Yu Jing, Motoko Fukuzawa, Yasumasa Sato, Y. Kimura
To the Editor, Japanese herbal medicine, known as Kampo, is a part of East Asian Chinese medicine. In the Huangdineijing (Yellow Emperer’s Canon of internal medicine), women’s health is thought to change every seven years, with a physical peak at 28 years old. Women are naturally conscious of physical and mental changes associated with their menstrual cycle, and often notice physical deterioration from around 40 years old. In this symposium, we would like to discuss how Kampo medicine contributes to women’s health care in Japan. The first presentation is “Analysis of Mesenteric Phlebosclerosis-Related Adverse Events Caused by Gardenia-containing Kampo Medicines Using the JADER Database.” Gardenia fruit is widely used in traditional medicine. Recent clinical reports have shown that longterm (≧5 years) administration of Gardenia fruit (called sanshishi in Japan) was associated with the incidence of mesenteric phlebosclerosis (MP). In this study, we assessed age (<50 years, 50–70 years and > 70 years groups) and gender differences among cases of MP caused by Gardenia-containing Kampo medicines to investigate the risk factors and the underlying mechanism to target the activation of sex hormone receptors. In all, 215 cases of MP caused by Gardenia-containing Kampo medicines were registered in the Japanese Adverse Drug Event Report database (JADER) from April 2004 to September 2021. We found statistically significant differences in MP cases by age and gender with a greater number in females over 50 years of age. We also analyzed whether geniposide, the major component of Gardenia, and its metabolized substance genipin, can directly activate estrogen receptors (ERα, ERβ) or androgen receptor (AR) by simulations of the performance of molecular docking using Molecular Operating Environment. The results showed that both geniposide and genipin have favorable binding ability with those sex hormone receptors, and that the binding energy with ERs is stronger than with AR. In conclusion, the results demonstrated the potential risks of MP being caused by Gardenia-containing Kampo medicines together with differences in aging and gender, and that sex hormone receptors were involved in the development of MP. The second presentation is “Kampo Medicines Treatment for Women.” Among patients who visit Kampo clinics, 70%–80% are women, which suggests that Kampo treatment is important to support women’s health and manage female health concerns. The Kampo medicine which is used today has evolved in its own unique way based on several classic texts of traditional Chinese medicine. Regarding women’s diseases, “Kinkiyoryaku”, which was written in China around 200 A.D., is the basis for the current treatment of women’s health problems in Japan. In this way, the importance of a medical approach to women-specific disorders has been recognized by Kampo medicine since ancient times. In this symposium, using case studies, the usefulness of Kampo treatment for treating various wome
{"title":"Kampo medicine for women's health care “1st International Symposium on Kampo Medicine”","authors":"Yu Jing, Motoko Fukuzawa, Yasumasa Sato, Y. Kimura","doi":"10.1002/tkm2.1326","DOIUrl":"https://doi.org/10.1002/tkm2.1326","url":null,"abstract":"To the Editor, Japanese herbal medicine, known as Kampo, is a part of East Asian Chinese medicine. In the Huangdineijing (Yellow Emperer’s Canon of internal medicine), women’s health is thought to change every seven years, with a physical peak at 28 years old. Women are naturally conscious of physical and mental changes associated with their menstrual cycle, and often notice physical deterioration from around 40 years old. In this symposium, we would like to discuss how Kampo medicine contributes to women’s health care in Japan. The first presentation is “Analysis of Mesenteric Phlebosclerosis-Related Adverse Events Caused by Gardenia-containing Kampo Medicines Using the JADER Database.” Gardenia fruit is widely used in traditional medicine. Recent clinical reports have shown that longterm (≧5 years) administration of Gardenia fruit (called sanshishi in Japan) was associated with the incidence of mesenteric phlebosclerosis (MP). In this study, we assessed age (<50 years, 50–70 years and > 70 years groups) and gender differences among cases of MP caused by Gardenia-containing Kampo medicines to investigate the risk factors and the underlying mechanism to target the activation of sex hormone receptors. In all, 215 cases of MP caused by Gardenia-containing Kampo medicines were registered in the Japanese Adverse Drug Event Report database (JADER) from April 2004 to September 2021. We found statistically significant differences in MP cases by age and gender with a greater number in females over 50 years of age. We also analyzed whether geniposide, the major component of Gardenia, and its metabolized substance genipin, can directly activate estrogen receptors (ERα, ERβ) or androgen receptor (AR) by simulations of the