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Injury to the human retrosplenial cortex: Two cases and a review of the literature 人脾后皮质损伤:两例及文献复习
Pub Date : 2020-01-01 DOI: 10.15761/TIM.1000230
Lin Song, P. Constanthin, N. Lin, Yong-jie Tian, L. An
Background: The human retrosplenial cortex (RSC) is the cortical region of the parietal lobe that lies directly behind the splenium of the corpus callosum. While recent fundamental research in animal models has suggested a very important role for the RSC in orientation, relatively few human cases of lesion to the RSC have been reported in the literature. Furthermore, those few cases have pointed at, in addition to the aforementioned role of this cortical structure in topographical orientation, a potential for other supplementary roles in higher-order cognitive functions such as memory processing and language. Cases presentation: In this article, we report two remarkably asymptomatic cases of extensive oncological lesions to the RSC in otherwise healthy patients younger than 35 years old. We report their surgical treatments and their release from our hospital. During the entire follow-up, patients never reported any issue with topographical orientation or language, which is remarkable compared to cases previously reported. Discussion and conclusions: We then discuss the available clinical literature about RSC lesions in human brain and the possible reasons for such a diversity of reported symptoms, or lack thereof, between cases for a seemingly similar radiological entity. Our cases reveal that understanding of the RSC and its lesions remain scarce and needs to be further investigated, both fundamentally and clinically.
背景:人脾后皮层(RSC)是顶叶的皮质区域,位于胼胝体脾的正后方。虽然最近在动物模型中的基础研究表明RSC在定向中起着非常重要的作用,但文献中报道的RSC病变的人类病例相对较少。此外,这些少数案例表明,除了上述这种皮质结构在地形取向中的作用外,在记忆处理和语言等高阶认知功能中还有其他补充作用的潜力。病例介绍:在这篇文章中,我们报告了两例明显无症状的RSC广泛肿瘤病变的病例,这些病例发生在年龄小于35岁的健康患者中。我们报告他们的手术治疗和出院情况。在整个随访期间,患者从未报告任何地形定位或语言问题,这与先前报道的病例相比是显着的。讨论和结论:我们随后讨论了关于人脑RSC病变的现有临床文献,以及在看似相似的放射实体的病例之间报告的症状多样性或缺乏症状的可能原因。我们的病例表明,对RSC及其病变的了解仍然很少,需要从根本上和临床上进一步研究。
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引用次数: 1
COVID 19: Clinical characteristics in cancer patients and chest X-ray findings 2019冠状病毒病:癌症患者的临床特征和胸部x线表现
Pub Date : 2020-01-01 DOI: 10.15761/TIM.1000250
L. Marinova, R. Georgiev, N. Evgeniev, H. Metev
Due to weakened immune system, the oncological patients are highly at risk with regard to the COVID-19 pandemic. The aim of this article is to contribute with a supplement for the database on symptomatology and chest imaging appearance in patients infected with COVID-19. During the course of radiotherapy (RT), in four oncological patients we observed a variety of atypical clinical and laboratory expression: cough without fever, uroinfection with hematuria, gastrointestinal symptoms, leukopenia, which is difficult to associate with COVID-19 infection. In three out of seven patients, diffuse bilaterally ground glass opacities (GGO) are presented on the chest CT. In oncological patients infected with COVID-19, a less common symptomatology such as gastrointestinal discomfort, dry cough without fever, which is difficult to associate with this viral infection, are observed. The features of pneumonia are accompanied by leukopenia, lymphopenia and accelerated ESR. Hematuria, proteinuria, elevated transaminases and Gamma-glutamyl transferase (GGT) levels are result of vasculitis which affects parenchymal organs like kidneys and liver. The radiological features of COVID-19 pneumonia are not specific. The ground glass opacities (GGO) are bilateral, asymmetrical, peripheral and subpleural in location, with predilection for the lower lobes. CT detection is very useful in time course of the disease with checking severity and prognosis of the disease.
