Pub Date : 2020-03-01DOI: 10.1142/s2575900020200025
X. Yao, Mengzhen Li, Cuiling Feng
The COVID-19 epidemic in China has been effectively controlled, a large number of patients have been released from isolation and discharged, and the treatment and rehabilitation programs in the recovery period need to be effectively implemented. The recovery of coronavirus disease 2019 is a syndrome of deficiency and solidity. The deficiency of qi and yin is dominant, and some patients have yang deficiency; phlegm and stasis are the main pathological products. We suggest that hierarchical management is recommended for patients in the recovery period. Asymptomatic patients with normal lung imaging results should take the respiratory rehabilitation program and have no need to take drugs. Patients with clinical symptoms with or without lung shadows, and patients who have no obvious symptoms but whose lung shadows are not completely absorbed, need to be treated according to syndrome differentiation.
{"title":"Opinions on the rehabilitation therapies of coronavirus disease 2019 (COVID-19)","authors":"X. Yao, Mengzhen Li, Cuiling Feng","doi":"10.1142/s2575900020200025","DOIUrl":"https://doi.org/10.1142/s2575900020200025","url":null,"abstract":"The COVID-19 epidemic in China has been effectively controlled, a large number of patients have been released from isolation and discharged, and the treatment and rehabilitation programs in the recovery period need to be effectively implemented. The recovery of coronavirus disease 2019 is a syndrome of deficiency and solidity. The deficiency of qi and yin is dominant, and some patients have yang deficiency; phlegm and stasis are the main pathological products. We suggest that hierarchical management is recommended for patients in the recovery period. Asymptomatic patients with normal lung imaging results should take the respiratory rehabilitation program and have no need to take drugs. Patients with clinical symptoms with or without lung shadows, and patients who have no obvious symptoms but whose lung shadows are not completely absorbed, need to be treated according to syndrome differentiation.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46720331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.1142/s2575900019300029
H. Cai, X. Hou, Yibo Ding, Zhongxing Fu, Ling Wang, Yan Du
Gastric cancer (GC) is one of the most commonly diagnosed malignancies worldwide, and is caused by complex interactions of multiple risk factors such as environmental (Helicobacter pylori and Epstein–Barr Virus), hereditary (genetic alterations and epigenetic modifications), as well as dietary and lifestyle factors. GC is usually detected at an advanced stage, with a dismal prognosis. Even for patients with similar clinical or pathologic stage receiving similar treatment, the outcomes are still uneven and unpredictable. To better incorporate genetic and epigenetic profiles into GC prognostic predication, gene expression signatures have been developed to predict GC outcomes. More recently, the advancement of high-throughput sequencing technology, also known as next-generation sequencing (NGS) technology, and analysis has provided the basis for accurate molecular classification of GC tumors. Here, we summarized and updated the literature related to NGS studies of GC, including whole-genome sequencing, whole-exome sequencing, RNA sequencing, and targeted sequencing, and discussed current progresses. NGS has facilitated the identification of genetic/epigenetic targets for screening as well as development of targeted agent therapy, thus enabling individualized patient management and treatment.
