F. Porzsolt, Christel Weiss, M. Weiss, K. Jauch, R. Kaplan
Nearly 100 years ago Archie Cochrane and Austin Bradford Hill proposed a three-dimensional assessment for evaluating clinical interventions: Can it Work? Does it work? Is it Worth it? [2, S1]. Table 1 proposes a strategy to answer these questions by description of three outcome dimensions that are assessed under two different conditions from three different perspectives. The strategy requires a different architecture of studies (form and function) and different tools.
{"title":"Demystification – a solution for assessment of real-world effective-ness?","authors":"F. Porzsolt, Christel Weiss, M. Weiss, K. Jauch, R. Kaplan","doi":"10.15761/TIM.1000231","DOIUrl":"https://doi.org/10.15761/TIM.1000231","url":null,"abstract":"Nearly 100 years ago Archie Cochrane and Austin Bradford Hill proposed a three-dimensional assessment for evaluating clinical interventions: Can it Work? Does it work? Is it Worth it? [2, S1]. Table 1 proposes a strategy to answer these questions by description of three outcome dimensions that are assessed under two different conditions from three different perspectives. The strategy requires a different architecture of studies (form and function) and different tools.","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80929150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Gilissen, S. Meijer, H. Flink, P. Friederich, Jos Ramaker, E. Schoon, A. Stronkhorst
Background: Quality measurement of endoscopic procedures is an actual and important subject. In the Netherlands endoscopists are obligated to register their Endoscopic Retrograde Cholangiopancreatography (ERCP) performances in a National ERCP quality registration (NEQR). NEQR is a self-assessment that evaluates ERCP quality and volume per centre and endoscopist, but complications and outcome of the procedure are both not registered in NEQR. The aim of this study is to examine whether NEQR correlates with objective post-ERCP clinical outcome in a tertiary referral centre. Material and methods: A retrospective cohort study of all ERCPs performed at a tertiary referral centre in 2016. Correlations between NEQR self-assessments and post-ERCP complications and mortality were measured. Results: 333 procedures were performed, of which 254 were registered in the NEQR (76.3%). No significant correlations were found between the subjective self- assessment and objective post-ERCP outcomes. Of all 333 procedures the total post-ERCP complication rate was 13.5% and the ERCP-related 30-day mortality rate was 0.6%. Conclusions: The currently used NEQR does not correlate with post-procedural clinical outcomes. Clinical outcome measures in a 30-day post-ERCP period, including complications, should be implemented to improve the usefulness of this specific quality registration.
{"title":"The Dutch national ERCP quality registration using self-assessment does not correlate with clinical ERCP outcome","authors":"L. Gilissen, S. Meijer, H. Flink, P. Friederich, Jos Ramaker, E. Schoon, A. Stronkhorst","doi":"10.15761/TIM.1000239","DOIUrl":"https://doi.org/10.15761/TIM.1000239","url":null,"abstract":"Background: Quality measurement of endoscopic procedures is an actual and important subject. In the Netherlands endoscopists are obligated to register their Endoscopic Retrograde Cholangiopancreatography (ERCP) performances in a National ERCP quality registration (NEQR). NEQR is a self-assessment that evaluates ERCP quality and volume per centre and endoscopist, but complications and outcome of the procedure are both not registered in NEQR. The aim of this study is to examine whether NEQR correlates with objective post-ERCP clinical outcome in a tertiary referral centre. Material and methods: A retrospective cohort study of all ERCPs performed at a tertiary referral centre in 2016. Correlations between NEQR self-assessments and post-ERCP complications and mortality were measured. Results: 333 procedures were performed, of which 254 were registered in the NEQR (76.3%). No significant correlations were found between the subjective self- assessment and objective post-ERCP outcomes. Of all 333 procedures the total post-ERCP complication rate was 13.5% and the ERCP-related 30-day mortality rate was 0.6%. Conclusions: The currently used NEQR does not correlate with post-procedural clinical outcomes. Clinical outcome measures in a 30-day post-ERCP period, including complications, should be implemented to improve the usefulness of this specific quality registration.","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79295690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Istituto Zooprofilattico Sperimentale of Puglia and Basilicata (IZSPB) processed toxicoepidemiological data on suspected veterinary intentional poisoning cases (small, farm and wild animals) in South-Eastern Italy. Suspected poisoned animals (SPAs) and supposed poisoning baits (SPBs) were collected between 2009 and 2019 by public health authorities, veterinary practitioners and owners and were analyzed for the presence of rodenticide (non-anticoagulant rodenticides and coumarin derivatives), molluschicide, herbicides, pesticide and other molecules (ethylene glycol and metals). Among SPAs analyzed, small animals were prominent (76.2%). In totally, 23.7% animals (408/1719) and 47.3% baits (224/474) were found positive. Small animals were positive in 26.0% of cases (341/1310) and the molecule more involved was metaldehyde, a molluschicide. Only 11.4% (16/123) farm animals were found positive prevalently for rodenticide and pesticide. Though wild ones 18.5% (53/286) were positive mainly for pesticide. In South-Eastern Italy, there are still limited, and fragmented data published on the topic, although this type of information is crucial in an attempt to reduce this illegal practice. rodenticides molluschicide, pesticide.
