Travel Medicine and Infectious Disease最新文献_第3页

The EP3622 clone of CD1a for diagnosing intestinal leishmaniasis in an acquired immunodeficiency syndrome patient in Colombia

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-01-28 DOI: 10.1016/j.tmaid.2025.102808

Diego Andrés Rodríguez-Lugo , Jorge Alfredo Morcillo Muñoz , Javier Hernández Moreno , Carolina Moreno Reyes , Luz Helena Patiño , David F. Martínez , Juan Fernando Contreras-Valero , Juan David Ramírez , Álvaro A. Faccini-Martínez

引用次数: 0

Challenging therapeutic management of visceral leishmaniasis (L. Infantum) in a patient with thymoma: Case report with literature review

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-01-26 DOI: 10.1016/j.tmaid.2025.102804

Serena Vita , Tommaso Ascoli Bartoli , Andrea Mariano , Gaetano Maffongelli , Laura Scorzolini , Angela Corpolongo , Maria Virginia Tomassi , Silvia Rosati , Francesca Faraglia , Claudia Palazzolo , Nazario Bevilacqua , Maria Letizia Giancola , Antonella Vulcano , Lorenzo Zammarchi , Alessandra D'Abramo , Emanuele Nicastri

引用次数: 0

Changes in the epidemiology of Crimean-Congo hemorrhagic fever: Impact of travel and a One Health approach in the European region

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-01-25 DOI: 10.1016/j.tmaid.2025.102806

Francesca F. Norman , Octavio A. Arce , Marta Díaz-Menéndez , Moncef Belhassen-García , Marta González-Sanz

Background

The World Health Organization has identified Crimean-Congo hemorrhagic fever (CCHF) as a priority disease for research and development in emergency contexts. The epidemiology of CCHF is evolving and this review highlights travel-associated cases and focuses on the need for a One Health approach in Europe.

Methods

For this narrative review, two searches were performed in PubMed and Google Scholar for the period 1980–October 2024. The first search identified travel-associated CCHF cases globally, additional cases were identified in the ProMED mail database and through healthmap.org. The second search, with a focus on the European region, aimed to analyse reports of CCHF virus (CCHFV) detected in ticks, CCHF seroprevalence studies in animals and/or humans, and autochthonous CCHF cases.

Results

Seventeen cases of imported CCHF, the majority acquired in Africa, were identified. Importation to European countries accounted for eight of the cases. Most patients presented with fever and hemorrhagic manifestations and the estimated case fatality rate was 35 %. In the WHO European region, at least 13 countries have reported ticks infected with different genotypes of CCHFV; 17 countries were found to have animals/humans with positive CCHF serology. Finally, 16 countries in the WHO European region have notified human cases of CCHF. The Russian Federation, Turkey, and several former USSR countries are considered highly endemic, followed by the Balkanic region, with sporadic cases emerging in Bulgaria, Greece, Spain, and recently Portugal.

Conclusions

Travel-associated CCHF is infrequent. However, given the recently reported increased geographical distribution in ticks and animals in the European region, additional human cases may be anticipated in the near future. Europe receives over half of all international tourist arrivals annually, so healthcare professionals should be aware of risk factors and current protocols for the management of suspected and confirmed cases.

背景：世界卫生组织已将克里米亚-刚果出血热（CCHF）确定为紧急情况下研究和开发的优先疾病。克里米亚-刚果出血热的流行病学正在发生变化，本综述重点关注与旅行有关的病例，并关注欧洲对 "统一健康 "方法的需求：为了撰写这篇叙述性综述，我们在 PubMed 和 Google Scholar 上进行了两次检索，时间跨度为 1980 年至 2024 年 10 月。第一次搜索在全球范围内发现了与旅行相关的 CCHF 病例，并在 ProMED 邮件数据库和 healthmap.org 中发现了其他病例。第二次检索的重点是欧洲地区，目的是分析在蜱虫中检测到的CCHF病毒（CCHFV）的报告、动物和/或人类的CCHF血清流行率研究以及本地CCHF病例：结果：共发现 17 例输入性 CCHF 病例，其中大多数在非洲感染。其中 8 例病例来自欧洲国家。大多数患者表现为发热和出血，估计病死率为 35%。在世卫组织欧洲区域，13 个国家报告了蜱虫感染不同基因型的 CCHFV；17 个国家发现了 CCHF 血清学呈阳性的动物/人类。最后，世卫组织欧洲地区有 16 个国家通报了人类感染 CCHF 的病例。俄罗斯联邦、土耳其和几个前苏联国家被认为是高流行区，其次是巴尔干地区，保加利亚、希腊、西班牙和最近的葡萄牙也出现了零星病例：结论：与旅行相关的 CCHF 并不常见。然而，鉴于最近报告的欧洲地区蜱虫和动物地理分布的增加，预计不久的将来会出现更多的人类病例。欧洲每年接待的国际游客人数占总人数的一半以上，因此医疗保健专业人员应了解风险因素以及疑似病例和确诊病例的现行管理规程。

