Pub Date : 2020-12-01DOI: 10.1142/s2575900020300064
Jie Xu, Ke Cao, Lin Zhao, Zhihui Feng, Zhizhong Dong, Jianke Li, Jiankang Liu
Metabolic syndrome, such as obesity, diabetes and cardiovascular disease, is becoming epidemic both in developing and developed countries in recent years. Vegetable and fruit consumptions have been associated with the prevention of metabolic syndrome. Pomegranate is a widely consumed fruit in Middle East and Asia. Currently, accumulating data showed that pomegranate exhibits antioxidant, anti-inflammatory, hypolipidemic and hypoglycemic activities in experimental and clinical studies. The beneficial effects of pomegranate may come from its rich polyphenols and be mediated by increasing the activity of AMPK, upregulating GLUT4, activating PPAR[Formula: see text]- ABCA1/CYP7A1 pathways and improving mitochondrial function. This review provides a systematical presentation of findings on the beneficial effects as well as the possible mechanisms of pomegranate and its major components on prevention and treatment of metabolic syndrome.
{"title":"The effects and mechanisms of pomegranate in the prevention and treatment of metabolic syndrome","authors":"Jie Xu, Ke Cao, Lin Zhao, Zhihui Feng, Zhizhong Dong, Jianke Li, Jiankang Liu","doi":"10.1142/s2575900020300064","DOIUrl":"https://doi.org/10.1142/s2575900020300064","url":null,"abstract":"Metabolic syndrome, such as obesity, diabetes and cardiovascular disease, is becoming epidemic both in developing and developed countries in recent years. Vegetable and fruit consumptions have been associated with the prevention of metabolic syndrome. Pomegranate is a widely consumed fruit in Middle East and Asia. Currently, accumulating data showed that pomegranate exhibits antioxidant, anti-inflammatory, hypolipidemic and hypoglycemic activities in experimental and clinical studies. The beneficial effects of pomegranate may come from its rich polyphenols and be mediated by increasing the activity of AMPK, upregulating GLUT4, activating PPAR[Formula: see text]- ABCA1/CYP7A1 pathways and improving mitochondrial function. This review provides a systematical presentation of findings on the beneficial effects as well as the possible mechanisms of pomegranate and its major components on prevention and treatment of metabolic syndrome.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46724651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To establish the decocting and formulation technology of Saifula granules, and establish a reliable TLC identification quality control standard. Methods: Orthogonal test was used to optimize the water extraction process and TLC was used for qualitative identification. Results: To optimize the process parameters of SFL granules, first, the content of total flavonoids and the total extraction rate were taken as the indexes. Through single factor and orthogonal test, the optimal extraction process was determined as follows: extraction time 1 h, solvent multiple 1:10, extract three times. After the process parameters were determined, in order to further explain the chemical composition of SFL extract, 15 compounds in SFL extract were identified by UHPLC-Q-Orbitrap-MS, 13 batches of SFL extracts were prepared, and their fingerprints were analyzed. The results showed that there were 28 common characteristic peaks in the 13 batches of SFL extracts. The similarity evaluation results of fingerprints showed that the similarities of 13 batches of SFL extracts were greater than 0.9. An HPLC-DAD method for the simultaneous determination of gallic acid, corilagin, and ellagic acid was established. The method has good repeatability, stability, and accurate results. Conclusion: The standard can comprehensively reflect the material basis of SFL granules, and the above methods are accurate, easy to operate, stable and feasible, and provide scientific basis and basis for the development, promotion, and clinical application of SFL granules.
