The prognosis of patients suffering from severe dyslipoproteinemia, sometimes combined with elevated lipoprotein (a) (Lp(a)), and coronary artery disease (CAD) refractory to diet and lipid-lowering drugs has been improved by the introduction of the lipoprotein-apheresis, and the human monoclonal antibodies (HMA) in different studies. All severe forms of dyslipoproteinemia can be treated successfully with these methods alone or in combination. Different lipoprotein-apheresis systems are available which reduce LDL cholesterol, Lp(a), triglycerides and others: cascade filtration or lipoproteinfiltration, immunoadsorption, heparin-induced LDL precipitation, dextran sulfate LDL adsorption, LDL hemoperfusion, and/or different HMA. There is a strong correlation between dyslipoproteinemia and atherosclerosis. Besides the elimination of other risk factors in severe dyslipoproteinemia therapeutic strategies focus on a drastic reduction of serum lipoproteins. In such patients in whom the maximum drug therapy failed, lipoprotein-apheresis (LA) is indicated. Technical and clinical aspects of these different lipoproteinapheresis methods and results of the application of HMA are shown here. The published data clearly demonstrate that treatment with lipoprotein-apheresis in patients suffering from severe dyslipoproteinemia refractory to conservative therapy are effective and safe in long application. A disadvantage is the high costs and the expensive technologies of the different lipoprotein-apheresis methods. The costs of the therapy with HMA are lower than the costs of the lipoprotein-apheresis but larger studies are necessary to show what method could be preferred. *Correspondence to: Rolf Bambauer, MD, PhD, Frankenstrasse 4, 66424 Homburg, Germany, Tel: 0049/(0)6841/68500; Fax: 0049/(0)6841/68561; E-mail: rolf.bambauer@t-online.de
{"title":"Dyslipoproteinemia therapy with lipoprotein-apheresis and/or human monoclonal antibodies","authors":"R. Bambauer, R. Schiel","doi":"10.15761/TIM.1000182","DOIUrl":"https://doi.org/10.15761/TIM.1000182","url":null,"abstract":"The prognosis of patients suffering from severe dyslipoproteinemia, sometimes combined with elevated lipoprotein (a) (Lp(a)), and coronary artery disease (CAD) refractory to diet and lipid-lowering drugs has been improved by the introduction of the lipoprotein-apheresis, and the human monoclonal antibodies (HMA) in different studies. All severe forms of dyslipoproteinemia can be treated successfully with these methods alone or in combination. Different lipoprotein-apheresis systems are available which reduce LDL cholesterol, Lp(a), triglycerides and others: cascade filtration or lipoproteinfiltration, immunoadsorption, heparin-induced LDL precipitation, dextran sulfate LDL adsorption, LDL hemoperfusion, and/or different HMA. There is a strong correlation between dyslipoproteinemia and atherosclerosis. Besides the elimination of other risk factors in severe dyslipoproteinemia therapeutic strategies focus on a drastic reduction of serum lipoproteins. In such patients in whom the maximum drug therapy failed, lipoprotein-apheresis (LA) is indicated. Technical and clinical aspects of these different lipoproteinapheresis methods and results of the application of HMA are shown here. The published data clearly demonstrate that treatment with lipoprotein-apheresis in patients suffering from severe dyslipoproteinemia refractory to conservative therapy are effective and safe in long application. A disadvantage is the high costs and the expensive technologies of the different lipoprotein-apheresis methods. The costs of the therapy with HMA are lower than the costs of the lipoprotein-apheresis but larger studies are necessary to show what method could be preferred. *Correspondence to: Rolf Bambauer, MD, PhD, Frankenstrasse 4, 66424 Homburg, Germany, Tel: 0049/(0)6841/68500; Fax: 0049/(0)6841/68561; E-mail: rolf.bambauer@t-online.de","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88546820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sepsis is an infectious agent attacking (invading) the organism, the immune response of the organism, the consequence of the cumulation of complex interaction developing between the inflammatory and coagulation systems [1-6]. The fundamental cornerstone of the determination of sepsis is the assumed or proved infection and the systemic inflammatory response reaction of the organism, (SIRS=systemic inflammatory response syndrome) accompanied with symptoms and clinical signs of fever, tachycardia, tachypnoea, hypotension and leucocytosis [1,7,8].