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引用次数: 0

Screening for schistosomiasis in a non-endemic setting: Accuracy of a rapid antibody test using finger prick blood

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-01-24 DOI: 10.1016/j.tmaid.2025.102807

Margherita Ortalli , Bianca Granozzi , Michele Bacchiega , Concettina Di Lillo , Greta Roncarati , Silvia Stefania Longoni , Cristina Mazzi , Elisa Vanino , Zeno Bisoffi , Stefania Varani

Human schistosomiasis is a chronic neglected tropical disease caused by blood flukes of the genus Schistosoma, infecting 250 million people worldwide, mostly in sub-Saharan Africa. Recently, thousands of cases have been reported in immigrants to non-endemic countries, including Italy. Serological screening is recommended but so far, no accurate point-of-care (POC) and lab-free test is available.

We carried out a prospective evaluation of the accuracy of a new immunochromatographic test (Black- ICT, IgG-IgM) using finger prick blood for screening of schistosomiasis at the University Hospital of Bologna. Eligible immigrants were recruited regardless the presence of symptoms. The other tests used were microscopy on stools and urine, a serum-ICT (SCHISTOSOMA ICT IgG-IgM, LDBIO Diagnostics), an ELISA (NovaLisa Schistosoma mansoni IgG, Novatec) and a Western Blot (SCHISTO II Western Blot IgG, LDBIO Diagnostics). Statistical analysis was performed using a Bayesian latent class model.

We enrolled 198 subjects in the study. Black-ICT had a sensitivity of 86.6 % (95 % credible interval 76.9–94.7) and a specificity of 88.4 % (82.0–94.3). At the estimated prevalence level for the study sample, 32.6 % (25.5–40.0), the positive and negative predictive values were 78.2 % (66.4–89.4) and 93.2 % (87.7–97.6), respectively. Good agreement was found with the other antibody tests, with the highest sensitivity being observed for serum-ICT (91.0 %, 84.7–96.4) and the highest specificity for ELISA (92.6 %, 87.5–96.7).

The novel POC test for schistosomiasis showed satisfactory results and could improve the detection of this parasitic infection in non-endemic settings, as the lab-free approach could greatly expand the target group.

{"title":"Screening for schistosomiasis in a non-endemic setting: Accuracy of a rapid antibody test using finger prick blood","authors":"Margherita Ortalli , Bianca Granozzi , Michele Bacchiega , Concettina Di Lillo , Greta Roncarati , Silvia Stefania Longoni , Cristina Mazzi , Elisa Vanino , Zeno Bisoffi , Stefania Varani","doi":"10.1016/j.tmaid.2025.102807","DOIUrl":"10.1016/j.tmaid.2025.102807","url":null,"abstract":"<div><div>Human schistosomiasis is a chronic neglected tropical disease caused by blood flukes of the genus <em>Schistosoma,</em> infecting 250 million people worldwide, mostly in sub-Saharan Africa. Recently, thousands of cases have been reported in immigrants to non-endemic countries, including Italy. Serological screening is recommended but so far, no accurate point-of-care (POC) and lab-free test is available.</div><div>We carried out a prospective evaluation of the accuracy of a new immunochromatographic test (Black- ICT, IgG-IgM) using finger prick blood for screening of schistosomiasis at the University Hospital of Bologna. Eligible immigrants were recruited regardless the presence of symptoms. The other tests used were microscopy on stools and urine, a serum-ICT (SCHISTOSOMA ICT IgG-IgM, LDBIO Diagnostics), an ELISA (NovaLisa Schistosoma mansoni IgG, Novatec) and a Western Blot (SCHISTO II Western Blot IgG, LDBIO Diagnostics). Statistical analysis was performed using a Bayesian latent class model.</div><div>We enrolled 198 subjects in the study. Black-ICT had a sensitivity of 86.6 % (95 % credible interval 76.9–94.7) and a specificity of 88.4 % (82.0–94.3). At the estimated prevalence level for the study sample, 32.6 % (25.5–40.0), the positive and negative predictive values were 78.2 % (66.4–89.4) and 93.2 % (87.7–97.6), respectively. Good agreement was found with the other antibody tests, with the highest sensitivity being observed for serum-ICT (91.0 %, 84.7–96.4) and the highest specificity for ELISA (92.6 %, 87.5–96.7).</div><div>The novel POC test for schistosomiasis showed satisfactory results and could improve the detection of this parasitic infection in non-endemic settings, as the lab-free approach could greatly expand the target group.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102807"},"PeriodicalIF":6.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical care and initial health status of French children returnees from jihadist group operation areas: A cross-sectional study from 2017 to 2020 in one referral French hospital

