Travel Medicine and Infectious Disease最新文献_第5页

Clinical features and outcomes of dengue and scrub typhus in hospitalized adults in the Maldives 马尔代夫住院成人登革热和恙虫病的临床特征和结局

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-10-01 DOI: 10.1016/j.tmaid.2025.102914

Rajib Kumar Dey , Fernando Mosler , Rifau Adam , Isha Ali , Aishath Sausan , Zaidhoon Jaleel , Rashda Mahir , Izza Abdul Habeeb , Aishath Maeesha , Nihla Ali Rasheed , Aminath Aroosha , Wasin Matsee , Hisham Ahmed Imad

Background

Dengue and scrub typhus are common causes of acute undifferentiated febrile illness in the Maldives.

Methods

This retrospective study compared the clinical characteristics of 184 hospitalized adults diagnosed with dengue (n = 94) or scrub typhus (n = 90) at a national referral hospital in the Maldives. Clinical data were collected from 2013 to 2021 for scrub typhus and from 2018 to 2021 for dengue, identified using ICD-10 codes from both physical and electronic records. National dengue and scrub typhus data from 2015 to 2024 were obtained from the Health Protection Agency of the Maldives.

Results

Scrub typhus patients were generally older, with a median age of 42.5 years compared to 27 years in dengue, were more often locals, and tended to present later in the course of illness, on day 10 compared to day 4. Furthermore, scrub typhus patients experienced more complications, 23.9 % compared to 3.2 % in dengue, which resulted in longer hospital stays. An eschar was observed in 63.1 % of scrub typhus cases, serving as a useful diagnostic clue. In contrast, dengue patients more often presented with chills, myalgia, arthralgia, bleeding, and thrombocytopenia. There were no fatalities in this cohort.

Conclusions

In acute undifferentiated febrile illness in the Maldives, certain clinical indicators, including eschar for scrub typhus and bleeding with severe thrombocytopenia can aid in bedside diagnosis. Identifying these features can help clinicians in resource-limited settings provide timely and appropriate care.

背景：登革热和恙虫病是马尔代夫急性未分化发热性疾病的常见病因。方法：本回顾性研究比较了184名在马尔代夫一家国家转诊医院诊断为登革热（n = 94）或恙虫病（n = 90）的住院成人的临床特征。收集了2013年至2021年恙虫病的临床数据和2018年至2021年登革热的临床数据，使用来自物理和电子记录的ICD-10代码进行识别。2015年至2024年的全国登革热和丛林斑疹伤寒数据来自马尔代夫卫生保护局。结果：恙虫病患者一般年龄较大，中位年龄为42.5岁，而登革热患者的中位年龄为27岁，多为当地人，且往往在病程较晚出现，第10天出现，而第4天出现。此外，恙虫病患者出现更多并发症（23.9%），而登革热患者为3.2%，这导致住院时间更长。63.1%的恙虫病病例有瘢痕，可作为诊断恙虫病的有效线索。相比之下，登革热患者更常表现为寒战、肌痛、关节痛、出血和血小板减少。该队列中没有死亡病例。结论：在马尔代夫的急性未分化发热性疾病中，某些临床指标，包括恙虫病的焦痂和严重血小板减少的出血，可以帮助床边诊断。识别这些特征可以帮助资源有限的临床医生提供及时和适当的护理。

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引用次数: 0

Ready for takeoff? exploring United States health care providers’ pretravel consultation priorities, gaps, barriers, and opportunities 准备起飞了吗？探索美国医疗保健提供者旅行前咨询的优先事项、差距、障碍和机会

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-09-30 DOI: 10.1016/j.tmaid.2025.102911

Katherine A. Reifler , Swati S. Sharma , Nicholas A. Bergren , Elizabeth D. Barnett , Lin H. Chen , Jeffery A. Goad , William B. Macleod , Laura Kogelman , Davidson H. Hamer

