Pub Date : 2025-11-01DOI: 10.1016/j.tmaid.2025.102929
Yu-Chieh Chang , Yu-Ting Hsiao , Hsi-Kung Kuo , Hsiu-Mei Huang , Jong-Jer Lee
Dengue fever (DF) is primarily recognized for its systemic manifestations; however, ocular involvement remains uncommon and is often overlooked. Dengue-associated retinopathy, a rare manifestation with poorly understood pathophysiological mechanisms, presents both diagnostic and therapeutic challenges. Although most patients recover spontaneously, some experience persistent visual impairment. We report a case of dengue-associated retinopathy with ischemic macular edema that progressed over 2 months following a diagnosis of DF. Owing to its ischemic nature and the patient's relative contraindications to intravitreal and systemic corticosteroids, intravitreal anti–vascular endothelial growth factor (anti-VEGF) therapy was administered, leading to the resolution of macular edema and improvement in visual function. To our knowledge, this is the first reported case demonstrating successful resolution of dengue-associated retinopathy with intravitreal anti-VEGF therapy. These findings suggest that anti-VEGF therapy may serve as an alternative treatment option for dengue-related ocular complications.
{"title":"Successful resolution of dengue-associated retinopathy following intravitreal Anti-VEGF therapy","authors":"Yu-Chieh Chang , Yu-Ting Hsiao , Hsi-Kung Kuo , Hsiu-Mei Huang , Jong-Jer Lee","doi":"10.1016/j.tmaid.2025.102929","DOIUrl":"10.1016/j.tmaid.2025.102929","url":null,"abstract":"<div><div>Dengue fever (DF) is primarily recognized for its systemic manifestations; however, ocular involvement remains uncommon and is often overlooked. Dengue-associated retinopathy, a rare manifestation with poorly understood pathophysiological mechanisms, presents both diagnostic and therapeutic challenges. Although most patients recover spontaneously, some experience persistent visual impairment. We report a case of dengue-associated retinopathy with ischemic macular edema that progressed over 2 months following a diagnosis of DF. Owing to its ischemic nature and the patient's relative contraindications to intravitreal and systemic corticosteroids, intravitreal anti–vascular endothelial growth factor (anti-VEGF) therapy was administered, leading to the resolution of macular edema and improvement in visual function. To our knowledge, this is the first reported case demonstrating successful resolution of dengue-associated retinopathy with intravitreal anti-VEGF therapy. These findings suggest that anti-VEGF therapy may serve as an alternative treatment option for dengue-related ocular complications.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"68 ","pages":"Article 102929"},"PeriodicalIF":4.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tmaid.2025.102936
Laura Vavassori , Silvan Hälg , Nadja Hedrich , Duschinka Guedes , Marcelo S. Paiva , Christian Beuret , Ulf Blanke , Andreas Neumayr , Pie Müller
Travellers visiting countries endemic for arboviral diseases may introduce arboviruses to new areas where competent vectors are already present, potentially leading to disease outbreaks in populations that have not previously been exposed. To assess exposure risks for travellers and identify which arboviruses they might import, we explored the use of international travellers to collect mosquito saliva samples at their travel destinations to map locally circulating arboviruses. We recruited 73 travellers from Switzerland visiting Brazil between August 2018 and June 2019 and provided each of them with five kits to collect viral RNA on Flinders Technology Association cards. We have chosen Brazil as a study area for a proof of concept for reasons of convenience, as this is a popular travel destination. We asked the travellers to place the kits at their destinations and use a smartphone app to track their locations. We received 155 kits back and screened the cards for arboviral RNA using reverse transcriptase PCR with consecutive sequencing of amplicons from positive samples. Due to RNA degradation during an extended storage period, 129 cards produced no positive signal. In contrast, among 26 cards that could be processed shortly after receipt, seven were positive for dengue virus serotype 4 and three for West Nile virus lineage 2 (WNV-2). To our knowledge, this is the first time WNV-2 has been reported from Brazil. Our ‘citizen science’ approach has the potential to contribute to arbovirus surveillance, extending the geographic range of sampling – particularly in regions lacking an arbovirus surveillance programme.