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-01-24 DOI: 10.1016/j.tmaid.2025.102805

J. Goutines , L.L. Pham , N. Lucidarme , C. Briand , A. Malka , C. Baker , M. Veyret-Morau , A. Mapelli , A. Klein , T. Baubet , L. De Pontual

Introduction

The return of foreign fighters's children whose parents joined the so called « islamic state » in the Iraq-Syrian area, had been a very controversial topic. Since 2017, a national procedure in France has been designed to coordinate their care, including a systematic pediatric medical assessment.

Methods

The aim of this cross-sectional study was to assess the prevalence rate of diseases diagnosed at their arrival in France. Demographic characteristics and clinical assessment of all the children included in this procedure in one paediatric center between 2017 and 2020 were retrospectively collected.

Findings

We included 70 children (44M, 26F; mean age: 4.9 years old (±3.8)). In average, they crossed two countries, mainly Syria (n = 55), Turkey (n = 53) and Iraq (n = 18). At least one parent was deceased or incarcerated in respectively 25 (36 %) and 50 cases (71 %). Main pathologies were infectious diseases (n = 14, 20 %), including one lymph node tuberculosis. Mild nutritional impairment (n = 55, 78%–95 %), stunting (n = 13, 19%–95 %), psychomotor troubles (n = 18, 26 %) and psychological or behavior troubles (n = 36, 51 %) were also reported. Nutritional impairment was associated with a longer stay abroad (aOR 4.34, 95 % CI [1.21–18.24], p = 0.03) whereas no significant association was found between the other diseases and age, birth country or length of stay abroad.

Conclusions

Nutritional impairment and psychomotor or behaviour troubles were more frequent than other diseases in our cohort. These results emphasize the importance of considering the developmental aspects of these young children who experimented multiple potentially psychic traumatic events.

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引用次数: 0

Clarification of factors associated with post-artesunate delayed hemolysis (PADH): Analysis of 327 patients with severe imported Plasmodium falciparum malaria in France

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-01-23 DOI: 10.1016/j.tmaid.2025.102801

Pierre-Louis Conan , Marc Thellier , Eric Kendjo , Sandrine Houzé , Rémonie Seng , Stéphane Jauréguiberry

Background

Post-Artesunate delayed hemolysis (PADH) occurs in approximately 15 % of treated patients 2–3 weeks after artesunate administration. Identifying risk markers for PADH would help predict which patients are at higher risk.

Methods

In this prospective national cohort study conducted in a non-malaria endemic area from 2011 to 2016, a Cox proportional hazards model was used to assess the association between clinical and biological data available at Day 0 and the occurrence of PADH within 30 days of artesunate administration.

Results

In the analyzed population (n = 327), 49 PADH events occurred after a median time of

14 days (IQR, 13–17) after artesunate initiation. Higher initial parasitemia was associated with an increased risk of PADH, with a significant interaction found with patient origin. The cumulative probability of PADH event at Day 30 post-artesunate was 65 % (95 % confidence interval [CI], 44–79) for European patients vs. 14 % (95 % CI, 0–26) for those with recent African ancestry [RAA] when the initial parasitemia was >10 %. After adjustment for weight, history of malaria, initial hemoglobin, very severe malaria and residence in an endemic area, compared to recent African ancestry with initial parasitemia <4 %, the adjusted hazard ratio for PADH occurrence was 18.8 (95 % CI, 4–89) for Europeans and 4.77 (95 % CI, 0.8–29.2) for recent African ancestry with initial parasitemia >10 %.