{"title":"Suspected veterinary poisoning cases: A retrospective toxicoepidemiology study (2009-2019) in south-eastern Italy","authors":"D. Chirizzi","doi":"10.15761/TIM.1000254","DOIUrl":"https://doi.org/10.15761/TIM.1000254","url":null,"abstract":"The Istituto Zooprofilattico Sperimentale of Puglia and Basilicata (IZSPB) processed toxicoepidemiological data on suspected veterinary intentional poisoning cases (small, farm and wild animals) in South-Eastern Italy. Suspected poisoned animals (SPAs) and supposed poisoning baits (SPBs) were collected between 2009 and 2019 by public health authorities, veterinary practitioners and owners and were analyzed for the presence of rodenticide (non-anticoagulant rodenticides and coumarin derivatives), molluschicide, herbicides, pesticide and other molecules (ethylene glycol and metals). Among SPAs analyzed, small animals were prominent (76.2%). In totally, 23.7% animals (408/1719) and 47.3% baits (224/474) were found positive. Small animals were positive in 26.0% of cases (341/1310) and the molecule more involved was metaldehyde, a molluschicide. Only 11.4% (16/123) farm animals were found positive prevalently for rodenticide and pesticide. Though wild ones 18.5% (53/286) were positive mainly for pesticide. In South-Eastern Italy, there are still limited, and fragmented data published on the topic, although this type of information is crucial in an attempt to reduce this illegal practice. rodenticides molluschicide, pesticide.","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82878942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osteoclastoma is an infrequent, benign, primary bone neoplasm initially scripted by Jaffe in 1940 [1]. Osteoclastoma is an osteolytic, locally aggressive tumefaction incriminating young adults with skeletal maturity and is accompanied by an unpredictable biological course. Osteoclastoma is constituted by mononuclear, spheroid to spindle-shaped cells intermingled with numerous, evenly distributed, osteoclastlike, multinucleated giant cells [1,2].
{"title":"The gargantuan benevolence - osteoclastoma","authors":"Anu Bajaj","doi":"10.15761/TIM.1000242","DOIUrl":"https://doi.org/10.15761/TIM.1000242","url":null,"abstract":"Osteoclastoma is an infrequent, benign, primary bone neoplasm initially scripted by Jaffe in 1940 [1]. Osteoclastoma is an osteolytic, locally aggressive tumefaction incriminating young adults with skeletal maturity and is accompanied by an unpredictable biological course. Osteoclastoma is constituted by mononuclear, spheroid to spindle-shaped cells intermingled with numerous, evenly distributed, osteoclastlike, multinucleated giant cells [1,2].","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87404278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Grilo, L. Vieira, E. Carolino, J. Ferreira, M. Neves
Background: Myocardial Perfusion Scintigraphy is a medical exam whose purpose is to evaluate myocardial perfusion. This examination due to their procedures can generate some anxiety in patients that can disturb the good performance of the exam. The main objective of this study is to perform an analysis of patient`s undergoing myocardial perfusion scintigraphy experience, assess patient`s anxiety and check Nuclear Medicine Department communication and information effectiveness. Material and methods: For this study, State-Trait Anxiety Inventory (STAI) and two Scan Experience Questionnaires were used. Sixty patients answered the questionnaires before and after myocardial perfusion scintigraphy. Results: Patients reported medium levels of scan-related anxiety before the myocardial perfusion scintigraphy. After the scan, there is a slight decrease in patients` anxiety. Results of the scan, radiation used, duration of the scan and the injection of the radiopharmaceutical are the most relevant patients` concerns before the scan. 15% of the sample did not receive the necessary information or the most effective way. Conclusions: The results suggest that there are several factors that tend to trigger patient`s experience and anxiety. Strategies to improve patient myocardial perfusion scintigraphy experience at Nuclear Medicine Department are presented. *Correspondence to: Ana M Grilo, ESTeSL-Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa. Av. D. João II, lote 4.69.01, Parque das Nações, 1990-096 Lisboa, Portugal, E-mail: ana.grilo@estesl.ipl.pt
