Pub Date : 2019-07-24DOI: 10.1142/S257590001950006X
Wenli Cao, Xinyao Pan, Feijun Ye, Jing Zhou, Zengshu Huang, Chuyu Li, Yanpu Zhang, Jian Fang, Yanlu Jiang, Hongyun Lian, Zhongxing Fu, Yan Du, Ling Wang
Objective: This study aimed to evaluate the semen quality of male adults whose spouses suffer from recurrent spontaneous abortion (RSA) in the island area, and to explore the association between RSA and occupational exposures. Methods: A total of 131 male patients were recruited and divided into two groups: spouse with recurrent spontaneous abortion group (RSA group, [Formula: see text]) and the normal fertility group (control group, [Formula: see text]). Information such as height, weight and occupational exposure history of 131 men were obtained. Semen samples were collected and analyzed. Differences in semen parameters and DNA fragmentation index (DFI) between the two groups were compared. Odds ratios (ORs) and their corresponding 95% confidence intervals were calculated to evaluate the association between occupational exposures and RSA status. Results: Overall, no significant difference was found in sperm concentration, progressive motility and normal morphology rate between RSA and control groups. Only DFI was observed to be significantly higher in the RSA group. Evaluation of the receiver operating characteristic (ROC) curve showed DFI (AUC: 0.623, [Formula: see text]) could discriminate between males from the couples with RSA and without RSA. Conclusion: The analysis of conventional semen parameters could not directly reflect their influence on embryonic development, and test of integrity of the sperm DNA is of paramount importance to fully understand male fertility. It is crucial to conduct studies regarding occupational exposures and pregnancy loss and/or RSA risk, since it will provide population-level data to aid in the identification of important risk factors that warrant further mechanistic investigation, and eventually lead to effective prevention and treatment strategies.
{"title":"Association between semen quality among men with different occupational exposures and risk of recurrent spontaneous abortion in island residents","authors":"Wenli Cao, Xinyao Pan, Feijun Ye, Jing Zhou, Zengshu Huang, Chuyu Li, Yanpu Zhang, Jian Fang, Yanlu Jiang, Hongyun Lian, Zhongxing Fu, Yan Du, Ling Wang","doi":"10.1142/S257590001950006X","DOIUrl":"https://doi.org/10.1142/S257590001950006X","url":null,"abstract":"Objective: This study aimed to evaluate the semen quality of male adults whose spouses suffer from recurrent spontaneous abortion (RSA) in the island area, and to explore the association between RSA and occupational exposures. Methods: A total of 131 male patients were recruited and divided into two groups: spouse with recurrent spontaneous abortion group (RSA group, [Formula: see text]) and the normal fertility group (control group, [Formula: see text]). Information such as height, weight and occupational exposure history of 131 men were obtained. Semen samples were collected and analyzed. Differences in semen parameters and DNA fragmentation index (DFI) between the two groups were compared. Odds ratios (ORs) and their corresponding 95% confidence intervals were calculated to evaluate the association between occupational exposures and RSA status. Results: Overall, no significant difference was found in sperm concentration, progressive motility and normal morphology rate between RSA and control groups. Only DFI was observed to be significantly higher in the RSA group. Evaluation of the receiver operating characteristic (ROC) curve showed DFI (AUC: 0.623, [Formula: see text]) could discriminate between males from the couples with RSA and without RSA. Conclusion: The analysis of conventional semen parameters could not directly reflect their influence on embryonic development, and test of integrity of the sperm DNA is of paramount importance to fully understand male fertility. It is crucial to conduct studies regarding occupational exposures and pregnancy loss and/or RSA risk, since it will provide population-level data to aid in the identification of important risk factors that warrant further mechanistic investigation, and eventually lead to effective prevention and treatment strategies.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S257590001950006X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45120637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-24DOI: 10.1142/S2575900019500095
Yuchun Chu, Ming Gao, Haifeng Gao, Ye Liu, Xunjia Cheng, Ruizhe Qian, Xiang-Feng Zhou, Yi Feng