Conclusions

This study showed that initial parasitemia and patient origin were the main predictors of developing PADH, with the highest risk observed in Europeans with an initial parasitemia >10 %.

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引用次数: 0

Analysis of consular assistance provided to Irish citizens abroad, 2014–2023

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-01-20 DOI: 10.1016/j.tmaid.2025.102803

Alan Alby , Aoife Power , Gerard T. Flaherty

Introduction

There has been limited literature reporting the nature of the consular assistance provided to travellers. This study aimed to describe the consular assistance activity of the Irish Department of Foreign Affairs.

Methods

Publicly available consular assistance data (2014–2023) were analysed descriptively. Consular missions were listed under 16–19 categories.

Results

A total of 26,378 consular assistance missions were recorded. The greatest proportion of missions related to COVID-19 repatriations (26.9 %, n = 7097), deaths overseas (10 %, n = 2650), and medical illness/mental health emergency abroad (11.6 %, n = 3047). Forensic incidents (arrests/victims of crime) accounted for 12.9 % (n = 3392) of consular assistance episodes.

Conclusion

This study highlights the characteristics and trends of consular assistance requests received by a national governmental agency. Future studies should explore traveller awareness of consular procedures and the extent to which they are addressed in travel medicine consultations.

{"title":"Analysis of consular assistance provided to Irish citizens abroad, 2014–2023","authors":"Alan Alby , Aoife Power , Gerard T. Flaherty","doi":"10.1016/j.tmaid.2025.102803","DOIUrl":"10.1016/j.tmaid.2025.102803","url":null,"abstract":"<div><h3>Introduction</h3><div>There has been limited literature reporting the nature of the consular assistance provided to travellers. This study aimed to describe the consular assistance activity of the Irish Department of Foreign Affairs.</div></div><div><h3>Methods</h3><div>Publicly available consular assistance data (2014–2023) were analysed descriptively. Consular missions were listed under 16–19 categories.</div></div><div><h3>Results</h3><div>A total of 26,378 consular assistance missions were recorded. The greatest proportion of missions related to COVID-19 repatriations (26.9 %, n = 7097), deaths overseas (10 %, n = 2650), and medical illness/mental health emergency abroad (11.6 %, n = 3047). Forensic incidents (arrests/victims of crime) accounted for 12.9 % (n = 3392) of consular assistance episodes.</div></div><div><h3>Conclusion</h3><div>This study highlights the characteristics and trends of consular assistance requests received by a national governmental agency. Future studies should explore traveller awareness of consular procedures and the extent to which they are addressed in travel medicine consultations.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"64 ","pages":"Article 102803"},"PeriodicalIF":6.3,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the effectiveness of dengue surveillance in the tropical and sub-tropical Asian nations through dengue case data from travelers returning to the five Western Pacific countries and territories 通过返回五个西太平洋国家和地区的旅行者的登革热病例数据，评估热带和亚热带亚洲国家登革热监测的有效性。

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-01-18 DOI: 10.1016/j.tmaid.2025.102802

Jong-Hun Kim , Ah-Young Lim , Sung Hye Kim

Introduction

Dengue, affecting over 3.9 billion people, is a significant health threat globally. Despite a tenfold increase in reported cases from 2000 to 2020, underreporting remains an issue. Our study utilized traveler data from the five Western Pacific countries and territories as sentinel sites, to examine dengue surveillance in Southeast and South Asia.

Methods

We reported dengue cases among returning travelers (2010–2018) and computed dengue incidence per 100,000 travelers for each destination country. We compared officially reported dengue incidence per 100,000 inhabitants of the destination country with estimated incidence per 100,000 travelers, using Pearson's correlation coefficient.

Results

Key findings revealed eight Southeast and South Asia countries as popular destinations for our sentinel sites, with Australia exhibiting the highest incidence (40.7 per 100,000 travelers). Dengue incidence variations were evident, with Malaysia showing a sharp increase over time. Correlation analysis showed strong links in Malaysia (r = 0.66–0.92) and weaker connections in India (r = −0.54–0.76) between dengue incidence among inhabitants and travelers.