肿瘤患者免疫系统较弱,是新冠肺炎大流行的高危人群。本文的目的是对COVID-19感染患者的症状学和胸部影像学表现数据库进行补充。在4例肿瘤患者的放疗过程中,我们观察到多种不典型的临床和实验室表达:咳嗽无发热,尿路感染伴血尿,胃肠道症状,白细胞减少,这很难与COVID-19感染相关联。7例患者中有3例胸部CT表现为弥漫性双侧磨玻璃影(GGO)。在感染COVID-19的肿瘤患者中,观察到胃肠道不适、干咳无发烧等较不常见的症状,这些症状很难与这种病毒感染联系起来。肺炎的特征是伴白细胞减少、淋巴减少和ESR加速。血尿、蛋白尿、转氨酶和γ -谷氨酰转移酶(GGT)水平升高是血管炎影响实质器官如肾脏和肝脏的结果。COVID-19肺炎的影像学特征不特异性。磨玻璃混浊(GGO)是双侧,不对称,周围和胸膜下的位置,优先于下叶。CT检查对疾病的严重程度和预后有及时的诊断价值。
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引用次数: 0
Medical assistants' attitude toward one-month education mission in deprived regions in Eastern of Iran 医务助理对伊朗东部贫困地区为期一个月的教育任务的态度
Pub Date : 2020-01-01 DOI: 10.15761/TIM.1000246
R. Bagheri, F. Keihanian, K. Ghazvini, M. Ahmadi, Seyed Ali Noorbakhsh Koomleh
Background: Recent investigations emphasize the beneficial learning chances for practitioners and the promising for make better healthcare support to deprived peoples who have no access to healthcare system appropriately. In Iran, all residents in the last year of their education should go to underserved areas for a month to give service the populations in those areas in healthcare centers. In this study we evaluated the attitude of residents participated in this one-month program for first time in Eastern Iran, Khorasan Razavi. Materials and method: This was a descriptive-analytical research study. We included all residents in their last year of education period occupied in Imam Reza and Qaem Hospitals and passed the one-month program of service to underserved regions population (two general educational centers) in Mashhad, 2015. The tool of research was a researcher-made questionnaire that its reliability and validity was confirmed in a pilot study. All data was entered in SPSS software version 21. Results: 49 last year residents were included in the study. The mean of their age was 34.17±4.75 years’ old. 31 of them was male (63.3%) and 18 were female (36.7%). 98% of them was residence in Mashhad (Capital of Khorasan Razavi Province). 28 participants answered the interest of work in the program: 14 subjects (50%): bad, 10 subjects (35.71%): good and 4 subjects (14.29%): moderate. In order to duration of program, most of residents expressed that it was enough (35, 74.47%), 8 of them (17.02%) indicated that it was not enough and others said that they did not have any comment (4, 8.51%). Conclusion: The system of medical training in mission is the unique in the world. In other studies, or programs, we can see that some voluntaries who participate in medical healthcare missions, however here, in Iran, this is a part of medical education. This can help physicians to be familiar with common problems in their specialties in last year of their education.
背景:最近的调查强调了从业人员有益的学习机会,并有希望为没有适当机会获得医疗保健系统的贫困人群提供更好的医疗保健支持。在伊朗,所有受教育的最后一年的居民都应该到服务欠缺的地区去一个月,在保健中心为这些地区的人口提供服务。在这项研究中,我们评估了首次在伊朗东部呼罗珊拉扎维参加为期一个月的计划的居民的态度。材料与方法:本研究为描述性分析研究。我们纳入了伊玛目礼萨医院和盖姆医院最后一年的所有住院医生,并于2015年在马什哈德对服务不足地区的人口(两个普通教育中心)进行了为期一个月的服务项目。研究工具为研究人员自行制作的问卷,其信度和效度在初步研究中得到证实。所有数据均在SPSS软件21版中输入。结果:去年有49名居民参与了这项研究。平均年龄34.17±4.75岁。其中男性31例(63.3%),女性18例(36.7%)。其中98%居住在马什哈德(呼罗珊·拉扎维省首府)。28人回答对节目的工作兴趣:14人(50%)回答“差”,10人(35.71%)回答“好”,4人(14.29%)回答“一般”。对于节目时长,大部分居民表示“足够”(35人,74.47%),8人表示“不够”(17.02%),其余居民表示“无话可说”(4人,8.51%)。结论:宣教医学培训体系在世界上是独一无二的。在其他研究或项目中,我们可以看到一些志愿者参与医疗保健任务,然而在伊朗,这是医学教育的一部分。这可以帮助医生在最后一年的教育中熟悉他们专业的常见问题。
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引用次数: 0
QTc interval prolongation and cirrhosis severity in non-alcoholic patients 非酒精患者QTc间期延长与肝硬化严重程度的关系
Pub Date : 2020-01-01 DOI: 10.15761/TIM.1000235
A. Saeidinia, A. Salari, A. Shafaghi, M. Ofoghi