performance of molecular docking using Molecular Operating Environment. The results showed that both geniposide and genipin have favorable binding ability with those sex hormone receptors, and that the binding energy with ERs is stronger than with AR. In conclusion, the results demonstrated the potential risks of MP being caused by Gardenia-containing Kampo medicines together with differences in aging and gender, and that sex hormone receptors were involved in the development of MP. The second presentation is “Kampo Medicines Treatment for Women.” Among patients who visit Kampo clinics, 70%–80% are women, which suggests that Kampo treatment is important to support women’s health and manage female health concerns. The Kampo medicine which is used today has evolved in its own unique way based on several classic texts of traditional Chinese medicine. Regarding women’s diseases, “Kinkiyoryaku”, which was written in China around 200 A.D., is the basis for the current treatment of women’s health problems in Japan. In this way, the importance of a medical approach to women-specific disorders has been recognized by Kampo medicine since ancient times. In this symposium, using case studies, the usefulness of Kampo treatment for treating various wome","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78310468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
the treatment of atopic dermatitis, we report an effective mechanism of medicine, from the aspect of molecular level and vascular inflammation. Orengedokuto has been shown to be effective in the treatment of atopic dermatitis in animal models ’ s regulation of EIF3F in with Sjögren
{"title":"Kampo medicine in the field of dermatology: basic and clinical aspects “1st International Symposium on Kampo Medicine”","authors":"T. Andoh, T. Shimizu, M. Toyoda, M. Maeda","doi":"10.1002/tkm2.1322","DOIUrl":"https://doi.org/10.1002/tkm2.1322","url":null,"abstract":"the treatment of atopic dermatitis, we report an effective mechanism of medicine, from the aspect of molecular level and vascular inflammation. Orengedokuto has been shown to be effective in the treatment of atopic dermatitis in animal models ’ s regulation of EIF3F in with Sjögren","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91441297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Muramatsu, M. Tamada, Yoshinao Harada, M. Raimura, Seungwon Kwon
To The Editor Although novel modalities including various antibodies are at the forefront of clinical practice, most neurological diseases are still intractable. In this symposium, we will present representative examples in which Kampo medicine is effective in treating conditions for which western drugs are ineffective or cannot be used due to adverse effects. Dr Tamada will present the application of keishikaryukotsuboreito (KSTRB) as the effective treatment of parasomnia and adult nocturnal enuresis. As a prodromal symptom of neurodegeneration, the number of elderly people with rapid eye movement (REM) sleep behavior disorders is increasing. KSTRB can be used for the disorders. Dr Harada demonstrates that goreisan (GRS) was most effective in a homogenous type of chronic subdural hematoma for preventing recurrence after operation. It is well known that GRS can regulate water balance. Dr Raimura shows keishibukuryogan (KBG) is effective for patients who have both menstruation-associated migraine and scintillating scotoma. He will also show a video that blood stasis of the conjunctiva was improved after treatment. Finally, Dr Kwon introduces the effective treatment of cerebrovascular diseases with traditional herb medicine in Korea. The first presentation, by Dr Tamada, is “KSTRB for the Treatment of Parasomnia and Adult Enuresis”. In Jin Gui Yao Lue, an ancient text of Chinese medicine, KSTRB was initially described as effective in treating decreased sexual desire, sexual malaise, rectus abdominis muscle hypertonia, genital coldness, diarrhea, anemia, dizziness, alopecia, and very weak pulse. KSTRB had been used for nocturnal emissions in men and sexually aroused dreams in women in traditional Japanese medicine. In this way, abnormal sexual nocturnal behaviors had been treated with KSTRB for many years. We expanded the application of KSTRB to more general symptoms of parasomnia, which is defined as undesirable behaviors or experiences during sleep. Seven elderly patients including four patients with Parkinson’s disease had parasomnias in non-REM or REM sleep. After they started to take KSTRB, symptoms such as dream-enacting behavior and nightmares disappeared within a few days. In one patient, the frequency and magnitude of spike–wave complexes induced by 3-Hz photic stimulation were reduced on electroencephalography, suggesting inhibitory effects of KSTRB on brain irritability. We also successfully treated a woman with nocturnal enuresis that persisted into adulthood by KSTRB. Adult cases of nocturnal enuresis are refractory and rarely heal spontaneously. We suggest that KSTRB is a safe treatment option for parasomnia and nocturnal enuresis. The second presentation, by Dr Harada, is “The Effect of GRS for Chronic Subdural Hematoma.” Chronic subdural hematoma (CSDH) has a reported postoperative recurrence rate of 3%–20% and the optimal therapeutic strategy remains controversial. Several pharmacological treatments have been used to treat patients