{"title":"Detection of circulating mosquito-borne arboviruses in Brazil using travellers as sentinels","authors":"Laura Vavassori , Silvan Hälg , Nadja Hedrich , Duschinka Guedes , Marcelo S. Paiva , Christian Beuret , Ulf Blanke , Andreas Neumayr , Pie Müller","doi":"10.1016/j.tmaid.2025.102936","DOIUrl":"10.1016/j.tmaid.2025.102936","url":null,"abstract":"<div><div>Travellers visiting countries endemic for arboviral diseases may introduce arboviruses to new areas where competent vectors are already present, potentially leading to disease outbreaks in populations that have not previously been exposed. To assess exposure risks for travellers and identify which arboviruses they might import, we explored the use of international travellers to collect mosquito saliva samples at their travel destinations to map locally circulating arboviruses. We recruited 73 travellers from Switzerland visiting Brazil between August 2018 and June 2019 and provided each of them with five kits to collect viral RNA on Flinders Technology Association cards. We have chosen Brazil as a study area for a proof of concept for reasons of convenience, as this is a popular travel destination. We asked the travellers to place the kits at their destinations and use a smartphone app to track their locations. We received 155 kits back and screened the cards for arboviral RNA using reverse transcriptase PCR with consecutive sequencing of amplicons from positive samples. Due to RNA degradation during an extended storage period, 129 cards produced no positive signal. In contrast, among 26 cards that could be processed shortly after receipt, seven were positive for dengue virus serotype 4 and three for West Nile virus lineage 2 (WNV-2). To our knowledge, this is the first time WNV-2 has been reported from Brazil. Our ‘citizen science’ approach has the potential to contribute to arbovirus surveillance, extending the geographic range of sampling – particularly in regions lacking an arbovirus surveillance programme.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"68 ","pages":"Article 102936"},"PeriodicalIF":4.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145530843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tmaid.2025.102937
Carlos Ramiro Silva-Ramos , Nicole L. Mendell , Patricia A. Crocquet-Valdes , Peter C. Melby , Patricia V. Aguilar , Miguel M. Cabada , Marylin Hidalgo , David H. Walker
Background
Scrub typhus, caused by Orientia spp., is a mite-borne disease historically restricted to the Asia-Pacific region. Autochthonous cases have been confirmed in southern Chile, while serological evidence has been reported in Peru, Honduras and Colombia, suggesting wider distribution in Latin America. Identifying recent exposure among febrile patients is essential to evaluate its role in acute undifferentiated febrile illness (AUFI) etiology.
Aim
To assess the possible implication of Orientia infection as a cause of AUFI in Villeta, Colombia.
Methods
Between September and December 2021, patients with AUFI were recruited. Whole-blood samples were tested for Orientia DNA by real-time PCR targeting the 16S rRNA gene. Acute and convalescent serum samples were analyzed for IgG antibodies by IFA and ELISA, with paired samples titration to assess seroconversion. Reactive sera were further confirmed by Western blot.
Results
Forty-one acute whole-blood samples were tested by qPCR; no Orientia DNA was detected. Serology identified antibodies in 27 % (11/41) of patients: six positive by ELISA, two by IFA, and three by both methods. Based on paired sera, eight cases (20 %) were classified as recent infections, including cases of seroconversion, and three (7 %) as previous exposures. Western blot confirmed specific reactivity against Orientia antigens in all positive samples.
Conclusions
This study provides serological evidence of Orientia circulation among febrile patients in Villeta, Colombia, including clear cases of seroconversion. Western blot validated reactivity against immunodominant proteins. Findings suggest a local scrub typhus–like illness and highlight the need for pathogen isolation and genetic characterization to clarify its contribution to AUFI.