{"title":"Prediction of gastric cancer prognosis in the next-generation sequencing era","authors":"H. Cai, X. Hou, Yibo Ding, Zhongxing Fu, Ling Wang, Yan Du","doi":"10.1142/s2575900019300029","DOIUrl":"https://doi.org/10.1142/s2575900019300029","url":null,"abstract":"Gastric cancer (GC) is one of the most commonly diagnosed malignancies worldwide, and is caused by complex interactions of multiple risk factors such as environmental (Helicobacter pylori and Epstein–Barr Virus), hereditary (genetic alterations and epigenetic modifications), as well as dietary and lifestyle factors. GC is usually detected at an advanced stage, with a dismal prognosis. Even for patients with similar clinical or pathologic stage receiving similar treatment, the outcomes are still uneven and unpredictable. To better incorporate genetic and epigenetic profiles into GC prognostic predication, gene expression signatures have been developed to predict GC outcomes. More recently, the advancement of high-throughput sequencing technology, also known as next-generation sequencing (NGS) technology, and analysis has provided the basis for accurate molecular classification of GC tumors. Here, we summarized and updated the literature related to NGS studies of GC, including whole-genome sequencing, whole-exome sequencing, RNA sequencing, and targeted sequencing, and discussed current progresses. NGS has facilitated the identification of genetic/epigenetic targets for screening as well as development of targeted agent therapy, thus enabling individualized patient management and treatment.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/s2575900019300029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41682598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The objective of this study was to evaluate (1) the association of blood pressure (BP) profiles and glucose profiles with diabetic retinopathy (DR) and (2) the interaction between BP profiles and glucose profiles in DR in a Chinese sample. Methods: This was a cross-sectional study of 984 DR patients. Demographic data, BP profiles, glucose profiles, renal function parameters, and medical histories were recorded. All the participants underwent testing for DR with digital nonmydriatic fundus photography and image analysis, using a standardized protocol. A multiple variable logistic regression (MLR) was employed to detect the associations and interactions of BP profiles and glucose profiles with DR. Results: Systolic blood pressure (SBP) and glycated hemoglobin (HbA1c) were significantly correlated with DR ([Formula: see text] for SBP, [Formula: see text]; [Formula: see text] for HbA1c, [Formula: see text]). An interaction between SBP and HbA1c was detected in a multiple logistic regression (MLR) model after adjustment for relevant potential confounders ([Formula: see text], [Formula: see text]). Conclusion: The present study suggested that SBP and HbA1c were independently and significantly associated with DR and that SBP interacted with HbA1c to impact on DR.
{"title":"Interaction analysis of systolic blood pressure and glycosylated hemoglobin in diabetic retinopathy: A Chinese sample","authors":"Xiangying Meng, Yuanhao Zhang, Qing Kong, Yu-bao Lv, Hailin Hu, Tao Chen, Zihui Tang","doi":"10.1142/s2575900019500101","DOIUrl":"https://doi.org/10.1142/s2575900019500101","url":null,"abstract":"Background: The objective of this study was to evaluate (1) the association of blood pressure (BP) profiles and glucose profiles with diabetic retinopathy (DR) and (2) the interaction between BP profiles and glucose profiles in DR in a Chinese sample. Methods: This was a cross-sectional study of 984 DR patients. Demographic data, BP profiles, glucose profiles, renal function parameters, and medical histories were recorded. All the participants underwent testing for DR with digital nonmydriatic fundus photography and image analysis, using a standardized protocol. A multiple variable logistic regression (MLR) was employed to detect the associations and interactions of BP profiles and glucose profiles with DR. Results: Systolic blood pressure (SBP) and glycated hemoglobin (HbA1c) were significantly correlated with DR ([Formula: see text] for SBP, [Formula: see text]; [Formula: see text] for HbA1c, [Formula: see text]). An interaction between SBP and HbA1c was detected in a multiple logistic regression (MLR) model after adjustment for relevant potential confounders ([Formula: see text], [Formula: see text]). Conclusion: The present study suggested that SBP and HbA1c were independently and significantly associated with DR and that SBP interacted with HbA1c to impact on DR.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/s2575900019500101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46875035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.1142/s2575900019100025
Z. Jiang, Ying Wei, Jingcheng Dong
With the transformation of health concepts and medical models, traditional medicine is receiving more and more attention from people all over the world. Traditional medicine has become an important part of health promotion and global health management improvement. This paper briefly describes the connotation and development trend of traditional medicine in the new era from the perspective of philosophical theory. Through a thorough analysis of the rational thinking and realistic basis for the integration and development of traditional medicine in the new era from the perspectives of time, space, content and technology, we come to the conclusion that, under the modern medical model supported by Big Health and Big Data, the deepening and improvement of the consolidation of multi-dimensional integration and multi-collaborative system of traditional medicine will play a more fundamental role in mankind’s health and hygiene. This paper also presents the paths of integrative development for the traditional medicine under the new circumstances, aiming to provide theoretical ideas for further promoting the systematic development of traditional medicine and helping the revival of traditional Chinese medical civilization.