Objective: This study aims to understand the current learning state, curriculum evaluation, and career planning of international Bachelor of Medicine, Bachelor of Surgery (MBBS) students in China in order to support educators and policy makers in developing interventions to support international MBBS students. Methods: A cross-sectional survey was conducted at Fudan University from March 2017 to May 2018. A self-administered questionnaire regarding medical teaching and evaluation methods and recommendations was used to collect the data from international MBBS students ([Formula: see text]) and native Chinese medical students ([Formula: see text]) currently at the school as well as teachers directly involved in teaching activities with these students ([Formula: see text]). Data were analyzed using GraphPad Prism 6, and all results are presented as frequencies (percentages). Results: Most of the international MBBS students had never studied at a university before (76%). The first and second most common reasons for choosing the MBBS program were an interest in medical science (79%) and relieving patients’ sufferings and realizing self-value (61%). The learning motivation of international MBBS students came mainly from the interests in medicine (90%). A total of 74% of international MBBS students considered the course setting to be appropriate or neutral. The top biggest problem in clinical practice reported by international MBBS students was communication barriers caused by the lack of language proficiency. The first choice of future work after graduation for international MBBS students was studying or working abroad. The top two recommendations among teachers for improving academic achievement were providing textbooks in students’ native languages (64%) and reading more medical books (47%). Conclusions: International MBBS students generally thought that the course setting was rational, and were mostly satisfied with the international MBBS program. The use of textbooks in the international MBBS students’ native languages was reported to be helpful for improving these students’ academic achievements.
{"title":"Current status of international medical education in China: A cross-sectional study","authors":"Yuchun Chu, Ming Gao, Haifeng Gao, Ye Liu, Xunjia Cheng, Ruizhe Qian, Xiang-Feng Zhou, Yi Feng","doi":"10.1142/S2575900019500095","DOIUrl":"https://doi.org/10.1142/S2575900019500095","url":null,"abstract":"Objective: This study aims to understand the current learning state, curriculum evaluation, and career planning of international Bachelor of Medicine, Bachelor of Surgery (MBBS) students in China in order to support educators and policy makers in developing interventions to support international MBBS students. Methods: A cross-sectional survey was conducted at Fudan University from March 2017 to May 2018. A self-administered questionnaire regarding medical teaching and evaluation methods and recommendations was used to collect the data from international MBBS students ([Formula: see text]) and native Chinese medical students ([Formula: see text]) currently at the school as well as teachers directly involved in teaching activities with these students ([Formula: see text]). Data were analyzed using GraphPad Prism 6, and all results are presented as frequencies (percentages). Results: Most of the international MBBS students had never studied at a university before (76%). The first and second most common reasons for choosing the MBBS program were an interest in medical science (79%) and relieving patients’ sufferings and realizing self-value (61%). The learning motivation of international MBBS students came mainly from the interests in medicine (90%). A total of 74% of international MBBS students considered the course setting to be appropriate or neutral. The top biggest problem in clinical practice reported by international MBBS students was communication barriers caused by the lack of language proficiency. The first choice of future work after graduation for international MBBS students was studying or working abroad. The top two recommendations among teachers for improving academic achievement were providing textbooks in students’ native languages (64%) and reading more medical books (47%). Conclusions: International MBBS students generally thought that the course setting was rational, and were mostly satisfied with the international MBBS program. The use of textbooks in the international MBBS students’ native languages was reported to be helpful for improving these students’ academic achievements.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2575900019500095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41869309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Based on the comprehensive observation of medicine, we made a diachronic summarization and synchronic comparison on medicine, including traditional medicine and modern medicine as well as Chinese traditional medicine (CTM) and Western traditional medicine. We focused on the connotation of several predominant medicines, the evolution of medical civilization, the problems and challenges of medicine at present, the prospect and framework of medicine in the future, and finally put forward the new system of CTM together with the integration of traditional medicine and modern medicine so as to contribute to the thinking, research and construction of medicine for mankind, which will add to its positive development and scientific practice.