Pretravel consultation by healthcare providers (HCPs) with travel medicine expertise can mitigate travel-related health risks. This analysis aimed to understand US-based HCPs' pretravel consultation educational gaps, priorities, barriers, and opportunities. An electronic survey was conducted May–June 2024, using a convenience sample of HCPs identified through the Med Learning Group and travel specialists from the International Society of Travel Medicine and American Society of Tropical Medicine and Hygiene. In total, 205 HCPs completed the survey, including physicians (50 %), nurse practitioners (19 %), nurses (12 %), pharmacists (11 %), physician associates (7 %). Most (66 %) provided pretravel consultations and only 21 % held formal travel medicine certification. HCPs not providing pretravel consultation were less comfortable with traveler's diarrhea self-treatment, malaria chemoprophylaxis, altitude illness prevention, yellow fever, Japanese encephalitis, rabies, and typhoid vaccination management. The most desired topics for education were travel vaccinations (94, 46 %), travel medicine insurance (89, 43 %), and altitude illness prevention (86, 42 %). Major barriers to providing pretravel consultation were lack of clarity about reimbursement (110, 54 %), lack of insurance coverage (89, 43 %), and inability to stock travel vaccines (73, 36 %). Top interventions suggested to increase access to and awareness of pretravel consultation included primary care physician education and community outreach. Most HCPs were interested in pretravel educational opportunities, but comfort varied by experience and certification, highlighting need for targeted training, especially for primary care providers. Top barriers were insurance coverage for pretravel consultation and access to travel vaccines, underscoring critical gaps in the US healthcare system.

具有旅行医学专业知识的医疗保健提供者（HCPs）在旅行前进行咨询可以减轻与旅行相关的健康风险。本分析旨在了解美国HCPs旅行前咨询的教育差距、优先事项、障碍和机会。2024年5月至6月进行了一项电子调查，使用了医学学习小组和国际旅行医学学会和美国热带医学与卫生学会的旅行专家确定的方便样本。共有205名医护人员完成了调查，包括医生（50%）、执业护士（19%）、护士（12%）、药剂师（11%）、医师助理（7%）。大多数（66%）提供旅行前咨询，只有21%持有正式的旅行医学认证。未提供旅行前咨询的医务人员对旅行者腹泻自我治疗、疟疾化学预防、高原病预防、黄热病、日本脑炎、狂犬病和伤寒疫苗接种管理不太满意。最想要的教育主题是旅行疫苗接种（94,46%）、旅行医疗保险（89,43%）和高原疾病预防（86,42%）。提供旅行前咨询的主要障碍是缺乏明确的报销（110.54%）、缺乏保险覆盖（89.43%）和无法储存旅行疫苗（73.36%）。建议的主要干预措施包括初级保健医生教育和社区外展，以增加旅行前咨询的机会和认识。大多数医护人员对旅行前的教育机会感兴趣，但根据经验和证书的不同，舒适度也有所不同，这突出了对有针对性培训的需求，特别是对初级保健提供者。最大的障碍是旅行前咨询的保险覆盖和获得旅行疫苗，这突出了美国医疗保健系统的重大差距。

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引用次数: 0

Intermittent preventive treatment regimens for malaria in HIV-positive pregnant women: Systematic review and meta-analysis of clinical trials hiv阳性孕妇疟疾间歇预防治疗方案：临床试验的系统回顾和荟萃分析。

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-09-17 DOI: 10.1016/j.tmaid.2025.102908

Ammar Elgadi , Tibyan Noorallah , Egbal Abdelazim , Sara Altraifi , Hajir Altraifi , Ammar Elhaj , Walaa Elnaiem , Lina Hemmeda

Background

The WHO recommended the use of intermittent preventive treatment (IPT) regimens for malaria in HIV-positive pregnant women living in endemic areas to prevent malaria-related perinatal complications. However, the high drug resistance rates make the effectiveness of the various available options questionable.

Methods

This systematic review and meta-analysis was conducted according to the PRISMA guidelines and registered in Prospero (ID: CRD42024579942). PubMed, Scopus, and Cochrane libraries were searched in June 2024 for relevant studies. Randomized clinical trials reporting the use of ITP for malaria in HIV-infected pregnant women were included. The incidence of peripheral malaria diagnosis was our primary extracted outcome. RevMan 5.3 was used for meta-analysis.