{"title":"A study on the preparation and quality standard of Saifula granules","authors":"M. Aisha, Atikanmu Wahafu, Yilifanjiang Kuerban, Akenmujiang Aierken, Refuhati Saimaiti, Maimaitiaili Kadi, Ainiwaer Talifu","doi":"10.1142/s2575900020500123","DOIUrl":"https://doi.org/10.1142/s2575900020500123","url":null,"abstract":"Objective: To establish the decocting and formulation technology of Saifula granules, and establish a reliable TLC identification quality control standard. Methods: Orthogonal test was used to optimize the water extraction process and TLC was used for qualitative identification. Results: To optimize the process parameters of SFL granules, first, the content of total flavonoids and the total extraction rate were taken as the indexes. Through single factor and orthogonal test, the optimal extraction process was determined as follows: extraction time 1 h, solvent multiple 1:10, extract three times. After the process parameters were determined, in order to further explain the chemical composition of SFL extract, 15 compounds in SFL extract were identified by UHPLC-Q-Orbitrap-MS, 13 batches of SFL extracts were prepared, and their fingerprints were analyzed. The results showed that there were 28 common characteristic peaks in the 13 batches of SFL extracts. The similarity evaluation results of fingerprints showed that the similarities of 13 batches of SFL extracts were greater than 0.9. An HPLC-DAD method for the simultaneous determination of gallic acid, corilagin, and ellagic acid was established. The method has good repeatability, stability, and accurate results. Conclusion: The standard can comprehensively reflect the material basis of SFL granules, and the above methods are accurate, easy to operate, stable and feasible, and provide scientific basis and basis for the development, promotion, and clinical application of SFL granules.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46207552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Glucocorticoids (GCs) have potential anti-inflammatory and immunosuppressive effects. There is plenty of controversy about the application of glucocorticoids in the treatment of coronavirus disease 2019 (COVID-19). This paper briefly summarizes the mechanism of glucocorticoids and their receptors and clinical applications in COVID-19. Through reviewing the current literature, our aim is to have a deeper understanding of the mechanism of GCs and their clinical applications, so as to find possible ways to enhance their efficacy and reduce drug resistance or side effects.
{"title":"Application of glucocorticoids in patients with novel coronavirus infection: From bench to bedside","authors":"Linwei Lu, Jianhua Huang, Xiaohong Deng, Xian-jun Sun, Jingcheng Dong","doi":"10.1142/s257590002030009x","DOIUrl":"https://doi.org/10.1142/s257590002030009x","url":null,"abstract":"Glucocorticoids (GCs) have potential anti-inflammatory and immunosuppressive effects. There is plenty of controversy about the application of glucocorticoids in the treatment of coronavirus disease 2019 (COVID-19). This paper briefly summarizes the mechanism of glucocorticoids and their receptors and clinical applications in COVID-19. Through reviewing the current literature, our aim is to have a deeper understanding of the mechanism of GCs and their clinical applications, so as to find possible ways to enhance their efficacy and reduce drug resistance or side effects.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48102316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.1142/s2575900020500135
Jiankang Liu
Traditional Chinese Medicine (TCM) modernization has been proposed for many years, but the progress is still slow due to both ideological and technical obstacles. When I went to Japan in 1989, I found Japan has made a great progress on TCM by using modern technology. Therefore, I have studied a fine extract prepared from medicinal herbs (renamed Yi-Zhi-Yi-Shou, YZYS), a prescription of Dowager Cixi’s Yanling-Yishou-Dan of Qing Dynasty, with the current drug investigation strategies. I examined its antioxidant activity both in vitro and in vivo. The in-vitro studies found that YZYS possesses strong antioxidant capacity, such as scavenging various kinds of free radicals, and inhibits free radical-induced peroxidation of brain homogenate, microsomes, mitochondria, amino acids, deoxyribose and DNA. The in-vivo study with immobilization-induced emotional stress in rats, showed that YZYS effectively inhibits stress-induced stomach ulcers and oxidative damage in plasma and the brain. In addition, YZYS is shown to be non-toxic in both acute and chronic toxicity tests. These studies demonstrate that YZYS is a potent natural antioxidant and offer theoretical evidence for the beneficial effect of YZYS on health and brain functions, and that TCM prescriptions can be studied scientifically as modern medical drugs.
