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Trends in parasitology最新文献

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Neoparamoeba perurans. Neoparamoeba perurans。
IF 7 1区 医学 Q1 PARASITOLOGY
Trends in parasitology
Pub Date : 2025-01-14 DOI: 10.1016/j.pt.2024.12.012
Martina Lisnerová, Hana Pecková, Ivan Fiala
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引用次数: 0
Sparicotyle chrysophrii.
IF 7 1区 医学 Q1 PARASITOLOGY
Trends in parasitology
Pub Date : 2025-01-14 DOI: 10.1016/j.pt.2024.12.013
Ivona Mladineo
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引用次数: 0
The type 2 immune response in gut homeostasis and parasite transmission in malaria. 肠道稳态中的2型免疫反应和疟疾中的寄生虫传播。
IF 7 1区 医学 Q1 PARASITOLOGY
Trends in parasitology
Pub Date : 2025-01-01 Epub Date: 2024-12-09 DOI: 10.1016/j.pt.2024.11.007
Nora Céspedes, Renée M Tsolis, Adrian M Piliponsky, Shirley Luckhart

Malaria predisposes to concomitant bacteremia, resulting in increased mortality risk. Previous studies indicated that malaria causes structural changes in the intestine, induces tolerogenic immune responses, inhibits neutrophil recruitment, suppresses innate synthesis of IFN-γ, dysregulates mast cells (MCs) and basophils, and induces Th2-type immune responses. These can reduce parasite control while increasing enteropathogenic dissemination. Moreover, there is growing evidence that Th2 immunity, while protecting the host from overwhelming inflammation, may also contribute to increased parasite transmission. This review explores the roles of the regulatory immune response in bacterial coinfections and parasite transmission in malaria.

疟疾易伴随菌血症，导致死亡风险增加。先前的研究表明，疟疾引起肠道结构改变，诱导耐受性免疫反应，抑制中性粒细胞募集，抑制先天合成IFN-γ，失调肥大细胞（MCs）和嗜碱性粒细胞，并诱导th2型免疫反应。这些措施可减少对寄生虫的控制，同时增加肠致病性传播。此外，越来越多的证据表明，Th2免疫在保护宿主免受压倒性炎症的同时，也可能导致寄生虫传播的增加。本文综述了调节免疫反应在疟疾细菌共感染和寄生虫传播中的作用。
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引用次数: 0
IMC1g knockdowns reveal malaria blood-stage alveolin functions. IMC1g 基因敲除揭示了疟疾血期肺泡素的功能。
IF 7 1区 医学 Q1 PARASITOLOGY
Trends in parasitology
Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1016/j.pt.2024.11.012
Annie Z Tremp, Sadia Saeed, Johannes T Dessens

Plasmodium alveolins are cytoskeletal proteins with important roles in cell shape, tensile strength, and motility of mosquito-stage ookinetes and sporozoites. Two recent studies by Cepeda Diaz et al. and Liu et al. employ inducible knockdown of the essential blood-stage-expressed alveolin IMC1g to identify new roles in merozoite intracellular survival, schizogonic cell division, and male gametogenesis.

Plasmodium alveolins是一种细胞骨架蛋白，在蚊子期卵胞体和孢子体的细胞形状、拉伸强度和运动中起重要作用。最近由Cepeda Diaz等人和Liu等人进行的两项研究通过诱导敲低必需血期表达的肺泡素IMC1g来确定其在分裂子细胞内存活、分裂细胞分裂和雄性配子体发生中的新作用。
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引用次数: 0
SPPIRIT: a network connecting Scottish early-career researchers in parasitology. 精神：一个连接苏格兰早期寄生虫学研究人员的网络。
IF 7 1区 医学 Q1 PARASITOLOGY
Trends in parasitology
Pub Date : 2025-01-01 Epub Date: 2024-12-09 DOI: 10.1016/j.pt.2024.11.009
Rebecca C S Edgar, Jack Hanna, Markéta Novotná, Marta Campillo Poveda, Mukul Rawat, Shikha Shikha, Frank Venter, Melanie C Ridgway
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引用次数: 0
Do tissue-dwelling trypanosomes sustain transmission populations? 生活在组织中的锥虫能维持传播种群吗？
IF 7 1区 医学 Q1 PARASITOLOGY
Trends in parasitology
Pub Date : 2025-01-01 Epub Date: 2024-12-16 DOI: 10.1016/j.pt.2024.12.001
Stephen D Larcombe, Jane C Munday, Richard McCulloch