Results

Thirteen clinical trials with 5226 HIV-positive pregnant patients were included. ITP showed 55 % lower odds of malaria during pregnancy or at delivery (OR = 0.45, 95 % CI: 0.36, 0.56, P ≤ 0.001), with IPTp-DP (Dihydroartemisinin-Piperaquine) being the most effective regimen. However, despite reducing the odds of placental malaria by 48 % (OR = 0.52, 95 % CI: 0.39, 0.70, P ≤ 0.001), ITP showed no significant effect on low birth weight, fetal loss, stillbirth, or preterm labor. Furthermore, IPT reduces the odds of maternal anemia by 18 % (OR = 0.82, 95 % CI: 0.69, 0.97, P = 0.03).

Conclusion

IPT was shown to be effective in reducing malaria-related maternal complications, including malaria during pregnancy, at delivery, or placental and maternal anemia. However, it showed no effective impact on adverse birth outcomes. Further research may be necessary to explore birth-related outcomes.

背景：世卫组织建议生活在疟疾流行地区的艾滋病毒阳性孕妇使用间歇性预防治疗（IPT）方案，以预防与疟疾相关的围产期并发症。然而，高耐药率使各种可用选择的有效性受到质疑。方法：本系统评价和荟萃分析按照PRISMA指南进行，并在Prospero注册（ID: CRD42024579942）。PubMed、Scopus和Cochrane图书馆于2024年6月检索了相关研究。纳入了报告在感染艾滋病毒的孕妇中使用ITP治疗疟疾的随机临床试验。外周疟疾诊断的发生率是我们的主要提取结果。采用RevMan 5.3进行meta分析。结果：纳入13项临床试验5226例hiv阳性孕妇。ITP显示妊娠期或分娩时疟疾发生率降低55% (or = 0.45, 95% CI: 0.36, 0.56, P≤0.001),IPTp-DP（双氢青蒿素-哌喹）是最有效的方案。然而，尽管ITP使胎盘疟疾的发生率降低了48% (OR = 0.52, 95% CI: 0.39, 0.70, P≤0.001)，但ITP对低出生体重、胎儿丢失、死胎或早产没有显著影响。此外，IPT使母体贫血的几率降低18% （OR = 0.82, 95% CI: 0.69, 0.97, P = 0.03）。结论：IPT可有效减少与疟疾相关的孕产妇并发症，包括妊娠、分娩或胎盘和孕产妇贫血期间的疟疾。然而，它没有显示出对不良出生结局的有效影响。可能需要进一步的研究来探索与出生相关的结果。

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引用次数: 0

Biodiversity of malaria ecosystems, challenges for control: When human diversity is forgotten 疟疾生态系统的生物多样性，控制的挑战：当人类的多样性被遗忘

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-09-01 DOI: 10.1016/j.tmaid.2025.102887

Florence Fouque , Konstantina Boutsika

Malaria has been affecting human beings since ever through a great biodiversity of transmission contexts, and only recently this vector-borne parasitic disease was controlled and eliminated due to the progress in the knowledge of the pathogens, the mosquito vectors and the transmission cycles, but also technological advances in diagnostic, prevention and control tools targeting both the parasite and the vector.

Within the past 150 years malaria was eliminated from all temperate countries of the northern hemisphere, and this success triggered the belief that human malaria could be eradicated with simple tools such as environmental management, impregnated nets and treatments. But this did not happen, and a resurgence of malaria burden started about 50 years ago, affecting mostly sub-Saharan Africa. Consequently, a strong worldwide mobilization after the 2000s was followed by a new decline of malaria incidence and a strong decline in malaria mortality, but the diversity of the transmission contexts did not allow the continuation of declined incidence. Further, this situation was concomitant with a great upsurge on mobility of human populations due to different reasons. Malaria control is now at crossroads where access to health is the main driver of the disease. Reaching the hard to reach and mobile populations will be essential to continue the progress on malaria control.