{"title":"Multi-dimensional resource integration concept and development path of traditional medicine in the new era","authors":"Z. Jiang, Ying Wei, Jingcheng Dong","doi":"10.1142/s2575900019100025","DOIUrl":"https://doi.org/10.1142/s2575900019100025","url":null,"abstract":"With the transformation of health concepts and medical models, traditional medicine is receiving more and more attention from people all over the world. Traditional medicine has become an important part of health promotion and global health management improvement. This paper briefly describes the connotation and development trend of traditional medicine in the new era from the perspective of philosophical theory. Through a thorough analysis of the rational thinking and realistic basis for the integration and development of traditional medicine in the new era from the perspectives of time, space, content and technology, we come to the conclusion that, under the modern medical model supported by Big Health and Big Data, the deepening and improvement of the consolidation of multi-dimensional integration and multi-collaborative system of traditional medicine will play a more fundamental role in mankind’s health and hygiene. This paper also presents the paths of integrative development for the traditional medicine under the new circumstances, aiming to provide theoretical ideas for further promoting the systematic development of traditional medicine and helping the revival of traditional Chinese medical civilization.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/s2575900019100025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45527951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The anti-asthma herbal medicine Bu–Shen–Yi–Qi Decoction (BSYQ Decoction), a combination of three traditional Chinese medicine herbs developed in our lab, has shown demonstrated efficacy in Ovalbumin (OVA)-induced acute bronchial asthma. However, the obscure substances, multiple potential targets and the unclear molecular mechanisms are obstacles to control drug quality, stability and standardization. Multi-component formulae with a clear pharmacodynamic material and specific mechanism are an innovation worth exploring. They may also partly reserve a potential synergistic and additive effect compared with single components extracted from traditional Chinese herbs. This study was designed to select three standard multi-component formulae of the combination of effective components preliminarily based on four effective components [total flavonoids of Herba Epimedii ([Formula: see text]; Astragalus polysaccharide ([Formula: see text]; Astragaloside ([Formula: see text]; and Catalpol ([Formula: see text]] in BSYQ Decoction. Methods: OVA-induced asthmatic murine models were established. A uniform design was applied to select 10 proportions from four target components, and 3 formulae which showed best effect aimed at IFN-[Formula: see text], IL-4 and IgE in the serum respectively were screened based on stepwise regression analysis. Results: According to the regression analysis, Formula I ([Formula: see text]:[Formula: see text]:[Formula: see text]:6:29), Formula II ([Formula: see text]:[Formula: see text]:[Formula: see text]:8:2) and Formula III ([Formula: see text]:[Formula: see text]:[Formula: see text]:[Formula: see text]:50:8:2) are the three potential proper ratios for the new multi-component formula aimed at serum IFN-[Formula: see text], IL-4 and IgE in OVA-induced asthma mice, respectively. Conclusion: Three multi-component formulae derived from BSYQ Decoction could exert anti-inflammatory effect against OVA-induced asthma, which might provide evidences and lay foundations for further study of standard modern Chinese drug for treating asthma based on BSYQ Decoction.