背景:心肌灌注显像是一种医学检查，其目的是评估心肌灌注。这种检查由于其程序可能会使患者产生一些焦虑，从而影响检查的良好效果。本研究的主要目的是分析患者接受心肌灌注显像的体验，评估患者的焦虑程度，检查核医学科沟通和信息的有效性。材料与方法:本研究采用状态-特质焦虑量表(STAI)和两份扫描体验问卷。60例患者在心肌灌注显像前后分别回答问卷。结果:患者在心肌灌注显像前报告了中等水平的扫描相关焦虑。扫描后，患者的焦虑感略有下降。扫描结果、使用的辐射、扫描时间和放射性药物的注射是患者在扫描前最关心的问题。15%的样本没有收到必要的信息或最有效的方式。结论:结果表明，有几个因素容易引发患者的体验和焦虑。提出提高核医学科患者心肌灌注显像体验的策略。通信给:Ana M Grilo, estel - escola高等技术学院Saúde，里斯本政治学院。Av. D. jo II, lote 4.69.01, Parque das Nações, 1990-096，葡萄牙里斯本，E-mail: ana.grilo@estesl.ipl.pt
{"title":"Addressing the patient experience in myocardial perfusion scintigraphy","authors":"A. Grilo, L. Vieira, E. Carolino, J. Ferreira, M. Neves","doi":"10.15761/TIM.1000175","DOIUrl":"https://doi.org/10.15761/TIM.1000175","url":null,"abstract":"Background: Myocardial Perfusion Scintigraphy is a medical exam whose purpose is to evaluate myocardial perfusion. This examination due to their procedures can generate some anxiety in patients that can disturb the good performance of the exam. The main objective of this study is to perform an analysis of patient`s undergoing myocardial perfusion scintigraphy experience, assess patient`s anxiety and check Nuclear Medicine Department communication and information effectiveness. Material and methods: For this study, State-Trait Anxiety Inventory (STAI) and two Scan Experience Questionnaires were used. Sixty patients answered the questionnaires before and after myocardial perfusion scintigraphy. Results: Patients reported medium levels of scan-related anxiety before the myocardial perfusion scintigraphy. After the scan, there is a slight decrease in patients` anxiety. Results of the scan, radiation used, duration of the scan and the injection of the radiopharmaceutical are the most relevant patients` concerns before the scan. 15% of the sample did not receive the necessary information or the most effective way. Conclusions: The results suggest that there are several factors that tend to trigger patient`s experience and anxiety. Strategies to improve patient myocardial perfusion scintigraphy experience at Nuclear Medicine Department are presented. *Correspondence to: Ana M Grilo, ESTeSL-Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa. Av. D. João II, lote 4.69.01, Parque das Nações, 1990-096 Lisboa, Portugal, E-mail: ana.grilo@estesl.ipl.pt","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85152462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad Hezarjaribi, M. Ranjbar, Sayed Moayed Alavian, Sohrab Aghabeigi
Background: In patients with hepatitis, it is important to identify drug-induced metabolic effects to improve diagnosis and treatment. Therefore, in this study, we aimed to determine the effects of sofosbuvir-based therapy on the metabolic status of patients with chronic hepatitis C virus (HCV) infection. Materials and Methods: In this observational before-after study, a total of 128 consecutive patients with chronic HCV infection, presenting to the Middle East Liver Disease Center (MELD) in Tehran, Iran, were enrolled. Metabolic indices, including triglyceride, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and fasting blood sugar (FBS), were determined before and after sofosbuvir-based therapy. Results: The mean FBS level was 108.3±33.8 and 106.2±36.4 mg/dL before and after treatment, respectively (P>0.05). Also, the mean triglyceride level was 101.8±46.4 and 110.5±54.8 mg/dL before and after treatment, respectively (P=0.03). The findings showed that the mean total cholesterol level was 150.9±34.9 and 168.0±40 mg/dL before and after treatment, respectively (P=0.001). Also, the mean LDL-cholesterol level was 82.4±27.5 and 95.8±31.6 mg/dL before and after treatment (P=0.001), and the mean HDL-cholesterol was 44.1±13.1 and 46.9±13.4 mg/dL before and after treatment, respectively (P=0.01). Conclusion: According to the results, it can be concluded that sofosbuvir-based therapy has effects on some metabolic parameters (lipid profile and blood glucose) of chronic HCV patients. Therefore, development of preventive strategies to reduce the burden of this disease seems necessary.
