerstein, P. Sheridan, J. Bosch, R. Goldberg, K. Kaspar, S. Drawert, R. Marcus, J. Kidde, L. Dibble, O. Addison, P. LaStayo, N. Scarmeas, Y. Stern, N. Schupf, J. Luchsinger, J. Sharkey, J. Laditka, S. Laditka, R. Liu, A. Hochhalter, J. Robare, N. Türner, M. Judge, T. Foster, B. Erdős, I. Cudykier, P. Scarpace, L. Weiss, J. Bergstrom, D. Kritz-Silverstein, E. Barrett-Connor, K. Yurko-Mauro, E. Nelson, J. Quinn, F. Sattler, C. Castaneda-Sceppa, E. Binder, E. Schroeder, Y. Wang, S. Bhasin, M. Kawakubo, Y. Stewart, C. Hahn, P. Colletti, R. Roubenoff, K. Yarasheski, S. Azen, Y. Aoki, T. Yamamoto, T. Otuka, C. Blanc-Bisson, I. Bourd","doi":"10.1007/BF02982702","DOIUrl":"https://doi.org/10.1007/BF02982702","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74000730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The PLASA study","authors":"S. Gauthier","doi":"10.1007/BF02982631","DOIUrl":"https://doi.org/10.1007/BF02982631","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91457268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical trials and aging section","authors":"S. Gauthier","doi":"10.1007/BF02982618","DOIUrl":"https://doi.org/10.1007/BF02982618","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84765475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-05-01DOI: 10.1197/J.AEM.2006.03.092
Haichao Wang, Wei Li, Jianhua Li, B. Rendon-Mitchell, M. Ochani, M. Ashok, Lihong Yang, Huan Yang, K. Tracey, Ping Wang, A. Sama
Despite recent advances in antibiotic therapy and intensive care, sepsis remains a widespread problem in critically ill patients. The high mortality from sepsis is in part mediated by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release early (e.g., tumor necrosis factor, interleukin-1, and interferon-gamma) and late [e.g., high mobility group box 1 protein (HMGB1)] proinflammatory cytokines. Our discovery of HMGB1 as a late mediator of lethal systemic inflammation has initiated a new field of investigation for the development of experimental therapeutics. A popular Chinese herb, Angelica sinensis (also known as Dang Gui or Dong Quai) has been used traditionally for treating women with gynecological disorders (such as dysmenorrheal and hot flashes). Here we examined the effect of Angelica sinensis extract on endotoxin-induced HMGB1 release in vitro, and explored its therapeutic potential in animal models of lethal endotoxemia and sepsis [induced by cecal ligation and puncture (CLP)] in vivo. We demonstrated that a low-molecular-weight (<10 kDa) fraction of A. sinensis extract significantly attenuated endotoxin-induced HMGB1 release in part through interfering with its cytoplasmic translocation in macrophage cultures. Prophylactic administration of an aqueous extract of A. sinensis significantly attenuated systemic HMGB1 accumulation in vivo, and conferred a dose-dependent protection against lethal endotoxemia. Furthermore, delayed administration of A. sinensis extract beginning 24 h after CLP attenuated systemic HMGB1 accumulation, and significantly rescued mice from lethal sepsis. Taken together, these data suggest that A. sinensis contains water-soluble components that exert protective effects against lethal endotoxemia and experimental sepsis in part by attenuating systemic accumulation of a late proinflammatory cytokine, HMGB1.
{"title":"The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis.","authors":"Haichao Wang, Wei Li, Jianhua Li, B. Rendon-Mitchell, M. Ochani, M. Ashok, Lihong Yang, Huan Yang, K. Tracey, Ping Wang, A. Sama","doi":"10.1197/J.AEM.2006.03.092","DOIUrl":"https://doi.org/10.1197/J.AEM.2006.03.092","url":null,"abstract":"Despite recent advances in antibiotic therapy and intensive care, sepsis remains a widespread problem in critically ill patients. The high mortality from sepsis is in part mediated by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release early (e.g., tumor necrosis factor, interleukin-1, and interferon-gamma) and late [e.g., high mobility group box 1 protein (HMGB1)] proinflammatory cytokines. Our discovery of HMGB1 as a late mediator of lethal systemic inflammation has initiated a new field of investigation for the development of experimental therapeutics. A popular Chinese herb, Angelica sinensis (also known as Dang Gui or Dong Quai) has been used traditionally for treating women with gynecological disorders (such as dysmenorrheal and hot flashes). Here we examined the effect of Angelica sinensis extract on endotoxin-induced HMGB1 release in vitro, and explored its therapeutic potential in animal models of lethal endotoxemia and sepsis [induced by cecal ligation and puncture (CLP)] in vivo. We demonstrated that a low-molecular-weight (<10 kDa) fraction of A. sinensis extract significantly attenuated endotoxin-induced HMGB1 release in part through interfering with its cytoplasmic translocation in macrophage cultures. Prophylactic administration of an aqueous extract of A. sinensis significantly attenuated systemic HMGB1 accumulation in vivo, and conferred a dose-dependent protection against lethal endotoxemia. Furthermore, delayed administration of A. sinensis extract beginning 24 h after CLP attenuated systemic HMGB1 accumulation, and significantly rescued mice from lethal sepsis. Taken together, these data suggest that A. sinensis contains water-soluble components that exert protective effects against lethal endotoxemia and experimental sepsis in part by attenuating systemic accumulation of a late proinflammatory cytokine, HMGB1.","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2006-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80597452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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