{"title":"A study on Dowager Cixi’s Yanling-Yishou-Dan of Qing Dynasty in a Japanese laboratory of biochemistry and molecular biology in 1990s: An attempt for TCM modernization","authors":"Jiankang Liu","doi":"10.1142/s2575900020500135","DOIUrl":"https://doi.org/10.1142/s2575900020500135","url":null,"abstract":"Traditional Chinese Medicine (TCM) modernization has been proposed for many years, but the progress is still slow due to both ideological and technical obstacles. When I went to Japan in 1989, I found Japan has made a great progress on TCM by using modern technology. Therefore, I have studied a fine extract prepared from medicinal herbs (renamed Yi-Zhi-Yi-Shou, YZYS), a prescription of Dowager Cixi’s Yanling-Yishou-Dan of Qing Dynasty, with the current drug investigation strategies. I examined its antioxidant activity both in vitro and in vivo. The in-vitro studies found that YZYS possesses strong antioxidant capacity, such as scavenging various kinds of free radicals, and inhibits free radical-induced peroxidation of brain homogenate, microsomes, mitochondria, amino acids, deoxyribose and DNA. The in-vivo study with immobilization-induced emotional stress in rats, showed that YZYS effectively inhibits stress-induced stomach ulcers and oxidative damage in plasma and the brain. In addition, YZYS is shown to be non-toxic in both acute and chronic toxicity tests. These studies demonstrate that YZYS is a potent natural antioxidant and offer theoretical evidence for the beneficial effect of YZYS on health and brain functions, and that TCM prescriptions can be studied scientifically as modern medical drugs.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48043443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.1142/s2575900020300040
Bo-han Lv, Tian An, Ting-Ye Wang, Xueli Bao, Juan Lian, Yan-xiang Wu, Yuan-yuan Hu, Jiajian Zhu, C. Zheng, Xue-qing Hu, Si-Hua Gao, G. Jiang
Danshen (Salvia miltiorrhiza) is a herb which has been widely used in China. Salvianolic acid B (SalB) is an aqueous bioactive component derived from Danshen. Here, we aimed to estimate the effect of SalB on glycometabolism and lipid metabolism in rats and mice. We searched four databases until November 2020. The outcome measures were fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDLc), and low-density lipoprotein cholesterol (LDLc). Twenty-four studies involving 547 animals were included. The meta-analysis showed effects of SalB on decreasing the level of FBG, TC, TG, LDLc, and increasing the level of HDLc compared with the control group. In conclusion, the result showed that SalB may regulate the glycometabolism and lipid metabolism in rats or mice, and may be a potential agent for treating metabolic diseases such as diabetes and hyperlipidemia.
{"title":"Effects of salvianolic acid B on glycometabolism and lipid metabolism in rodents: Meta-analysis","authors":"Bo-han Lv, Tian An, Ting-Ye Wang, Xueli Bao, Juan Lian, Yan-xiang Wu, Yuan-yuan Hu, Jiajian Zhu, C. Zheng, Xue-qing Hu, Si-Hua Gao, G. Jiang","doi":"10.1142/s2575900020300040","DOIUrl":"https://doi.org/10.1142/s2575900020300040","url":null,"abstract":"Danshen (Salvia miltiorrhiza) is a herb which has been widely used in China. Salvianolic acid B (SalB) is an aqueous bioactive component derived from Danshen. Here, we aimed to estimate the effect of SalB on glycometabolism and lipid metabolism in rats and mice. We searched four databases until November 2020. The outcome measures were fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDLc), and low-density lipoprotein cholesterol (LDLc). Twenty-four studies involving 547 animals were included. The meta-analysis showed effects of SalB on decreasing the level of FBG, TC, TG, LDLc, and increasing the level of HDLc compared with the control group. In conclusion, the result showed that SalB may regulate the glycometabolism and lipid metabolism in rats or mice, and may be a potential agent for treating metabolic diseases such as diabetes and hyperlipidemia.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43870753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.1142/s2575900020100035
Wenxian Liu, Jing-jing Le, Jingcheng Dong
According to the period development and the typical characteristics of medical stages, traditional medicine can be divided into six aspects: legendary traditional medicine, instinctive traditional medicine, witchcraft traditional medicine, empirical traditional medicine, theoretical traditional medicine and integrated traditional medicine. Among them, instinctive traditional medicine and legendary traditional medicine belong to the stage of ignorance according to the level of human cognition (“not knowing reason and result”, “only knowing result” and “knowing reason and result”). It belongs to the immature and hazy development period of human traditional medicine before it became “medicine” from the perspective of the development of traditional medicine, which can be summarized as the pre-medical period. Scientific understanding of traditional medicine and instinctive traditional medicine is helpful for people to understand and grasp the development of traditional medicine and even the whole medicine.