{"title":"Community-acquired pneumonia as a cause of sepsis","authors":"G. Bozóky, É. Ruby","doi":"10.15761/tim.1000185","DOIUrl":"https://doi.org/10.15761/tim.1000185","url":null,"abstract":"Sepsis is an infectious agent attacking (invading) the organism, the immune response of the organism, the consequence of the cumulation of complex interaction developing between the inflammatory and coagulation systems [1-6]. The fundamental cornerstone of the determination of sepsis is the assumed or proved infection and the systemic inflammatory response reaction of the organism, (SIRS=systemic inflammatory response syndrome) accompanied with symptoms and clinical signs of fever, tachycardia, tachypnoea, hypotension and leucocytosis [1,7,8].","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88861609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yumatov Ea, Potapov Vyu, Karatygin Na, Dudnik En, Pertsov Ss
An existing polygraph technique to evaluate the faithfulness of the verbal response is based on recoding of psychophysiological and somatic-and-autonomic indices, which do not reflect the actual deceitful or truthful state of the subject's brain. The advanced method of electroencephalogram wavelet transform was developed in recent years. This approach allowed us to determine a principle possibility for the direct, objective recording of mental activity in the human brain. The overall goal of the research is to develop a fundamentally new information technology to identify a truthful and deceitful state in the brain mental activity, which suggests the wavelet transform of the electroencephalogram and machine learning. For this purpose, an experimental model and software have been created and described in the article for recognizing the truthful and false mental responses of a person based on the electroencephalogram analysis. The software was developed with Microsoft Visual Studio 2017 and Net Framework 4.5. This software is simple in use and works with the Russian language interface. The developed experimental model and information-software allow us to compare electroencephalographic indicators of two mental states of brain activity, one of which is deceitful, and the other is truthful. *Correspondence to: Yumatov EA, PK Anokhin Research Institute of Normal Physiology, Moscow, Russia, E-mail: eayumatov@mail.ru
现有的一种测谎技术是基于对心理生理和身体自主指数的重新编码来评估口头反应的真实性，而这些指数并不能反映受试者大脑的真实或欺骗状态。脑电图小波变换是近年来发展起来的一种先进的方法。这种方法使我们确定了直接、客观地记录人脑心理活动的基本可能性。该研究的总体目标是开发一种全新的信息技术，以识别大脑心理活动中的真实和欺骗状态，这暗示了脑电图的小波变换和机器学习。为此，本文创建并描述了一个实验模型和软件，用于根据脑电图分析识别人的真实和虚假心理反应。该软件是使用Microsoft Visual Studio 2017和。Net Framework 4.5开发的。该软件使用简单，并与俄语界面工作。开发的实验模型和信息软件使我们能够比较大脑活动的两种精神状态的脑电图指标，其中一种是欺骗性的，另一种是真实的。*通信:Yumatov EA, PK Anokhin正常生理研究所，莫斯科，俄罗斯，E-mail: eayumatov@mail.ru
{"title":"Experimental approach to the recognition of truthful and false mental responses based on the wavelet transform of the electroencephalogram","authors":"Yumatov Ea, Potapov Vyu, Karatygin Na, Dudnik En, Pertsov Ss","doi":"10.15761/tim.1000199","DOIUrl":"https://doi.org/10.15761/tim.1000199","url":null,"abstract":"An existing polygraph technique to evaluate the faithfulness of the verbal response is based on recoding of psychophysiological and somatic-and-autonomic indices, which do not reflect the actual deceitful or truthful state of the subject's brain. The advanced method of electroencephalogram wavelet transform was developed in recent years. This approach allowed us to determine a principle possibility for the direct, objective recording of mental activity in the human brain. The overall goal of the research is to develop a fundamentally new information technology to identify a truthful and deceitful state in the brain mental activity, which suggests the wavelet transform of the electroencephalogram and machine learning. For this purpose, an experimental model and software have been created and described in the article for recognizing the truthful and false mental responses of a person based