{"title":"Effects of sofosbuvir-based therapy on the metabolic status of patients with chronic hepatitis C infection","authors":"Ahmad Hezarjaribi, M. Ranjbar, Sayed Moayed Alavian, Sohrab Aghabeigi","doi":"10.15761/tim.1000212","DOIUrl":"https://doi.org/10.15761/tim.1000212","url":null,"abstract":"Background: In patients with hepatitis, it is important to identify drug-induced metabolic effects to improve diagnosis and treatment. Therefore, in this study, we aimed to determine the effects of sofosbuvir-based therapy on the metabolic status of patients with chronic hepatitis C virus (HCV) infection. Materials and Methods: In this observational before-after study, a total of 128 consecutive patients with chronic HCV infection, presenting to the Middle East Liver Disease Center (MELD) in Tehran, Iran, were enrolled. Metabolic indices, including triglyceride, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and fasting blood sugar (FBS), were determined before and after sofosbuvir-based therapy. Results: The mean FBS level was 108.3±33.8 and 106.2±36.4 mg/dL before and after treatment, respectively (P>0.05). Also, the mean triglyceride level was 101.8±46.4 and 110.5±54.8 mg/dL before and after treatment, respectively (P=0.03). The findings showed that the mean total cholesterol level was 150.9±34.9 and 168.0±40 mg/dL before and after treatment, respectively (P=0.001). Also, the mean LDL-cholesterol level was 82.4±27.5 and 95.8±31.6 mg/dL before and after treatment (P=0.001), and the mean HDL-cholesterol was 44.1±13.1 and 46.9±13.4 mg/dL before and after treatment, respectively (P=0.01). Conclusion: According to the results, it can be concluded that sofosbuvir-based therapy has effects on some metabolic parameters (lipid profile and blood glucose) of chronic HCV patients. Therefore, development of preventive strategies to reduce the burden of this disease seems necessary.","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73491816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Identification of causes of infertility could improve the chances for the management. The unexplained or idiopathic causes represent up to 30% for the infertility cases. One of such causes might be the unprotected anal intercourse due to the high possibility of lacerations and injuries occurring through the thin mucosa of anal canal. Escape of sperms into the injured female tissues might encourage her body to develop antibodies against the seminal content of male partner and causing infertility. Future studies are recommended to clarify such possibility as well as to develop a new contraceptive method depending on the immunity. *Correspondence to: Abdelmonem Awad Hegazy, Professor and Former Chairman of Anatomy and Embryology Department, Consultant of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt, E-mail: dr.abdelmonemhegazy@yahoo.com
{"title":"Anal intercourse and idiopathic infertility: Anatomical considerations and authors’ perspective","authors":"Abdelmonem Awad Hegazy, M. Hegazy","doi":"10.15761/TIM.1000170","DOIUrl":"https://doi.org/10.15761/TIM.1000170","url":null,"abstract":"Identification of causes of infertility could improve the chances for the management. The unexplained or idiopathic causes represent up to 30% for the infertility cases. One of such causes might be the unprotected anal intercourse due to the high possibility of lacerations and injuries occurring through the thin mucosa of anal canal. Escape of sperms into the injured female tissues might encourage her body to develop antibodies against the seminal content of male partner and causing infertility. Future studies are recommended to clarify such possibility as well as to develop a new contraceptive method depending on the immunity. *Correspondence to: Abdelmonem Awad Hegazy, Professor and Former Chairman of Anatomy and Embryology Department, Consultant of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt, E-mail: dr.abdelmonemhegazy@yahoo.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85423637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of diameter and length on the success rate of dental implant: Prospective clinical study","authors":"Liqaa S Farhan","doi":"10.15761/tim.1000194","DOIUrl":"https://doi.org/10.15761/tim.1000194","url":null,"abstract":"","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79889953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qing-li Ren, W. Gong, Rongjie Huang, Lifeng Liang, Kexiang Chen, D. Gao, Zhihui Li, Yan Gao, Heliang Liu, Changsheng Chen, Jian-ping Huang, Cheng-gang Zhang