{"title":"Unprecedented reorganization of development history of traditional medicine: Part I","authors":"Wenxian Liu, Jing-jing Le, Jingcheng Dong","doi":"10.1142/s2575900020100035","DOIUrl":"https://doi.org/10.1142/s2575900020100035","url":null,"abstract":"According to the period development and the typical characteristics of medical stages, traditional medicine can be divided into six aspects: legendary traditional medicine, instinctive traditional medicine, witchcraft traditional medicine, empirical traditional medicine, theoretical traditional medicine and integrated traditional medicine. Among them, instinctive traditional medicine and legendary traditional medicine belong to the stage of ignorance according to the level of human cognition (“not knowing reason and result”, “only knowing result” and “knowing reason and result”). It belongs to the immature and hazy development period of human traditional medicine before it became “medicine” from the perspective of the development of traditional medicine, which can be summarized as the pre-medical period. Scientific understanding of traditional medicine and instinctive traditional medicine is helpful for people to understand and grasp the development of traditional medicine and even the whole medicine.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48646827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.1142/s2575900020300088
Baolu Zhao
Tea is the most frequently consumed beverage worldwide besides water. Generally, there are five most popular types of tea: green, white, black, Pu’er, and oolong. Tea possesses significant antioxidant, anti-inflammatory, antimicrobial, anticarcinogenic, antihypertensive, neuroprotective, and cholesterol-lowering properties. Several research investigations, epidemiological studies, and meta-analyses suggest that tea and its bioactive polyphenolic constituents have numerous beneficial effects on health, including the prevention of many diseases, such as cancer, diabetes, arthritis, cardiovascular disease, stroke, and obesity. Recently, there are many reports about the resistance of tea to COVID-19 virus on the Internet, which has attracted a lot of attention to tea drinking and the discussion about the pros and cons of tea drinking. Based on our research results and relevant reports form literatures, this review is intended to highlight the beneficial effects and possible side-effects associated with tea consumption, answer 10 questions and point out a few matters for attention.