on the electroencephalogram analysis. The software was developed with Microsoft Visual Studio 2017 and Net Framework 4.5. This software is simple in use and works with the Russian language interface. The developed experimental model and information-software allow us to compare electroencephalographic indicators of two mental states of brain activity, one of which is deceitful, and the other is truthful. *Correspondence to: Yumatov EA, PK Anokhin Research Institute of Normal Physiology, Moscow, Russia, E-mail: eayumatov@mail.ru","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73947609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Subclavian aneurysm presenting as a massive hemoptysis has never been reported in the literature, the aim of the current study is to report for the first time, subclavian aneurysm-tracheal fistula presenting with massive hemoptysis. Case report: A 56-year-old female presented with massive hemoptysis which was aggravated in the last two days. The patient was known case of TB received antituberculosis and cured. General examination showed pallor. Chest X-ray, CT scan and bronchoscopy was normal. Subclavian conventional angiography showed a fistula between left proximanl subclavian artery aneurysm and upper part of the trachea. After stabilization, the patient underwent operation, ligation of the right proximal subclavian artery, division, and transposition of the subclavian artery to the left bracheocephalic trunk. Conclusion: Subclavian aneurysm-tracheal fistula presenting with massive hemoptysis has been reported for the first time in the literature. It presented as a diagnostic dilemma to the emergency room personnel. *Correspondence to: Logn Falsk, MD, Blekinge Hospital, Department of Vascular Surgery, Karlskrona, Sweden, Tel: 00467234652; Fax: 105157247950; E-mail: lognfalsk1@gmail.com
{"title":"Subclavian aneurysm-tracheal fistula presenting with massive hemoptysis, a diagnostic dilemma to the emergency room personnel - A case report","authors":"Logn Falsk","doi":"10.15761/TIM.1000169","DOIUrl":"https://doi.org/10.15761/TIM.1000169","url":null,"abstract":"Introduction: Subclavian aneurysm presenting as a massive hemoptysis has never been reported in the literature, the aim of the current study is to report for the first time, subclavian aneurysm-tracheal fistula presenting with massive hemoptysis. Case report: A 56-year-old female presented with massive hemoptysis which was aggravated in the last two days. The patient was known case of TB received antituberculosis and cured. General examination showed pallor. Chest X-ray, CT scan and bronchoscopy was normal. Subclavian conventional angiography showed a fistula between left proximanl subclavian artery aneurysm and upper part of the trachea. After stabilization, the patient underwent operation, ligation of the right proximal subclavian artery, division, and transposition of the subclavian artery to the left bracheocephalic trunk. Conclusion: Subclavian aneurysm-tracheal fistula presenting with massive hemoptysis has been reported for the first time in the literature. It presented as a diagnostic dilemma to the emergency room personnel. *Correspondence to: Logn Falsk, MD, Blekinge Hospital, Department of Vascular Surgery, Karlskrona, Sweden, Tel: 00467234652; Fax: 105157247950; E-mail: lognfalsk1@gmail.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":"13 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91421305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Areti-zoi Cheimonidou, D. Lamnisos, A. Lisacek-Kiosoglous, C. Chimonas, D. Stasinopoulos
1Physiotherapy Program, Department of Health Sciences, School of Sciences, European University Cyprus, Diogenes 6 Street. Engomi, P.O.Box 22006, 1516, Nicosia, Cyprus 2Department of Health Sciences, School of Sciences, European University Cyprus, Diogenes 6 Street. Engomi, P.O. Box 22006, 1516, Nicosia, Cyprus 3School of Medicine, European University Cyprus, Diogenes 6 Street. Engomi, P.O. Box 22006, 1516, Nicosia, Cyprus 4Director of Cyprus Musculoskeletal and Sports Trauma Research Centre (CYMUSTREC), Diogenes 6 Street. Engomi, P.O. Box 22006, 1516, Nicosia, Cyprus
