Hui‐Yu Chung, Motoki Yuasa, Fu‐Shih Chen, K. Yukawa, Y. Motoo, Ichiro Arai
The Japanese government defined integrative/integrated medicine (IM) as “medical practice led by physicians, cooperating with other specialists.” Therefore, the basics of comprehensive medical education should be provided in medical universities. We investigated the situation of IM with special reference to Kampo medicines in the national core curricula, national examination standards and the syllabuses for lectures published on the universities' websites.
{"title":"The status of education for integrative medicine in Japanese medical universities with special reference to Kampo medicines","authors":"Hui‐Yu Chung, Motoki Yuasa, Fu‐Shih Chen, K. Yukawa, Y. Motoo, Ichiro Arai","doi":"10.1002/tkm2.1365","DOIUrl":"https://doi.org/10.1002/tkm2.1365","url":null,"abstract":"The Japanese government defined integrative/integrated medicine (IM) as “medical practice led by physicians, cooperating with other specialists.” Therefore, the basics of comprehensive medical education should be provided in medical universities. We investigated the situation of IM with special reference to Kampo medicines in the national core curricula, national examination standards and the syllabuses for lectures published on the universities' websites.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79180134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In recent years, multidisciplinary treatment of cancer has greatly improved the results of cancer treatment. In particular, the development of molecular targeted drugs and cancer immunotherapy drugs has been carried out for many carcinomas, and this has had an important role in improving outcomes. At the same time, there have been important advances in supportive care‐related drugs, with a focus on antiemesis or neutropenia. Here, we overview the clinical roles and potential of the use and utilization of Kampo medicine.
{"title":"Roles of Kampo medicine in chemotherapy‐related adverse events","authors":"T. Nishiuchi, Kotone Nomura, Yushitada Suezawa","doi":"10.1002/tkm2.1367","DOIUrl":"https://doi.org/10.1002/tkm2.1367","url":null,"abstract":"In recent years, multidisciplinary treatment of cancer has greatly improved the results of cancer treatment. In particular, the development of molecular targeted drugs and cancer immunotherapy drugs has been carried out for many carcinomas, and this has had an important role in improving outcomes. At the same time, there have been important advances in supportive care‐related drugs, with a focus on antiemesis or neutropenia. Here, we overview the clinical roles and potential of the use and utilization of Kampo medicine.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80439852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer treatment is one of the major projects in the world due to the highest number of deaths. In recent years, chemotherapy, surgical treatment, radiation and immune checkpoint therapy have been used for the treatment of cancer patients. In association with these treatments, the number of cancer survivors has also increased. On the other hand, the number of patients suffering from side effects of cancer treatment is increasing, and the importance of cancer supportive care is being emphasized.
{"title":"The importance and requirement of evidence‐based medicine to expand the use of Kampo medicine","authors":"Y. Uezono","doi":"10.1002/tkm2.1364","DOIUrl":"https://doi.org/10.1002/tkm2.1364","url":null,"abstract":"Cancer treatment is one of the major projects in the world due to the highest number of deaths. In recent years, chemotherapy, surgical treatment, radiation and immune checkpoint therapy have been used for the treatment of cancer patients. In association with these treatments, the number of cancer survivors has also increased. On the other hand, the number of patients suffering from side effects of cancer treatment is increasing, and the importance of cancer supportive care is being emphasized.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85979752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Traditional & Kampo MedicineVolume 10, Issue 1 p. 82-82 ACKNOWLEDGMENT Acknowledgment First published: 28 February 2023 https://doi.org/10.1002/tkm2.1360Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume10, Issue1April 2023Pages 82-82 RelatedInformation
{"title":"Acknowledgment","authors":"","doi":"10.1002/tkm2.1360","DOIUrl":"https://doi.org/10.1002/tkm2.1360","url":null,"abstract":"Traditional & Kampo MedicineVolume 10, Issue 1 p. 82-82 ACKNOWLEDGMENT Acknowledgment First published: 28 February 2023 https://doi.org/10.1002/tkm2.1360Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume10, Issue1April 2023Pages 82-82 RelatedInformation","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135678119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer has been the number one cause of death in Japan since 1981. Advanced or recurrent cancers need strong chemotherapies to control their growth. On the other hand, tumor‐bearing patients experience pain, fatigue, anorexia, cold sensation, sarcopenia, and frailty. Surgery and radiation therapy also cause adverse events such as ileus, infection, oral mucositis and diarrhea.