{"title":"Probable scrub typhus-like infection in Colombia: seroconversion and serological reactivity to Orientia spp. among patients with acute undifferentiated febrile illness in Villeta municipality","authors":"Carlos Ramiro Silva-Ramos , Nicole L. Mendell , Patricia A. Crocquet-Valdes , Peter C. Melby , Patricia V. Aguilar , Miguel M. Cabada , Marylin Hidalgo , David H. Walker","doi":"10.1016/j.tmaid.2025.102937","DOIUrl":"10.1016/j.tmaid.2025.102937","url":null,"abstract":"<div><h3>Background</h3><div>Scrub typhus, caused by <em>Orientia</em> spp., is a mite-borne disease historically restricted to the Asia-Pacific region. Autochthonous cases have been confirmed in southern Chile, while serological evidence has been reported in Peru, Honduras and Colombia, suggesting wider distribution in Latin America. Identifying recent exposure among febrile patients is essential to evaluate its role in acute undifferentiated febrile illness (AUFI) etiology.</div></div><div><h3>Aim</h3><div>To assess the possible implication of <em>Orientia</em> infection as a cause of AUFI in Villeta, Colombia.</div></div><div><h3>Methods</h3><div>Between September and December 2021, patients with AUFI were recruited. Whole-blood samples were tested for <em>Orientia</em> DNA by real-time PCR targeting the 16S rRNA gene. Acute and convalescent serum samples were analyzed for IgG antibodies by IFA and ELISA, with paired samples titration to assess seroconversion. Reactive sera were further confirmed by Western blot.</div></div><div><h3>Results</h3><div>Forty-one acute whole-blood samples were tested by qPCR; no <em>Orientia</em> DNA was detected. Serology identified antibodies in 27 % (11/41) of patients: six positive by ELISA, two by IFA, and three by both methods. Based on paired sera, eight cases (20 %) were classified as recent infections, including cases of seroconversion, and three (7 %) as previous exposures. Western blot confirmed specific reactivity against <em>Orientia</em> antigens in all positive samples.</div></div><div><h3>Conclusions</h3><div>This study provides serological evidence of <em>Orientia</em> circulation among febrile patients in Villeta, Colombia, including clear cases of seroconversion. Western blot validated reactivity against immunodominant proteins. Findings suggest a local scrub typhus–like illness and highlight the need for pathogen isolation and genetic characterization to clarify its contribution to AUFI.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"68 ","pages":"Article 102937"},"PeriodicalIF":4.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145517081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tmaid.2025.102927
Silvia Otero-Rodriguez , Martin Casapia-Morales , Lilia-Lorena Pinedo-Ramirez , Esperanza Merino , Eva H. Clark , José-Manuel Ramos-Rincón
Introduction
Chagas disease (CD) - Trypanosoma cruzi infection - in people living with HIV (PWH), particularly those with advanced CD4 T cell depletion, can lead to severe syndromes affecting the central nervous system and the heart.
Methods
We performed a cross-sectional study to screen for CD among PWH in Iquitos, Peru, between October 2023 and May 2024, with the objective of understanding the frequency of infection in this population. Adults with confirmed HIV attending outpatient services at two regional hospitals were enrolled. Two ELISA tests (lysate and recombinant) were used, and discordant results were adjudicated by indirect chemiluminescence immunoassay (CLIA).
Result
Of 534 PWH, the median age was 41 years (IQR 32–49), 66.1 % were male, the median current CD4+ count was 443/μL, and 75.8 % had an undetectable viral load. Two discordant serologic results were resolved with a negative CLIA, resulting in no confirmed CD cases.
Conclusion
The prevalence of T. cruzi infection is likely very low in urban and peri-urban areas of Iquitos. Continued epidemiological surveillance is essential to monitor potential changes over time.