{"title":"Origin and future of medicine","authors":"Wenxian Liu, Zhen Gao, Linwei Lu, Hu Zhang, Shan Jiang, Cheng Ma, Zhao Tang, Qiuping Li, N. Mohammadtursun, Lingli Hu, Wuniqiemu Tulake, Zexi Lv, Jingcheng Dong","doi":"10.1142/S2575900019100013","DOIUrl":"https://doi.org/10.1142/S2575900019100013","url":null,"abstract":"Based on the comprehensive observation of medicine, we made a diachronic summarization and synchronic comparison on medicine, including traditional medicine and modern medicine as well as Chinese traditional medicine (CTM) and Western traditional medicine. We focused on the connotation of several predominant medicines, the evolution of medical civilization, the problems and challenges of medicine at present, the prospect and framework of medicine in the future, and finally put forward the new system of CTM together with the integration of traditional medicine and modern medicine so as to contribute to the thinking, research and construction of medicine for mankind, which will add to its positive development and scientific practice.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2575900019100013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48554553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To explore the personality characteristics of Traditional Uyghur Medicine (TUM) abnormal body fluid type major depressive disorder in patients and provide a theoretical basis for the clinical treatment and prevention of depression. Method: Eysenck Personality Questionnaire (EPQ) was used to test the 238 patients with depression, responses were compared with normal mode group, test results were obtained using SPSS 21.0 statistical software for data analysis, the two groups were compared using [Formula: see text]-test, variance analysis was used in the comparison, pairwise comparison was made with the LSD method and [Formula: see text] was found to be statistically significant. Results: The mental qualities namely Psychoticism/Socialization (P), Extroversion/Introversion (E), Neuroticism/Stability (N) and Lie/Social Desirability (L) of patients with depression were found to be higher than the normal mode group, and the difference was statistically significant; the scores of [Formula: see text]- and [Formula: see text]-scales were higher in the patients with abnormal cold and dry type depression than those in the normal group, compared with other abnormal body fluid type depressions. Conclusion: Research results indicate that abnormal body fluid and personality both play a role in the pathogenesis of depression. In particular, the personality characteristics of patients with abnormal cold and dry type body fluid play an important role in the occurence and development of depression.
{"title":"A survey and analysis of traditional Uyghur medicine abnormal body fluid type major depressive disorder with personality traits","authors":"Aman Gul, Palidan Wushuer, Hua Rui, Aikeranmu Aihemaiti, Nassirhadjy Memtily, Ainiwaer Talifu","doi":"10.1142/S2575900019500034","DOIUrl":"https://doi.org/10.1142/S2575900019500034","url":null,"abstract":"Objective: To explore the personality characteristics of Traditional Uyghur Medicine (TUM) abnormal body fluid type major depressive disorder in patients and provide a theoretical basis for the clinical treatment and prevention of depression. Method: Eysenck Personality Questionnaire (EPQ) was used to test the 238 patients with depression, responses were compared with normal mode group, test results were obtained using SPSS 21.0 statistical software for data analysis, the two groups were compared using [Formula: see text]-test, variance analysis was used in the comparison, pairwise comparison was made with the LSD method and [Formula: see text] was found to be statistically significant. Results: The mental qualities namely Psychoticism/Socialization (P), Extroversion/Introversion (E), Neuroticism/Stability (N) and Lie/Social Desirability (L) of patients with depression were found to be higher than the normal mode group, and the difference was statistically significant; the scores of [Formula: see text]- and [Formula: see text]-scales were higher in the patients with abnormal cold and dry type depression than those in the normal group, compared with other abnormal body fluid type depressions. Conclusion: Research results indicate that abnormal body fluid and personality both play a role in the pathogenesis of depression. In particular, the personality characteristics of patients with abnormal cold and dry type body fluid play an important role in the occurence and development of depression.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2575900019500034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43724455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-06DOI: 10.1142/S2575900019500010
Alimjan Parhat, H. Huojiaaihemaiti, Nabijan Mohammadturusn, M. Nurahmat