{"title":"Kampo treatment for neurological diseases “1st International Symposium on Kampo Medicine”","authors":"S. Muramatsu, M. Tamada, Yoshinao Harada, M. Raimura, Seungwon Kwon","doi":"10.1002/tkm2.1335","DOIUrl":"https://doi.org/10.1002/tkm2.1335","url":null,"abstract":"To The Editor Although novel modalities including various antibodies are at the forefront of clinical practice, most neurological diseases are still intractable. In this symposium, we will present representative examples in which Kampo medicine is effective in treating conditions for which western drugs are ineffective or cannot be used due to adverse effects. Dr Tamada will present the application of keishikaryukotsuboreito (KSTRB) as the effective treatment of parasomnia and adult nocturnal enuresis. As a prodromal symptom of neurodegeneration, the number of elderly people with rapid eye movement (REM) sleep behavior disorders is increasing. KSTRB can be used for the disorders. Dr Harada demonstrates that goreisan (GRS) was most effective in a homogenous type of chronic subdural hematoma for preventing recurrence after operation. It is well known that GRS can regulate water balance. Dr Raimura shows keishibukuryogan (KBG) is effective for patients who have both menstruation-associated migraine and scintillating scotoma. He will also show a video that blood stasis of the conjunctiva was improved after treatment. Finally, Dr Kwon introduces the effective treatment of cerebrovascular diseases with traditional herb medicine in Korea. The first presentation, by Dr Tamada, is “KSTRB for the Treatment of Parasomnia and Adult Enuresis”. In Jin Gui Yao Lue, an ancient text of Chinese medicine, KSTRB was initially described as effective in treating decreased sexual desire, sexual malaise, rectus abdominis muscle hypertonia, genital coldness, diarrhea, anemia, dizziness, alopecia, and very weak pulse. KSTRB had been used for nocturnal emissions in men and sexually aroused dreams in women in traditional Japanese medicine. In this way, abnormal sexual nocturnal behaviors had been treated with KSTRB for many years. We expanded the application of KSTRB to more general symptoms of parasomnia, which is defined as undesirable behaviors or experiences during sleep. Seven elderly patients including four patients with Parkinson’s disease had parasomnias in non-REM or REM sleep. After they started to take KSTRB, symptoms such as dream-enacting behavior and nightmares disappeared within a few days. In one patient, the frequency and magnitude of spike–wave complexes induced by 3-Hz photic stimulation were reduced on electroencephalography, suggesting inhibitory effects of KSTRB on brain irritability. We also successfully treated a woman with nocturnal enuresis that persisted into adulthood by KSTRB. Adult cases of nocturnal enuresis are refractory and rarely heal spontaneously. We suggest that KSTRB is a safe treatment option for parasomnia and nocturnal enuresis. The second presentation, by Dr Harada, is “The Effect of GRS for Chronic Subdural Hematoma.” Chronic subdural hematoma (CSDH) has a reported postoperative recurrence rate of 3%–20% and the optimal therapeutic strategy remains controversial. Several pharmacological treatments have been used to treat patients ","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84790178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Yoshinaga, Kiyoshi Minamizawa, S. Nabeshima, Sagar Kamprath
Japan faces multifaceted challenges including a rapidly aging population, escalating healthcare costs, and economic decline. These situations require physicians who can adapt as well as provide comprehensive medical care. Therefore, primary care which includes general internal medicine (GIM) and family medicine, has become a vital component of a well-functioning health system. Both GIM doctors in Japan and family medicine physicians in the US offer medical services in the clinic and hospital settings; however, family medicine doctors see patient of all ages. The Japanese healthcare system also supports Kampo, hence doctors in Japan are allowed to prescribe Kampo medicine as well as modern medicine. Kampo has been integrated into the Japanese national health care system since 1967. Research shows that about 90%of doctors prescribe Kampo formulas on a daily basis. Evidence to show the effectiveness of Kampo therapies has been reported in both outpatient and inpatient settings (1). Here, we aim to introduce the role of Kampo therapies in GIM, in addition discussing research involving Kampo therapies against infectious diseases and its potential for incorporation into the field of integrativemedicine in theUS. In Japan, the first GIM