Introduction: Chronic liver disease is a major health problem and important causes of mortality and morbidity. Cirrhosis is associated with cardiovascular abnormalities. QT interval prolongation is one of the electrophysiological indicators of cirrhotic cardiomyopathy. So in this study we evaluated the QTc interval prolongation and cirrhosis severity in non-alcoholic patients admitted in Razi hospital in Rasht during 2011-2012. Material & methods: This survey was conducted as a cross-sectional descriptive study. A 12-lead surface ECG and echocardiographic study was obtained from all subjects. A 12-lead electrocardiogram recorded at 50 mm/second to measure the QT interval. The mean QT interval in every 12 leads was documented for each patient. The QT corrected for RR (QTc) was calculated. The quantitative and qualitative data were analyzed by Chi-square, ANOVA, Linear regression test and Fisher’s exact tests. Results: The mean of age was 52.78±15.2. Sixty-three persons were male, and others were female. The most common cause of cirrhosis in our study population was Hepatitis C virus. Prolonged QTc interval was seen in 48% of subjects. There was no significant correlation between age and mean of laboratory data and QTc prolongation (P>0.05). There was no significant correlation between causes of cirrhosis and QTc prolongation (P>0.05). There was significant correlation between severity of cirrhosis and QTc (P=0.020). Conclusion: Majority of patients with cirrhosis showed QTc interval prolongation, which related significantly with worsening the severity of the disease, regardless of the etiology of cirrhosis.
慢性肝病是主要的健康问题,也是导致死亡和发病的重要原因。肝硬化与心血管异常有关。QT间期延长是肝硬化心肌病的电生理指标之一。因此,本研究对2011-2012年在拉希特市拉兹医院住院的非酒精患者的QTc间期延长和肝硬化严重程度进行了评估。材料与方法:本调查采用横断面描述性研究。对所有受试者进行12导联体表心电图和超声心动图检查。以50毫米/秒的速度记录12导联心电图,测量QT间期。记录每位患者每12导联的平均QT间期。计算经RR校正的QT (QTc)。定量和定性资料采用卡方检验、方差分析、线性回归检验和Fisher精确检验。结果:患者平均年龄为52.78±15.2岁。其中63人为男性,其余为女性。在我们的研究人群中,肝硬化最常见的原因是丙型肝炎病毒。48%的受试者QTc间期延长。年龄、实验室数据平均值与QTc延长无显著相关(P < 0.05)。肝硬化原因与QTc延长无显著相关性(P < 0.05)。肝硬化严重程度与QTc有显著相关性(P=0.020)。结论:绝大多数肝硬化患者QTc间期延长,且与肝硬化的病因无关,QTc间期延长与病情加重有显著关系。
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引用次数: 0
The frequency and spectrum of birth defects among 486 longlivers from Ivano-Frankivsk region (West Ukraine) 乌克兰西部伊凡诺-弗兰科夫斯克地区486名长寿者出生缺陷的频率和频谱分析
Pub Date : 2020-01-01 DOI: 10.15761/TIM.1000245
R. Kozovyi, L. Kovalchuk, N. Kitsera
Birth defects (BD) have a significant impact on the health and further development of the child and its adaptation in society. The purpose of this study was to document the epidemiological features of BD in longlivers from Precarpathian region (West Ukraine). Methods : cytogenetic, clinical, genealogical. Results : The medical history of BDs, somatic pathology and karyotyping was observed in 486 longlivers aged 90-102 from Ivano-Frankivsk region (West Ukraine) during 17 years (1998–2014 yy). In the group of 486 longlivers there were 15 (3.1%) patients with BD which in our study were isolated. The following defects have been diagnosed: cleft lip and cleft palate (2 men and 1 female), genital organs (1 man) and musculoskeletal system (2 men and 9 female). So patients lived for so long and it did not really affect the quality of their lives). In the longlivers prevailed cleft lip with or without palate, syndactyly and congenital complete absence of upper limb and significant difference was found (p<0.05) in Eurocat. Stable chromosomal aberrations in any longlivers person is not identified. In a group of 15 longlivers with BDs and in the group of 130 longlivers without BDs, there were no significant differences (p>0.05) in the frequency of chromosomal aberrations. Conclusion Our study also showed that no significantly risk of BDs among longlivers 3.1% and population of Ukraine -2.32% and Eurocat- 2.55%. The spectrum of chromosomal aberrations of the proband with BD and longlivers without BD had no significant difference (p>0.05) among them.
