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Comparison of the Effect of Direct Transcranial Electrical Stimulation of Motor and Vision Cortex on Working Memory and Motor Performance in Children with Developmental Coordination Disorder 经颅直接电刺激运动和视觉皮层对发育性协调障碍儿童工作记忆和运动表现影响的比较
Pub Date : 2022-07-01 DOI: 10.52547/shefa.10.3.1
F. Jazini, M. Sheikh
Introduction: The purpose of the current study was to compare the effect of direct transcranial electrical stimulation (tDCS) of the motor and vision cortex on working memory and motor performance in girls with developmental coordination disorder (DCD). Materials and Methods: In this semi-experimental study with a pre-test-post-test research design and a follow-up period of 1 and 42 days, 48 girls with developmental coordination disorder with an age range of 7 to 10 years were selected. There are randomly divided into 4 groups of 12 subjects, including motor cortex tDCS, visual cortex tDCS, sham stimulation, and control. Participants in the pre-test performed 3 working memory tests and 10 throwing and catching skills. The intervention phase was performed for 5 consecutive days. Each day, electrical stimulation of the brain on the motor cortex (C3 anode and Fp2 cathode), visual cortex (Oz anode and Cz cathode), and sham stimulation were performed. Participants performed 3 working memory tests and 10 throwing and catching skills. In the last session, the post-test phase was performed. 1 day and 42 days after the post-test phase, short-term and long-term follow-up phases were performed, respectively. Results: Results indicated the persistence of working memory and motor performance in girls with DCD in short-term and long-term follow-up tests. However, no significant difference was found between the effect of tDCS on the motor and vision cortex on working memory and motor performance. Conclusion: tDCS of the motor cortex and visual cortex significantly improved working memory and motor performance in girls with developmental coordination disorders.s
摘要:本研究的目的是比较运动和视觉皮层直接经颅电刺激(tDCS)对发育性协调障碍(DCD)女孩工作记忆和运动表现的影响。材料与方法:本半实验研究采用前测后测研究设计,随访1天和42天,选取7 ~ 10岁发育协调障碍女童48例。随机分为运动皮质tDCS组、视觉皮质tDCS组、假刺激组和对照组,每组12人。在预测试中,参与者进行了3项工作记忆测试和10项抛接球技能测试。干预期为连续5天。每天对大脑运动皮层(C3阳极和Fp2阴极)、视觉皮层(Oz阳极和Cz阴极)进行电刺激和假刺激。参与者进行了3项工作记忆测试和10项抛接球技能测试。在最后一个会话中,执行了后测试阶段。试验后第1天和第42天分别进行短期随访和长期随访。结果:在短期和长期随访测试中,结果表明DCD女孩的工作记忆和运动表现持续存在。然而,tDCS对运动和视觉皮层的影响在工作记忆和运动表现上没有显著差异。结论:运动皮质和视觉皮质的tDCS可显著改善发育性协调障碍女孩的工作记忆和运动表现
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引用次数: 0
A Narrative Review of the Role of Orexin in the Epileptogenesis 食欲素在癫痫发生中的作用述评
Pub Date : 2022-07-01 DOI: 10.52547/shefa.10.3.123
T. Ghantabpour, F. Karimzadeh
1. Orexins 2. Epilepsy 3. Neurotransmitter Agents Introduction: Epilepsy is a neurological disorder characterized by seizures and affects about 65-70 million people worldwide. Many pathways and molecules are altered in the epilepsy process that can be used as targets in the treatment of epilepsy. Orexin or hypocretin is a type of neurotransmitter that has a role in the epileptogenic process. Conclusion: The orexin system, by acting on the brainstem, modulates the activities of the limbic and neocortical areas, which is involved in epilepsy. In this study, the role of orexin in epilepsy and its potential mechanisms have been reviewed.d ABSTRACT Article Info: Received: 7 June 2021 Revised: 28 June 2022 Accepted: 9 July 2022
1. 促食素2。癫痫3。癫痫是一种以癫痫发作为特征的神经系统疾病,全世界约有6500万至7000万人受其影响。许多通路和分子在癫痫过程中发生改变,可以作为治疗癫痫的靶点。食欲素或下丘脑分泌素是一种神经递质,在致癫痫过程中起作用。结论:食欲素系统通过作用于脑干,调节大脑边缘和新皮层的活动,参与癫痫的发生。本文就食欲素在癫痫中的作用及其可能的机制作一综述。d摘要文章信息:收稿日期:2021年6月7日修稿日期:2022年6月28日收稿日期:2022年7月9日
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引用次数: 0