{"title":"Screening for Trypanosoma cruzi in patients living with the human immunodeficiency virus (PWH) in the Peruvian Amazon","authors":"Silvia Otero-Rodriguez , Martin Casapia-Morales , Lilia-Lorena Pinedo-Ramirez , Esperanza Merino , Eva H. Clark , José-Manuel Ramos-Rincón","doi":"10.1016/j.tmaid.2025.102927","DOIUrl":"10.1016/j.tmaid.2025.102927","url":null,"abstract":"<div><h3>Introduction</h3><div>Chagas disease (CD) - <em>Trypanosoma cruzi</em> infection - in people living with HIV (PWH), particularly those with advanced CD4 T cell depletion, can lead to severe syndromes affecting the central nervous system and the heart.</div></div><div><h3>Methods</h3><div>We performed a cross-sectional study to screen for CD among PWH in Iquitos, Peru, between October 2023 and May 2024, with the objective of understanding the frequency of infection in this population. Adults with confirmed HIV attending outpatient services at two regional hospitals were enrolled. Two ELISA tests (lysate and recombinant) were used, and discordant results were adjudicated by indirect chemiluminescence immunoassay (CLIA).</div></div><div><h3>Result</h3><div>Of 534 PWH, the median age was 41 years (IQR 32–49), 66.1 % were male, the median current CD4<sup>+</sup> count was 443/μL, and 75.8 % had an undetectable viral load. Two discordant serologic results were resolved with a negative CLIA, resulting in no confirmed CD cases.</div></div><div><h3>Conclusion</h3><div>The prevalence of <em>T. cruzi</em> infection is likely very low in urban and peri-urban areas of Iquitos. <em>Continued epidemiological surveillance is essential to monitor potential changes over time.</em></div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"68 ","pages":"Article 102927"},"PeriodicalIF":4.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tmaid.2025.102934
Patricia Marques Moralejo Bermudi , Raquel Gardini Sanches Palasio , Monica Pirani , Lidia Maria Reis Santana , Gerson Laurindo Barbosa , Marta Blangiardo , Francisco Chiaravalloti-Neto
Background
Despite its burden, dengue remains neglected, with few studies comparing its incidence, mortality, case-fatality, and key variables such as socioeconomic factors, healthcare access, and serotype distribution.
Methods
This ecological study analyzed dengue cases and deaths (2014–2024) in intermediate regions of Brazil. Covariates included illiteracy rate, hospital bed availability, serotype distribution, and private healthcare coverage. High- and low-risk spatial clusters were identified using the SaTScan Poisson model. Statistical analysis assessed significant covariate differences between risk groups.
Results
High-incidence clusters were found in areas with lower illiteracy rates, whereas high-case fatality clusters were found in areas with higher illiteracy rates. DENV-2 was associated with high-risk case-fatality areas; in contrast, DENV-1 showed the opposite pattern, appearing to be more common but associated with lower severity.
Conclusions
These findings provide a basis for generating hypotheses for future modeling studies on these associations.
{"title":"Dengue incidence, mortality, and case-fatality in Brazil: spatial patterns, socioeconomic contrasts, and serotype impact","authors":"Patricia Marques Moralejo Bermudi , Raquel Gardini Sanches Palasio , Monica Pirani , Lidia Maria Reis Santana , Gerson Laurindo Barbosa , Marta Blangiardo , Francisco Chiaravalloti-Neto","doi":"10.1016/j.tmaid.2025.102934","DOIUrl":"10.1016/j.tmaid.2025.102934","url":null,"abstract":"<div><h3>Background</h3><div>Despite its burden, dengue remains neglected, with few studies comparing its incidence, mortality, case-fatality, and key variables such as socioeconomic factors, healthcare access, and serotype distribution.</div></div><div><h3>Methods</h3><div>This ecological study analyzed dengue cases and deaths (2014–2024) in intermediate regions of Brazil. Covariates included illiteracy rate, hospital bed availability, serotype distribution, and private healthcare coverage. High- and low-risk spatial clusters were identified using the SaTScan Poisson model. Statistical analysis assessed significant covariate differences between risk groups.</div></div><div><h3>Results</h3><div>High-incidence clusters were found in areas with lower illiteracy rates, whereas high-case fatality clusters were found in areas with higher illiteracy rates. DENV-2 was associated with high-risk case-fatality areas; in contrast, DENV-1 showed the opposite pattern, appearing to be more common but associated with lower severity.</div></div><div><h3>Conclusions</h3><div>These findings provide a basis for generating hypotheses for future modeling studies on these associations.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"68 ","pages":"Article 102934"},"PeriodicalIF":4.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tmaid.2025.102931
Romain Gueneau , Lei Tanaka , Pierre Reimbold , Julien Harroche , Cécile Nabet , Stéphane Jauréguiberry
Conidiobolomycosis is a rare tropical mycosis that is often difficult to diagnose and treat.
Method
We describe here an imported case that highlights these issues.
