Pub Date : 2024-09-01DOI: 10.1016/j.tmaid.2024.102751
Ying Zhang , Yingzi Ming
Background
Despite the gradual decline of schistosomiasis due to the efforts of the WHO and various countries, with the WHO setting a goal to eliminate schistosomiasis by 2030, a comprehensive global assessment of the current status of schistosomiasis has not been conducted.
Objectives
To provide a detailed description of the changes in schistosomiasis from 1990 to 2019 by using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 database.
Methods
We obtained all relevant data on schistosomiasis worldwide from the Global Burden of Diseases (GBD) database from 1990 to 2019. The mortality, prevalence, disability-adjusted life-years (DALYs), Years of Life Lost (YLLs), Years Lived with Disability (YLDs) of schistosomiasis were examined by Socio-demographic Index (SDI), age, sex, and year at the global, region and national level.
Results
From 1990 to 2019, the age-standardized rate(ASR)-prevalence of schistosomiasis has decreased from 2600.9 per 100,000(95% uncertainty interval (UI) 2191.2 to 3059.3) to 1805.0 per 100,000(95% UI 1503.4 to 2146.9). The estimated annual percentage change (EAPC) from 1990 to 2019 was 1.28 (95% UI 1.22 to 1.33) in high SDI regions and −2.45 (95% UI −3.03 to −1.86) in low SDI regions. In North Africa and the Middle East, the most substantial reduction in DALYs occurred, with an observed EAPC of −5.36.
Conclusion
The burden of schistosomiasis has decreased over the past three decades worldwide. However, the high SDI regions have shown the increasing burden of schistosomiasis. Besides, Multiple countries in Africa still bear a significant burden of schistosomiasis, necessitating robust prevention and control efforts.
{"title":"Burden of schistosomiasis in global, regional, and national 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019","authors":"Ying Zhang , Yingzi Ming","doi":"10.1016/j.tmaid.2024.102751","DOIUrl":"10.1016/j.tmaid.2024.102751","url":null,"abstract":"<div><h3>Background</h3><p>Despite the gradual decline of schistosomiasis due to the efforts of the WHO and various countries, with the WHO setting a goal to eliminate schistosomiasis by 2030, a comprehensive global assessment of the current status of schistosomiasis has not been conducted.</p></div><div><h3>Objectives</h3><p>To provide a detailed description of the changes in schistosomiasis from 1990 to 2019 by using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 database.</p></div><div><h3>Methods</h3><p>We obtained all relevant data on schistosomiasis worldwide from the Global Burden of Diseases (GBD) database from 1990 to 2019. The mortality, prevalence, disability-adjusted life-years (DALYs), Years of Life Lost (YLLs), Years Lived with Disability (YLDs) of schistosomiasis were examined by Socio-demographic Index (SDI), age, sex, and year at the global, region and national level.</p></div><div><h3>Results</h3><p>From 1990 to 2019, the age-standardized rate(ASR)-prevalence of schistosomiasis has decreased from 2600.9 per 100,000(95% uncertainty interval (UI) 2191.2 to 3059.3) to 1805.0 per 100,000(95% UI 1503.4 to 2146.9). The estimated annual percentage change (EAPC) from 1990 to 2019 was 1.28 (95% UI 1.22 to 1.33) in high SDI regions and −2.45 (95% UI −3.03 to −1.86) in low SDI regions. In North Africa and the Middle East, the most substantial reduction in DALYs occurred, with an observed EAPC of −5.36.</p></div><div><h3>Conclusion</h3><p>The burden of schistosomiasis has decreased over the past three decades worldwide. However, the high SDI regions have shown the increasing burden of schistosomiasis. Besides, Multiple countries in Africa still bear a significant burden of schistosomiasis, necessitating robust prevention and control efforts.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102751"},"PeriodicalIF":6.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S147789392400067X/pdfft?md5=649351e9f2019b059a88b11421bab373&pid=1-s2.0-S147789392400067X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.tmaid.2024.102753