Objective: This study aimed to evaluate the value of the flexible fasting (FF) technology in helping hypertension improvement in patients with essential hypertension and obesity. Method: We recruited and ultimately selected 86 volunteers with essential hypertension and obesity in this study as a quasi experiment. The volunteers went through three phases, namely, the baseline anti-hypertensive therapy stage (Phase-1), the FF intervention stage (Phase-2), the normal diet recovery stage (Phase-3), each for seven days. During the Phase-2, all subjects fasted and began to substitute the FF food for conventional food. Patients' systolic/diastolic blood pressure (abbreviated as SBP/DBP), body mass index (BMI) and body weight were monitored in details each day. The trial data of all subjects were statistically analyzed using self-controlled designs. Result: After the FF intervention, the subjects' blood pressure, body mass and BMI all showed naturally decreases by comparison to that before the intervention. The remarkable decreases in SBP/DBP, Body Mass and BMI were observed in Phase-3 after FF intervention when compared to Phase-1 [SBP: (115.2±8.492) vs (121.2±13.72) mmHg, q=34.14, P<0.001]; [DBP: (76.03±5.37) vs (78.36±7.094) mmHg, q=10.96, P<0.05)]; [Body Mass: (68.86±13.04) vs (73.11±13.49)kg, q=61.56, P<0.0001]; [BMI: (25.42±3.359) vs (27.03±3.45) kg/m2, q=100, P<0.0001]. All patients did not experience any discomfort or symptoms during the trial. Conclusion: The FF technology is an effective approach to improve hypertension. *Correspondence to: Chenggang Zhang, Professor, PhD., Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Research Center for the Military Cognitive and Mental Health of PLA, Beijing 100850, China, Tel: +86 10 66931590; E-mail: zcgweb@126.com Jiangnan Huang, PhD., The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China, Tel: +86 771 5356566; E-mail: huangjn1998@163.com Changsheng Chen, PhD., Department of Health Statistics, School of Military Preventive Medicine, The Fourth Military Medical University, Xi’an 710032, China, Tel: +86 29 84774853; E-mail: chencs@fmmu.edu.cn
{"title":"The flexible fasting technology can improve hypertension: A pilot study in self-controlled designs","authors":"Qing-li Ren, W. Gong, Rongjie Huang, Lifeng Liang, Kexiang Chen, D. Gao, Zhihui Li, Yan Gao, Heliang Liu, Changsheng Chen, Jian-ping Huang, Cheng-gang Zhang","doi":"10.15761/tim.1000204","DOIUrl":"https://doi.org/10.15761/tim.1000204","url":null,"abstract":"Objective: This study aimed to evaluate the value of the flexible fasting (FF) technology in helping hypertension improvement in patients with essential hypertension and obesity. Method: We recruited and ultimately selected 86 volunteers with essential hypertension and obesity in this study as a quasi experiment. The volunteers went through three phases, namely, the baseline anti-hypertensive therapy stage (Phase-1), the FF intervention stage (Phase-2), the normal diet recovery stage (Phase-3), each for seven days. During the Phase-2, all subjects fasted and began to substitute the FF food for conventional food. Patients' systolic/diastolic blood pressure (abbreviated as SBP/DBP), body mass index (BMI) and body weight were monitored in details each day. The trial data of all subjects were statistically analyzed using self-controlled designs. Result: After the FF intervention, the subjects' blood pressure, body mass and BMI all showed naturally decreases by comparison to that before the intervention. The remarkable decreases in SBP/DBP, Body Mass and BMI were observed in Phase-3 after FF intervention when compared to Phase-1 [SBP: (115.2±8.492) vs (121.2±13.72) mmHg, q=34.14, P<0.001]; [DBP: (76.03±5.37) vs (78.36±7.094) mmHg, q=10.96, P<0.05)]; [Body Mass: (68.86±13.04) vs (73.11±13.49)kg, q=61.56, P<0.0001]; [BMI: (25.42±3.359) vs (27.03±3.45) kg/m2, q=100, P<0.0001]. All patients did not experience any discomfort or symptoms during the trial. Conclusion: The FF technology is an effective approach to improve hypertension. *Correspondence to: Chenggang Zhang, Professor, PhD., Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Research Center for the Military Cognitive and Mental Health of PLA, Beijing 100850, China, Tel: +86 10 66931590; E-mail: zcgweb@126.com Jiangnan Huang, PhD., The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China, Tel: +86 771 5356566; E-mail: huangjn1998@163.com Changsheng Chen, PhD., Department of Health Statistics, School of Military Preventive Medicine, The Fourth Military Medical University, Xi’an 710032, China, Tel: +86 29 84774853; E-mail: chencs@fmmu.edu.cn","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76077495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana M. Gómez, Y. Lone, Luz M. Salazar, J. Trojan.