{"title":"Significance of Kampo medicine for cancer supportive care: Overview","authors":"Y. Motoo, S. Cameron","doi":"10.1002/tkm2.1363","DOIUrl":"https://doi.org/10.1002/tkm2.1363","url":null,"abstract":"Cancer has been the number one cause of death in Japan since 1981. Advanced or recurrent cancers need strong chemotherapies to control their growth. On the other hand, tumor‐bearing patients experience pain, fatigue, anorexia, cold sensation, sarcopenia, and frailty. Surgery and radiation therapy also cause adverse events such as ileus, infection, oral mucositis and diarrhea.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88691871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Takayama, T. Namiki, T. Makino, Ryutaro Arita, H. Odaguchi, Takashi Ito
first
第一个
{"title":"Kampo medicine for COVID‐19 prevention, treatment, and recovery in clinical and pharmacological aspect","authors":"S. Takayama, T. Namiki, T. Makino, Ryutaro Arita, H. Odaguchi, Takashi Ito","doi":"10.1002/tkm2.1361","DOIUrl":"https://doi.org/10.1002/tkm2.1361","url":null,"abstract":"first","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79953554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hainosan (painongsan), composed of Platycodon grandiflorum root (PG), Paeonia lactiflora root (PL), and Citrus aurantium immature fruit (AF), is a formula used in traditional Japanese (Kampo) and Chinese medicine to treat purulent diseases, including gingivitis. In this study, we investigated the anti‐inflammatory effects of hainosan extract (HNS) using both traditional direct and serum pharmacological techniques.
{"title":"Inhibitory effect of extracts of hainosan (painongsan) and its constituent crude drugs on production of monocyte chemoattractant protein‐1 and interleukin‐6 in murine fibroblasts treated with Porphyromonas gingivalis","authors":"M. Minami, Masayo Taira, T. Makino","doi":"10.1002/tkm2.1359","DOIUrl":"https://doi.org/10.1002/tkm2.1359","url":null,"abstract":"Hainosan (painongsan), composed of Platycodon grandiflorum root (PG), Paeonia lactiflora root (PL), and Citrus aurantium immature fruit (AF), is a formula used in traditional Japanese (Kampo) and Chinese medicine to treat purulent diseases, including gingivitis. In this study, we investigated the anti‐inflammatory effects of hainosan extract (HNS) using both traditional direct and serum pharmacological techniques.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75612529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Mukaino, M. Fujimoto, M. Kainuma, S. Nakane, Yutaka Shimada
Autoimmune autonomic ganglionopathy (AAG) is a rare autoimmune disease characterized by various autonomic symptoms and is caused by anti-ganglionic acetylcholine receptor (gAChR) antibodies. The gAChR consists of two α3 and three β4 subunits and mediates fast synaptic transmission in all peripheral autonomic ganglia in the autonomic nervous system. Most patients with AAG are treated with immunotherapy followed by oral prednisolone or immunosuppressants. No cases of AAG treated with immunotherapy combined with Kampo medicine have been reported. Herein, we report an AAG patient who showed clinical improvement after immunotherapy concurrent with saikokaryukotsuboreito (SRBT) and hochuekkito (HET). A 24-year-old woman presented with post-infection cough that first appeared nine months prior to presentation. She was admitted to our hospital because of a four-month history of orthostatic dizziness, palpitation, headache, early satiety, appetite loss, nausea, and vomiting. The patient was positive for anti-gAChRα3 antibodies (Abs) (antibody index [AI]: 1.712 [normal range < 1.0]). She was diagnosed with AAG and subsequently treated with two courses of intravenous methylprednisolone therapy (IVMP). Her autonomic symptoms and orthostatic tachycardia gradually improved, and her anti-gAChRα3 Ab serum level returned to within the normal range (AI: 0.602). However, her orthostatic dizziness, palpitations, and cough relapsed after she suffered from nephritis six months later, and she was readmitted to our hospital. Her height, weight, and body mass index were 159.8 cm, 49.7 kg, and 19.46 kg/m, respectively. Her pulse rate increased to 150 beats/min immediately after standing, and she exhibited syncope 1 min after