Ranjit Sah , Vasso Apostolopoulos , Rachana Mehta, Ranjana Rohilla, Sanjit Sah, Aroop Mohanty, Vini Mehta, Jack Feehan, Camila Luna, Francisco Javier Membrillo de Novales, Jaffar A. Al-Tawfiq, Antonio Cascio, Ana Johanna Samayoa-Bran, D. Katterine Bonilla-Aldana, Alfonso J. Rodriguez-Morales
{"title":"Mpox strikes once more in 2024: Declared again as a public health emergency of international concern","authors":"Ranjit Sah , Vasso Apostolopoulos , Rachana Mehta, Ranjana Rohilla, Sanjit Sah, Aroop Mohanty, Vini Mehta, Jack Feehan, Camila Luna, Francisco Javier Membrillo de Novales, Jaffar A. Al-Tawfiq, Antonio Cascio, Ana Johanna Samayoa-Bran, D. Katterine Bonilla-Aldana, Alfonso J. Rodriguez-Morales","doi":"10.1016/j.tmaid.2024.102753","DOIUrl":"10.1016/j.tmaid.2024.102753","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102753"},"PeriodicalIF":6.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S147789392400070X/pdfft?md5=12c923273d676b58e6254c6266eb74e9&pid=1-s2.0-S147789392400070X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.tmaid.2024.102732
Antoine Alvarez, Olivier Maillard, Yves-Marie Diarra, Antoine Bertolotti, Patrick Gérardin
{"title":"Corrigendum to “Hepatitis and secondary dengue on Reunion island” [Trav Med Infect Dis 59 (2024) 102717]","authors":"Antoine Alvarez, Olivier Maillard, Yves-Marie Diarra, Antoine Bertolotti, Patrick Gérardin","doi":"10.1016/j.tmaid.2024.102732","DOIUrl":"10.1016/j.tmaid.2024.102732","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102732"},"PeriodicalIF":6.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000486/pdfft?md5=b96643a517540382614bd30b64dcd8c0&pid=1-s2.0-S1477893924000486-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-24DOI: 10.1016/j.tmaid.2024.102752
L. Balerdi-Sarasola , C. Parolo , P. Fleitas , A. Cruz , C. Subirà , N. Rodríguez-Valero , A. Almuedo-Riera , L. Letona , M.J. Álvarez-Martínez , M Eugenia Valls , I. Vera , A. Mayor , J. Muñoz , D. Camprubí-Ferrer
{"title":"Corrigendum to “Host biomarkers for early identification of severe imported Plasmodium falciparum malaria” [Trav. Med. Infect. Dis. 54 (2023) 102608]","authors":"L. Balerdi-Sarasola , C. Parolo , P. Fleitas , A. Cruz , C. Subirà , N. Rodríguez-Valero , A. Almuedo-Riera , L. Letona , M.J. Álvarez-Martínez , M Eugenia Valls , I. Vera , A. Mayor , J. Muñoz , D. Camprubí-Ferrer","doi":"10.1016/j.tmaid.2024.102752","DOIUrl":"10.1016/j.tmaid.2024.102752","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102752"},"PeriodicalIF":6.3,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000693/pdfft?md5=bf8b9183c7fb053e24eeea842fc3e3a3&pid=1-s2.0-S1477893924000693-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142050090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-08DOI: 10.1016/j.tmaid.2024.102750
Mareen Braunstein , Markus Wörnle
Background
Emergency departments (ED) are frequently visited after suspected rabies exposure (SRE) and the potential need for rabies post-exposure prophylaxis (R-PEP). However, data on the number of visits, patients' demographics, travel history and the medical treatment is still rare. Therefore, the aim of this study was to assess the number of R-PEP and the appropriateness of medical management including wound treatment, vaccination regime and immunoglobulin application following SRE in a university hospital ED.
Method
We conducted a monocentric retrospective observational study on emergency patients treated in the ED of the LMU University Hospital, Ludwig-Maximilians-University Munich, Germany, between June 1st, 2023 and January 31st, 2024. Patients requiring post-exposure prophylaxis due to SRE abroad or in Germany were included. Demographic data, travel history, clinical findings, wound treatment, and R-PEP vaccination regimen were recorded.
