We previously reported that oral administration of mokuboito (a Japanese Kampo medicine) significantly improved symptoms in hospitalized patients with heart failure (HF). However, it remains unclear whether mokuboito treatment affects the long‐term clinical prognosis in patients with HF.
{"title":"Effects of mokuboito, a Japanese Kampo medicine, on long‐term clinical outcomes in patients with heart failure","authors":"H. Ezaki, M. Ayaori, Hiroki Sato, M. Sakurada","doi":"10.1002/tkm2.1310","DOIUrl":"https://doi.org/10.1002/tkm2.1310","url":null,"abstract":"We previously reported that oral administration of mokuboito (a Japanese Kampo medicine) significantly improved symptoms in hospitalized patients with heart failure (HF). However, it remains unclear whether mokuboito treatment affects the long‐term clinical prognosis in patients with HF.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74062908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuto Nishidono, Hina Yahata, Kotaro Niwa, Aoi Kitajima, Yasuhiro Tezuka, Shiro Watanabe, Ken Tanaka
The subterranean tissues of Panax ginseng, especially the root, have long been used in traditional Asian medicine. In traditional medicine, various formulas contain ginseng to relieve fatigue, improve splenic function, and strengthen immunity, while recent studies have reported many additional benefits, including improvement of Alzheimer's dementia. Multiple ginsenosides, polyacetylenes, and polysaccharides in ginseng root and rhizome contribute to these therapeutic activities. Most ginseng used today is cultivated and takes a long time to mature, so changes in the bioactive constituent profile with age could alter the potential health benefits. However, most studies on such age‐dependent changes in chemical composition have focused on ginsenosides. To examine the full spectrum of age‐dependent changes, the current study analyzed the contents of multiple secondary metabolites and primary metabolites in samples cultivated from one to five years.
{"title":"Fluctuations in the chemical constituents of Panax ginseng subterranean tissues with cultivation duration","authors":"Yuto Nishidono, Hina Yahata, Kotaro Niwa, Aoi Kitajima, Yasuhiro Tezuka, Shiro Watanabe, Ken Tanaka","doi":"10.1002/tkm2.1309","DOIUrl":"https://doi.org/10.1002/tkm2.1309","url":null,"abstract":"The subterranean tissues of Panax ginseng, especially the root, have long been used in traditional Asian medicine. In traditional medicine, various formulas contain ginseng to relieve fatigue, improve splenic function, and strengthen immunity, while recent studies have reported many additional benefits, including improvement of Alzheimer's dementia. Multiple ginsenosides, polyacetylenes, and polysaccharides in ginseng root and rhizome contribute to these therapeutic activities. Most ginseng used today is cultivated and takes a long time to mature, so changes in the bioactive constituent profile with age could alter the potential health benefits. However, most studies on such age‐dependent changes in chemical composition have focused on ginsenosides. To examine the full spectrum of age‐dependent changes, the current study analyzed the contents of multiple secondary metabolites and primary metabolites in samples cultivated from one to five years.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88999289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Maeda, Haruna Hosaka, Yuki Nakamura, Shuuji Mawaribuchi, T. Nagai, M. Endo, N. Ito, Hiroaki Kiyohara
Inulooligosaccharides in a Kampo formula, hochuekkito, have been shown to participate in the regulation of the pulmonary immune system. Difference in chain length distribution of the oligosaccharides strongly affects their immunopharmacological activities. This phenomenon cannot be explained by bifidogenic activity and/or short‐chain fatty acids produced by intestinal microflora from the oligosaccharides. Effects of intermediate‐size inulooligosaccharides, which have a similar chain length distribution as the oligosaccharides obtained from hochuekkito containing Atractylodis rhizoma, were analyzed on immunocompetent cells in Peyer’s patches.
{"title":"Fibroblastic reticular cells and type 3 innate lymphoid cells in Peyer’s patches: Target cell candidates for inulooligosaccharides in hochuekkito formula containing Atractylodis rhizoma","authors":"T. Maeda, Haruna Hosaka, Yuki Nakamura, Shuuji Mawaribuchi, T. Nagai, M. Endo, N. Ito, Hiroaki Kiyohara","doi":"10.1002/tkm2.1307","DOIUrl":"https://doi.org/10.1002/tkm2.1307","url":null,"abstract":"Inulooligosaccharides in a Kampo formula, hochuekkito, have been shown to participate in the regulation of the pulmonary immune system. Difference in chain length distribution of the oligosaccharides strongly affects their immunopharmacological activities. This phenomenon cannot be explained by bifidogenic activity and/or short‐chain fatty acids produced by intestinal microflora from the oligosaccharides. Effects of intermediate‐size inulooligosaccharides, which have a similar chain length distribution as the oligosaccharides obtained from hochuekkito containing Atractylodis rhizoma, were analyzed on immunocompetent cells in Peyer’s patches.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91034195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced glycation end products (AGEs) associated with diabetes, renal failure, and non‐alcoholic fatty liver disease have recently been receiving attention. The present study aimed to investigate therapeutic effects of Astragali Radix (AR) using skin autofluorescence (SAF) to evaluate AGEs. Treatment group (May 2019 to May 2020) was 18 patients. AR administration period was six months. SAF, body mass index, mean blood pressure, hemoglobin A1c, serum creatinine, estimated glomerular filtration rate (eGFR), aspartate transaminase, and alanine transaminase (ALT) were used.