Results
A 24-year-old HIV positive patient was diagnosed and treated for a conidiobolomycosis due to Conidiobolus coronatus. Imaging showed extensive facial invasion. Biopsy and fungal culture confirmed conidiobolomycosis, resistant to standard antifungals. Initial therapy with liposomal amphotericin B and itraconazole failed due to drug interactions. After adjusting treatment and performing surgery, the patient's condition improved. Despite high MICs, clinical response was favorable. He completed 14 months of itraconazole without recurrence four months post-treatment. Serial beta-D-glucan assays showed promise as a reliable biomarker for therapeutic monitoring.
Conclusion
This case highlights the complex medicosurgical management of a rare imported tropical mycosis, the diagnostic aspects of conidiobolomycosis, and the promising potential benefit of beta-D-glucan for the management and follow-up of this severe tropical deep-sited mycosis.
分生孢子菌病是一种罕见的热带真菌病，通常难以诊断和治疗。方法：我们在这里描述一个导入的案例，突出了这些问题。结果：1例24岁的HIV阳性患者因冠状孢子虫引起的分生孢子菌病被诊断并治疗。影像学显示广泛的面部侵犯。活检和真菌培养证实为分生孢子菌病，对标准抗真菌药有耐药性。由于药物相互作用，最初用两性霉素B脂质体和伊曲康唑治疗失败。经过调整治疗和手术治疗，患者病情好转。尽管mic较高，但临床反应良好。他完成了14个月的伊曲康唑治疗，治疗后4个月无复发。一系列β - d -葡聚糖测定显示出作为治疗监测可靠的生物标志物的前景。结论：本病例强调了一种罕见的输入性热带真菌病的复杂内科手术治疗，分生孢子菌病的诊断方面，以及β - d -葡聚糖对这种严重热带深部真菌病的治疗和随访的潜在益处。
{"title":"Rhino-orbital conidiobolomycosis in non-endemic Settings. A diagnostic and therapeutic challenge","authors":"Romain Gueneau , Lei Tanaka , Pierre Reimbold , Julien Harroche , Cécile Nabet , Stéphane Jauréguiberry","doi":"10.1016/j.tmaid.2025.102931","DOIUrl":"10.1016/j.tmaid.2025.102931","url":null,"abstract":"<div><div>Conidiobolomycosis is a rare tropical mycosis that is often difficult to diagnose and treat.</div></div><div><h3>Method</h3><div>We describe here an imported case that highlights these issues.</div></div><div><h3>Results</h3><div>A 24-year-old HIV positive patient was diagnosed and treated for a conidiobolomycosis due to <em>Conidiobolus coronatus.</em> Imaging showed extensive facial invasion. Biopsy and fungal culture confirmed conidiobolomycosis, resistant to standard antifungals. Initial therapy with liposomal amphotericin B and itraconazole failed due to drug interactions. After adjusting treatment and performing surgery, the patient's condition improved. Despite high MICs, clinical response was favorable. He completed 14 months of itraconazole without recurrence four months post-treatment. Serial beta-D-glucan assays showed promise as a reliable biomarker for therapeutic monitoring.</div></div><div><h3>Conclusion</h3><div>This case highlights the complex medicosurgical management of a rare imported tropical mycosis, the diagnostic aspects of conidiobolomycosis, and the promising potential benefit of beta-D-glucan for the management and follow-up of this severe tropical deep-sited mycosis.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"68 ","pages":"Article 102931"},"PeriodicalIF":4.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tmaid.2025.102942
Flora Delamaire , Pierre Kergoat , Jean-Marc Tadié , Nicolas Terzi
{"title":"Opsoclonus-myoclonus following West Nile virus encephalitis: when the virus enters the equation","authors":"Flora Delamaire , Pierre Kergoat , Jean-Marc Tadié , Nicolas Terzi","doi":"10.1016/j.tmaid.2025.102942","DOIUrl":"10.1016/j.tmaid.2025.102942","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"68 ","pages":"Article 102942"},"PeriodicalIF":4.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145517080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tmaid.2025.102943
Nadja Hedrich , Thibault Lovey , Julian Bernhard , Martin P. Grobusch , Philippe Gautret , Patricia Schlagenhauf , ITIT Global Network
Background
International travel is growing exponentially. Monitoring infectious disease in travellers is increasingly important to identify infection trends and signals. The ITIT (illness Tracking in Travellers) app project aims to monitor travel-related illness in a prospective, real-time surveillance study (ClinicalTrials.gov NCT04672577) integrating geolocation and environmental data.