standing. Upon admission, she presented with a wide range of autonomic symptoms related to orthostatic intolerance (OI) including lightheadedness and palpitations, dry mouth, paroxysmal coughing, decreased trunk sweating, hyperhidrosis of the palms and soles, cold hands and feet, peripheral paresthesia, nausea, vomiting, early satiety, constipation, and nocturia. She also complained of frustration and depressed mood because of chronic work stress, difficulty falling asleep, susceptibility to fatigue and cold, rare menstruation, menstrual pain and muscle cramps. The physical examination findings were: pulse signs, medium pattern; tongue signs, purple with white coating; abdominal signs, intermediate; epigastric discomfort and resistance, right hypochondriac discomfort and resistance, brisk pulsation in both the supraand para-umbilical region, right para-umbilical tenderness and resistance, and weakness of the lower abdominal region. When her anti-gAChRα3 Ab level became positive (AI: 1.359), she was treated with two courses of IVMP, followed by oral administration of 20 mg of prednisolone (PSL) per day along with 7.5 g of SRBT (TJ-12, Tsumura & Co., Tokyo, Japan) and 7.5 g of HET (TJ-41, Tsumura & Co.) (Table 1) according to the physical findings. Her
{"title":"Combination of immunotherapy and Kampo medicines for a patient with autoimmune autonomic ganglionopathy","authors":"A. Mukaino, M. Fujimoto, M. Kainuma, S. Nakane, Yutaka Shimada","doi":"10.1002/tkm2.1357","DOIUrl":"https://doi.org/10.1002/tkm2.1357","url":null,"abstract":"Autoimmune autonomic ganglionopathy (AAG) is a rare autoimmune disease characterized by various autonomic symptoms and is caused by anti-ganglionic acetylcholine receptor (gAChR) antibodies. The gAChR consists of two α3 and three β4 subunits and mediates fast synaptic transmission in all peripheral autonomic ganglia in the autonomic nervous system. Most patients with AAG are treated with immunotherapy followed by oral prednisolone or immunosuppressants. No cases of AAG treated with immunotherapy combined with Kampo medicine have been reported. Herein, we report an AAG patient who showed clinical improvement after immunotherapy concurrent with saikokaryukotsuboreito (SRBT) and hochuekkito (HET). A 24-year-old woman presented with post-infection cough that first appeared nine months prior to presentation. She was admitted to our hospital because of a four-month history of orthostatic dizziness, palpitation, headache, early satiety, appetite loss, nausea, and vomiting. The patient was positive for anti-gAChRα3 antibodies (Abs) (antibody index [AI]: 1.712 [normal range < 1.0]). She was diagnosed with AAG and subsequently treated with two courses of intravenous methylprednisolone therapy (IVMP). Her autonomic symptoms and orthostatic tachycardia gradually improved, and her anti-gAChRα3 Ab serum level returned to within the normal range (AI: 0.602). However, her orthostatic dizziness, palpitations, and cough relapsed after she suffered from nephritis six months later, and she was readmitted to our hospital. Her height, weight, and body mass index were 159.8 cm, 49.7 kg, and 19.46 kg/m, respectively. Her pulse rate increased to 150 beats/min immediately after standing, and she exhibited syncope 1 min after standing. Upon admission, she presented with a wide range of autonomic symptoms related to orthostatic intolerance (OI) including lightheadedness and palpitations, dry mouth, paroxysmal coughing, decreased trunk sweating, hyperhidrosis of the palms and soles, cold hands and feet, peripheral paresthesia, nausea, vomiting, early satiety, constipation, and nocturia. She also complained of frustration and depressed mood because of chronic work stress, difficulty falling asleep, susceptibility to fatigue and cold, rare menstruation, menstrual pain and muscle cramps. The physical examination findings were: pulse signs, medium pattern; tongue signs, purple with white coating; abdominal signs, intermediate; epigastric discomfort and resistance, right hypochondriac discomfort and resistance, brisk pulsation in both the supraand para-umbilical region, right para-umbilical tenderness and resistance, and weakness of the lower abdominal region. When her anti-gAChRα3 Ab level became positive (AI: 1.359), she was treated with two courses of IVMP, followed by oral administration of 20 mg of prednisolone (PSL) per day along with 7.5 g of SRBT (TJ-12, Tsumura & Co., Tokyo, Japan) and 7.5 g of HET (TJ-41, Tsumura & Co.) (Table 1) according to the physical findings. Her ","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84655783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Utsunomiya, Den-ichiro Yamaoka, T. Asakawa, Eichi Ishii, Yasutsugu Takada