{"title":"Evaluating advanced glycation end products by the clinical effects of Astragali Radix using skin autofluorescence","authors":"Shunsuke Watanabe, Shigeo Aoyama","doi":"10.1002/tkm2.1308","DOIUrl":"https://doi.org/10.1002/tkm2.1308","url":null,"abstract":"Advanced glycation end products (AGEs) associated with diabetes, renal failure, and non‐alcoholic fatty liver disease have recently been receiving attention. The present study aimed to investigate therapeutic effects of Astragali Radix (AR) using skin autofluorescence (SAF) to evaluate AGEs. Treatment group (May 2019 to May 2020) was 18 patients. AR administration period was six months. SAF, body mass index, mean blood pressure, hemoglobin A1c, serum creatinine, estimated glomerular filtration rate (eGFR), aspartate transaminase, and alanine transaminase (ALT) were used.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85653048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soichiro Tsutsumi, Takuya Watanabe, Akinobu Hatae, M. Hirata, Hiroya Omori, Chise Taniguchi, Masaki Nagao, Kaori Kubota, S. Katsurabayashi, K. Iwasaki
Ninjinyoeito (NYT) is a Kampo medicine prescribed for patients with decreased mental and physical energy. Clinical studies demonstrate that NYT ameliorates depressive symptoms in patients with various diseases. However, the underlying therapeutic mechanisms of action remain unclear. The monoaminergic system has been implicated in the neuropathology of depression. Using immobility in the tail suspension test to evaluate depression‐like behavior, we aimed to examine the effects of NYT and the involvement of the α1‐adrenoceptor and serotonin (5‐HT)1A receptor in its mechanism of action.
{"title":"Ninjinyoeito exerts an antidepressant‐like effect by enhancing the central noradrenergic system","authors":"Soichiro Tsutsumi, Takuya Watanabe, Akinobu Hatae, M. Hirata, Hiroya Omori, Chise Taniguchi, Masaki Nagao, Kaori Kubota, S. Katsurabayashi, K. Iwasaki","doi":"10.1002/tkm2.1306","DOIUrl":"https://doi.org/10.1002/tkm2.1306","url":null,"abstract":"Ninjinyoeito (NYT) is a Kampo medicine prescribed for patients with decreased mental and physical energy. Clinical studies demonstrate that NYT ameliorates depressive symptoms in patients with various diseases. However, the underlying therapeutic mechanisms of action remain unclear. The monoaminergic system has been implicated in the neuropathology of depression. Using immobility in the tail suspension test to evaluate depression‐like behavior, we aimed to examine the effects of NYT and the involvement of the α1‐adrenoceptor and serotonin (5‐HT)1A receptor in its mechanism of action.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88850889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Toshiharu Kitamura, H. Nakae, Yasuhito Irie, K. Satoh, Nobuhisa Hirasawa, Koumei Kameyama, Yuya Suzuki, Kyohei Maeno, Kenji Yoshida, M. Okuyama
The incidence of adverse events associated with Kampo prescriptions is still unclear. We retrospectively studied the adverse events in 1104 patients prescribed jidabokuippo (JDI) to examine the safety of JDI based on adverse event rate.
{"title":"Safety of jidabokuippo administration based on adverse event rate","authors":"Toshiharu Kitamura, H. Nakae, Yasuhito Irie, K. Satoh, Nobuhisa Hirasawa, Koumei Kameyama, Yuya Suzuki, Kyohei Maeno, Kenji Yoshida, M. Okuyama","doi":"10.1002/tkm2.1305","DOIUrl":"https://doi.org/10.1002/tkm2.1305","url":null,"abstract":"The incidence of adverse events associated with Kampo prescriptions is still unclear. We retrospectively studied the adverse events in 1104 patients prescribed jidabokuippo (JDI) to examine the safety of JDI based on adverse event rate.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89218129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Qi-deficiency Fever Successfully Treated with Hochuekkito","authors":"","doi":"10.3937/kampomed.73.81","DOIUrl":"https://doi.org/10.3937/kampomed.73.81","url":null,"abstract":"","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74743097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Kampo Medicine Treatment for Acute Antebrachial Compartment Syndrome in the Arm Caused with Percutaneous Coronary Intervention Via Radial Artery","authors":"Isao Fukuda, H. Nakata, M. Kusakado, T. Kosuge","doi":"10.3937/kampomed.73.402","DOIUrl":"https://doi.org/10.3937/kampomed.73.402","url":null,"abstract":"","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76084672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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