Objective: To evaluate the hyperglycemic effects of Kursi Ziyabet (KZ) tablets on the rat models of diabetes mellitus. Methods: In total, 58 male SD rats were assigned randomly to six groups. All except the normal group were transformed into experimental diabetes mellitus rat models by injecting streptozocin. The hyperglycemic effect and the mechanism of Ziyabet were evaluated by body weight, food and water intake, fasting blood sugar, and related parameters by measuring the oxidative stress-related factors and lipid metabolism indicator level by the corresponding kits using the rat experimental models. Results: Compared with the model group, body weight markedly increased after 3–6 weeks of intragastric administration of Ziyabet tablets ([Formula: see text]), while the water intake significantly decreased in the same period of time ([Formula: see text]). Food intake and fasting blood sugar level also decreased with the high dosage of Ziyabet tablets ([Formula: see text]). There is no significant difference in pancreas’ MDA content of the Ziyabet groups when compared to the model group ([Formula: see text]), while significant increase in SOD level was observed in high-dosage KZ group ([Formula: see text]). The blood serum insulin and free fatty acid level also decreased in the high-dosage KZ group compared with the model group ([Formula: see text]). Conclusion: We conclude that Ziyabet tablets demonstrated protective effects on the diabetic rat models.
{"title":"Experimental study on the effects of Kursi Ziyabet on the rat model of diabetes mellitus","authors":"Alimjan Parhat, H. Huojiaaihemaiti, Nabijan Mohammadturusn, M. Nurahmat","doi":"10.1142/S2575900019500010","DOIUrl":"https://doi.org/10.1142/S2575900019500010","url":null,"abstract":"Objective: To evaluate the hyperglycemic effects of Kursi Ziyabet (KZ) tablets on the rat models of diabetes mellitus. Methods: In total, 58 male SD rats were assigned randomly to six groups. All except the normal group were transformed into experimental diabetes mellitus rat models by injecting streptozocin. The hyperglycemic effect and the mechanism of Ziyabet were evaluated by body weight, food and water intake, fasting blood sugar, and related parameters by measuring the oxidative stress-related factors and lipid metabolism indicator level by the corresponding kits using the rat experimental models. Results: Compared with the model group, body weight markedly increased after 3–6 weeks of intragastric administration of Ziyabet tablets ([Formula: see text]), while the water intake significantly decreased in the same period of time ([Formula: see text]). Food intake and fasting blood sugar level also decreased with the high dosage of Ziyabet tablets ([Formula: see text]). There is no significant difference in pancreas’ MDA content of the Ziyabet groups when compared to the model group ([Formula: see text]), while significant increase in SOD level was observed in high-dosage KZ group ([Formula: see text]). The blood serum insulin and free fatty acid level also decreased in the high-dosage KZ group compared with the model group ([Formula: see text]). Conclusion: We conclude that Ziyabet tablets demonstrated protective effects on the diabetic rat models.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2575900019500010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42606216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-06DOI: 10.1142/S2575900019500058
D. D. Ibragimov, S. Boymuradov
Background: Our aim is to study the effectiveness of immunomodulatory therapy with Polyoxidonium in the complex treatment of patients with combined craniofacial injuries. Methods: In accordance with the intended purpose of this study, we conducted a comprehensive immunological examination of patients with combined craniofacial injuries in the dynamics of treatment with the drug authorized for use in healthcare practice: Polyoxidonium. In total 22 patients with combined craniofacial injuries in the complex therapy received Polyoxidonium at a dosage level of 6[Formula: see text]mg/m once for 5 days. Results: We conducted a comprehensive immunological study of the clinical course of the post-traumatic period in patients with combined craniofacial injuries which showed that the immunomodulatory therapy with Polyoxidonium during the complex treatment has a high clinical and immunological efficacy. Conclusions: Thus, in patients with combined craniofacial injuries, there is an immunodeficiency state involving both cellular immunity, manifested by a decrease in the level of T-lymphocytes, T-helpers, NK-cells and B-lymphocytes, and decrease of immunoglobulin production. The use of Polyoxidonium immunomodulator in complex therapy in patients with combined craniofacial injuries helped in improving the condition of patients in a shorter period of time and in preventing the development of purulent-inflammatory complications due to the positive dynamics of cellular and humoral immunity.
