P. Heaton, Catrina F Reed, S. Mann, R. Ransley, J. Stevenson, C. Charlton, Brigitte H. E. Smith, E. Harper, J. Rawlings
We studied the effects of feeding an antioxidant blend of vitamins, minerals and carotenoids to a mixed adult dog population (n = 40, mean 4.4 +/- 1.85 y) for a 16-wk period. Compared to the control group of dogs (n = 20), the antioxidant (AOX)-supplemented group of dogs (n = 20) demonstrated significant increases in plasma levels of vitamin E and taurine by 4 wk of supplementation (P < 0.01) and total antioxidant activity (as measured by ferric-reducing antioxidant power assay) by 8 wk of supplementation (P < 0.05). Following 8 wk of supplementation, the AOX-supplemented dogs also showed significant reductions in both endogenous and exogenous DNA damage (P < 0.005) compared to that of the control dogs, as measured by the comet assay. Over an 8-wk rabies vaccination course that started at 8 wk supplementation, the AOX-supplemented dogs also demonstrated significantly higher vaccine-specific virus-neutralizing antibody levels at 2, 4 and 6 wk postvaccination (P < 0.05) and a tendency toward establishing a vaccine-specific antibody response quicker than did the control group of dogs. These findings in dogs suggest that antioxidant supplementation can achieve sustained increases in circulating levels of antioxidants that exert a protective effect by a decrease in DNA damage, leading to improved immunological performance. These findings also have implications in a wider context where free-radical damage has been associated with a variety of degenerative disorders and the aging process in general.
{"title":"Role of dietary antioxidants to protect against DNA damage in adult dogs.","authors":"P. Heaton, Catrina F Reed, S. Mann, R. Ransley, J. Stevenson, C. Charlton, Brigitte H. E. Smith, E. Harper, J. Rawlings","doi":"10.1093/jn/132.6.1720S","DOIUrl":"https://doi.org/10.1093/jn/132.6.1720S","url":null,"abstract":"We studied the effects of feeding an antioxidant blend of vitamins, minerals and carotenoids to a mixed adult dog population (n = 40, mean 4.4 +/- 1.85 y) for a 16-wk period. Compared to the control group of dogs (n = 20), the antioxidant (AOX)-supplemented group of dogs (n = 20) demonstrated significant increases in plasma levels of vitamin E and taurine by 4 wk of supplementation (P < 0.01) and total antioxidant activity (as measured by ferric-reducing antioxidant power assay) by 8 wk of supplementation (P < 0.05). Following 8 wk of supplementation, the AOX-supplemented dogs also showed significant reductions in both endogenous and exogenous DNA damage (P < 0.005) compared to that of the control dogs, as measured by the comet assay. Over an 8-wk rabies vaccination course that started at 8 wk supplementation, the AOX-supplemented dogs also demonstrated significantly higher vaccine-specific virus-neutralizing antibody levels at 2, 4 and 6 wk postvaccination (P < 0.05) and a tendency toward establishing a vaccine-specific antibody response quicker than did the control group of dogs. These findings in dogs suggest that antioxidant supplementation can achieve sustained increases in circulating levels of antioxidants that exert a protective effect by a decrease in DNA damage, leading to improved immunological performance. These findings also have implications in a wider context where free-radical damage has been associated with a variety of degenerative disorders and the aging process in general.","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":"60 1","pages":"1720S-4S"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84887667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum response of ponies to beta-carotene fed by grass meal or a synthetic beadlet preparation with and without added dietary fat.","authors":"E. Kienzle, C. Kaden, P. Hoppe, B. Opitz","doi":"10.1093/JN/132.6.1774S","DOIUrl":"https://doi.org/10.1093/JN/132.6.1774S","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":"97 1","pages":"1774S-5S"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74838769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retinol and retinyl ester responses in the blood plasma and urine of dogs after a single oral dose of vitamin A.","authors":"J. Raila, R. Radon, A. Trüpschuch, F. Schweigert","doi":"10.1093/jn/132.6.1673S","DOIUrl":"https://doi.org/10.1093/jn/132.6.1673S","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":"90 10 1","pages":"1673S-5S"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86550894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meri Stratton-Phelps, R. Backus, Q. Rogers, A. Fascetti
{"title":"Dietary rice bran decreases plasma and whole-blood taurine in cats.","authors":"Meri Stratton-Phelps, R. Backus, Q. Rogers, A. Fascetti","doi":"10.1093/jn/132.6.1745S","DOIUrl":"https://doi.org/10.1093/jn/132.6.1745S","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":"3 1","pages":"1745S-7S"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83901931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. L. Streiff, B. Zwischenberger, R. Butterwick, E. Wagner, C. Iben, J. Bauer
Maintaining the health of dogs and cats by feeding wholesome nutritional diets is an important component of responsible pet ownership. Numerous improvements in companion animal nutrition have resulted in a wide array of foods providing complete and balanced nutrition. In spite of these developments, some pet owners prefer preparing food at home for their animals (1). Although owners generally have good intentions, some of them may lack the scientific knowledge or other resources to recognize important nutritional needs of their pets. Thus the potential for nutrient deficiencies, excesses and imbalances exists. This study was conducted to compare the nutritional adequacy of home-prepared diets in young and adult dogs using data gathered from a population of dogs and their owners in Vienna, Austria. Representative samples of home-prepared diets were analyzed and compared to commercial pet foods and to recommendations set by the American Association of Feed Control Officials (AAFCO) (2).