Results
During the observation period of 245 days 43 patients presented to our ED for R-PEP. There was a total of 51 presentation appointments, as 5 patients returned for further treatment. Most patients (27, 52.9 %) presented at the ED on a Saturday, Sunday, or a public holiday. 17 (39.5 %) patients had a category II exposure, and 26 (60.5 %) had a category III exposure. In our ED, there were 28 (55.0 %) active vaccinations and 23 (45.0 %) both active and passive vaccinations.
Conclusions
Our data show that patients frequently present for R-PEP in ED. Therefore, there is a high need for education on indication for R-PEP and for implementation of precise R-PEP treatment guidelines in daily clinical practice.
{"title":"Rabies post-exposure prophylaxis in the emergency department: A monocentric retrospective observational study","authors":"Mareen Braunstein , Markus Wörnle","doi":"10.1016/j.tmaid.2024.102750","DOIUrl":"10.1016/j.tmaid.2024.102750","url":null,"abstract":"<div><h3>Background</h3><p>Emergency departments (ED) are frequently visited after suspected rabies exposure (SRE) and the potential need for rabies post-exposure prophylaxis (R-PEP). However, data on the number of visits, patients' demographics, travel history and the medical treatment is still rare. Therefore, the aim of this study was to assess the number of R-PEP and the appropriateness of medical management including wound treatment, vaccination regime and immunoglobulin application following SRE in a university hospital ED.</p></div><div><h3>Method</h3><p>We conducted a monocentric retrospective observational study on emergency patients treated in the ED of the LMU University Hospital, Ludwig-Maximilians-University Munich, Germany, between June 1st<sup>,</sup> 2023 and January 31st<sup>,</sup> 2024. Patients requiring post-exposure prophylaxis due to SRE abroad or in Germany were included. Demographic data, travel history, clinical findings, wound treatment, and R-PEP vaccination regimen were recorded.</p></div><div><h3>Results</h3><p>During the observation period of 245 days 43 patients presented to our ED for R-PEP. There was a total of 51 presentation appointments, as 5 patients returned for further treatment. Most patients (27, 52.9 %) presented at the ED on a Saturday, Sunday, or a public holiday. 17 (39.5 %) patients had a category II exposure, and 26 (60.5 %) had a category III exposure. In our ED, there were 28 (55.0 %) active vaccinations and 23 (45.0 %) both active and passive vaccinations.</p></div><div><h3>Conclusions</h3><p>Our data show that patients frequently present for R-PEP in ED. Therefore, there is a high need for education on indication for R-PEP and for implementation of precise R-PEP treatment guidelines in daily clinical practice.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102750"},"PeriodicalIF":6.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000668/pdfft?md5=659034fcf303c9a9474be79a580fc542&pid=1-s2.0-S1477893924000668-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-31DOI: 10.1016/j.tmaid.2024.102749
Pauline Di Paola, Christine Ngo Ngai, Margaux Froidefond, Barbara Doudier, Pierre Dudouet, Jean-Christophe Lagier, Coralie L’Ollivier, Coline Mortier
{"title":"Spontaneous regression of cutaneous lesions caused by Leishmania panamensis in a traveller returning from Costa Rica","authors":"Pauline Di Paola, Christine Ngo Ngai, Margaux Froidefond, Barbara Doudier, Pierre Dudouet, Jean-Christophe Lagier, Coralie L’Ollivier, Coline Mortier","doi":"10.1016/j.tmaid.2024.102749","DOIUrl":"10.1016/j.tmaid.2024.102749","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102749"},"PeriodicalIF":6.3,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000656/pdfft?md5=ad9b5fabe29e39f44f64f0f04a78598b&pid=1-s2.0-S1477893924000656-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-31DOI: 10.1016/j.tmaid.2024.102747
D. Henares , V. Monsalvez , Pedro Brotons , Maria Luisa Machado , Silvia Capilla , Aina Gomila-Grange , Paula Bierge , Meritxell Cubero , Oscar Q. Pich , Ana Requena-Méndez , C. Muñoz-Almagro , O. Gasch
Objective
The objective of this study was to evaluate whether long stays in non-European countries influence the composition, diversity, and dynamics of gut microbiota, considering the potential impact of travelling, close contact with new people, and consumption of water and food.