{"title":"Efficiency of immunomodulatory therapy in the complex treatment of patients with combined craniofacial injuries","authors":"D. D. Ibragimov, S. Boymuradov","doi":"10.1142/S2575900019500058","DOIUrl":"https://doi.org/10.1142/S2575900019500058","url":null,"abstract":"Background: Our aim is to study the effectiveness of immunomodulatory therapy with Polyoxidonium in the complex treatment of patients with combined craniofacial injuries. Methods: In accordance with the intended purpose of this study, we conducted a comprehensive immunological examination of patients with combined craniofacial injuries in the dynamics of treatment with the drug authorized for use in healthcare practice: Polyoxidonium. In total 22 patients with combined craniofacial injuries in the complex therapy received Polyoxidonium at a dosage level of 6[Formula: see text]mg/m once for 5 days. Results: We conducted a comprehensive immunological study of the clinical course of the post-traumatic period in patients with combined craniofacial injuries which showed that the immunomodulatory therapy with Polyoxidonium during the complex treatment has a high clinical and immunological efficacy. Conclusions: Thus, in patients with combined craniofacial injuries, there is an immunodeficiency state involving both cellular immunity, manifested by a decrease in the level of T-lymphocytes, T-helpers, NK-cells and B-lymphocytes, and decrease of immunoglobulin production. The use of Polyoxidonium immunomodulator in complex therapy in patients with combined craniofacial injuries helped in improving the condition of patients in a shorter period of time and in preventing the development of purulent-inflammatory complications due to the positive dynamics of cellular and humoral immunity.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2575900019500058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47916465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: We report on the association between traditional Chinese medicine (TCM) constitution and diabetes mellitus (DM) and provide epidemiological evidence for the theory of correlation between constitution and disease. Methods: A total of 3748 participants were used for data analysis, and all study subjects underwent a complete clinical baseline characteristics evaluation to collect related information. DM was determined by an oral glucose tolerance test. Multiple logistic regression (MLR) models were employed to detect the associations. Results: In total, 16.84% of the participants had DM in the total sample. Significant differences were found in age, height, weight, and heart rate, between the DM and non-DM groups. Univariate linear regression analyses indicated that the variables Qi_Deficient and Yang_Deficient were significantly associated with the outcome, and a negative correlation between TCM constitution and DM was found. After adjustment for relevant potential confounding factors, the MLR detected significant associations between both the Qi_Deficient and Yang_Deficient variables and DM ([Formula: see text]-value [Formula: see text] 0.015 for Qi_Deficient and [Formula: see text]-value [Formula: see text] for Yang_Deficient). In Qi_Deficient and Yin_Deficient participants, the odds ratios (ORs) for DM were 0.778 and 0.646, respectively. Conclusion: Qi_Deficient and Yang_Deficient were significantly associated with DM. These findings may provide insights for clinical practice for the prevention and diagnosis of DM.
