The current article investigates the application of Artificial Intelligence (AI) to evaluate the Buongiorno thermal enhancement model with a Darcy–Forchheimer formulation (BTEM-IDFE). AI-driven radial basis function neural networks (RBFNNs) are employed to accurately forecast magnetohydrodynamic (MHD) nanofluid flow over a stretching boundary, accounting for entropy production and fluctuating fluid properties. RBFNNs are used to simulate and predict complex heat-transfer dynamics in such environments, yielding more accurate and efficient analyses than conventional numerical methods. We investigate the effects of the Maxwell slip velocity, the Smoluchowski slip temperature, and the Arrhenius activation energy. A synthetic dataset was generated via the Lobatto III-A computational integration approach. The proposed RBFNN algorithm is then applied to the obtained datasets, yielding outputs with negligible error that closely align with the numerical experiments across all model variants. A comprehensive graphical examination of liquid motion, entropy generation, concentration, and temperature distribution is conducted. Our findings indicate that applying the RBFNN to the proposed framework effectively captures the interactions and interdependencies among key parameters, including radiation parameters, temperature-dependent conductivity, porosity, velocity slip parameters, and thermophoresis effects, in relation to temperature and entropy rates. The efficacy of RBFNN is demonstrated through comprehensive experiments, including iterative convergence curves for mean squared error, optimization control measures, error distributions via histograms, and robust regression analysis.
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