Methods
Two prospective cohorts were analyzed: (i) A longitudinal cohort comprising long-term travellers who provided fecal samples before and after their travels. (ii) A cohort consisting of long-term travellers and recently arrived migrants from non-European countries, which was compared with non-traveller controls. Each participant self-collected fecal samples and provided demographic and epidemiological data. Microbiota was characterized through 16 S rRNA gene sequencing.
Results
The longitudinal cohort comprised 17 subjects. A trend toward higher bacterial diversity was observed after travelling (Shannon index 3.12vs3.26). When comparing 84 travellers/migrants with 97 non-travellers, a confirmed association of higher diversity levels with travelling was observed (Phylogenetic diversity: 22.1vs20.9). Specific genera enriched in travellers' gut microbiota were identified, including Escherichia/Shigella, Bacteroides, and Parabacteroides. The analysis revealed three major clusters with profound differences in their bacterial composition, which exhibited differential distribution between travellers and non-travellers (Adonis P < 0.001; R2 = 30.6 %). Two clusters were more frequently observed in travellers: The first cluster, characterized by dominance of Escherichia/Shigella, exhibited the lowest levels of richness and diversity. The second cluster, dominated by Faecalibacterium and Bacteroides, displayed the highest richness and diversity patterns.
Conclusion
These findings highlight the diverse impact of international travel on gut microbiota composition and underscore the importance of considering microbiota resilience and diversity in understanding the health implications.
{"title":"Human gut microbiota composition associated with international travels","authors":"D. Henares , V. Monsalvez , Pedro Brotons , Maria Luisa Machado , Silvia Capilla , Aina Gomila-Grange , Paula Bierge , Meritxell Cubero , Oscar Q. Pich , Ana Requena-Méndez , C. Muñoz-Almagro , O. Gasch","doi":"10.1016/j.tmaid.2024.102747","DOIUrl":"10.1016/j.tmaid.2024.102747","url":null,"abstract":"<div><h3>Objective</h3><p>The objective of this study was to evaluate whether long stays in non-European countries influence the composition, diversity, and dynamics of gut microbiota, considering the potential impact of travelling, close contact with new people, and consumption of water and food.</p></div><div><h3>Methods</h3><p>Two prospective cohorts were analyzed: (i) A longitudinal cohort comprising long-term travellers who provided fecal samples before and after their travels. (ii) A cohort consisting of long-term travellers and recently arrived migrants from non-European countries, which was compared with non-traveller controls. Each participant self-collected fecal samples and provided demographic and epidemiological data. Microbiota was characterized through 16 S rRNA gene sequencing.</p></div><div><h3>Results</h3><p>The longitudinal cohort comprised 17 subjects. A trend toward higher bacterial diversity was observed after travelling (Shannon index 3.12<em>vs</em>3.26). When comparing 84 travellers/migrants with 97 non-travellers, a confirmed association of higher diversity levels with travelling was observed (Phylogenetic diversity: 22.1<em>vs</em>20.9). Specific genera enriched in travellers' gut microbiota were identified, including <em>Escherichia/Shigella, Bacteroides,</em> and <em>Parabacteroides</em>. The analysis revealed three major clusters with profound differences in their bacterial composition, which exhibited differential distribution between travellers and non-travellers (Adonis P < 0.001; R2 = 30.6 %). Two clusters were more frequently observed in travellers: The first cluster, characterized by dominance of <em>Escherichia/Shigella,</em> exhibited the lowest levels of richness and diversity. The second cluster, dominated by <em>Faecalibacterium</em> and <em>Bacteroides</em>, displayed the highest richness and diversity patterns.