Trypanosoma brucei infectious populations are marked by considerable diversity in the parasite's major antigen, the variant surface glycoprotein (VSG). However, most parasites in the bloodstream are non-replicating, questioning how VSG diversity arises. Beaver et al. show that extravascular parasites in host tissues many explain this paradox and provide insight into trypanosome transmission.

布鲁氏锥虫感染人群的特点是其主要抗原变异表面糖蛋白（VSG）具有相当大的多样性。然而，血液中的大多数寄生虫都是不复制的，这就质疑了VSG多样性是如何产生的。Beaver等人的研究表明，宿主组织中的血管外寄生虫可以解释这一悖论，并为锥虫的传播提供了见解。
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引用次数: 0
Entering the spatial age of parasite genomics. 进入寄生虫基因组学的空间时代。
IF 7 1区 医学 Q1 PARASITOLOGY
Trends in parasitology
Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1016/j.pt.2024.11.010
Sarah K Buddenborg, Stephen R Doyle

Reconciling organism-scale biology at cellular-scale resolution has been a monumental challenge. Recently, Gramberg et al. uncovered the spatial organisation of gene expression in the common liver fluke, Fasciola hepatica. These data provide new insights and opportunities for understanding the fundamental developmental and functional biology of parasites and new targets for control.

在细胞尺度的分辨率下协调有机体尺度的生物学是一个巨大的挑战。最近，Gramberg等人发现了常见肝吸虫肝片吸虫基因表达的空间组织。这些数据为了解寄生虫的基本发育和功能生物学以及新的控制靶点提供了新的见解和机会。
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引用次数: 0
From invasion to outbreak: tick introductions and disease. 从入侵到爆发：蜱虫的引入和疾病。
IF 7 1区 医学 Q1 PARASITOLOGY
Trends in parasitology
Pub Date : 2025-01-01 Epub Date: 2024-12-04 DOI: 10.1016/j.pt.2024.11.005
Payton Phillips, Mekala Sundaram

Introductions of tick disease vectors are inevitable in our changing world. While recent attention to tick invasions has increased following prominent invasion events worldwide, our understanding of how tick community ecology drives infection dynamics is lacking. Interactions between invasive and resident ticks can have profound impacts on human diseases.

在我们不断变化的世界中，蜱病媒介的引入是不可避免的。虽然最近对蜱虫入侵的关注随着世界范围内的突出入侵事件而增加，但我们对蜱虫群落生态如何驱动感染动态的理解是缺乏的。入侵蜱和常驻蜱之间的相互作用可能对人类疾病产生深远的影响。
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引用次数: 0
Leishmania (Leishmania) amazonensis. 亚马逊利什曼病（利什曼病）。
IF 7 1区 医学 Q1 PARASITOLOGY
Trends in parasitology
Pub Date : 2025-01-01 Epub Date: 2024-11-20 DOI: 10.1016/j.pt.2024.10.023
Marcus S A Garcia, Virlânio A Oliveira Filho, Mariana B C Brioschi, Karen Minori, Danilo Ciccone Miguel
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引用次数: 0
Rhipicephalus microplus (Southern cattle tick; Asian blue tick). 微型鼻头蜱(南方牛蜱；亚洲蓝蜱)。
IF 7 1区 医学 Q1 PARASITOLOGY
Trends in parasitology
Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1016/j.pt.2024.11.004
Kennan Oyen, Karen C Poh
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引用次数: 0
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