{"title":"Association study of diabetes mellitus and body constitution of traditional Chinese medicine","authors":"Nabijan Mohammadturusn, Yizhe Xu, Fei Xu, Yuanhao Zhang, Zihui Tang, Wenxian Liu","doi":"10.1142/S2575900019500022","DOIUrl":"https://doi.org/10.1142/S2575900019500022","url":null,"abstract":"Objective: We report on the association between traditional Chinese medicine (TCM) constitution and diabetes mellitus (DM) and provide epidemiological evidence for the theory of correlation between constitution and disease. Methods: A total of 3748 participants were used for data analysis, and all study subjects underwent a complete clinical baseline characteristics evaluation to collect related information. DM was determined by an oral glucose tolerance test. Multiple logistic regression (MLR) models were employed to detect the associations. Results: In total, 16.84% of the participants had DM in the total sample. Significant differences were found in age, height, weight, and heart rate, between the DM and non-DM groups. Univariate linear regression analyses indicated that the variables Qi_Deficient and Yang_Deficient were significantly associated with the outcome, and a negative correlation between TCM constitution and DM was found. After adjustment for relevant potential confounding factors, the MLR detected significant associations between both the Qi_Deficient and Yang_Deficient variables and DM ([Formula: see text]-value [Formula: see text] 0.015 for Qi_Deficient and [Formula: see text]-value [Formula: see text] for Yang_Deficient). In Qi_Deficient and Yin_Deficient participants, the odds ratios (ORs) for DM were 0.778 and 0.646, respectively. Conclusion: Qi_Deficient and Yang_Deficient were significantly associated with DM. These findings may provide insights for clinical practice for the prevention and diagnosis of DM.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2575900019500022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47555354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Epimedium flavonoids (EF), the raw extract of medicinal herb Epimedium, have been shown to have broad beneficial effects in the elderly including those with neurodegeneration. The goal of this study is to investigate whether EF is protective against proteotoxicity and whether it extends healthspan in C. elegans. Methods: Animals were treated with EF supplemented in the growth medium. Two C. elegans models of human proteotoxic disease, CL4176 expressing an aggregated amyloid-[Formula: see text] (1–42) peptide (A[Formula: see text]1–42) and AM140 expressing a polyglutamine (polyQ) protein, were exploited to test the anti-proteotoxicity of EF. Proteotoxicity-induced paralysis in CL4176 and AM140 was evaluated. Lifespan, stress resistance, and locomotion were tested in wild-type N2 C. elegans. Lifespan assays were also performed in CF1038, a daf-16 null mutant strain. DAF-16 nuclear translocation was analyzed in TJ356, a strain expressing a functional DAF-16::GFP fusion protein. The mRNA levels of downstream targets of DAF-16 were measured by qPCR. Results: EF significantly reduced A[Formula: see text]1–42- and polyQ-induced paralysis in CL4176 and AM140, indicating the anti-proteotoxic potency of EF. EF significantly extended the lifespan and promoted stress resistance and locomotion in N2, demonstrating a healthspan extension effect of EF. DAF-16 nuclear localization and its downstream targets, sod-3 and hsp-16.2 mRNA levels, were significantly elevated with EF. EF did not increase the lifespan of daf-16 null mutant CF1038, revealing a DAF-16-dependent mechanism of EF effect on lifespan. Conclusion: We found that EF, a natural extract from a widely used medicinal herb Epimedium, protects against proteotoxicity and extends the healthspan via DAF-16 in C. elegans. Our work may provide molecular insights into the clinical benefits of EF and Epimedium.