{"title":"Validity and reliability of the finkelstein test","authors":"Areti-zoi Cheimonidou, D. Lamnisos, A. Lisacek-Kiosoglous, C. Chimonas, D. Stasinopoulos","doi":"10.15761/tim.1000183","DOIUrl":"https://doi.org/10.15761/tim.1000183","url":null,"abstract":"1Physiotherapy Program, Department of Health Sciences, School of Sciences, European University Cyprus, Diogenes 6 Street. Engomi, P.O.Box 22006, 1516, Nicosia, Cyprus 2Department of Health Sciences, School of Sciences, European University Cyprus, Diogenes 6 Street. Engomi, P.O. Box 22006, 1516, Nicosia, Cyprus 3School of Medicine, European University Cyprus, Diogenes 6 Street. Engomi, P.O. Box 22006, 1516, Nicosia, Cyprus 4Director of Cyprus Musculoskeletal and Sports Trauma Research Centre (CYMUSTREC), Diogenes 6 Street. Engomi, P.O. Box 22006, 1516, Nicosia, Cyprus","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":"57 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91514143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Mould infection on the human skin is one of important effects of mould on human health. Skin mould infection is normally caused by Aspegillus, Penicillium and Rhizopus. To date, orange oil has been applied in the present study to inhibit mould infection by adding it into fungal paper. Fungal paper made from Trametes versicolor was used to absorb and slow down the release of orange oil vapour. Therefore, the objective of this work was to investigate the effect of orange oil in fungal paper on growth of infected skin mould as a model in vitro test. Methods: Orange oil and the main component (limonene) was prepared in the Malt Extract Agar (MEA) and added into fungal paper made from T. versicolor at concentrations of 0 (control), 20, 40, 60, 80 and 100 μg g−1. Each of mycelium and spores of Aspergillus niger, Aspergillus flavus, Penicillium chrysogenum and Rhizopus spp were placed on the MEA. A spore of mould was sprayed on the fungal paper. Results: Using 60 μg g−1 of orange oil in MEA and 80 μg g−1 of orange oil in the fungal paper exhibited complete inhibition of growth of all moulds in this test. Limonene alone could not inhibit all moulds in this test; therefore, some minor components of orange can play a significant role in mould growth inhibition. Moreover, fungal paper made from T. versicolor exhibited slow release of orange oil components with active to inhibit mould at least 30 days. Conclusions: Thus, this research demonstrated the potential of fungal paper containing orange oil to control the growth of infected moulds and that this combination could be applied in medicine to control infection of skin in the future. *Correspondence to: Narumol Matan, Food Science and Technology, School of Agricultural Technology, Walailak University, Nakhon Si Thammarat 80160, Thailand and Research Center of Excellence in Innovation of Essential oil, Walailak University, Nakhon Si Thammarat 80160, Thailand, Tel: 6675672359; Fax: 6675672971; E-mail: nnarumol@wu.ac.th; nnarumol@yahoo.com
人体皮肤霉菌感染是霉菌对人体健康的重要影响之一。皮肤霉菌感染通常是由曲霉、青霉和根霉引起的。迄今为止，本研究已将橙油添加到真菌纸中，以抑制霉菌感染。用彩板菌制成的真菌纸来吸收和减缓橙油蒸汽的释放。因此，本研究以真菌纸中的橙油为模型，探讨其对感染皮肤霉菌生长的影响。方法:在麦芽提取物琼脂(MEA)中制备橙油和主要成分柠檬烯，分别以0(对照)、20、40、60、80和100 μg−1的浓度加入到由花枝霉制成的真菌纸中。将黑曲霉、黄曲霉、黄化青霉和根霉的菌丝体和孢子分别置于MEA上。将霉菌孢子喷在真菌纸上。结果:在MEA中添加60 μg−1的橙油，在真菌纸中添加80 μg−1的橙油，对本试验中所有霉菌的生长均有完全的抑制作用。单用柠檬烯不能抑制所有霉菌;因此，橙中的一些微量成分可以起到显著的抑制霉菌生长的作用。此外，以紫皮霉为原料制成的真菌纸，其橙油成分释放缓慢，对霉菌的抑制作用至少为30天。结论:本研究证明了含橙油真菌纸具有控制感染霉菌生长的潜力，该组合可在未来用于医学上控制皮肤感染。*通讯:Narumol Matan，食品科学与技术，Walailak大学农业技术学院，Nakhon Si Thammarat 80160，泰国;Narumol Matan, Walailak大学精油创新卓越研究中心，Nakhon Si Thammarat 80160，泰国，电话:6675672359;传真:6675672971;电子邮件:nnarumol@wu.ac.th;nnarumol@yahoo.com