出生缺陷对儿童的健康和进一步发展及其对社会的适应具有重要影响。本研究的目的是记录来自乌克兰西部不稳定巴阡山脉地区的长寿者BD的流行病学特征。方法:细胞遗传学、临床、家谱学。结果:对乌克兰西部伊凡诺-弗兰科夫斯克地区486例90 ~ 102岁的长寿者(1998 ~ 2014年)进行了17年(1998 ~ 2014年)bd病史、躯体病理及核型分析。在我们的研究中,486名长寿者中有15名(3.1%)患者患有BD。以下缺陷已被诊断:唇腭裂(2男1女),生殖器官(1男)和肌肉骨骼系统(2男9女)。所以病人活了这么长时间,这并没有真正影响他们的生活质量)。长肝患者中唇裂伴、无腭裂、并指畸形和先天性上肢完全缺失的染色体畸变发生率差异有统计学意义(p0.05)。结论我们的研究还显示,长寿人群(3.1%)、乌克兰人群(2.32%)和欧洲人群(2.55%)发生BDs的风险不显著。先证者与无BD者的染色体畸变谱差异无统计学意义(p>0.05)。
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引用次数: 0
The relation between anxiety and functional constipation: A multicenter study in Iranian medical interns 焦虑与功能性便秘的关系:一项针对伊朗医学实习生的多中心研究
Pub Date : 2020-01-01 DOI: 10.15761/tim.1000227
A. Yousefi, Babak Kardarian, Seyed Mojtaba Hashemi, S. Noorbakhsh
Background: Functional constipation and its-related predisposing factors are so frequent among medical staff. The aim of study: To determine the prevalence of functional constipation and its relation to psychological disorders among Iranian medical interns. Methods: This multicenter, cross-sectional study was performed on 369 medical interns working at 5 main educational hospitals affiliated by universities of medical sciences in Iran during 2016-2017. The questionnaires related to the ROME criteria definitive for functional constipation were raised to confirm or reject definitive diagnosis of disease. To assess depression, anxiety and stress status of the participants, it was used the Persian version of the DASS-21 questionnaire that was previously validated by the Iranian researchers. Results: Overall, the prevalence of functional constipation in medical interns was 26.3%; and was more frequent in female gender (p=0.043). It was not related to depression in cases (p=0.1) or baseline parameters (marital status, body mass index, severity of depression, or degree of stress status). But was related to severity of anxiety (p=0.004) and irregular eating breakfast (p=0.041); deliberately ignoring defecation (p=0.010). Conclusion: It can be concluded high prevalence of functional constipation in medical interns especially in female gender, cases with low rate of eating breakfast, and deliberately ignoring defecation all might indicate the major role for anxiety in functional constipation in Iranian medical interns. Thus, the psychologic consults programs for modifying the anxiety in cases with functional constipation might be helpful.