疟疾一直通过多种传播环境影响着人类，直到最近，由于对病原体、蚊子媒介和传播周期的认识取得进展，以及针对寄生虫和媒介的诊断、预防和控制工具方面的技术进步，这种病媒传播的寄生虫病才得到控制和消除。在过去的150年里，北半球所有温带国家都消灭了疟疾，这一成功引发了人们的信念，即人类疟疾可以通过环境管理、浸渍蚊帐和治疗等简单工具根除。但这并没有发生，大约50年前，疟疾负担重新抬头，主要影响撒哈拉以南非洲地区。因此，本世纪头十年后，在全球范围内进行了强有力的动员之后，疟疾发病率出现了新的下降，疟疾死亡率也出现了大幅下降，但传播环境的多样性不允许发病率继续下降。此外，这种情况还伴随着由于各种原因造成的人口流动的急剧增加。疟疾控制目前处于十字路口，获得卫生保健是该疾病的主要驱动因素。接触难以接触到的人口和流动人口对于继续在疟疾控制方面取得进展至关重要。

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引用次数: 0

Assessing scalability factors of a malaria intervention using Malakit and target drug administration among hard-to-reach populations: An original approach focusing on key stakeholders – implementers and decision-makers – in the Guiana shield 在难以接触到的人群中评估使用Malakit和靶向药物管理的疟疾干预措施的可扩展性因素：一种侧重于圭亚那盾的关键利益相关者（实施者和决策者）的原始方法

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-09-01 DOI: 10.1016/j.tmaid.2025.102847

Carlotta Carboni , Alice Sanna , Yann Lambert , Lorraine Plessis , Teddy Bardon , Antoine Adenis , Mathieu Nacher , Stephen Vreden , Martha Suárez-Mutis , Maylis Douine

Introduction

The Guiana Shield faces significant malaria challenges due to a mobile, hard-to-reach population involved in goldmining. Interventions like Malakit (self-testing and self-treatment kits), Targeted Drug Administration against P. vivax, or their combination, aim to combat malaria. These community-based interventions, evaluated in Brazil, French Guiana, and Suriname, show promising results and potential for scale-up. The research aimed to assess the scalability of these interventions by identifying and mapping stakeholders and doing a SWOT analysis for scale-up.

Methods

This pre-planning assessment, conducted from June 2023 to March 2024, involved a collaborative, participatory approach. The process included working sessions with the resource team, semi-structured interviews with stakeholders, and participant observation during formal meetings with stakeholders and the resource team. Field notes have been taken and deductive qualitative analysis has been made using the ExpandNet/WHO Framework. Data was used to design Mendelow's Matrix and SWOT analysis.

Results

Stakeholders were categorized into implementers, decision-makers, beneficiaries, and partners. Mendelow's matrix and SWOT analysis highlighted strengths like Malakit's effectiveness, while weaknesses included data gaps and regulatory challenges. Opportunities for scaling up were linked to malaria elimination initiatives in Brazil, French Guiana, and Suriname, while funding and regulatory issues posed threats.

Discussion and conclusion

Stakeholder analysis is crucial in scaling up public health interventions, identifying key contributors and challenges. Financial and regulatory barriers can hinder scalability, but political and epidemiological factors offer opportunities. Effective collaboration across countries, engaging stakeholders, and advocating for evidence-based decisions are essential for malaria elimination in Brazil, French Guiana, and Suriname.