{"title":"Development of antifungal paper from Trametes versicolor containing orange oil against fungal skin infections: A model based on in vitro studies","authors":"Sirimas Sukmas, T. Aewsiri, N. Matan","doi":"10.15761/TIM.1000186","DOIUrl":"https://doi.org/10.15761/TIM.1000186","url":null,"abstract":"Introduction: Mould infection on the human skin is one of important effects of mould on human health. Skin mould infection is normally caused by Aspegillus, Penicillium and Rhizopus. To date, orange oil has been applied in the present study to inhibit mould infection by adding it into fungal paper. Fungal paper made from Trametes versicolor was used to absorb and slow down the release of orange oil vapour. Therefore, the objective of this work was to investigate the effect of orange oil in fungal paper on growth of infected skin mould as a model in vitro test. Methods: Orange oil and the main component (limonene) was prepared in the Malt Extract Agar (MEA) and added into fungal paper made from T. versicolor at concentrations of 0 (control), 20, 40, 60, 80 and 100 μg g−1. Each of mycelium and spores of Aspergillus niger, Aspergillus flavus, Penicillium chrysogenum and Rhizopus spp were placed on the MEA. A spore of mould was sprayed on the fungal paper. Results: Using 60 μg g−1 of orange oil in MEA and 80 μg g−1 of orange oil in the fungal paper exhibited complete inhibition of growth of all moulds in this test. Limonene alone could not inhibit all moulds in this test; therefore, some minor components of orange can play a significant role in mould growth inhibition. Moreover, fungal paper made from T. versicolor exhibited slow release of orange oil components with active to inhibit mould at least 30 days. Conclusions: Thus, this research demonstrated the potential of fungal paper containing orange oil to control the growth of infected moulds and that this combination could be applied in medicine to control infection of skin in the future. *Correspondence to: Narumol Matan, Food Science and Technology, School of Agricultural Technology, Walailak University, Nakhon Si Thammarat 80160, Thailand and Research Center of Excellence in Innovation of Essential oil, Walailak University, Nakhon Si Thammarat 80160, Thailand, Tel: 6675672359; Fax: 6675672971; E-mail: nnarumol@wu.ac.th; nnarumol@yahoo.com","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76816704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Popović-Grle, Višnja Dukić, Josipa Škugor, D. Oroz, D. Ogresta
Aim: Estimation of the difference in frequency and type of comorbidities in patients with chronic obstructive pulmonary disease (COPD), grouped by COPD severity stages according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD), from 1 to 4. The data subjects and methods: This study included 168 COPD patients with an equal share of patients in each GOLD stage (GOLD I 47 subjects, GOLD II 43, GOLD III 41 and GOLD IV 37 subjects). All data subjects, 106 men and 62 women (median age 66), were processed according to the successive arrival at the Clinical Center for Pulmonary Diseases Jordanovac, University Hospital Center Zagreb, for their medical examination. Results: The most common comorbidities were cardiovascular diseases with 60.1%, regardless of the GOLD stage. These are followed by pneumonia in 25.6% of COPD patients, anxiety and depression in 16.1%, diabetes in 12.5% and osteoporosis in 11.9% of the COPD patients. The most frequent malignant disease was the urinary bladder cancer. The share of the patients who suffered from pneumonia is consistently increasing with the severity of GOLD stages. Conclusion: The average number of comorbidities in GOLD I stage was 1.5, in GOLD II stage 1.8, GOLD III stage 2.1 and in GOLD IV stage 1.7. This suggests that the difference in the number of comorbidities according to the GOLD stages could be significant. This preliminary result was confirmed by a statistical chi-squared test with a significance level of 5% ( α = 0.05), whereas the difference in the types of comorbidities according to the GOLD stages was not statistically significant.