背景:功能性便秘及其相关易感因素在医务人员中较为常见。研究目的:了解伊朗实习医师中功能性便秘的患病率及其与心理障碍的关系。方法:对2016-2017年在伊朗5所主要医学大学附属教育医院实习的369名医学实习生进行多中心横断面研究。提出与功能性便秘的ROME标准相关的问卷,以确认或拒绝疾病的明确诊断。为了评估参与者的抑郁、焦虑和压力状态,使用了先前由伊朗研究人员验证的波斯版das -21问卷。结果:总体而言,实习医师功能性便秘患病率为26.3%;且女性发病较多(p=0.043)。它与病例(p=0.1)或基线参数(婚姻状况、体重指数、抑郁严重程度或压力状态程度)无关。但与焦虑严重程度(p=0.004)和不规律吃早餐(p=0.041)有关;故意忽略排便(p=0.010)。结论:伊朗实习医生功能性便秘发生率高,尤其是女性,吃早餐率低,故意忽略排便,均可能提示焦虑在伊朗实习医生功能性便秘中的主要作用。因此,对功能性便秘患者进行心理咨询可能会有所帮助。
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引用次数: 0
Factors affecting satisfaction with emergency medical services among elderly Koreans 影响韩国老年人急救医疗服务满意度的因素
Pub Date : 2020-01-01 DOI: 10.15761/TIM.1000251
Ju Moon Park, A. Sohn
Objective: Using representative nationwide Korea Health Panel Survey data, this study examined differences and factors influencing the level of satisfaction with EMS among the elderly. Method: This study used cross-sectional analyses with 2016 KHPS data released to the public in 2019. Using both descriptive and logistic regression analyses, this paper analyzed data from the 2016 Korean Health Panel Survey (n=4,216). Results: 4,216 respondents, 15.09% were dissatisfied and 84.91% were satisfied. In logistic multivariate analysis, Age (OR, 0.817; 95%CI:0.679-0.983; p=0.032), (OR, 095%CI:0.773-0.933; p<0.01), of ER (OR, or a proxy p<0.01), for ER (OR, 95%CI:0.565-0.888; p<0.01), in the ER (OR, 95%CI:0.613- 0.939; p=0.011, and post-services measures (OR, 0.862;95%CI:0.782-0.950; p<0.01) were inversely associated with the satisfaction of EMS. Residence (OR, 1.325; 95%CI:1.287-1.616; p<0.01) and health status (OR, 1.353;95%CI:1.125-1.627; p<0.01) were significantly associated with EMS satisfaction. Conclusion: such an age, residence, health status, the respondent is a or a proxy, and of ER had significant differences in EMS satisfaction. In addition, waiting time, reasons for visiting the emergency room, and post-service measures were factors that affected satisfaction that could be used as an indicator of the quality of emergency medical services.
目的:利用具有代表性的全国韩国健康小组调查数据,研究老年人EMS满意度的差异及其影响因素。方法:本研究使用2019年向公众发布的2016年KHPS数据进行横断面分析。使用描述性和逻辑回归分析,本文分析了2016年韩国健康小组调查(n= 4216)的数据。结果:4216名被调查者中,不满意的占15.09%,满意的占84.91%。logistic多因素分析中,年龄(OR, 0.817;95%置信区间:0.679—-0.983;p=0.032), (OR, 095%CI:0.773-0.933;p<0.01), ER (OR,或代理p<0.01), ER (OR, 95%CI:0.565-0.888;p<0.01), ER组(OR, 95%CI:0.613- 0.939;p=0.011,离职后测量(OR, 0.862;95%CI:0.782-0.950;p<0.01)与EMS满意度呈负相关。居住地(OR, 1.325;95%置信区间:1.287—-1.616;p<0.01)和健康状况(OR, 1.353;95%CI:1.125 ~ 1.627;p<0.01)与EMS满意度显著相关。结论:年龄、居住地、健康状况、被调查者是本人还是代理人,以及对急诊的满意度有显著差异。此外,等候时间、去急诊室的原因和服务后措施是影响满意度的因素,可以作为紧急医疗服务质量的指标。
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引用次数: 0
Iranian participatory research impacts: A knowledge translation perspective 伊朗参与性研究的影响:知识翻译的视角
Pub Date : 2020-01-01 DOI: 10.15761/TIM.1000244
N. Loori, J. Ahmadzadeh, Kazhal Mobaraki, Ensiyeh Jamshidi, N. Gholizadeh, R. Majdzadeh
Purpose: The aim of this study is to examine the impacts of Iranian participatory research in practice. Materials/methods: A review of participatory studies conducted to find out published articles (Persian or English) in Iran. The keywords “knowledge translation, knowledge utilization, participatory research, participatory action research, outcome assessment, impact assessment, results” were searched in several domestic and international databases such as Pubmed, Medline, Embase, Iranmedex, SID and Iranpsych. This study included papers published during 2006-2008, to ensure that enough time (ten years) had passed for changes to track the short and long-term effects of researches in the next part as a cross-sectional