{"title":"Epimedium flavonoids mitigate proteotoxicity and extend healthspan via DAF-16 in C. elegans","authors":"Waijiao Cai, Junzhen Wu, Xinliumei Wang, Jianhua Huang, Zi-yin Shen, Xiqun Chen","doi":"10.1142/S2575900019500046","DOIUrl":"https://doi.org/10.1142/S2575900019500046","url":null,"abstract":"Objective: Epimedium flavonoids (EF), the raw extract of medicinal herb Epimedium, have been shown to have broad beneficial effects in the elderly including those with neurodegeneration. The goal of this study is to investigate whether EF is protective against proteotoxicity and whether it extends healthspan in C. elegans. Methods: Animals were treated with EF supplemented in the growth medium. Two C. elegans models of human proteotoxic disease, CL4176 expressing an aggregated amyloid-[Formula: see text] (1–42) peptide (A[Formula: see text]1–42) and AM140 expressing a polyglutamine (polyQ) protein, were exploited to test the anti-proteotoxicity of EF. Proteotoxicity-induced paralysis in CL4176 and AM140 was evaluated. Lifespan, stress resistance, and locomotion were tested in wild-type N2 C. elegans. Lifespan assays were also performed in CF1038, a daf-16 null mutant strain. DAF-16 nuclear translocation was analyzed in TJ356, a strain expressing a functional DAF-16::GFP fusion protein. The mRNA levels of downstream targets of DAF-16 were measured by qPCR. Results: EF significantly reduced A[Formula: see text]1–42- and polyQ-induced paralysis in CL4176 and AM140, indicating the anti-proteotoxic potency of EF. EF significantly extended the lifespan and promoted stress resistance and locomotion in N2, demonstrating a healthspan extension effect of EF. DAF-16 nuclear localization and its downstream targets, sod-3 and hsp-16.2 mRNA levels, were significantly elevated with EF. EF did not increase the lifespan of daf-16 null mutant CF1038, revealing a DAF-16-dependent mechanism of EF effect on lifespan. Conclusion: We found that EF, a natural extract from a widely used medicinal herb Epimedium, protects against proteotoxicity and extends the healthspan via DAF-16 in C. elegans. Our work may provide molecular insights into the clinical benefits of EF and Epimedium.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2575900019500046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43808393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: This study aimed to explore the associations between constitutions of traditional Chinese medicine (TCM) and coronary artery disease (CAD).Methods: A large-scale, community-based, cross-sectional study was performed to investigate the associations. A total of 3,748 participants were available for analysis in this study. The assessment of the constitution of TCM was based on recommendations by the Association for Chinese Medicine in China. In this study, a diagnosis of CAD was based on self-reported medical history. The associations were analyzed using univariate and multivariable logistic regression (MLR).Results: Univariate analysis showed Phlegm–dampness, Qi-deficiency, Yang-deficiency and Yin-deficiency constitutions were significantly associated with CAD, respectively ([Formula: see text] for Phlegm–dampness, [Formula: see text] for Qi-deficiency, [Formula: see text] for Yang-deficiency and [Formula: see text] for Yin-deficiency). Furthermore, MLR demonstrated significant associations among the four constitutions and CAD, after controlling for potential confounding factors (Phlegm–dampness: [Formula: see text], [Formula: see text]; Qi-deficient: [Formula: see text], [Formula: see text], Yang-Deficient: [Formula: see text], [Formula: see text]; Yin-deficient: [Formula: see text], [Formula: see text]). As compared with Neutral participants, participants with the four constitutions of TCM had higher prevalence of CAD.Conclusion: Our findings provided evidence that the four constitutions of TCM including Phlegm-dampness, Qi-deficiency, Yan-deficiency and Yin-deficiency were significantly associated with CAD, respectively. (This study was registered in clinicaltrials.gov with the ID: NCT02998944.)