{"title":"Does COPD severity stage change comorbidities pattern?","authors":"S. Popović-Grle, Višnja Dukić, Josipa Škugor, D. Oroz, D. Ogresta","doi":"10.15761/tim.1000209","DOIUrl":"https://doi.org/10.15761/tim.1000209","url":null,"abstract":"Aim: Estimation of the difference in frequency and type of comorbidities in patients with chronic obstructive pulmonary disease (COPD), grouped by COPD severity stages according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD), from 1 to 4. The data subjects and methods: This study included 168 COPD patients with an equal share of patients in each GOLD stage (GOLD I 47 subjects, GOLD II 43, GOLD III 41 and GOLD IV 37 subjects). All data subjects, 106 men and 62 women (median age 66), were processed according to the successive arrival at the Clinical Center for Pulmonary Diseases Jordanovac, University Hospital Center Zagreb, for their medical examination. Results: The most common comorbidities were cardiovascular diseases with 60.1%, regardless of the GOLD stage. These are followed by pneumonia in 25.6% of COPD patients, anxiety and depression in 16.1%, diabetes in 12.5% and osteoporosis in 11.9% of the COPD patients. The most frequent malignant disease was the urinary bladder cancer. The share of the patients who suffered from pneumonia is consistently increasing with the severity of GOLD stages. Conclusion: The average number of comorbidities in GOLD I stage was 1.5, in GOLD II stage 1.8, GOLD III stage 2.1 and in GOLD IV stage 1.7. This suggests that the difference in the number of comorbidities according to the GOLD stages could be significant. This preliminary result was confirmed by a statistical chi-squared test with a significance level of 5% ( α = 0.05), whereas the difference in the types of comorbidities according to the GOLD stages was not statistically significant.","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":"263 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79698531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Javier Solá Martínez, M. L. G. Gutiérrez, Maria Rodriguez, E. Vera, Ana Montoro De Francisco, Elena Laffond Yges, D. H. Rojas, M. R. Mosquera, Lourdes Pérez González, S. Cimbollek, A. M. Pulido, N. Cancelliere, B. López, Javier Herranz
{"title":"Evaluation of the adherence to subcutaneous immunotherapy in patients with pollen allergy in usual clinical practice: The CITY study","authors":"Francisco Javier Solá Martínez, M. L. G. Gutiérrez, Maria Rodriguez, E. Vera, Ana Montoro De Francisco, Elena Laffond Yges, D. H. Rojas, M. R. Mosquera, Lourdes Pérez González, S. Cimbollek, A. M. Pulido, N. Cancelliere, B. López, Javier Herranz","doi":"10.15761/TIM.1000196","DOIUrl":"https://doi.org/10.15761/TIM.1000196","url":null,"abstract":"","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82779988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Díaz-García, Arianna Yglesias-Rivera, Jenny L. Ruiz-Fuentes, Rayner Ochoa-Cardentey, Jose Raúl Torres Viltres, Hermis Rodríguez-Sánchez, Tania Gómez Peña