department was established in 1976. Since then, the number of GIM departments has increased and the role of GIM has become important due to Japan’s aging population. GIM received official recognition from the JapanMedical Specialty Board as the 19th area in the new medical specialty training system in 2018. In outpatient care, physicians treat a wide variety of patients who have chronic and degenerative diseases, functional and psychosomatic disorders, medically unexplained symptoms, and elderly comorbidities. Application of Kampo therapies can have a positive effect on these conditions and offer additional treatment options for these complex patients (2). Kampo therapies are also useful for inpatient care. As Japan ages, more elderly will need inpatient care, placing increased demands on limited resources. Even the best modern therapy cannot stand without primary preventive care for sustainability. Kampo does not directly affect the illness itself but helps stimulate patients to heal alongside modern medical therapies. As modern medicine mostly focuses on symptom suppression or killing infective pathogens and sometimes leads to issues such as resistance, conditioning patients with Kampo medicine in combination with modern therapy will help stimulate patients’ own immune systems for symptom improvement and possible increased resilience to future disease processes. For example, maoto has been effective against influenzawith further uses for COVID-19 described below. Recently, many GIM physicians participate in the teams caring for patients with COVID-19. In addition, some studies reveal the effectiveness of Kampo medicines against infectious diseases. Maoto exerts anti-viral effects on influenza and respiratory syncytial
{"title":"Role of Kampo medicine and integrative medicine in general internal medicine “1st International Symposium on Kampo Medicine”","authors":"R. Yoshinaga, Kiyoshi Minamizawa, S. Nabeshima, Sagar Kamprath","doi":"10.1002/tkm2.1325","DOIUrl":"https://doi.org/10.1002/tkm2.1325","url":null,"abstract":"Japan faces multifaceted challenges including a rapidly aging population, escalating healthcare costs, and economic decline. These situations require physicians who can adapt as well as provide comprehensive medical care. Therefore, primary care which includes general internal medicine (GIM) and family medicine, has become a vital component of a well-functioning health system. Both GIM doctors in Japan and family medicine physicians in the US offer medical services in the clinic and hospital settings; however, family medicine doctors see patient of all ages. The Japanese healthcare system also supports Kampo, hence doctors in Japan are allowed to prescribe Kampo medicine as well as modern medicine. Kampo has been integrated into the Japanese national health care system since 1967. Research shows that about 90%of doctors prescribe Kampo formulas on a daily basis. Evidence to show the effectiveness of Kampo therapies has been reported in both outpatient and inpatient settings (1). Here, we aim to introduce the role of Kampo therapies in GIM, in addition discussing research involving Kampo therapies against infectious diseases and its potential for incorporation into the field of integrativemedicine in theUS. In Japan, the first GIM department was established in 1976. Since then, the number of GIM departments has increased and the role of GIM has become important due to Japan’s aging population. GIM received official recognition from the JapanMedical Specialty Board as the 19th area in the new medical specialty training system in 2018. In outpatient care, physicians treat a wide variety of patients who have chronic and degenerative diseases, functional and psychosomatic disorders, medically unexplained symptoms, and elderly comorbidities. Application of Kampo therapies can have a positive effect on these conditions and offer additional treatment options for these complex patients (2). Kampo therapies are also useful for inpatient care. As Japan ages, more elderly will need inpatient care, placing increased demands on limited resources. Even the best modern therapy cannot stand without primary preventive care for sustainability. Kampo does not directly affect the illness itself but helps stimulate patients to heal alongside modern medical therapies. As modern medicine mostly focuses on symptom suppression or killing infective pathogens and sometimes leads to issues such as resistance, conditioning patients with Kampo medicine in combination with modern therapy will help stimulate patients’ own immune systems for symptom improvement and possible increased resilience to future disease processes. For example, maoto has been effective against influenzawith further uses for COVID-19 described below. Recently, many GIM physicians participate in the teams caring for patients with COVID-19. In addition, some studies reveal the effectiveness of Kampo medicines against infectious diseases. Maoto exerts anti-viral effects on influenza and respiratory syncytial ","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84896069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Oh‐oka, K. Torimoto, Miyabi Inoue, H. Ide, Y. Sekiguchi