Neuroprotective Effect of Alpha-Pinene on Focal Cerebral Ischemia in Rats α -蒎烯对大鼠局灶性脑缺血的神经保护作用
Pub Date : 2022-07-01 DOI: 10.52547/shefa.10.3.37
Mahdieh khoshnazar, Bahram Farhadi Maghadam
The the transient focal ischemia at the beginning of reperfusion at ischemic areas.s
缺血区域再灌注开始时的短暂局灶性缺血
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引用次数: 0
Anti-Inflammatory Effects of Nano- Curcumin on a Glioblastoma Cell Line 纳米姜黄素对胶质母细胞瘤细胞系的抗炎作用
Pub Date : 2022-07-01 DOI: 10.52547/shefa.10.3.48
Golamhossein Tondro, Ghadir Rajabzade, Ali Mohammadi, H. Moradi, Sajad Sahab Negah
superior of a nano-form of curcumin vs. free-form on the secretion of pro-inflammatory cytokines profile (i.e., IL6 and TNF-α) in the U87 cell line. Materials and Methods: The U87 cell line was purchased from the Iranian Biological Resource Center and expanded in the DMEM/F12 media with 10% FBS and 1% Pen/Strep. To synthesize nanoniosome containing curcumin, the thin-film hybridization method was used. To evaluate the production of IL6 and TNF-α by ELISA method, U87 cells were treated with 84.87 µg/ml of Nano-curcumin and 47 µg/ml of free curcumin. Results: Our results indicated that the production of IL6 and TNF-α was significantly decreased when treated with nano-form and free curcumin. Interestingly, we observed that nano-curcumin could significantly inhibit the secretion of IL6 and TNF-α compared to the curcumin group. Conclusion: The most obvious finding to emerge from this study is that nano-curcumin exerts antiimflammatory effects on glioblastoma. a
在U87细胞系中,纳米形式的姜黄素比自由形式的姜黄素在促炎细胞因子谱(即il - 6和TNF-α)的分泌上更优越。材料和方法:U87细胞系购自伊朗生物资源中心,在含有10% FBS和1% Pen/Strep的DMEM/F12培养基中扩增。采用薄膜杂交法制备了姜黄素纳米体。以84.87µg/ml纳米姜黄素和47µg/ml游离姜黄素处理U87细胞,采用ELISA法评价其il - 6和TNF-α的生成。结果:我们的研究结果表明,纳米形式和游离姜黄素处理显著降低了il - 6和TNF-α的产生。有趣的是,我们发现与姜黄素组相比,纳米姜黄素可以显著抑制il - 6和TNF-α的分泌。结论:本研究最明显的发现是纳米姜黄素对胶质母细胞瘤具有抗炎作用。一个
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引用次数: 0
The Effectiveness of Transcranial Electrical Stimulation on the Pattern of Brain Waves and Blood Pressure in Patients with Generalized Anxiety Disorder 经颅电刺激对广泛性焦虑障碍患者脑电波模式和血压的影响
Pub Date : 2022-07-01 DOI: 10.52547/shefa.10.3.26
Mahtab Baghaei, M. Tabatabaei
Introduction: considered one of the treatment methods for mental disorders. Materials and Methods: The aim of this study was to evaluate the effectiveness of transcranial direct current stimulation on the delta, theta, alpha, beta, and systolic and diastolic blood pressure in patients with generalized anxiety disorder. The present study was a double-blind intervention with a pre-test and post-test design on people with generalized anxiety disorder in Tabriz, Iran. 30 patients with generalized anxiety disorder were selected by purposive sampling method based on the criteria specified in DSM-5 and randomly divided into an experimental group (n = 15) and a control group (n=15). The experimental group received 10 sessions of 30 minutes of transcranial direct current stimulation with an intensity of 2mA in the dorsolateral prefrontal cortex and the control group also received artificial stimulation. Results: The results showed that transcranial direct current stimulation reduced delta and theta waves and increased beta and brain alpha waves in the experimental group. On the other hand, this method also showed a significant decrease in systolic and diastolic blood pressure in these patients. Conclusion: The results show that transcranial direct current stimulation has a significant effect on brain waves and blood pressure. Furthermore, this non-invasive method can be used as a therapeutic approach in people with generalized anxiety disorder.r