{"title":"A preliminary strategy for screening the combination of active components based on Bu–Shen–Yi–Qi Decoction for bronchial asthma","authors":"Chen Yan, Q. Luo, Cheng Ma, Jiaqi Liu, Jingcheng Dong","doi":"10.1142/s2575900019500137","DOIUrl":"https://doi.org/10.1142/s2575900019500137","url":null,"abstract":"Objective: The anti-asthma herbal medicine Bu–Shen–Yi–Qi Decoction (BSYQ Decoction), a combination of three traditional Chinese medicine herbs developed in our lab, has shown demonstrated efficacy in Ovalbumin (OVA)-induced acute bronchial asthma. However, the obscure substances, multiple potential targets and the unclear molecular mechanisms are obstacles to control drug quality, stability and standardization. Multi-component formulae with a clear pharmacodynamic material and specific mechanism are an innovation worth exploring. They may also partly reserve a potential synergistic and additive effect compared with single components extracted from traditional Chinese herbs. This study was designed to select three standard multi-component formulae of the combination of effective components preliminarily based on four effective components [total flavonoids of Herba Epimedii ([Formula: see text]; Astragalus polysaccharide ([Formula: see text]; Astragaloside ([Formula: see text]; and Catalpol ([Formula: see text]] in BSYQ Decoction. Methods: OVA-induced asthmatic murine models were established. A uniform design was applied to select 10 proportions from four target components, and 3 formulae which showed best effect aimed at IFN-[Formula: see text], IL-4 and IgE in the serum respectively were screened based on stepwise regression analysis. Results: According to the regression analysis, Formula I ([Formula: see text]:[Formula: see text]:[Formula: see text]:6:29), Formula II ([Formula: see text]:[Formula: see text]:[Formula: see text]:8:2) and Formula III ([Formula: see text]:[Formula: see text]:[Formula: see text]:[Formula: see text]:50:8:2) are the three potential proper ratios for the new multi-component formula aimed at serum IFN-[Formula: see text], IL-4 and IgE in OVA-induced asthma mice, respectively. Conclusion: Three multi-component formulae derived from BSYQ Decoction could exert anti-inflammatory effect against OVA-induced asthma, which might provide evidences and lay foundations for further study of standard modern Chinese drug for treating asthma based on BSYQ Decoction.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/s2575900019500137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49217061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-30DOI: 10.1142/s2575900019500113
Aman Gul, Nassirhadjy Memtily, Pirdun Mijit, M. Imin, Hua Rui, Palidan Wushuer, Ainiwaer Talifu
Objective: To evaluate the clinical effect of Üstikuddus sherbiti (US), a traditional herbal prescription of Uyghur medicine, in the treatment of cold and dry-type major depression disorder (MDD) patients with comorbid anxiety. Methods: A total of 150 cold and dry-type depressive patients with comorbid anxiety were randomly divided into three groups of 50 patients; then they were, respectively, treated with US, modern medicine Fluoxetine, and the combination of Fluoxetine and US. The depression degrees of patients were evaluated zero and six weeks after the treatment based on the Hamilton Anxiety Scale (HAMA), in the clinical study. Analysis of variance (ANOVA) was used to detect significant differences at various time points or among the three groups. Statistical analysis was performed by SPSS version 21.0. Results: The main results are as follows: After taking the medicine, the depressive condition of patients with comorbid anxiety in the three groups was getting better with the passage of time; particularly, the clinical efficacy of US combined with Fluoxetine was significantly improved, indicating that the effect of combined treatment is better than treatment with pure Fluoxetine or pure US treatment. Statistical difference exists between the end time point within groups, but not among the three groups. Moreover, in the detection process of the patient’s physical indicators, no obvious side effects were found. These results together suggested that US can strengthen the curative effect of modern medicine in the treatment of depression, which would lay a foundation for studying the molecular mechanism and potential target of US. Conclusion: Fluoxetine and US combination therapy played a significant role in the treatment of depressive symptoms, suggesting that it can improve the curative effect of depression. The study provided a new way of thinking to clarify the US molecular mechanism for the treatment of depression and potential target.