Methods
Adults (>18 years) traveling internationally (>2 days), provided e-consent and used the ITIT app to record daily illness symptoms, which were analysed together with geospatial and climate data. All data are encrypted. A pre-travel survey collected demographic and itinerary data and follow-up surveys assessed post-travel diagnoses and self-treatment.
Results
1355 participants enrolled until December 2024; 676 completed symptom surveys covering 703 trips. Symptoms were reported in 42 % of trips, with gastrointestinal, respiratory and general symptoms being the most common. Post-travel diagnoses were reported in 6 % of respondents, including malaria, COVID-19, and schistosomiasis. Self-treatment was reported by 20 % of travellers. Participants visited 95 countries and reported symptoms in 70. The most common destinations of travel with symptoms reported were Indonesia, Thailand and Pakistan. Duration of travel and the age of the traveller were the most important demographic factors for predicting symptom occurrence.
Conclusion
ITIT enables real-time global health surveillance in travellers and can augment traditional surveillance systems, particularly in regions with limited infrastructure.
{"title":"Real-time illness monitoring in travellers: an international, prospective, digital surveillance study","authors":"Nadja Hedrich , Thibault Lovey , Julian Bernhard , Martin P. Grobusch , Philippe Gautret , Patricia Schlagenhauf , ITIT Global Network","doi":"10.1016/j.tmaid.2025.102943","DOIUrl":"10.1016/j.tmaid.2025.102943","url":null,"abstract":"<div><h3>Background</h3><div>International travel is growing exponentially. Monitoring infectious disease in travellers is increasingly important to identify infection trends and signals. The ITIT (illness Tracking in Travellers) app project aims to monitor travel-related illness in a prospective, real-time surveillance study (ClinicalTrials.gov NCT04672577) integrating geolocation and environmental data.</div></div><div><h3>Methods</h3><div>Adults (>18 years) traveling internationally (>2 days), provided e-consent and used the ITIT app to record daily illness symptoms, which were analysed together with geospatial and climate data. All data are encrypted. A pre-travel survey collected demographic and itinerary data and follow-up surveys assessed post-travel diagnoses and self-treatment.</div></div><div><h3>Results</h3><div>1355 participants enrolled until December 2024; 676 completed symptom surveys covering 703 trips. Symptoms were reported in 42 % of trips, with gastrointestinal, respiratory and general symptoms being the most common. Post-travel diagnoses were reported in 6 % of respondents, including malaria, COVID-19, and schistosomiasis. Self-treatment was reported by 20 % of travellers. Participants visited 95 countries and reported symptoms in 70. The most common destinations of travel with symptoms reported were Indonesia, Thailand and Pakistan. Duration of travel and the age of the traveller were the most important demographic factors for predicting symptom occurrence.</div></div><div><h3>Conclusion</h3><div>ITIT enables real-time global health surveillance in travellers and can augment traditional surveillance systems, particularly in regions with limited infrastructure.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"68 ","pages":"Article 102943"},"PeriodicalIF":4.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tmaid.2025.102905
Carlos Arturo Alvarez-Moreno , Jorge Alberto Cortes , Carlos Humberto Saavedra , Álvaro A. Faccini-Martínez , Sonia Isabel Cuervo-Maldonado , Alfonso J. Rodriguez-Morales
{"title":"Renaming the tropical febrile syndrome: A clinical and semantic imperative in global health","authors":"Carlos Arturo Alvarez-Moreno , Jorge Alberto Cortes , Carlos Humberto Saavedra , Álvaro A. Faccini-Martínez , Sonia Isabel Cuervo-Maldonado , Alfonso J. Rodriguez-Morales","doi":"10.1016/j.tmaid.2025.102905","DOIUrl":"10.1016/j.tmaid.2025.102905","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"68 ","pages":"Article 102905"},"PeriodicalIF":4.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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