</p></div><div><h3>Conclusion</h3><p>These findings highlight the diverse impact of international travel on gut microbiota composition and underscore the importance of considering microbiota resilience and diversity in understanding the health implications.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102747"},"PeriodicalIF":6.3,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000632/pdfft?md5=8379c9e1e0e1721a3e295756e8dec7e7&pid=1-s2.0-S1477893924000632-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-30DOI: 10.1016/j.tmaid.2024.102748
Daniel Celis-Giraldo, María Alejandra Fajardo, Diana Camila Romo Arteaga, Álvaro A. Faccini-Martínez
{"title":"Primaquine-induced hemolysis in a Colombian patient with glucose-6-phosphate dehydrogenase deficiency","authors":"Daniel Celis-Giraldo, María Alejandra Fajardo, Diana Camila Romo Arteaga, Álvaro A. Faccini-Martínez","doi":"10.1016/j.tmaid.2024.102748","DOIUrl":"10.1016/j.tmaid.2024.102748","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102748"},"PeriodicalIF":6.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000644/pdfft?md5=4e3c5f2ceb640fbbd38d59d2c5ab4a44&pid=1-s2.0-S1477893924000644-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-23DOI: 10.1016/j.tmaid.2024.102744
Joaquín Salas-Coronas , M. Dolores Bargues , Pedro Fernández-Soto , Manuel J. Soriano-Pérez , Patricio Artigas , José Vázquez-Villegas , Antonio Villarejo-Ordoñez , José C. Sánchez-Sánchez , María I. Cabeza-Barrera , Begoña Febrer-Sendra , Alejandra De Elías-Escribano , Beatriz Crego-Vicente , María C. Fantozzi , Juan García-Bernalt Diego , Nerea Castillo-Fernández , Jaime Borrego-Jiménez , Antonio Muro , María P. Luzón-García
Background
Species hybridization represents a real concern in terms of parasite transmission, epidemiology and morbidity of schistosomiasis. It is greatly important to better understand the impact of species hybridization for the clinical management.
Methods
A prospective observational study was carried out in sub-Saharan migrants who were diagnosed with confirmed genitourinary schistosomiasis. A tailored protocol was applied, including Schistosoma serology, a specific urine LAMP tests for schistosomiasis and an ultrasound examination before treatment with praziquantel. A scheduled follow-up was performed at 3, 6 and 12 months to monitor treatment response, comparing patients carriers of Schistosoma hybrids with carriers of only genetically pure forms.
Results
A total of 31 male patients from West Africa were included in the study with a mean age of 26.5 years. Twelve (38.7 %) of the patients were carriers of Schistosoma hybrids. As compared with patients infected with S. haematobium alone, hybrid carriers had lower haemoglobin levels (13.8 g/dL [SD 1.8] vs 14.8 g/dL [SD 1.4], p = 0.04), a greater frequency of hematuria (100 % vs 52.6 %, p = 0.005), a higher ultrasound score (2.64, SD 2.20 vs 0.89, SD 0.99; p = 0.02). However, the presence of hybrids did not result in differences in clinical and analytical responses after treatment.
Conclusions
The presence of Schistosoma hybrids seems to cause increased morbidity in infected individuals. However, it does not appear to result in differences in diagnostic tests or in clinical and analytical responses after treatment.