study. Results: The findings of the cross-sectional study indicated that the greatest changes occurred at participation (92.3%) and empowerment (76.9%) levels in people/ patients; participation and capacity building (38.5%) in researchers; participation and awareness (30.8%) in health care providers groups of stakeholders. Also, the highest scores were attributed to inter-sectoral collaboration (38.5%, 53.8%) and decision-making (30.8%, 38.5%) in health policy-makers and organizational managers, respectively. Conclusions: Community-based participatory research can have a great impact on community participation in the research process, as well as on capacity building and knowledge sharing among researchers. It can also have moderate effects on improving managerial decision-making and inter-sectoral collaboration among organizational managers. translation,
目的:本研究的目的是检视伊朗参与式研究在实践中的影响。材料/方法:对参与性研究进行回顾,以找出在伊朗发表的文章(波斯语或英语)。关键词“知识转化、知识利用、参与式研究、参与式行动研究、结果评估、影响评估、结果”在Pubmed、Medline、Embase、Iranmedex、SID、Iranpsych等国内外数据库中进行检索。本研究纳入了2006-2008年期间发表的论文,以确保足够的时间(十年)已经过去,以便在下一部分中作为横断面研究跟踪研究的短期和长期影响。结果:横断面研究的结果表明,最大的变化发生在人/患者的参与(92.3%)和授权(76.9%)水平;科研人员的参与和能力建设(38.5%);保健提供者利益相关者群体的参与和认识(30.8%)。此外,得分最高的是卫生政策制定者和组织管理者的部门间协作(38.5%,53.8%)和决策(30.8%,38.5%)。结论:基于社区的参与式研究可以对社区参与研究过程、能力建设和知识共享产生重大影响。它还可以对改善管理决策和组织管理者之间的部门间协作产生适度的影响。翻译,
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引用次数: 0
Mechanically ventilated patients in internal medicine wards: Survival and outcome one-year post-discharge 内科病房机械通气患者:出院后1年生存率和转归
Pub Date : 2020-01-01 DOI: 10.15761/TIM.1000243
Bathish Jlal, M. Mahmud, B. Galina, Zeidman Aliza
Mechanical ventilation in internal medicine wards is challenging. Weaning the patients from mechanical ventilation (MV) is an even bigger challenge. The aim of this study was to characterize the mechanically ventilated patient`s population in an internal medicine ward, their weaning rate, and one-year mortality and survival rate. Methods : The study was designed as a retrospective study. We collected and analyzed data on MV patients that were hospitalized during 2016-2017 in Internal Medicine Department B, Hasharon Hospital, Rabin Medical Center, Israel. The data was analyzed according to age, gender, ethnicity, background diseases, functional status at admission, marital status and residence of the patient (home or nursing facility). We followed the patients for one year after first admission and analyzed survival and mortality rate, weaning rate, readmission, and reintubation rates. Results : Data were collected from 200 computerized patient records who were ventilated and admitted to Internal Medicine Department B during 2016-2017. A significant statistical relationship was found between the age of the patients (over 75 years) and mortality after one year. There was also a significant statistical relationship between the patient's independence and residence (home or nursing facility) for the first year after intubation. Only 6% of the elderly non-ambulatory patients who came from nursing homes survived one year after discharge. No relationship was found between the patient's gender, ethnicity or marital status for survival or mortality after one year. There was also no relationship between where the intubation took place (home/hospital/ward) and survival or mortality. Conclusions : Older MV patients coming from nursing homes and in need of nursing care had the lowest survival rates. When discussing intubation with the patient, family, medical and nursing staff and interns, these factors should be presented along with an in-depth discussion and awareness of the dying patient law.
