Pub Date : 2026-01-01DOI: 10.1016/j.tube.2025.102710
Eileen M. Murphy , G. Michael Taylor , Tom A. Mendum , Graham R. Stewart
Eight burials from the multi-period rural settlement site of Ranelagh near Roscommon town, Ireland, with palaeopathological lesions suggestive of skeletal tuberculosis or brucellosis were examined by ancient DNA (aDNA) testing. Tuberculosis infection (MTB complex DNA) was confirmed in five individuals – an 11th-13th CE adolescent female (14.5–17.5 years), two young adults females (18–35 years, 7th-10th CE), one adolescent of unknown sex and one middle-aged adult (35–50 years, medieval in date). In the latter case, the differential diagnosis included brucellosis due to the presence of small multifocal lytic lesions in the lower spinal vertebrae. However, this individual and all cases tested negative for Brucella species DNA. In two positive cases, lineage 4 (Euro-American) Mycobacterium tuberculosis DNA was identified in extracts obtained from tooth pulp cavities. These are the first archaeological individuals from Ireland to have had tuberculosis infection confirmed through aDNA analysis.
{"title":"First confirmation of Mycobacterium tuberculosis complex from medieval Ireland by aDNA analysis – palaeopathological and microbial findings","authors":"Eileen M. Murphy , G. Michael Taylor , Tom A. Mendum , Graham R. Stewart","doi":"10.1016/j.tube.2025.102710","DOIUrl":"10.1016/j.tube.2025.102710","url":null,"abstract":"<div><div>Eight burials from the multi-period rural settlement site of Ranelagh near Roscommon town, Ireland, with palaeopathological lesions suggestive of skeletal tuberculosis or brucellosis were examined by ancient DNA (aDNA) testing. Tuberculosis infection (MTB complex DNA) was confirmed in five individuals – an 11th-13th CE adolescent female (14.5–17.5 years), two young adults females (18–35 years, 7th-10th CE), one adolescent of unknown sex and one middle-aged adult (35–50 years, medieval in date). In the latter case, the differential diagnosis included brucellosis due to the presence of small multifocal lytic lesions in the lower spinal vertebrae. However, this individual and all cases tested negative for <em>Brucella</em> species DNA. In two positive cases, lineage 4 (Euro-American) <em>Mycobacterium tuberculosis</em> DNA was identified in extracts obtained from tooth pulp cavities. These are the first archaeological individuals from Ireland to have had tuberculosis infection confirmed through aDNA analysis.</div></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"156 ","pages":"Article 102710"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.tube.2025.102722
Safiya Mehraj , Shazia Ali , Chetan Kumar , Asif Ali , Zahoor Ahmad
{"title":"Corrigendum to “Inhibition of mycobacteria proliferation in macrophages by diaryl ether derivatives of Dehydrozingerone compound and repurposed drugs (Rebamipide, Sofalcone) via NF-κB pathway inhibition” [Tuberculosis, 155(2025), 102706]","authors":"Safiya Mehraj , Shazia Ali , Chetan Kumar , Asif Ali , Zahoor Ahmad","doi":"10.1016/j.tube.2025.102722","DOIUrl":"10.1016/j.tube.2025.102722","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"156 ","pages":"Article 102722"},"PeriodicalIF":2.9,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.tube.2025.102723
Qiangsen Zhong , Xiaochun Wang , Yun Xu , Runlin Wang , Mingming Zhou , Xinkuang Liu
{"title":"Response to “Constructive appraisal of Zhong et al.’s study on Mycobacterium tuberculosis dormant antigens and PB2-DIMQ vaccine: Opportunities for translational strengthening”","authors":"Qiangsen Zhong , Xiaochun Wang , Yun Xu , Runlin Wang , Mingming Zhou , Xinkuang Liu","doi":"10.1016/j.tube.2025.102723","DOIUrl":"10.1016/j.tube.2025.102723","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"156 ","pages":"Article 102723"},"PeriodicalIF":2.9,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1016/j.tube.2025.102720
Anuradha Rajamanickam , Evangeline Ann Daniel , Nikhil Gupte , Kannan Thiruvengadam , Padmapriyadarsini Chandrasekaran , Sathyamurthi Pattabiraman , Brindha Bhanu , Amsaveni Sivaprakasam , Mandar Paradkar , Vandana Kulkarni , Rajesh Karyakarte , Vidya Mave , Amita Gupta , Luke Elizabeth Hanna , Subash Babu
Background
Identifying host biomarkers associated with progression from Mycobacterium tuberculosis infection to active tuberculosis (TB) could support early risk stratification in household contacts (HHCs). This exploratory study evaluated baseline plasma immune biomarkers in HHCs of pulmonary TB (PTB) patients to assess their association with subsequent disease development.