A 29-year-old man visited a previous doctor because of fever; he was diagnosed with COVID-19 and underwent home care. On the fourth day, he visited the emergency department of a hospital owing to difficulty with oral intake and abdominal pain. The patient had marked tenderness mainly in the right lower quadrant of the abdomen and localized muscle guarding. He had difficulty walking on his own owing to the right lower abdominal pain. The following were the Kampo medical findings: absence of tongue swelling, prominent sublingual veins, intermediate floating and sunken pulse, and strong abdomen. Based on Kampo medicine, he was diagnosed with blood stasis and an excess heat pattern. Laboratory findings revealed normal white blood cell (WBC) count (7100/μl) and C-reactive protein (CRP) level (0.31 mg/dl). However, computed tomography (CT) revealed acute appendicitis with fecaliths (Figure 1a). Emergency surgery was required; however, all hospitals in our prefecture that could perform emergency surgery were unable to accept him. Therefore, he was managed conservatively and received daiobotanpito (DBT; extract TJ-33, Tsumura, Tokyo, Japan)
{"title":"Acute appendicitis with fecaliths requiring surgery in a patient with COVID‐19 successfully treated with daiobotanpito and antibiotics","authors":"T. Utsunomiya, Den-ichiro Yamaoka, T. Asakawa, Eichi Ishii, Yasutsugu Takada","doi":"10.1002/tkm2.1358","DOIUrl":"https://doi.org/10.1002/tkm2.1358","url":null,"abstract":"A 29-year-old man visited a previous doctor because of fever; he was diagnosed with COVID-19 and underwent home care. On the fourth day, he visited the emergency department of a hospital owing to difficulty with oral intake and abdominal pain. The patient had marked tenderness mainly in the right lower quadrant of the abdomen and localized muscle guarding. He had difficulty walking on his own owing to the right lower abdominal pain. The following were the Kampo medical findings: absence of tongue swelling, prominent sublingual veins, intermediate floating and sunken pulse, and strong abdomen. Based on Kampo medicine, he was diagnosed with blood stasis and an excess heat pattern. Laboratory findings revealed normal white blood cell (WBC) count (7100/μl) and C-reactive protein (CRP) level (0.31 mg/dl). However, computed tomography (CT) revealed acute appendicitis with fecaliths (Figure 1a). Emergency surgery was required; however, all hospitals in our prefecture that could perform emergency surgery were unable to accept him. Therefore, he was managed conservatively and received daiobotanpito (DBT; extract TJ-33, Tsumura, Tokyo, Japan)","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77111818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Utsunomiya, Den-ichiro Yamaoka, Yukio Mizumoto, Eichi Ishii, Yasutsugu Takada
A 65-year-old woman was bitten by a Japanese mamushi (Gloydius blomhoffii) on her right index finger. The swelling progressed to the right wrist, and she was referred to our hospital for additional treatment. She was obese, with a height of 151 cm and a weight of 86.2 kg. The swelling of her right hand had spread beyond the wrist to the forearm. She had rheumatoid arthritis and was taking multiple immunosuppressive drugs. Despite using multiple immunosuppressive medications, the swelling of the right hand had expanded toward the body, so we treated her in the hospital with mamushi antivenom. On the day after admission to our hospital, the swelling and redness began to extend beyond the shoulder joint to the trunk (Figure. 1a). The right palm was swollen and had no wrinkles (Figure. 