{"title":"The Üstikuddus sherbiti in the treatment of abnormal cold and dry-type depression patients with comorbid anxiety: A randomized and controlled clinical trial","authors":"Aman Gul, Nassirhadjy Memtily, Pirdun Mijit, M. Imin, Hua Rui, Palidan Wushuer, Ainiwaer Talifu","doi":"10.1142/s2575900019500113","DOIUrl":"https://doi.org/10.1142/s2575900019500113","url":null,"abstract":"Objective: To evaluate the clinical effect of Üstikuddus sherbiti (US), a traditional herbal prescription of Uyghur medicine, in the treatment of cold and dry-type major depression disorder (MDD) patients with comorbid anxiety. Methods: A total of 150 cold and dry-type depressive patients with comorbid anxiety were randomly divided into three groups of 50 patients; then they were, respectively, treated with US, modern medicine Fluoxetine, and the combination of Fluoxetine and US. The depression degrees of patients were evaluated zero and six weeks after the treatment based on the Hamilton Anxiety Scale (HAMA), in the clinical study. Analysis of variance (ANOVA) was used to detect significant differences at various time points or among the three groups. Statistical analysis was performed by SPSS version 21.0. Results: The main results are as follows: After taking the medicine, the depressive condition of patients with comorbid anxiety in the three groups was getting better with the passage of time; particularly, the clinical efficacy of US combined with Fluoxetine was significantly improved, indicating that the effect of combined treatment is better than treatment with pure Fluoxetine or pure US treatment. Statistical difference exists between the end time point within groups, but not among the three groups. Moreover, in the detection process of the patient’s physical indicators, no obvious side effects were found. These results together suggested that US can strengthen the curative effect of modern medicine in the treatment of depression, which would lay a foundation for studying the molecular mechanism and potential target of US. Conclusion: Fluoxetine and US combination therapy played a significant role in the treatment of depressive symptoms, suggesting that it can improve the curative effect of depression. The study provided a new way of thinking to clarify the US molecular mechanism for the treatment of depression and potential target.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45668139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic obstructive pulmonary disease (COPD) has become an important public health problem in the world. According to reports, COPD ranks fourth in the global cause of death, causing a serious economic burden on society. The pathogenesis of COPD is complex, making it difficult to simulate the pathological changes and clinical features of COPD. Moreover, the COPD animal model has an irreplaceable role in the study of etiology, pathology and treatment. It is worth noting that the risk factors for chronic obstructive pulmonary disease persist, and the economic burden of global chronic obstructive pulmonary disease is expected to continue to increase in the coming decades. Establishing a standardized, a clinically realistic COPD animal model has always been a research direction that scholars are keen on. Therefore, it is essential to establish an economical animal model. The establishment of a suitable animal model can accurately simulate the pathological features of human chronic obstructive pulmonary disease and help to develop effective interventions and treatments in a short period of time. This review integrates the experimental animal species selected in the animal models used in COPD studies. Subsequently, different methods and mechanisms for establishing animal models were summarized according to different modeling factors. Finally, the criteria for evaluating existing animal models are discussed. It is hoped that the summary of this paper will guide the establishment of relevant animal models for future COPD research.
{"title":"Recent advances on animal models related to chronic obstructive pulmonary disease","authors":"Shan Jiang, Nabjian Mohammadtursun, Jian Qiu, Qiuping Li, Jing Sun, Jingcheng Dong","doi":"10.1142/s2575900019300017","DOIUrl":"https://doi.org/10.1142/s2575900019300017","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) has become an important public health problem in the world. According to reports, COPD ranks fourth in the global cause of death, causing a serious economic burden on society. The pathogenesis of COPD is complex, making it difficult to simulate the pathological changes and clinical features of COPD. Moreover, the COPD animal model has an irreplaceable role in the study of etiology, pathology and treatment. It is worth noting that the risk factors for chronic obstructive pulmonary disease persist, and the economic burden of global chronic obstructive pulmonary disease is expected to continue to increase in the coming decades. Establishing a standardized, a clinically realistic COPD animal model has always been a research direction that scholars are keen on. Therefore, it is essential to establish an economical animal model. The establishment of a suitable animal model can accurately simulate the pathological features of human chronic obstructive pulmonary disease and help to develop effective interventions and treatments in a short period of time. This review integrates the experimental animal species selected in the animal models used in COPD studies. Subsequently, different methods and mechanisms for establishing animal models were summarized according to different modeling factors. Finally, the criteria for evaluating existing animal models are discussed. It is hoped that the summary of this paper will guide the establishment of relevant animal models for future COPD research.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/s2575900019300017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43985929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-24DOI: 10.1142/S2575900019200015
Chuyu Li, Xinyao Pan, W. Leung, Zengshu Huang, Jing Zhou, Ling Wang
On 25 October 2018, National Essential Medicine List (NEML) of China was formally published by National Health Commission and it has been executed since 1 November. The new NEML, which includes 685 drugs with more than 1110 kinds of dosage forms and more than 1810 kinds of specifications, further standardizes dosage forms and specifications of drugs. The new catalog not only increases the number of categories, but also optimizes the structure of the drug list. It highlights the need for basic drugs in aspects of common diseases, chronic diseases, serious diseases and public health. Besides, the normalization of dosage forms and specifications, and the persistence of emphasizing the combination of Western and Chinese medicine are both the characteristics of it. This news report is composed of several parts including brief introduction of NEML, the difference between NEML and National Directory of Health Insurance (NDHI) which is likely to be confused with NEML, the dissection of the change of medicine varieties, relevant policies and potential issues of NEML. We intend to give a comprehensive interpretation of NEML from different perspectives.