{"title":"The pros and cons of drinking tea","authors":"Baolu Zhao","doi":"10.1142/s2575900020300088","DOIUrl":"https://doi.org/10.1142/s2575900020300088","url":null,"abstract":"Tea is the most frequently consumed beverage worldwide besides water. Generally, there are five most popular types of tea: green, white, black, Pu’er, and oolong. Tea possesses significant antioxidant, anti-inflammatory, antimicrobial, anticarcinogenic, antihypertensive, neuroprotective, and cholesterol-lowering properties. Several research investigations, epidemiological studies, and meta-analyses suggest that tea and its bioactive polyphenolic constituents have numerous beneficial effects on health, including the prevention of many diseases, such as cancer, diabetes, arthritis, cardiovascular disease, stroke, and obesity. Recently, there are many reports about the resistance of tea to COVID-19 virus on the Internet, which has attracted a lot of attention to tea drinking and the discussion about the pros and cons of tea drinking. Based on our research results and relevant reports form literatures, this review is intended to highlight the beneficial effects and possible side-effects associated with tea consumption, answer 10 questions and point out a few matters for attention.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44113608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.1142/s2575900020300052
Dongyue Du, Lin Zhao, Meihua Shen, M. Noda, S. Qin, J. Long, Xuejun Sun, Jiankang Liu
Gas medicine, including O2, NO, H2S, CO, CH4, has played important roles in prevention and treatment of diseases for a long time. Molecular hydrogen (H2), the smallest diatomic molecule in nature, has become a rising star in gas medicine in the past decades. Many studies have shown that H2 has preventive and therapeutic effects on various diseases through its selective antioxidant activity. H2, as a non-toxic gas for the human body and convenience to obtain, has provided a great possibility to be used widely. Currently, the main difficulties in hydrogen medicine are lack of definitive clinical evidence and the molecular basis of hydrogen effects. In this paper, the authors have conducted a comprehensive review and analysis of these issues, and also proposed the possibility of developing Hydrogen Biology and Hydrogen Medicine as new disciplines of biology and medicine.
{"title":"Hydrogen medicine: A rising star in gas medicine","authors":"Dongyue Du, Lin Zhao, Meihua Shen, M. Noda, S. Qin, J. Long, Xuejun Sun, Jiankang Liu","doi":"10.1142/s2575900020300052","DOIUrl":"https://doi.org/10.1142/s2575900020300052","url":null,"abstract":"Gas medicine, including O2, NO, H2S, CO, CH4, has played important roles in prevention and treatment of diseases for a long time. Molecular hydrogen (H2), the smallest diatomic molecule in nature, has become a rising star in gas medicine in the past decades. Many studies have shown that H2 has preventive and therapeutic effects on various diseases through its selective antioxidant activity. H2, as a non-toxic gas for the human body and convenience to obtain, has provided a great possibility to be used widely. Currently, the main difficulties in hydrogen medicine are lack of definitive clinical evidence and the molecular basis of hydrogen effects. In this paper, the authors have conducted a comprehensive review and analysis of these issues, and also proposed the possibility of developing Hydrogen Biology and Hydrogen Medicine as new disciplines of biology and medicine.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44605208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The affiliations 2–4 have been corrected. The second affiliation should be “Beijing University of Chinese Medicine”, and the third and fourth affiliations should be “Dongfang Hospital, Second Affiliated Hospital of Beijing University of Chinese Medicine” and “Dongzhimen Hospital, First Affiliated Hospital of Beijing University of Chinese Medicine”, respectively.
{"title":"Erratum: The clinical application of a traditional Chinese medicine prescription issued by Professor Liangduo Jiang in the prevention of coronavirus disease 2019 (COVID-19)","authors":"Jinfang Yao, Jian Yang, Zhenping Yu, J. Chui, Simin Lee, Xiaomei Zhang, Liang-duo Jiang","doi":"10.1142/s2575900020920019","DOIUrl":"https://doi.org/10.1142/s2575900020920019","url":null,"abstract":"The affiliations 2–4 have been corrected. The second affiliation should be “Beijing University of Chinese Medicine”, and the third and fourth affiliations should be “Dongfang Hospital, Second Affiliated Hospital of Beijing University of Chinese Medicine” and “Dongzhimen Hospital, First Affiliated Hospital of Beijing University of Chinese Medicine”, respectively.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46527057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.1142/S2575900020500068