{"title":"A comparison of the nutritional adequacy of home-prepared and commercial diets for dogs.","authors":"E. L. Streiff, B. Zwischenberger, R. Butterwick, E. Wagner, C. Iben, J. Bauer","doi":"10.1093/jn/132.6.1698S","DOIUrl":"https://doi.org/10.1093/jn/132.6.1698S","url":null,"abstract":"Maintaining the health of dogs and cats by feeding wholesome nutritional diets is an important component of responsible pet ownership. Numerous improvements in companion animal nutrition have resulted in a wide array of foods providing complete and balanced nutrition. In spite of these developments, some pet owners prefer preparing food at home for their animals (1). Although owners generally have good intentions, some of them may lack the scientific knowledge or other resources to recognize important nutritional needs of their pets. Thus the potential for nutrient deficiencies, excesses and imbalances exists. This study was conducted to compare the nutritional adequacy of home-prepared diets in young and adult dogs using data gathered from a population of dogs and their owners in Vienna, Austria. Representative samples of home-prepared diets were analyzed and compared to commercial pet foods and to recommendations set by the American Association of Feed Control Officials (AAFCO) (2).","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":"15 1","pages":"1698S-700S"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87837759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Voluntary exercise has only limited effects on activity of antioxidant enzymes and does not cause oxidative damage in a small mammal.","authors":"C. Selman, J. McLaren, A. Collins, J. Speakman","doi":"10.1093/jn/132.6.1784S","DOIUrl":"https://doi.org/10.1093/jn/132.6.1784S","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":"5 1","pages":"1784S-6S"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89141713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of multifrequency bioelectrical impedance analysis for the assessment of extracellular and total body water in healthy cats.","authors":"D. Elliott, R. Backus, M. Van Loan, Q. Rogers","doi":"10.1093/jn/132.6.1757S","DOIUrl":"https://doi.org/10.1093/jn/132.6.1757S","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":"104 1","pages":"1757S-9S"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80812525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Calculation of gross energy in pet foods: do we have the right values for heat of combustion?","authors":"E. Kienzle, I. Schrag, R. Butterwick, B. Opitz","doi":"10.1093/jn/132.6.1799S","DOIUrl":"https://doi.org/10.1093/jn/132.6.1799S","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":"6 1","pages":"1799S-800S"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73071366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Heaton, D. Blount, S. Mann, P. Devlin, S. Koelsch, Brigitte H. E. Smith, J. Stevenson, E. Harper, J. Rawlings
{"title":"Assessing age-related changes in peripheral blood leukocyte phenotypes in domestic shorthaired cats using flow cytometry.","authors":"P. Heaton, D. Blount, S. Mann, P. Devlin, S. Koelsch, Brigitte H. E. Smith, J. Stevenson, E. Harper, J. Rawlings","doi":"10.1093/jn/132.6.1607S","DOIUrl":"https://doi.org/10.1093/jn/132.6.1607S","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":"68 1","pages":"1607S-9S"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86126344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extracellular water and total body water estimated by multifrequency bioelectrical impedance analysis in healthy cats: a cross-validation study.","authors":"D. Elliott, R. Backus, M. Van Loan, Q. Rogers","doi":"10.1093/jn/132.6.1760S","DOIUrl":"https://doi.org/10.1093/jn/132.6.1760S","url":null,"abstract":"","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":"12 1","pages":"1760S-2S"},"PeriodicalIF":0.0,"publicationDate":"2002-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87834514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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