To The Editor Urology treats many diseases around urogenital organs in men and women, that is, the kidneys, adrenal glands, ureters, urethra, prostate, testis and pelvic floor. Thus, the world of urology is wider than expected. In addition, urology is advancing in the research field of quality-oflife (QOL) diseases. The important targets of Kampo are the treatment of symptoms of QOL diseases that are not sufficiently covered by modern medicine. There are many results of Kampo treatments for urological QOL diseases. This urology session introduces Kampo treatments for various complaints in urological diseases. The first presentation is about basic research on choreito for overactive bladder. The second presentation covers clinical research of hachimijiogan and goshajinkigan for benign prostate hyperplasia and interstitial cystitis/ bladder pain syndrome. The third presentation concerns clinical research of choreito and seishinrenshiin for chronic urinary tract infection. Finally, basic and clinical research on Kampo medicine for testosterone and cognitive function with urological cancer is presented. Please enjoy the varied world of Kampo medicine for urological diseases. The first presentation is entitled “Therapeutic Effects of Choreito on Urological Diseases.” Choreito (CRT) is one of the most commonly prescribed Kampo medicines in urology and has a “water utilization effect,” a combination of the diuretic effect and an improvement in water imbalance. Therefore, CRT is administered to relieve lower urinary tract symptoms associated with inflammation by promoting the excretion of urinary stones and alleviating edema of the lower body. Kampo medicines work well when administered according to the appropriate body patterns; however, their mechanisms of action remain largely unclear. Although CRT is typically administered to and works best in patients exhibiting decreased urine excretion and thirst, therapeutic effects are observed regardless of whether these symptoms are present. Attempts have been made to elucidate the mechanisms of action of CRT through basic research on rats and cats. These studies suggested the possibility of a water restriction effect in the nocturnal polyuria model, an effect of suppressing detrusor overactivity in the overactive bladder model, and an improvement effect in the urinary component. We hope that these reports will provide an opportunity to further expand the use of CRT. The second presentation is “Lower Urinary Tract Symptoms and Kampo Medicine.” Lower Urinary Tract Symptoms (LUTS) are classified into (1) storage symptoms, (2) voiding symptoms, and (3) postmicturition symptoms. BPH (benign prostatic hyperplasia) is a typical disease that presents all three symptoms, and OAB (overactive bladder) and IC/BPS (interstitial cystitis/bladder pain syndrome) are typical diseases that present storage symptoms. There are kidney supplements (hachimijiogan, goshajinkigan [GJG]) employed for BPH, but there are no randomized c
{"title":"Significance of Kampo medicine in the urological field “1st International Symposium on Kampo Medicine”","authors":"H. Oh‐oka, K. Torimoto, Miyabi Inoue, H. Ide, Y. Sekiguchi","doi":"10.1002/tkm2.1331","DOIUrl":"https://doi.org/10.1002/tkm2.1331","url":null,"abstract":"To The Editor Urology treats many diseases around urogenital organs in men and women, that is, the kidneys, adrenal glands, ureters, urethra, prostate, testis and pelvic floor. Thus, the world of urology is wider than expected. In addition, urology is advancing in the research field of quality-oflife (QOL) diseases. The important targets of Kampo are the treatment of symptoms of QOL diseases that are not sufficiently covered by modern medicine. There are many results of Kampo treatments for urological QOL diseases. This urology session introduces Kampo treatments for various complaints in urological diseases. The first presentation is about basic research on choreito for overactive bladder. The second presentation covers clinical research of hachimijiogan and goshajinkigan for benign prostate hyperplasia and interstitial cystitis/ bladder pain syndrome. The third presentation concerns clinical research of choreito and seishinrenshiin for chronic urinary tract infection. Finally, basic and clinical research on Kampo medicine for testosterone and cognitive function with urological cancer is presented. Please enjoy the varied world of Kampo medicine for urological diseases. The first presentation is entitled “Therapeutic Effects of Choreito on Urological Diseases.” Choreito (CRT) is one of the most commonly prescribed Kampo medicines in urology and has a “water utilization effect,” a combination of the diuretic effect and an improvement in water imbalance. Therefore, CRT is administered to relieve lower urinary tract symptoms associated with inflammation by promoting the