Qing Ye, Xiqun Chen, Yuqing Hu, Jie Zhou, Chen Gao, Zhenguo Liu
Objective: To investigate the effects of “Shudi Pingchan Decoction” combined with repetitive transcranial magnetic stimulation (rTMS) on sleep disorders in Parkinson’s disease (PD). Methods: A randomized, single-blind, placebo/sham-controlled trial was performed on 144 PD patients with sleep disorders. Participants were randomized into rTMS (rTMS with placebo decoction), Chinese medicine (Shudi Pingchan Decoction with sham stimulation), or Shudi Pingchan Decoction combined with rTMS group over a 12-month course. The efficacy was evaluated by Unified Parkinson’s Disease Rating Scale (UPDRS) I–IV scores, cardiopulmonary coupling (CPC) sleep quality assessment, Hamilton Depression Scale (HAMD), and Hamilton Anxiety Scale (HAMA). Results: (1) After 12 weeks of treatment, rTMS treatment group showed markedly improved UPDRS I score, whereas Chinese medicine treatment group reported improved UPDRS II and UPDRS III scores than rTMS. At the same time, combined therapy improved the UPDRS I–III scores. (2) CPC sleep quality assessment showed that compared with baseline before treatment, sleep latency was significantly shortened after 12 weeks of Chinese medicine treatment. In the rTMS group, the scores of sleep awakening period were significantly decreased after six weeks and 12 weeks of treatment. The total sleep time was significantly extended after six weeks and 12 weeks of treatment in both groups. The sleep-improving effect was stronger in combined treatment group than the single treatment groups after 12 weeks of treatment. (3) Compared with baseline before treatment, the HAMD scores of rTMS group were significantly lower at six weeks and 12 weeks, the HAMA scores of Chinese medicine treatment group were significantly lower at 12 weeks, and the combined treatment resulted in stronger effects. Conclusion: The combined treatment of “Shudi Pingchan Decoction” with rTMS has significant curative effect on PD complicated with sleep disorders, and the combined therapy has complementary advantages.
{"title":"Shudi Pingchan Decoction combined with repetitive transcranial magnetic stimulation in the treatment of Parkinson’s disease with sleep disorders","authors":"Qing Ye, Xiqun Chen, Yuqing Hu, Jie Zhou, Chen Gao, Zhenguo Liu","doi":"10.1142/S2575900020500068","DOIUrl":"https://doi.org/10.1142/S2575900020500068","url":null,"abstract":"Objective: To investigate the effects of “Shudi Pingchan Decoction” combined with repetitive transcranial magnetic stimulation (rTMS) on sleep disorders in Parkinson’s disease (PD). Methods: A randomized, single-blind, placebo/sham-controlled trial was performed on 144 PD patients with sleep disorders. Participants were randomized into rTMS (rTMS with placebo decoction), Chinese medicine (Shudi Pingchan Decoction with sham stimulation), or Shudi Pingchan Decoction combined with rTMS group over a 12-month course. The efficacy was evaluated by Unified Parkinson’s Disease Rating Scale (UPDRS) I–IV scores, cardiopulmonary coupling (CPC) sleep quality assessment, Hamilton Depression Scale (HAMD), and Hamilton Anxiety Scale (HAMA). Results: (1) After 12 weeks of treatment, rTMS treatment group showed markedly improved UPDRS I score, whereas Chinese medicine treatment group reported improved UPDRS II and UPDRS III scores than rTMS. At the same time, combined therapy improved the UPDRS I–III scores. (2) CPC sleep quality assessment showed that compared with baseline before treatment, sleep latency was significantly shortened after 12 weeks of Chinese medicine treatment. In the rTMS group, the scores of sleep awakening period were significantly decreased after six weeks and 12 weeks of treatment. The total sleep time was significantly extended after six weeks and 12 weeks of treatment in both groups. The sleep-improving effect was stronger in combined treatment group than the single treatment groups after 12 weeks of treatment. (3) Compared with baseline before treatment, the HAMD scores of rTMS group were significantly lower at six weeks and 12 weeks, the HAMA scores of Chinese medicine treatment group were significantly lower at 12 weeks, and the combined treatment resulted in stronger effects. Conclusion: The combined treatment of “Shudi Pingchan Decoction” with rTMS has significant curative effect on PD complicated with sleep disorders, and the combined therapy has complementary advantages.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46995963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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