{"title":"Interpretation of the changes in 2018 National Essential Medicine List (NEML) from the specialists","authors":"Chuyu Li, Xinyao Pan, W. Leung, Zengshu Huang, Jing Zhou, Ling Wang","doi":"10.1142/S2575900019200015","DOIUrl":"https://doi.org/10.1142/S2575900019200015","url":null,"abstract":"On 25 October 2018, National Essential Medicine List (NEML) of China was formally published by National Health Commission and it has been executed since 1 November. The new NEML, which includes 685 drugs with more than 1110 kinds of dosage forms and more than 1810 kinds of specifications, further standardizes dosage forms and specifications of drugs. The new catalog not only increases the number of categories, but also optimizes the structure of the drug list. It highlights the need for basic drugs in aspects of common diseases, chronic diseases, serious diseases and public health. Besides, the normalization of dosage forms and specifications, and the persistence of emphasizing the combination of Western and Chinese medicine are both the characteristics of it. This news report is composed of several parts including brief introduction of NEML, the difference between NEML and National Directory of Health Insurance (NDHI) which is likely to be confused with NEML, the dissection of the change of medicine varieties, relevant policies and potential issues of NEML. We intend to give a comprehensive interpretation of NEML from different perspectives.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2575900019200015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49659217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-24DOI: 10.1142/S2575900019500083
Ye Li, Cheng Ma, Z. Lv, Changhai Shao, Jun Zhang, Wenye Geng, Lan Zheng
Objective: The present study was designed to investigate the cytoprotective effects of ginsenoside Rg1 (GS-Rg1) against malondialdehyde (MDA)-suppressed proliferation of the mesenchymal stem cells (MSCs) and its possible mechanisms in vitro. Methods: Murine bone marrow-derived MSCs were treated with GS-Rg1 (10, 50, 100[Formula: see text]mg/L) for 24[Formula: see text]h before being incubated with MDA in vitro, CFU-Fassay, the cell viability and BrdU incorporation assay were examined, the expression of cyclin-dependent kinase 2 (CDK2), p21 and cyclin E of MSC were examined by Q-RT-PCR and Western blotting. Results: The results showed that the number and size of murine bone marrow MSC colonies, the number of colony-forming cells, methyl thiazolyltetrazolium (MTT) absorbed value greatly and percentage of BrdU-positive cells increased significantly in MSC pretreated with GS-Rg1. GS-Rgl pretreatment markedly decreased the expression level of p21 and increased the expression of CDK2 and cyclin E. GS-Rg1 protects MSCs from MDA-suppressed proliferation. Conclusion: The protective mechanism could be related to its ability to increase the expression of CDK2 and cyclin E, and to reduce the expression of p21.