圭亚那地盾面临着重大的疟疾挑战，因为那里有从事金矿开采的流动人口，难以接触到他们。Malakit（自我检测和自我治疗工具包）、针对间日疟原虫的靶向药物管理或它们的组合等干预措施旨在对抗疟疾。在巴西、法属圭亚那和苏里南对这些以社区为基础的干预措施进行了评估，显示出有希望的结果和扩大规模的潜力。该研究旨在通过识别和绘制利益相关者并对规模进行SWOT分析来评估这些干预措施的可扩展性。方法本次规划前评估于2023年6月至2024年3月开展，采用协作、参与式方法。该过程包括与资源团队的工作会议，与利益相关者的半结构化访谈，以及在与利益相关者和资源团队的正式会议期间的参与者观察。利用扩展网/世卫组织框架进行了实地记录和演绎定性分析。采用数据设计门德罗矩阵和SWOT分析。利益相关者被分为实施者、决策者、受益者和合作伙伴。Mendelow的矩阵和SWOT分析突出了Malakit的优势，如有效性，而劣势包括数据缺口和监管挑战。扩大规模的机会与巴西、法属圭亚那和苏里南的消除疟疾行动有关，而资金和监管问题则构成威胁。讨论和结论利益相关者分析对于扩大公共卫生干预措施、确定主要贡献者和挑战至关重要。金融和监管障碍可能阻碍可扩展性，但政治和流行病学因素提供了机会。在巴西、法属圭亚那和苏里南消除疟疾的过程中，各国之间的有效合作、利益攸关方的参与以及倡导基于证据的决策至关重要。

{"title":"Assessing scalability factors of a malaria intervention using Malakit and target drug administration among hard-to-reach populations: An original approach focusing on key stakeholders – implementers and decision-makers – in the Guiana shield","authors":"Carlotta Carboni , Alice Sanna , Yann Lambert , Lorraine Plessis , Teddy Bardon , Antoine Adenis , Mathieu Nacher , Stephen Vreden , Martha Suárez-Mutis , Maylis Douine","doi":"10.1016/j.tmaid.2025.102847","DOIUrl":"10.1016/j.tmaid.2025.102847","url":null,"abstract":"<div><h3>Introduction</h3><div>The Guiana Shield faces significant malaria challenges due to a mobile, hard-to-reach population involved in goldmining. Interventions like Malakit (self-testing and self-treatment kits), Targeted Drug Administration against <em>P. vivax</em>, or their combination, aim to combat malaria. These community-based interventions, evaluated in Brazil, French Guiana, and Suriname, show promising results and potential for scale-up. The research aimed to assess the scalability of these interventions by identifying and mapping stakeholders and doing a SWOT analysis for scale-up.</div></div><div><h3>Methods</h3><div>This pre-planning assessment, conducted from June 2023 to March 2024, involved a collaborative, participatory approach. The process included working sessions with the resource team, semi-structured interviews with stakeholders, and participant observation during formal meetings with stakeholders and the resource team. Field notes have been taken and deductive qualitative analysis has been made using the ExpandNet/WHO Framework. Data was used to design Mendelow's Matrix and SWOT analysis.</div></div><div><h3>Results</h3><div>Stakeholders were categorized into implementers, decision-makers, beneficiaries, and partners. Mendelow's matrix and SWOT analysis highlighted strengths like Malakit's effectiveness, while weaknesses included data gaps and regulatory challenges. Opportunities for scaling up were linked to malaria elimination initiatives in Brazil, French Guiana, and Suriname, while funding and regulatory issues posed threats.</div></div><div><h3>Discussion and conclusion</h3><div>Stakeholder analysis is crucial in scaling up public health interventions, identifying key contributors and challenges. Financial and regulatory barriers can hinder scalability, but political and epidemiological factors offer opportunities. Effective collaboration across countries, engaging stakeholders, and advocating for evidence-based decisions are essential for malaria elimination in Brazil, French Guiana, and Suriname.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102847"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimation of the magnitude of plastic and chemical pollution related to the abandonment of insecticide treated nets in the environment: From a KAP survey conducted in Benin in July 2023 与环境中废弃杀虫剂处理过的蚊帐有关的塑料和化学污染程度的估计：来自2023年7月在贝宁进行的一项KAP调查

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-09-01 DOI: 10.1016/j.tmaid.2025.102826

Rachidou Ouorou , Ibigbé Amour Sabin Bohissou , Prudence Kuessi , Frédérick Gay

Background

Malaria remains a significant public health threat, particularly in vulnerable populations. Insecticide-treated mosquito nets (ITNs) have been a cornerstone of malaria prevention efforts for decades. ITNs have demonstrably reduced malaria morbidity and mortality. However, their widespread use has raised concerns about a potential unintended consequence: environmental pollution.