Acne is one of the most common epithelial diseases affecting approximately 80% of the world's population between the ages of 16 and 35. It is caused by multiple factors such as genetic predisposition and hormonal alteration including growth factor IGF-I, among others. Acne being related to IGF-I expression, is involved in possible apparition of malignant diseases. The pathology of acne is limited to the pilosebaceous unit. The evolution is governed by the increase in colonization of the bacteria Propionibacterium acnes (P. acnes). Acne is clinically manifested by the appearance of comedones with a tendency to inflammation. Finally causes scarring damaging self-esteem and quality of life of those who suffer it. As proposed therapies, external treatments have been developed such as inhibitors of IGF-I among others. As an internal treatment, the innate response of the patient's immune system to the presence of an invading microorganism has been studied, highlighting anti-microbial peptides as the host's own defense molecules. This work shows a compilation of the most relevant and current antimicrobial peptides that could be used as potential therapeutic agents against microorganisms located in the skin and related to acne disease. *Correspondence to: D.M. Gomez, Faculty of Sciences, Dept. Chemistry, Univ. Nacional, Bogotá D.C., Colombia, E-mail: dimgomezmo@unal.edu.co J. Trojan, ICGT, Cll 128 b, Kr 18-11, Bogotá D.C., Colombia, E-mail: genetherapy@hotmail.fr
{"title":"Antimicrobial peptides, novel solution for the treatment of precancerous disease acne - A review","authors":"Diana M. Gómez, Y. Lone, Luz M. Salazar, J. Trojan.","doi":"10.15761/tim.1000210","DOIUrl":"https://doi.org/10.15761/tim.1000210","url":null,"abstract":"Acne is one of the most common epithelial diseases affecting approximately 80% of the world's population between the ages of 16 and 35. It is caused by multiple factors such as genetic predisposition and hormonal alteration including growth factor IGF-I, among others. Acne being related to IGF-I expression, is involved in possible apparition of malignant diseases. The pathology of acne is limited to the pilosebaceous unit. The evolution is governed by the increase in colonization of the bacteria Propionibacterium acnes (P. acnes). Acne is clinically manifested by the appearance of comedones with a tendency to inflammation. Finally causes scarring damaging self-esteem and quality of life of those who suffer it. As proposed therapies, external treatments have been developed such as inhibitors of IGF-I among others. As an internal treatment, the innate response of the patient's immune system to the presence of an invading microorganism has been studied, highlighting anti-microbial peptides as the host's own defense molecules. This work shows a compilation of the most relevant and current antimicrobial peptides that could be used as potential therapeutic agents against microorganisms located in the skin and related to acne disease. *Correspondence to: D.M. Gomez, Faculty of Sciences, Dept. Chemistry, Univ. Nacional, Bogotá D.C., Colombia, E-mail: dimgomezmo@unal.edu.co J. Trojan, ICGT, Cll 128 b, Kr 18-11, Bogotá D.C., Colombia, E-mail: genetherapy@hotmail.fr","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88615086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：