{"title":"Protective effect and mechanisms of ginsenoside Rg1 against MDA-suppressed proliferation in mesenchymal stem cells derived from murine bone marrow","authors":"Ye Li, Cheng Ma, Z. Lv, Changhai Shao, Jun Zhang, Wenye Geng, Lan Zheng","doi":"10.1142/S2575900019500083","DOIUrl":"https://doi.org/10.1142/S2575900019500083","url":null,"abstract":"Objective: The present study was designed to investigate the cytoprotective effects of ginsenoside Rg1 (GS-Rg1) against malondialdehyde (MDA)-suppressed proliferation of the mesenchymal stem cells (MSCs) and its possible mechanisms in vitro. Methods: Murine bone marrow-derived MSCs were treated with GS-Rg1 (10, 50, 100[Formula: see text]mg/L) for 24[Formula: see text]h before being incubated with MDA in vitro, CFU-Fassay, the cell viability and BrdU incorporation assay were examined, the expression of cyclin-dependent kinase 2 (CDK2), p21 and cyclin E of MSC were examined by Q-RT-PCR and Western blotting. Results: The results showed that the number and size of murine bone marrow MSC colonies, the number of colony-forming cells, methyl thiazolyltetrazolium (MTT) absorbed value greatly and percentage of BrdU-positive cells increased significantly in MSC pretreated with GS-Rg1. GS-Rgl pretreatment markedly decreased the expression level of p21 and increased the expression of CDK2 and cyclin E. GS-Rg1 protects MSCs from MDA-suppressed proliferation. Conclusion: The protective mechanism could be related to its ability to increase the expression of CDK2 and cyclin E, and to reduce the expression of p21.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2575900019500083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41488488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-24DOI: 10.1142/S2575900019500071
Qiuping Li, Qing Kong, Zihui Tang
Objective: This study aimed at investigating the association between dyslipidemia and body constitution of traditional Chinese medicine (BCTCM) may be clinically meaningful for the early diagnosis and treatment of dyslipidemia. Methods: More than 4,000 participants were invited to a screening visit between 2011 and 2014, and 3,748 participants were available for data analysis. All study subjects underwent complete clinical baseline characteristics evaluation. Differences were determined using one-way analysis and [Formula: see text] analysis. Univariate regression analyses and multiple-variable logistic regressions (MLRs) determined the association between BCTCM variables and outcomes. Results: In the dyslipidemia group, the Qi-deficient and Yang-deficient types accounted for more participants than others, and these two types were significantly associated with the outcome ([Formula: see text]). MLRs detected significant associations between the Qi-deficient and Yang-deficient types with dyslipidemia ([Formula: see text] for the two), and their odds ratios (ORs) for dyslipidemia were 1.211 and 1.234, respectively. Conclusion: Qi-deficient and Yang-deficient types are independently and significantly associated with dyslipidemia. Participants with Qi-deficient and Yang-deficient constitutions have a higher incidence of dyslipidemia.
{"title":"Dyslipidemia associated with body constitution in Traditional Chinese Medicine","authors":"Qiuping Li, Qing Kong, Zihui Tang","doi":"10.1142/S2575900019500071","DOIUrl":"https://doi.org/10.1142/S2575900019500071","url":null,"abstract":"Objective: This study aimed at investigating the association between dyslipidemia and body constitution of traditional Chinese medicine (BCTCM) may be clinically meaningful for the early diagnosis and treatment of dyslipidemia. Methods: More than 4,000 participants were invited to a screening visit between 2011 and 2014, and 3,748 participants were available for data analysis. All study subjects underwent complete clinical baseline characteristics evaluation. Differences were determined using one-way analysis and [Formula: see text] analysis. Univariate regression analyses and multiple-variable logistic regressions (MLRs) determined the association between BCTCM variables and outcomes. Results: In the dyslipidemia group, the Qi-deficient and Yang-deficient types accounted for more participants than others, and these two types were significantly associated with the outcome ([Formula: see text]). MLRs detected significant associations between the Qi-deficient and Yang-deficient types with dyslipidemia ([Formula: see text] for the two), and their odds ratios (ORs) for dyslipidemia were 1.211 and 1.234, respectively. Conclusion: Qi-deficient and Yang-deficient types are independently and significantly associated with dyslipidemia. Participants with Qi-deficient and Yang-deficient constitutions have a higher incidence of dyslipidemia.","PeriodicalId":23184,"journal":{"name":"Traditional Medicine and Modern Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S2575900019500071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46648369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：