excretion of urinary stones and alleviating edema of the lower body. Kampo medicines work well when administered according to the appropriate body patterns; however, their mechanisms of action remain largely unclear. Although CRT is typically administered to and works best in patients exhibiting decreased urine excretion and thirst, therapeutic effects are observed regardless of whether these symptoms are present. Attempts have been made to elucidate the mechanisms of action of CRT through basic research on rats and cats. These studies suggested the possibility of a water restriction effect in the nocturnal polyuria model, an effect of suppressing detrusor overactivity in the overactive bladder model, and an improvement effect in the urinary component. We hope that these reports will provide an opportunity to further expand the use of CRT. The second presentation is “Lower Urinary Tract Symptoms and Kampo Medicine.” Lower Urinary Tract Symptoms (LUTS) are classified into (1) storage symptoms, (2) voiding symptoms, and (3) postmicturition symptoms. BPH (benign prostatic hyperplasia) is a typical disease that presents all three symptoms, and OAB (overactive bladder) and IC/BPS (interstitial cystitis/bladder pain syndrome) are typical diseases that present storage symptoms. There are kidney supplements (hachimijiogan, goshajinkigan [GJG]) employed for BPH, but there are no randomized c","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80255142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Endo, Shiori Utagawa, T. Nagai, T. Hanawa, H. Odaguchi, Hiroaki Kiyohara
Hochuekkito has been used for gastrointestinal immune depression. Among its 10 herbal components, Atractylodis rhizoma (AtR) and Atractylodis lanceae rhizoma (ALR), and also Hedysari radix (HR) and Astragali radix (AR), can be interchanged based on the patient's symptoms. However, the difference between these formulas for improving gastrointestinal immune depression is not clear. The aim of this study was to compare the effect of AtR‐ and ALR‐hochuekkkito on a T‐cell‐mediated systemic and small intestinal mucosal inflammation model. We also analyzed the active ingredients and mechanism of action of AtR‐hochuekkito on the antiapoptotic effect in the Fas/FasL‐mediated signaling cascade on intestinal epithelial cells.
{"title":"Elucidation of improving effects of a traditional Japanese herbal formula, hochuekkito, comprising Atractylodis rhizoma, on T‐cell‐mediated intestinal mucositis in mice","authors":"M. Endo, Shiori Utagawa, T. Nagai, T. Hanawa, H. Odaguchi, Hiroaki Kiyohara","doi":"10.1002/tkm2.1332","DOIUrl":"https://doi.org/10.1002/tkm2.1332","url":null,"abstract":"Hochuekkito has been used for gastrointestinal immune depression. Among its 10 herbal components, Atractylodis rhizoma (AtR) and Atractylodis lanceae rhizoma (ALR), and also Hedysari radix (HR) and Astragali radix (AR), can be interchanged based on the patient's symptoms. However, the difference between these formulas for improving gastrointestinal immune depression is not clear. The aim of this study was to compare the effect of AtR‐ and ALR‐hochuekkkito on a T‐cell‐mediated systemic and small intestinal mucosal inflammation model. We also analyzed the active ingredients and mechanism of action of AtR‐hochuekkito on the antiapoptotic effect in the Fas/FasL‐mediated signaling cascade on intestinal epithelial cells.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86315358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaori Kubota, Takuya Watanabe, S. Katsurabayashi, K. Iwasaki
Ninjinyoeito (NYT), a Japanese herbal medicine, is widely used to treat patients with insomnia, anemia, amnesia, and neurosis. Recently, NYT was reported to be clinically effective in Alzheimer's disease (AD). We investigated the effects of NYT in a neurodegeneration model comprising cultured autaptic neurons exposed to β‐amyloid (Aβ)25–35.
{"title":"Ninjinyoeito reduces β‐amyloid25–35‐induced axon damage via nerve growth factor","authors":"Kaori Kubota, Takuya Watanabe, S. Katsurabayashi, K. Iwasaki","doi":"10.1002/tkm2.1320","DOIUrl":"https://doi.org/10.1002/tkm2.1320","url":null,"abstract":"Ninjinyoeito (NYT), a Japanese herbal medicine, is widely used to treat patients with insomnia, anemia, amnesia, and neurosis. Recently, NYT was reported to be clinically effective in Alzheimer's disease (AD). We investigated the effects of NYT in a neurodegeneration model comprising cultured autaptic neurons exposed to β‐amyloid (Aβ)25–35.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74015688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Gotoh, K. Torimoto, Takashi Iwamoto, Y. Morizawa, S. Hori, Y. Itami, M. Miyake, S. Anai, Shuya Hirao, N. Tanaka, K. Fujimoto
Urolithiasis is a common disorder of the urinary tract. Medical expulsive therapy is recommended for calculi with diameters <10 mm. This study was conducted to determine the effect of choreito, an herbal medication with discharging effects, on the spontaneous passage of urinary calculi.