简介:被认为是精神障碍的治疗方法之一。材料和方法:本研究的目的是评估经颅直流电刺激对广泛性焦虑障碍患者的δ、θ、α、β、收缩压和舒张压的影响。本研究对伊朗大不里士地区广泛性焦虑障碍患者采用前测后测双盲干预设计,根据DSM-5标准,采用有目的抽样方法,选取30例广泛性焦虑障碍患者,随机分为实验组(n=15)和对照组(n=15)。实验组在前额皮质背外侧接受10次30分钟强度为2mA的经颅直流电刺激,对照组也接受人工刺激。结果:经颅直流电刺激使实验组的δ波和θ波减少,β波和α波增加。另一方面,这种方法也显示了这些患者的收缩压和舒张压的显著降低。结论:经颅直流电刺激对大鼠脑电波及血压有显著影响。此外,这种非侵入性方法可用于广泛性焦虑症患者的治疗方法
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引用次数: 0
Evaluation of Neuropharmacological Effects of Ginger: A Narrative Review 生姜神经药理作用的评价综述
Pub Date : 2022-07-01 DOI: 10.52547/shefa.10.3.113
Mahan Kajkolah, F. Mousavi, A. Asgari, A. Asadi, A. Abdolmaleki
1Department of Plant Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University,Tehran, Iran 2Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran 3Minab Higher Education Center, University of Hormozgan, Bandar Abbas, Iran 4Department of Bioinformatics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran
1伊朗德黑兰Shahid Beheshti大学生命科学与生物技术学院植物科学与生物技术系2伊朗阿达比勒mohaghh Ardabili大学理学院生物系3伊朗阿巴斯港霍尔木兹甘大学米纳布高等教育中心4伊朗纳明mohaghh Ardabili大学先进技术学院生物信息学系
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引用次数: 0
The Effectiveness of Acceptance and Commitment-Based Therapy on Uncertainty Intolerance, Turmoil Tolerance, and Sexual Function in Betrayed Women 接受与承诺为基础的治疗对被背叛女性不确定耐受性、动荡耐受性与性功能的影响
Pub Date : 2022-07-01 DOI: 10.52547/shefa.10.3.57
M. Aghili, sara kashiri
Introduction: Marital infidelity is one of the most destructive problems in a relationship and also one of the issues that usually leads to divorce. This study aimed to evaluate the effectiveness of acceptance and commitment therapy on intolerance of uncertainty, tolerance of turmoil, and sexual function in betrayed women. Materials and Methods: The research method was quasi-experimental with a pre-test-post-test design. The statistical population of the study consisted of all betrayed women in Gorgan, Iran who were referred to Aramesh and Roshna Counseling Centers from July to August 2021 to receive counseling services. Among them, 30 people were selected by the available sampling method and randomly divided into two groups; experimental (15 people) and control (15 people). The research instruments were Fristen et al.’s Uncertainty Intolerance Questionnaire, Simmons and Gahr Confusion Tolerance Questionnaire, and Rosen Sexual Function Questionnaire. Research data were analyzed by multivariate analysis of covariance. Results: The results showed that there was a significant difference between the experimental and control groups in terms of intolerance, confusion tolerance, and sexual function. In other words, treatment based on acceptance and commitment significantly improved intolerance, turbulence tolerance, and sexual function in betrayed women. Conclusion: It is recommended that clinical psychologists and therapists use acceptance and commitment therapy along with other educational methods to improve the mental health of betrayed women.
婚姻不忠是一段关系中最具破坏性的问题之一,也是通常导致离婚的问题之一。本研究旨在评估接受与承诺治疗对被背叛女性不确定耐受性、混乱耐受性及性功能的影响。材料与方法:研究方法为准实验设计,采用前测后测设计。该研究的统计人群包括2021年7月至8月期间被转介到Aramesh和Roshna咨询中心接受咨询服务的伊朗戈尔根所有被背叛的妇女。其中,采用现有抽样方法选取30人,随机分为两组;实验组(15人)和对照组(15人)。研究工具为Fristen et al.的不确定性耐受问卷、Simmons and Gahr困惑耐受问卷和Rosen性功能问卷。对研究资料进行多变量协方差分析。结果:实验组与对照组在不耐受、混淆耐受性、性功能方面存在显著差异。换句话说,基于接受和承诺的治疗显著改善了被背叛女性的不耐受、动荡耐受性和性功能。结论:建议临床心理学家和治疗师采用接纳与承诺疗法结合其他教育方法来改善被背叛妇女的心理健康。
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引用次数: 0
Human-Induced Pluripotent Stem Cells are a Unique Approach for Modeling Schizophrenia: Calcium Homeostasis 人诱导的多能干细胞是一种独特的方法来模拟精神分裂症:钙稳态
Pub Date : 2022-07-01 DOI: 10.52547/shefa.10.3.98
Farzaneh Nazari Serenjeh, Narjes Lotfi-Ghadikolaii, Saeed Mohsenipour, Z. Ghasemzadeh