背景:物种杂交是血吸虫病寄生虫传播、流行病学和发病率方面的一个现实问题。更好地了解物种杂交对临床管理的影响非常重要:方法:对确诊患有泌尿生殖系统血吸虫病的撒哈拉以南地区移民进行了一项前瞻性观察研究。在使用吡喹酮治疗前,采用了一套量身定制的方案,包括血吸虫血清学检查、血吸虫特异性尿液 LAMP 检测和超声波检查。在3个月、6个月和12个月时进行定期随访,以监测治疗反应,并将血吸虫杂合型携带者与纯合型携带者进行比较:共有31名来自西非的男性患者参与了研究,他们的平均年龄为26.5岁。其中 12 名患者(38.7%)为血吸虫杂交型携带者。与单纯感染血吸虫的患者相比,血吸虫杂交携带者的血红蛋白水平较低(13.8 g/dL [SD 1.8] vs 14.8 g/dL [SD 1.4],p=0.04),出现血尿的频率较高(100% vs 52.6%,p= 0.005),超声波评分较高(2.64,SD 2.20 vs 0.89,SD 0.99;p= 0.02)。然而,杂合体的存在并未导致治疗后临床和分析反应的差异:结论:血吸虫杂交体的存在似乎会增加感染者的发病率。结论:血吸虫杂交体的存在似乎会增加感染者的发病率,但似乎不会导致诊断测试或治疗后临床和分析反应的差异。
{"title":"Impact of species hybridization on the clinical management of schistosomiasis: A prospective study","authors":"Joaquín Salas-Coronas , M. Dolores Bargues , Pedro Fernández-Soto , Manuel J. Soriano-Pérez , Patricio Artigas , José Vázquez-Villegas , Antonio Villarejo-Ordoñez , José C. Sánchez-Sánchez , María I. Cabeza-Barrera , Begoña Febrer-Sendra , Alejandra De Elías-Escribano , Beatriz Crego-Vicente , María C. Fantozzi , Juan García-Bernalt Diego , Nerea Castillo-Fernández , Jaime Borrego-Jiménez , Antonio Muro , María P. Luzón-García","doi":"10.1016/j.tmaid.2024.102744","DOIUrl":"10.1016/j.tmaid.2024.102744","url":null,"abstract":"<div><h3>Background</h3><p>Species hybridization represents a real concern in terms of parasite transmission, epidemiology and morbidity of schistosomiasis. It is greatly important to better understand the impact of species hybridization for the clinical management.</p></div><div><h3>Methods</h3><p>A prospective observational study was carried out in sub-Saharan migrants who were diagnosed with confirmed genitourinary schistosomiasis. A tailored protocol was applied, including <em>Schistosoma</em> serology, a specific urine LAMP tests for schistosomiasis and an ultrasound examination before treatment with praziquantel. A scheduled follow-up was performed at 3, 6 and 12 months to monitor treatment response, comparing patients carriers of <em>Schistosoma</em> hybrids with carriers of only genetically pure forms.</p></div><div><h3>Results</h3><p>A total of 31 male patients from West Africa were included in the study with a mean age of 26.5 years. Twelve (38.7 %) of the patients were carriers of <em>Schistosoma</em> hybrids. As compared with patients infected with <em>S. haematobium</em> alone, hybrid carriers had lower haemoglobin levels (13.8 g/dL [SD 1.8] vs 14.8 g/dL [SD 1.4], p = 0.04), a greater frequency of hematuria (100 % <em>vs</em> 52.6 %, p = 0.005), a higher ultrasound score (2.64, SD 2.20 vs 0.89, SD 0.99; p = 0.02). However, the presence of hybrids did not result in differences in clinical and analytical responses after treatment.</p></div><div><h3>Conclusions</h3><p>The presence of <em>Schistosoma</em> hybrids seems to cause increased morbidity in infected individuals. However, it does not appear to result in differences in diagnostic tests or in clinical and analytical responses after treatment.</p></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102744"},"PeriodicalIF":6.3,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000607/pdfft?md5=4ec115016baa650e8c87d491a5132279&pid=1-s2.0-S1477893924000607-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.1016/j.tmaid.2024.102746
Pierluigi Francesco Salvo, Gianmaria Baldin, Elena Visconti, Simona Di Giambenedetto
{"title":"Necrotizing mpox with persistent microbiological positivity despite the use of tecovirimat: A case report","authors":"Pierluigi Francesco Salvo, Gianmaria Baldin, Elena Visconti, Simona Di Giambenedetto","doi":"10.1016/j.tmaid.2024.102746","DOIUrl":"10.1016/j.tmaid.2024.102746","url":null,"abstract":"","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"61 ","pages":"Article 102746"},"PeriodicalIF":6.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1477893924000620/pdfft?md5=08d5d947215ca3b3272a25ae86577697&pid=1-s2.0-S1477893924000620-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}