Frequency of scorpion venom extraction could influence the quality of venom and as a result may vary their biological activity, whether pharmacological or toxicological behavior, due to venom regeneration is an asynchronous process. In the present study we evaluate the protein content, concentration and biological activity of Rhopalurus junceus scorpion varying the extended periods of venom collection. Three scorpion groups were re-milked at 7, 15 and 21 days after first extraction. Differences in protein content were analyzed by SDSPAGE and HPLC techniques. The biological effect against A549, C6/36HT and Vero cells was assayed by MTT using different venom concentration (0.062; 0.125; 0.25; 0.5; 1 mg/mL). Venom from day 7 and 15 showed significant differences in protein concentration (p<0.05) respect to first extraction. SDS-PAGE and HPLC showed the highest and lowest variation in venom content, at day 7 and 21 respectively. Vero normal cells viability was not affected at all extraction periods. Meanwhile, insect cells, C6/36HT was sensitive at all extraction periods. Extended periods of venom collection was positively correlated with the regeneration of venom composition and the increase of cytotoxic effect against A549 cancer cells. R. junceus venom regeneration showed to be asynchronous depending of the target cell. Besides, venom seems to be completely renewal after 21 days showing high protein content and reproducible results against cancer cells respect to former extraction. *Correspondence to: Alexis Díaz-García, Millennium Nucleus of Ion ChannelsAssociated Diseases (MiNICAD), University of Chile, Faculty of Medicine, North Campus, Ave. Independencia 1027 Hall B, First Floor, Chile, E-mail: alexisdg76@gmail.com
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Nívea Maria de Oliveira Jacques, Felipe J Aidar, L. Leitão, M. Espada, Aldo M. Costa, Ana Pereira
Systemic arterial hypertension represents one of the principal risk factors for the increase of cardiovascular diseases, especially in the elderly people. On post-exercise, blood pressure responses (BP) may decrease and this effect have a relevant clinical importance. However, further studies are needed to better understand the effects of different intensities and exercise modes. The aim of this study was to analyse the hypotensive effect of resistance exercises on BP of controlled hypertensive women performed at different intensities. The study sample was composed by 13 hypertensive elderly women (65.5±4.2 years), submitted to two different training intensities: 50% and 70% of 10 RM. After the resistant exercise systolic and diastolic blood pressure were measured during 1 hour and every 10 minutes. Significant differences were found only in diastolic blood pressure (DBP) measured at 10 (p=0.034), 20 (p=0.042), 30 (p=0.031), 45 (p=0.035) and 60 minutes (p=0.017) after the effort. Our data suggest that resistance exercise does not result in PEH in hypertensive elderly women without significant effects on diastolic blood pressure at different intensities. *Correspondence to: Aldo M. Costa, Department of Sports Sciences, University of Beira Interior, Covilhã, Portugal, Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, Vila Real, Portugal, Health Sciences Research Center, CICS-UBI, Covilhã, Portugal, E-mail: anapereiraphd@gmail.com
系统性动脉高血压是心血管疾病增加的主要危险因素之一，特别是在老年人中。在运动后，血压反应(BP)可能会降低，这种影响具有相关的临床意义。然而，需要进一步的研究来更好地了解不同强度和运动模式的影响。本研究的目的是分析不同强度的抗阻运动对控制高血压妇女血压的降压作用。研究样本由13名老年高血压女性(65.5±4.2岁)组成，接受两种不同的训练强度:10 RM的50%和70%。抗阻运动后，每隔10分钟测一次收缩压和舒张压。只有在术后10分钟(p=0.034)、20分钟(p=0.042)、30分钟(p=0.031)、45分钟(p=0.035)和60分钟(p=0.017)测量的舒张压(DBP)存在显著差异。我们的数据表明，阻力运动不会导致老年高血压妇女的PEH，对不同强度的舒张压没有显著影响。*通信对象:Aldo M. Costa，贝拉内河大学体育科学系，Covilhã，葡萄牙，葡萄牙雷亚尔市CIDESD体育科学、健康科学和人类发展研究中心，CICS-UBI健康科学研究中心，Covilhã，葡萄牙，E-mail: anapereiraphd@gmail.com
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