valid cellular phenotypes for drug testing and development. Conclusion: The iPSCs model is a powerful tool for elucidating the mechanism of Ca2+ homeostasis, understanding SZ pathophysiology, and drug development. t
有效的细胞表型用于药物测试和开发。结论:iPSCs模型是阐明Ca2+稳态机制、了解SZ病理生理和药物开发的有力工具。t
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引用次数: 0
An Investigation of the Difference in Reaction Time to Visual and Auditory Stimuli in Two Groups of Patients with Multiple Sclerosis and Healthy People 两组多发性硬化症患者与正常人对视觉和听觉刺激反应时间差异的研究
Pub Date : 2022-07-01 DOI: 10.52547/shefa.10.3.13
nazanin Fateme Rajabi, K. Asgari, M. Etemadifar
1. Multiple Sclerosis 2. Reaction Time 3. Patients Introduction: Multiple sclerosis (MS), is an inflammatory chronic disease of the central nervous system, usually starting in the most productive years of the patient’s life, and its cognitive consequence may affect on patient’s behavior, social functions, daily life, and occupation. One of the most important cognitive variables, which may be affected through MS, is reaction time. The aim of this study was to investigate the reaction time of patients with MS (SPMS and RRMS types) toward visual and auditory stimuli. Materials and Methods: The study design was a retrospective, causal-comparative type, in which the sample was selected through an accessible and purposive sampling method from the patients who were referred to the MS center and MS institute of Isfahan, Iran. The control group was selected from the healthy patient’s family members or their relatives. A total of 159 subjects participated in this study, each group consisted of 53 subjects. The reaction time of the three groups toward the visual and auditory stimuli was measured. The instruments comprised a reaction timer and a multiple sclerosis impact scale. Results: The results showed that the reaction time in the patients was significantly slower than in healthy people. Furthermore, it was revealed that patients with SPMS type were slower in reaction time in comparison to RRMS patients. Conclusion: The speed of information processing in patients with MS, has become slower, due to the slowing of the conduction through nerve pulses, which is due to demyelination in damaged pathways. The decrease in processing speed may lead to an inability of the patients to accomplish mental and cognitive tasks, and this deficit is finally depicted in the inability of MS patients in responding to visual and auditory stimuli.i ABSTRACT Article Info:
1. 多发性硬化症3.反应时间患者简介:多发性硬化症(Multiple sclerosis, MS)是一种中枢神经系统炎症性慢性疾病,通常发病于患者生命中最具生产力的年龄,其认知后果可能影响患者的行为、社交功能、日常生活和职业。反应时间是最重要的认知变量之一,可能会受到多发性硬化症的影响。本研究旨在探讨多发性硬化症(SPMS型和RRMS型)患者对视觉和听觉刺激的反应时间。材料和方法:本研究设计为回顾性、因果比较型,通过可获得的、有目的的抽样方法从转诊到伊朗伊斯法罕质谱中心和质谱研究所的患者中选择样本。对照组从健康患者的家属或其亲属中选取。共159名受试者参与本研究,每组53名受试者。测量三组受试者对视觉和听觉刺激的反应时间。这些仪器包括一个反应计时器和一个多发性硬化症影响量表。结果:患者的反应时间明显慢于健康人。此外,SPMS型患者的反应时间比RRMS型患者慢。结论:MS患者的信息处理速度变慢,其原因是受损通路脱髓鞘导致神经脉冲传导减慢。处理速度的下降可能导致患者无法完成心理和认知任务,这种缺陷最终被描述为MS患者无法对视觉和听觉刺激做出反应。文章摘要:
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引用次数: 0
Investigating the Effects of Architectural Space on Cognition and Brain Activities: A Systematic Review 研究建筑空间对认知和大脑活动的影响:一项系统综述
Pub Date : 2022-07-01 DOI: 10.52547/shefa.10.3.68
mahbubeh zamani, M. Kheirollahi, mohammad javad asghari ebrahim abad, H. Rezaee, F. Vafaee
attention, and emphasis on visual elements and human experiences. EEG technique, fMRI, and some auxiliary tools, such as eye tracking, have been used to measure the effect of architectural space on the brain. n
注意,并强调视觉元素和人的体验。脑电图技术、功能磁共振成像和一些辅助工具,如眼动追踪,已经被用来测量建筑空间对大脑的影响。n
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引用次数: 0
期刊
The Neuroscience Journal of Shefaye Khatam
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