Methods

To assess the potential environmental impact of ITNs in a real-world setting, a Knowledge, Attitudes and Practices (KAP) survey was conducted in Djougou, a high malaria burden in Northen Benin. The survey employed a two-stage stratified random sampling approach.

Results

There is an average of 2.4 people per ITN. Half of the ITNs are less than 2 months old, indicating a recent distribution campaign. The reported ITNs used the night before the survey was 73 %. Over half of the households (52 %) reported losing at least one ITN in the past year, with an average of 2.53 nets lost per household. The most common ITN brand contains alpha-cypermethrin and chlorfenapyr insecticides. We can estimate that Djougou releases approximately 133 kg of insecticides and 57.6 tons of plastic waste annually from discarded ITNs. Extrapolations to Benin and to Sub-Saharan Africa suggest a large potential environmental impacts.

Conclusion

The study highlights a potential environmental challenge associated with large-scale ITN use – plastic and insecticide waste from discarded nets. Further research is needed to quantify the environmental impact of abandoned nets. ITNs distribution programs should be complemented by collection and potential recycling initiatives. A circular economy approach could transform waste into a resource for fuel generation.

疟疾仍然是一个重大的公共卫生威胁，特别是在脆弱人群中。几十年来，经杀虫剂处理的蚊帐一直是疟疾预防工作的基石。蚊帐明显降低了疟疾发病率和死亡率。然而，它们的广泛使用引发了人们对潜在的意外后果的担忧：环境污染。方法为了评估ITNs在现实环境中的潜在环境影响，在贝宁北部疟疾高负担地区Djougou开展了一项知识、态度和实践（KAP）调查。调查采用两阶段分层随机抽样方法。结果平均每个ITN有2.4人。一半的蚊帐使用不到两个月，这表明最近进行了一次分发活动。调查前一晚报告的itn使用率为73%。超过一半的家庭（52%）报告在过去一年中至少损失了一顶蚊帐，平均每户损失2.53顶蚊帐。最常见的ITN品牌含有高效氯氰菊酯和氯虫腈杀虫剂。我们可以估计，Djougou每年从废弃的ITNs中释放约133公斤杀虫剂和57.6吨塑料废物。对贝宁和撒哈拉以南非洲的推断表明，潜在的巨大环境影响。该研究强调了与大规模使用ITN相关的潜在环境挑战——废弃蚊帐产生的塑料和杀虫剂废物。需要进一步研究以量化废弃渔网对环境的影响。ITNs的分发计划应辅以收集和潜在的再循环倡议。循环经济方法可以将废物转化为燃料生产的资源。

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引用次数: 0

Prevalence of health problems related to marine tourism among travelers in the Andaman Coast provinces of Southern Thailand 泰国南部安达曼海岸各省游客中与海洋旅游有关的健康问题的流行情况。

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-09-01 DOI: 10.1016/j.tmaid.2025.102913

Vitat Tipphayawong , Pat Chantapinya , Ranida Techasuwanna , Amornphat Kitro

Background

Marine tourism is increasing in popularity in Thailand, contributing to a rise in associated medical issues. The aim of this report was to assess the prevalence and severity of marine-related health problems and associated risk factors.

Methods

A retrospective study was conducted from October 2021 to September 2024 across three healthcare centers in southern Thailand.

Results

520 cases were analyzed, 57 % (n = 295) were male and 93.7 % (n = 487) were international travelers, 62.7 % (n = 326) from Europe. Common diagnoses included marine envenomation (24.0 %, n = 125), ear infection (21.7 %, n = 113), and trauma (18.7 %, n = 97). Most health incidents occurred coastal areas (46.7 %, n = 243). 29.0 % (n = 151) visited emergency department and 6.0 % (n = 31) resulted in death. Severe outcomes were associated with male gender, age over 40 years, and sea-based activities.

Conclusion

Most marine-related health issues were non-severe, specific risks varied by location, highlighting the need for location-specific preventive measures.