Conclusion

Systematically collected dengue surveillance data from returning travelers can serve as a proxy for dengue incidence in the destination country and can be used to assess the robustness of the country's dengue surveillance.

导言：登革热影响着39亿多人，是全球重大的健康威胁。尽管从2000年到2020年报告的病例增加了10倍，但漏报仍然是一个问题。我们的研究利用来自西太平洋五个国家和地区的旅行者数据作为哨点，检查东南亚和南亚的登革热监测情况。方法：我们报告了2010-2018年返回旅行者中的登革热病例，并计算了每个目的地国家每10万名旅行者的登革热发病率。我们使用Pearson相关系数比较了官方报告的目的地国每10万居民的登革热发病率与每10万旅行者的估计发病率。结果：主要调查结果显示，八个东南亚和南亚国家是我们哨点的热门目的地，其中澳大利亚的发病率最高（每10万游客中有40.7人）。登革热发病率变化明显，马来西亚随着时间的推移出现急剧上升。相关分析显示，马来西亚居民和旅行者登革热发病率之间存在很强的联系（r = 0.66-0.92），而印度的联系较弱（r = -0.54-0.76）。结论：系统收集的回国旅行者登革热监测数据可作为目的地国家登革热发病率的代表，并可用于评估该国登革热监测的稳健性。

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引用次数: 0

Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia 汉坦病毒和钩端螺旋体是非特异性急性发热综合征的重要病因，哥伦比亚Meta。

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-01-17 DOI: 10.1016/j.tmaid.2025.102800

Liliana Sánchez-Lerma , Salim Mattar , Verónica Contreras , Jorge Miranda , Vaneza Tique , Virginia Rodríguez , Derly Rodriguez , Sonia Lopez , Andrés Rojas-Gulloso

Introduction

Acute undifferentiated febrile illnesses are fevers lasting less than fourteen days without an evident focus of infection on the initial physical examination or with inconclusive laboratory tests.

Objective

Carry out epidemiological surveillance of the etiology of acute undifferentiated febrile syndrome in the Meta department.

Methods

A descriptive, prospective cross-sectional study was carried out between February 2021 and June 2023 in a first-level hospital in the department of Meta, Colombia. All enrolled patients underwent routine hematology and blood biochemistry examinations. RT-qPCR was performed for Dengue and serology for laboratory diagnoses using ELISA and MAT for Hantavirus and Leptospirosis, respectively. A descriptive and bivariate analysis was performed using SPSS vr 23.0.

Results

Of the study's total of one hundred patients, 14 % showed antibodies against hantavirus IgG, of which two were seroconverted. In addition, a risk factor OR = 8.3 (CI = 1.8–38.4) for Hantavirus was found in those patients who had contact with farm animals. Regarding leptospirosis, 3 % of the sera agglutinated with titers greater than 1:400, resulting in a primary infection; 11 % of the sera presented agglutination with titers no greater than 1:200 as exposure to leptospirosis. The bivariate analysis showed an OR = 2.4; CI = 0.75–7.4 with water recreational activities in the last 30 days before the onset of symptoms.

Conclusions

Our study demonstrates the importance of Hantavirus, Dengue, and leptospirosis as a cause of acute undifferentiated febrile illnesses. Coinfections are frequent in one of the tropical areas of Colombia, so it is crucial to establish a more precise diagnosis.

急性未分化发热性疾病是指持续少于14天的发热，在最初的体格检查中没有明显的感染焦点或实验室检查不确定。目的：对梅塔科急性无分化热综合征的病因进行流行病学监测。方法：于2021年2月至2023年6月在哥伦比亚Meta的一家一级医院进行了一项描述性、前瞻性横断面研究。所有入组患者均接受常规血液学和血液生化检查。对登革热进行RT-qPCR检测，对汉坦病毒和钩端螺旋体病分别采用ELISA和MAT进行血清学检测。采用SPSS vr 23.0进行描述性和双变量分析。结果：在该研究的100例患者中，14%的患者出现汉坦病毒IgG抗体，其中2例血清转化。此外，与农场动物接触的患者汉坦病毒风险因子OR=8.3 （CI=1.8-38.4）。关于钩端螺旋体病，3%的血清凝集，滴度大于1:400，导致原发性感染；暴露于钩端螺旋体病的血清中有11%出现凝集，滴度不大于1:200。双变量分析OR = 2.4；CI=0.75-7.4，在出现症状前30天内有水上娱乐活动。结论：我们的研究证明了汉坦病毒、登革热和钩端螺旋体病作为急性未分化发热性疾病病因的重要性。在哥伦比亚的一个热带地区，合并感染很常见，因此建立更精确的诊断至关重要。