1b). Due to severe pain, she desired additional treatment, and hence we used the Japanese herbal medicine eppikajutsuto (EPJT). Her Kampo medical findings were: upon examination, the patient showed a good appetite and had no mood disturbance. Her skin was not dry. She was edematous throughout the body. Her right arm was reddish and hot. The tongue showed no swelling. Sublingual veins were less prominent. Her pulse was intermediate floating and sunken. Abdominal strength was strong. There were no other abdominal signs and findings. Kampo medical diagnosis: the patient was diagnosed as having fluid disturbance, excess and heat pattern. On the day after the start of EPJT, there was marked improvement in both the swelling and redness in the right upper limb (Figure. 1c), and wrinkles appeared on the right palm (Figure. 1d). The swelling in the right palm almost disappeared on the third day after the start of EPJT. She was discharged on day 7 of admission. As there is yet no reliable treatment for mamushi bites, management of the general condition is the mainstay of treatment. It has been reported that the treatment of mamushi bites is based on the grade of associated symptoms [1]. In our patient, the swelling in the right hand rapidly spread to the upper arm. Hence, we decided to use antivenom and injected it within 6 h from the mamushi bite. However, on the day after admission, the swelling and redness in the right hand had spread to the trunk. To the best of our knowledge, there have been no new and effective methods to control disease progression in such cases. However, Japanese herbal medicine could provide an alternative.
{"title":"Successful treatment of swelling caused by a mamushi (Gloydius blomhoffii) bite with herbal medicine eppikajutsuto","authors":"T. Utsunomiya, Den-ichiro Yamaoka, Yukio Mizumoto, Eichi Ishii, Yasutsugu Takada","doi":"10.1002/tkm2.1355","DOIUrl":"https://doi.org/10.1002/tkm2.1355","url":null,"abstract":"A 65-year-old woman was bitten by a Japanese mamushi (Gloydius blomhoffii) on her right index finger. The swelling progressed to the right wrist, and she was referred to our hospital for additional treatment. She was obese, with a height of 151 cm and a weight of 86.2 kg. The swelling of her right hand had spread beyond the wrist to the forearm. She had rheumatoid arthritis and was taking multiple immunosuppressive drugs. Despite using multiple immunosuppressive medications, the swelling of the right hand had expanded toward the body, so we treated her in the hospital with mamushi antivenom. On the day after admission to our hospital, the swelling and redness began to extend beyond the shoulder joint to the trunk (Figure. 1a). The right palm was swollen and had no wrinkles (Figure. 1b). Due to severe pain, she desired additional treatment, and hence we used the Japanese herbal medicine eppikajutsuto (EPJT). Her Kampo medical findings were: upon examination, the patient showed a good appetite and had no mood disturbance. Her skin was not dry. She was edematous throughout the body. Her right arm was reddish and hot. The tongue showed no swelling. Sublingual veins were less prominent. Her pulse was intermediate floating and sunken. Abdominal strength was strong. There were no other abdominal signs and findings. Kampo medical diagnosis: the patient was diagnosed as having fluid disturbance, excess and heat pattern. On the day after the start of EPJT, there was marked improvement in both the swelling and redness in the right upper limb (Figure. 1c), and wrinkles appeared on the right palm (Figure. 1d). The swelling in the right palm almost disappeared on the third day after the start of EPJT. She was discharged on day 7 of admission. As there is yet no reliable treatment for mamushi bites, management of the general condition is the mainstay of treatment. It has been reported that the treatment of mamushi bites is based on the grade of associated symptoms [1]. In our patient, the swelling in the right hand rapidly spread to the upper arm. Hence, we decided to use antivenom and injected it within 6 h from the mamushi bite. However, on the day after admission, the swelling and redness in the right hand had spread to the trunk. To the best of our knowledge, there have been no new and effective methods to control disease progression in such cases. However, Japanese herbal medicine could provide an alternative.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75808605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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