背景：海洋旅游在泰国越来越受欢迎，导致相关医疗问题的增加。本报告的目的是评估与海洋有关的健康问题的普遍程度和严重程度以及相关的风险因素。方法：回顾性研究于2021年10月至2024年9月在泰国南部的三个医疗中心进行。结果：520例病例中，男性占57% (n=295)，国际旅行者占93.7% (n=487)，其中欧洲旅行者占62.7% （n=326）。常见的诊断包括海洋中毒（24.0%,n=125）、耳部感染（21.7%,n=113）和外伤（18.7%,n=97）。大多数健康事故发生在沿海地区（46.7%,n = 243）。29.0% （n=151）就诊于急诊科，6.0% （n=31）死亡。严重的结果与男性、年龄超过40岁和海上活动有关。结论：大多数与海洋有关的健康问题不严重，具体风险因地点而异，强调需要采取针对地点的预防措施。

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引用次数: 0

Genetic characterization of enteric protozoan microorganisms in newly arrived migrants in Italy and correlation with the gut microbiome layout 意大利新移民肠道原生动物微生物的遗传特征及其与肠道微生物群布局的相关性

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-09-01 DOI: 10.1016/j.tmaid.2025.102901

Marianna Marangi , Giorgia Palladino , Felice Valzano , Daniel Scicchitano , Silvia Turroni , Simone Rampelli , Marco Candela , Fabio Arena

The prevalence of the enteric protozoan microorganisms, its genetic characterization as well as its associated gut microbiome has been molecularly and 16S metagenomic characterized in a cohort of newly arrived migrants in Italy from African countries over the period 2022–2024. Out of 199 individuals, 92 (46.2%) were found to be carrier of protozoan microorganisms with a higher prevalence of Blastocystis sp. (15.5%), followed by Giardia duodenalis (12.6%), Dientamoeba fragilis (7.5%), Cryptosporidium parvum (6.5%), and Entamoeba histolytica (4%). Subtypes ST1, ST2 and ST3 were genetically characterized for Blastocystis sp., assemblages A and B for G. duodenalis, subtypes families IIa and IIc for C. parvum and genotype 1 for D. fragilis. High prevalence of Butyrivibrio, Lachnospiraceae UGC 10 and Paraprevotella, were identified in the protozoan non-carrier individual group. This work shed lights on the circulation of enteric protozoan microorganisms in apparently healthy migrants from African countries and the potential relationship with the host-microbiome composition. Moreover, these results give an overview of the importance of microbiological surveys among migrants and asylum seekers arriving to hosting countries in order to evaluate the reliable risk of several microorganisms introduction though migration. Ultimately, further investigation of interplays between the intestinal microbiota and protozoan microorganisms will provide new approaches in the diagnosis and treatment of intestinal infections.

在2022-2024年期间从非洲国家来到意大利的一组新移民中，对肠道原生动物微生物的流行、遗传特征及其相关肠道微生物组进行了分子和16S宏基因组特征分析。199个个体中，92个（46.2% %）携带原生动物微生物，其中囊虫（15.5% %）患病率较高，其次是十二指肠贾第虫（12.6% %）、脆弱地阿米巴（7.5% %）、细小隐孢子虫（6.5% %）和溶组织内阿米巴（4% %）。Blastocystis sp.的ST1、ST2和ST3亚型，G. duodenalis的A和B组合，C. parum的IIa和IIc亚型，D. fragilis的1基因型。在原生动物非携带者个体组中，发现丁酸弧菌、毛螺科UGC 10和Paraprevotella高发。这项工作阐明了肠道原生动物微生物在来自非洲国家的明显健康移民中的循环，以及与宿主-微生物组组成的潜在关系。此外，这些结果概述了在抵达东道国的移民和寻求庇护者中进行微生物调查的重要性，以便评估通过移民引入几种微生物的可靠风险。最终，进一步研究肠道微生物群与原生动物微生物之间的相互作用将为肠道感染的诊断和治疗提供新的途径。

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引用次数: 0

Malaria in hard-to-reach populations: Challenges and solutions 难以接触人群中的疟疾：挑战和解决办法