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引用次数: 0

Aedes-borne arboviral human infections in Europe from 2000 to 2023: A systematic review and meta-analysis 2000-2023年欧洲伊蚊传播的虫媒病毒人类感染：系统回顾和荟萃分析

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-01-10 DOI: 10.1016/j.tmaid.2025.102799

Nadja Hedrich , Maria Bekker-Nielsen Dunbar , Martin P. Grobusch , Patricia Schlagenhauf

Introduction

Aedes-borne arboviral infections, both imported and autochthonous, are reported in Europe. We evaluated the landscape of these infections in Europe over 23 years and attempted to pre-empt the trajectory of impact of these infections in the climatic context of Aedes mosquito expansion in Europe.

Methods

This systematic review was conducted in accordance with PRISMA guidelines and registered in Prospero (CRD42023360259). PubMed, Embase, Web of Science, IEEE Xplore, and Cochrane Central Register of Controlled Trials (CENTRAL) databases and the European Centre for Disease Prevention and Control (ECDC) websites were searched for publications reporting on cases of Aedes-borne infection in Europe between January 1st, 2000, and December 31st, 2023.

Results

Some 353 papers were included, covering 59,589 cases of infection in Europe by seven arboviruses: dengue, Zika, chikungunya, yellow fever, Mayaro, Ross River, and Rift Valley. Most cases (55,924) were travel related, while 5 % were autochthonous. There were 59 cases of non-vector-borne transmission, primarily Zika-related sexual transmissions. Nineteen deaths were reported, of which three were associated with chikungunya virus infection, 12 with dengue, and four with yellow fever. Notable sequelae included persistent arthralgia from chikungunya and neurological effects in Zika-infected infants. The meta-analysis of 31 studies revealed a pooled prevalence of 0.047 (95 % CI: 0.03–0.07) in symptomatic returning travelers.

Conclusion

The systematic review provides a comprehensive overview of over 20 years of Aedes -borne infections in Europe, highlighting the dynamic nature of virus transmission influenced by global travel patterns, climate change, the expanding spread of Aedes populations, and evolving public health campaigns.

欧洲报告了输入性和本地伊蚊传播的虫媒病毒感染。我们评估了23年来欧洲这些感染的情况，并试图在伊蚊在欧洲扩张的气候背景下预防这些感染的影响轨迹。方法：本系统评价按照PRISMA指南进行，并在Prospero注册（CRD42023360259）。检索了PubMed、Embase、Web of Science、IEEE explore、Cochrane Central Register of Controlled Trials （Central）数据库和欧洲疾病预防与控制中心（ECDC）网站，检索了2000年1月1日至2023年12月31日欧洲伊蚊传播感染病例的出版物。结果：共收录论文353篇，涵盖欧洲登革热、寨卡病毒、基孔肯雅病毒、黄热病、马雅罗病毒、罗斯河病毒和裂谷病毒7种虫媒病毒感染病例59589例。大多数病例（55,924例）与旅行有关，5%为本地病例。有59例非媒介传播，主要是与寨卡病毒有关的性传播。据报告有19人死亡，其中3人与基孔肯雅病毒感染有关，12人与登革热有关，4人与黄热病有关。显著的后遗症包括基孔肯雅热引起的持续关节痛和寨卡感染婴儿的神经系统影响。31项研究的荟萃分析显示，有症状的回国旅行者的总患病率为0.047 （95% CI: 0.03-0.07）。结论：系统综述提供了20多年来欧洲伊蚊传播感染的全面概述，强调了受全球旅行模式、气候变化、伊蚊种群扩大传播和不断发展的公共卫生运动影响的病毒传播的动态性质。

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引用次数: 0