{"title":"Coronary arterial disease correlates with constitutions of Traditional Chinese Medicine: A cross-sectional study in a Chinese cohort","authors":"Fei Xu, Genlong Wu, Jianlong Miao, Rui-Juan Liu, Zihui Tang, Jingcheng Dong","doi":"10.1142/S2575900018500118","DOIUrl":"https://doi.org/10.1142/S2575900018500118","url":null,"abstract":"Introduction: This study aimed to explore the associations between constitutions of traditional Chinese medicine (TCM) and coronary artery disease (CAD).Methods: A large-scale, community-based, cross-sectional study was performed to investigate the associations. A total of 3,748 participants were available for analysis in this study. The assessment of the constitution of TCM was based on recommendations by the Association for Chinese Medicine in China. In this study, a diagnosis of CAD was based on self-reported medical history. The associations were analyzed using univariate and multivariable logistic regression (MLR).Results: Univariate analysis showed Phlegm–dampness, Qi-deficiency, Yang-deficiency and Yin-deficiency constitutions were significantly associated with CAD, respectively ([Formula: see text] for Phlegm–dampness, [Formula: see text] for Qi-deficiency, [Formula: see text] for Yang-deficiency and [Formula: see text] for Yin-deficiency). Furthermore, MLR demonstrated significant associations among the four constitutions and CAD, after controlling for potential confounding factors (Phlegm–dampness: [Formula: see text], [Formula: see text]; Qi-deficient: [Formula: see text], [Formula: see text], Yang-Deficient: [Formula: see text], [Formula: see text]; Yin-deficient: [Formula: see text], [Formula: see text]). As compared with Neutral participants, participants with the four constitutions of TCM had higher prevalence of CAD.Conclusion: Our findings provided evidence that the four constitutions of TCM including Phlegm-dampness, Qi-deficiency, Yan-deficiency and Yin-deficiency were significantly associated with CAD, respectively. (This study was registered in clinicaltrials.gov with the ID: NCT02998944.)","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2575900018500118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48398337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The objective of this study is to preliminarily evaluate the efficacy of the combination of baicalein and docetaxel on non-small cell lung cancer (NSCLC) in vivo. Methods: The subcutaneous model was established by inoculation of A549 cells, and then these tumor-bearing mice were randomly assigned to eight groups to receive normal saline (NS) as control, baicalein alone, Taxotere[Formula: see text] (docetaxel injection) alone or the combination of baicalein and Taxotere[Formula: see text]. The effect of the combination treatment was evaluated by [Formula: see text] value. Tumors were harvested for TUNEL and CD31 immunohistochemical staining and important organs for H&E staining. Results: Baicalein 50[Formula: see text]mg/kg plus docetaxel 10[Formula: see text]mg/kg significantly reduced tumor weight and inhibited the growth rate of tumor, displaying the additive effect indicated by the [Formula: see text] value. Increased apoptosis and decreased tumor angiogenesis also provided pathological evidence. Additionally, baicalein 50[Formula: see text]mg/kg plus docetaxel 10[Formula: see text]mg/kg did not increase toxicity in lung, liver and kidney. Conclusion: Baicalein 50[Formula: see text]mg/kg plus docetaxel 10[Formula: see text]mg/kg additively inhibits the growth of NSCLC in vivo, and the mechanism underlying remains to be discovered.
{"title":"Combination of baicalein and docetaxel additively inhibits the growth of non-small cell lung cancer in vivo","authors":"Linwei Lu, Zhengxiao Zhao, Lumei Liu, Weiyi Gong, Jingcheng Dong","doi":"10.1142/S2575900018500131","DOIUrl":"https://doi.org/10.1142/S2575900018500131","url":null,"abstract":"Objective: The objective of this study is to preliminarily evaluate the efficacy of the combination of baicalein and docetaxel on non-small cell lung cancer (NSCLC) in vivo. Methods: The subcutaneous model was established by inoculation of A549 cells, and then these tumor-bearing mice were randomly assigned to eight groups to receive normal saline (NS) as control, baicalein alone, Taxotere[Formula: see text] (docetaxel injection) alone or the combination of baicalein and Taxotere[Formula: see text]. The effect of the combination treatment was evaluated by [Formula: see text] value. Tumors were harvested for TUNEL and CD31 immunohistochemical staining and important organs for H&E staining. Results: Baicalein 50[Formula: see text]mg/kg plus docetaxel 10[Formula: see text]mg/kg significantly reduced tumor weight and inhibited the growth rate of tumor, displaying the additive effect indicated by the [Formula: see text] value. Increased apoptosis and decreased tumor angiogenesis also provided pathological evidence. Additionally, baicalein 50[Formula: see text]mg/kg plus docetaxel 10[Formula: see text]mg/kg did not increase toxicity in lung, liver and kidney. Conclusion: Baicalein 50[Formula: see text]mg/kg plus docetaxel 10[Formula: see text]mg/kg additively inhibits the growth of NSCLC in vivo, and the mechanism underlying remains to be discovered.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2575900018500131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47736976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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