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-09-01 DOI: 10.1016/j.tmaid.2025.102906

Florence Fouque , Damiana Ravasi , Ghafar Abdul Masoudi , Alfonso J. Rodriguez-Morales

引用次数: 0

Cutaneous myiasis in a Serbian traveller returning from Kenya 从肯尼亚返回的塞尔维亚旅行者皮肤蝇蛆病。

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease

Pub Date : 2025-09-01 DOI: 10.1016/j.tmaid.2025.102904

Stefan Momčilović , Anson V. Koehler , Robin B. Gasser

Background

Cutaneous myiasis is an ectoparasitic disease caused by fly larvae. In non-endemic regions it is rare, often unfamiliar to clinicians and readily misdiagnosed.

Case presentation

A 24-year-old Serbian traveller developed painful furuncular lesions on the thigh after returning from Kenya. The lesions were initially treated as insect bites with intramuscular corticosteroid, antihistamines and topical betamethasone–gentamicin. Spontaneous expulsion of a larva led to the recognition of myiasis.

Methods and results

Three third-instar (L3) larvae were surgically removed. Morphological features and mitochondrial cox1 sequencing identified Cordylobia anthropophaga. Genetic analysis confirmed 99 % identity with reference sequences.

Conclusion

This case highlights the challenges associated with diagnosis of furuncular myiasis in travellers. Awareness of travel history, maintenance of clinical suspicion and molecular analysis are essential for accurate diagnosis. Timely larval removal and prophylactic antibiotics minimise complications and improve outcomes.

背景：皮肤蝇蛆病是一种由蝇类幼虫引起的体外寄生虫病。在非流行地区很少见，临床医生往往不熟悉，容易误诊。病例介绍：一名24岁的塞尔维亚旅行者从肯尼亚返回后，大腿出现疼痛性疖性病变。病变最初作为昆虫叮咬治疗，肌肉注射皮质类固醇、抗组胺药和局部使用倍他米松-庆大霉素。幼虫的自发排出导致了对蝇蛆病的识别。方法与结果：手术切除3只3龄（L3）幼虫。形态特征和线粒体cox1测序鉴定了嗜人虫草。基因分析证实与参考序列同源性99%。结论：本病例强调了旅行者镰状丝虫病诊断的挑战。了解旅行史，保持临床怀疑和分子分析对准确诊断至关重要。及时清除幼虫和预防性抗生素可最大限度地减少并发症并改善结果。

{"title":"Cutaneous myiasis in a Serbian traveller returning from Kenya","authors":"Stefan Momčilović , Anson V. Koehler , Robin B. Gasser","doi":"10.1016/j.tmaid.2025.102904","DOIUrl":"10.1016/j.tmaid.2025.102904","url":null,"abstract":"<div><h3>Background</h3><div>Cutaneous myiasis is an ectoparasitic disease caused by fly larvae. In non-endemic regions it is rare, often unfamiliar to clinicians and readily misdiagnosed.</div></div><div><h3>Case presentation</h3><div>A 24-year-old Serbian traveller developed painful furuncular lesions on the thigh after returning from Kenya. The lesions were initially treated as insect bites with intramuscular corticosteroid, antihistamines and topical betamethasone–gentamicin. Spontaneous expulsion of a larva led to the recognition of myiasis.</div></div><div><h3>Methods and results</h3><div>Three third-instar (L3) larvae were surgically removed. Morphological features and mitochondrial <em>cox</em>1 sequencing identified <em>Cordylobia anthropophaga</em>. Genetic analysis confirmed 99 % identity with reference sequences.</div></div><div><h3>Conclusion</h3><div>This case highlights the challenges associated with diagnosis of furuncular myiasis in travellers. Awareness of travel history, maintenance of clinical suspicion and molecular analysis are essential for accurate diagnosis. Timely larval removal and prophylactic antibiotics minimise complications and improve outcomes.</div></div>","PeriodicalId":23312,"journal":{"name":"Travel Medicine and Infectious Disease","volume":"67 ","pages":"Article 102904"},"PeriodicalIF":4.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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