{"title":"Efficacy of medical expulsive therapy using the traditional Japanese medicine (kampo) choreito for the spontaneous passage of proximal ureteric stones: A retrospective analysis","authors":"D. Gotoh, K. Torimoto, Takashi Iwamoto, Y. Morizawa, S. Hori, Y. Itami, M. Miyake, S. Anai, Shuya Hirao, N. Tanaka, K. Fujimoto","doi":"10.1002/tkm2.1315","DOIUrl":"https://doi.org/10.1002/tkm2.1315","url":null,"abstract":"Urolithiasis is a common disorder of the urinary tract. Medical expulsive therapy is recommended for calculi with diameters <10 mm. This study was conducted to determine the effect of choreito, an herbal medication with discharging effects, on the spontaneous passage of urinary calculi.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90747244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angiotensin II receptor blockers (ARBs) effectively reduce urinary protein. An increase in aldosterone after ARB is termed aldosterone breakthrough and mineralocorticoid receptor antagonists (MRAs) are useful against this phenomenon. The Japanese traditional medicine saireito has the potential to reduce proteinuria. MRAs may suppress licorice‐induced pseudoaldosteronism.
{"title":"Remission inductive efficacy of the combination of ARB, MRA, and saireito for nephrotic syndrome of membranous nephropathy","authors":"T. Ono, H. Nagai, Noriyuki Suzuki, F. Nogaki","doi":"10.1002/tkm2.1314","DOIUrl":"https://doi.org/10.1002/tkm2.1314","url":null,"abstract":"Angiotensin II receptor blockers (ARBs) effectively reduce urinary protein. An increase in aldosterone after ARB is termed aldosterone breakthrough and mineralocorticoid receptor antagonists (MRAs) are useful against this phenomenon. The Japanese traditional medicine saireito has the potential to reduce proteinuria. MRAs may suppress licorice‐induced pseudoaldosteronism.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77729125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Seo, Tetsuya Watanabe, Takahisa Yamada, T. Morita, M. Kawasaki, A. Kikuchi, T. Kawai, J. Nakamura, K. Kayama, Kunpei Ueda, Daisuke Sakamoto, Takehiro Kogame, Yuto Tamura, Takeshi Fujita, Keisuke Nishigaki, Yuki Kokubu, Yuto Fukuda, M. Fukunami
Although malnutrition is an important prognostic factor in patients with chronic heart failure (CHF), no effective treatment for malnutrition has been established. Rikkunshito (RKT) is a Japanese herbal drug that has been used in daily practice for patients with loss of appetite. However, no data have demonstrated whether or not RKT can improve the body composition in patients with CHF. The aim of this study was to elucidate the effect of RKT on the nutritional status of patients with CHF.
{"title":"Effect of the Japanese herbal drug rikkunshito for the treatment of malnutrition in patients with chronic heart failure","authors":"M. Seo, Tetsuya Watanabe, Takahisa Yamada, T. Morita, M. Kawasaki, A. Kikuchi, T. Kawai, J. Nakamura, K. Kayama, Kunpei Ueda, Daisuke Sakamoto, Takehiro Kogame, Yuto Tamura, Takeshi Fujita, Keisuke Nishigaki, Yuki Kokubu, Yuto Fukuda, M. Fukunami","doi":"10.1002/tkm2.1313","DOIUrl":"https://doi.org/10.1002/tkm2.1313","url":null,"abstract":"Although malnutrition is an important prognostic factor in patients with chronic heart failure (CHF), no effective treatment for malnutrition has been established. Rikkunshito (RKT) is a Japanese herbal drug that has been used in daily practice for patients with loss of appetite. However, no data have demonstrated whether or not RKT can improve the body composition in patients with CHF. The aim of this study was to elucidate the effect of RKT on the nutritional status of patients with CHF.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89972436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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