Acute cholecystitis is a common acute abdomen, and the traditional treatment includes drug therapy and surgical intervention. With the development of medical technology, percutaneous hepatic puncture cholecystectomy (PTGBD) has been widely used in the treatment of acute cholecystitis. However, how to optimize the treatment effect and reduce complications is still the focus of clinical research. In this study, a certain number of patients with acute cholecystitis were selected to evaluate the heat distribution of their gallbladder and surrounding tissues by medical thermal modeling technology, then percutaneous hepatic puncture cholecystectomy was performed, and laparoscopic cholecystectomy was performed after the condition was stabilized. The results of the study showed that the treatment regimen based on medical thermal modeling significantly shortened the recovery time of patients and reduced the incidence of postoperative complications. Thermal modeling technology can effectively predict the inflammation degree and hemodynamic changes of gallbladder, and provide a reliable basis for personalized treatment. Therefore, the treatment of acute cholecystitis by percutaneous hepatic puncture gallbladder drainage combined with laparoscopic surgery based on medical thermal modeling can effectively improve the treatment effect and reduce complications, and is worthy of promotion and application in clinical practice. Further research will focus on the potential application of thermal modeling in other surgical fields.