内科病房机械通气具有一定的挑战性。让病人脱离机械通气(MV)是一个更大的挑战。本研究的目的是表征内科病房机械通气患者的人群,他们的脱机率,一年死亡率和生存率。方法:采用回顾性研究。我们收集并分析了2016-2017年在以色列Rabin医疗中心Hasharon医院B内科住院的MV患者的数据。根据患者的年龄、性别、种族、疾病背景、入院时的功能状况、婚姻状况和住所(家庭或护理机构)对数据进行分析。我们在首次入院后对患者进行了一年的随访,并分析了生存率、死亡率、脱机率、再入院率和再插管率。结果:收集2016-2017年内科B科200例换气住院的计算机病历资料。患者年龄(75岁以上)与1年后死亡率之间存在显著的统计学关系。在插管后的第一年,患者的独立性和居住(家庭或护理机构)之间也有显著的统计关系。只有6%来自养老院的老年非门诊患者在出院后一年内存活。一年后,患者的性别、种族或婚姻状况与生存率和死亡率没有关系。插管地点(家庭/医院/病房)与存活或死亡率之间也没有关系。结论:来自养老院且需要护理的老年MV患者生存率最低。当与病人、家属、医护人员和实习生讨论插管时,这些因素应与深入讨论和了解临终病人法一起提出。
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引用次数: 0
Hypertonic saline nasal irrigation and gargling as an inexpensive practical adjunctive weapon to combat asymptomatic SARS-CoV-2 infections. A case report 高渗盐水洗鼻漱口作为一种廉价实用的辅助武器对抗无症状的SARS-CoV-2感染。病例报告
Pub Date : 2020-01-01 DOI: 10.15761/TIM.1000249
Paola Rosati, U. Giordano, C. Concato
Background: Preventive policies and harmful lockdowns in Italy, Western Europe, the United States, as well as in other developing countries worldwide seem unable to contain the intensive care burden and deaths for severe acute respiratory syndrome coronavirus 2 (COVID-19), especially in nursing homes. Prompted by the limited evidence available, we wonder why until now only one publication (JAMA Otolaryngol Head Neck Surg doi:10.1001/jamaoto.2020.1622) has documented how repetitive nasal rinsing and gargling with hypertonic saline (a solution three to four times as salty as normotonic saline) could quickly contribute as an adjunctive cost-free weapon to current health policies for use against new coronavirus 2019 (SARS-CoV-2) infections at an early stage, also in quarantined people, and in developing countries. Case presentation: We report the case of a 54-year-old asymptomatic SARS-CoV-2 infected physician (positive nasopharyngeal swab test) quarantined in Rome in whom hypertonic saline nasal rinsing and gargling several times a day at home induced a rapid successful response. The infected physician remained asymptomatic, and serum immunoglobulin IgG for SARS-CoV-2 tested negative two months after the infection. Discussion and conclusions: Our case report, describing at more than two months after the SARS-CoV-2 infection negative serum IgG, seemingly supports recent evidence suggesting that asymptomatic subjects treated early with hypertonic saline solutions avoid multi-organ inflammation needing intensive care. In the current urgency state, health authorities could advocate hypertonic saline nasal rinsing and gargling as an adjunctive inexpensive procedure for SARS-CoV-2 “wash-out”. This proven, generally safe saline expedient might help as an adjunctive weapon like handwashing to combat the SARS-CoV-2 infection early in developed and developing countries, or returning as second COVID-19 waves.
背景:意大利、西欧、美国以及世界上其他发展中国家的预防政策和有害的封锁似乎无法控制严重急性呼吸综合征冠状病毒2 (COVID-19)的重症监护负担和死亡,特别是在养老院。由于现有证据有限,我们想知道为什么到目前为止只有一篇出版物(JAMA耳鼻喉头颈外科doi:10.1001/jamaoto.2020.1622)记录了用高渗盐水(一种盐浓度为正渗盐水三到四倍的溶液)反复漱口和漱口如何迅速成为当前卫生政策的一种无成本辅助武器,用于在早期阶段对抗新型冠状病毒2019 (SARS-CoV-2)感染,也适用于被隔离的人群。在发展中国家也是如此。病例介绍:我们报告了一名54岁无症状的SARS-CoV-2感染医生(鼻咽拭子试验阳性)在罗马被隔离的病例,该病例每天在家多次高渗盐水鼻冲洗和漱口引起了快速成功的反应。感染医师无症状,感染2个月后血清sars - cov - IgG检测呈阴性。讨论和结论:我们的病例报告描述了SARS-CoV-2感染后两个多月的血清IgG阴性,似乎支持了最近的证据,即无症状患者早期用高渗盐水治疗可避免多器官炎症,需要重症监护。在目前的紧急状态下,卫生当局可以提倡高渗盐水鼻冲洗和漱口,作为一种廉价的辅助措施,以“清除”SARS-CoV-2。这种经过验证的、通常安全的生理盐水权宜之计可能有助于作为一种辅助武器,如洗手,在发达国家和发展中国家早期对抗SARS-CoV-2感染,或在第二波COVID-19中回归。
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引用次数: 7
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Trends in Medicine
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