Methods
We analyzed baseline plasma samples from 15 progressors and 29 non-progressors enrolled from PTB-affected households. Acute-phase proteins (α-2-macroglobulin (α-2-M), C-reactive protein [CRP], haptoglobin (Hp), serum amyloid P (SAP)) and microbial translocation markers (lipopolysaccharide, lipid-binding protein, endotoxin core antibodies IgG, intestinal fatty acid-binding protein [iFABP], sCD14, and zonulin) were measured using Luminex and ELISA. Logistic regression and ROC analyses were performed as exploratory assessments of biomarker associations.
Results
Higher baseline levels of CRP, iFABP, and zonulin were observed among progressors compared with non-progressors. In univariable analyses, these biomarkers showed strong discriminatory ability (AUC ≥0.90), although estimates should be interpreted cautiously given the small sample size. A combined model including CRP, iFABP, and zonulin demonstrated high discriminatory performance (AUC 0.99 [95 % CI: 0.97–1.00]), but confidence intervals reflect the imprecision inherent to the limited dataset.
Conclusions
In this exploratory cohort, elevated CRP, iFABP, and zonulin were associated with progression to active TB among household contacts. These preliminary findings suggest potential involvement of inflammatory and gut-barrier pathways in TB progression and warrant validation in larger, independent cohorts to define their translational utility.
{"title":"Plasma biomarkers CRP, iFABP, and zonulin as predictors of tuberculosis progression in household contacts of pulmonary TB patients","authors":"Anuradha Rajamanickam , Evangeline Ann Daniel , Nikhil Gupte , Kannan Thiruvengadam , Padmapriyadarsini Chandrasekaran , Sathyamurthi Pattabiraman , Brindha Bhanu , Amsaveni Sivaprakasam , Mandar Paradkar , Vandana Kulkarni , Rajesh Karyakarte , Vidya Mave , Amita Gupta , Luke Elizabeth Hanna , Subash Babu","doi":"10.1016/j.tube.2025.102720","DOIUrl":"10.1016/j.tube.2025.102720","url":null,"abstract":"<div><h3>Background</h3><div>Identifying host biomarkers associated with progression from <em>Mycobacterium tuberculosis</em> infection to active tuberculosis (TB) could support early risk stratification in household contacts (HHCs). This exploratory study evaluated baseline plasma immune biomarkers in HHCs of pulmonary TB (PTB) patients to assess their association with subsequent disease development.</div></div><div><h3>Methods</h3><div>We analyzed baseline plasma samples from 15 progressors and 29 non-progressors enrolled from PTB-affected households. Acute-phase proteins (α-2-macroglobulin (α-2-M), C-reactive protein [CRP], haptoglobin (Hp), serum amyloid P (SAP)) and microbial translocation markers (lipopolysaccharide, lipid-binding protein, endotoxin core antibodies IgG, intestinal fatty acid-binding protein [iFABP], sCD14, and zonulin) were measured using Luminex and ELISA. Logistic regression and ROC analyses were performed as exploratory assessments of biomarker associations.</div></div><div><h3>Results</h3><div>Higher baseline levels of CRP, iFABP, and zonulin were observed among progressors compared with non-progressors. In univariable analyses, these biomarkers showed strong discriminatory ability (AUC ≥0.90), although estimates should be interpreted cautiously given the small sample size. A combined model including CRP, iFABP, and zonulin demonstrated high discriminatory performance (AUC 0.99 [95 % CI: 0.97–1.00]), but confidence intervals reflect the imprecision inherent to the limited dataset.</div></div><div><h3>Conclusions</h3><div>In this exploratory cohort, elevated CRP, iFABP, and zonulin were associated with progression to active TB among household contacts. These preliminary findings suggest potential involvement of inflammatory and gut-barrier pathways in TB progression and warrant validation in larger, independent cohorts to define their translational utility.</div></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"156 ","pages":"Article 102720"},"PeriodicalIF":2.9,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145782650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1016/j.tube.2025.102721
K.M. Venkatesh , Nicolas Lopez-Villalobos , Sandeep K. Gupta , Garry B. Udy , Richard Laven , Shih-Jiuan Chiu , Piyush Bugde , Yoichi Furuya , Venkata Sayoji Rao Dukkipati
{"title":"Responses to comments on “A comparative study between milk- and serum-based antibody detection assays for Johne's disease in New Zealand dairy cattle”","authors":"K.M. Venkatesh , Nicolas Lopez-Villalobos , Sandeep K. Gupta , Garry B. Udy , Richard Laven , Shih-Jiuan Chiu , Piyush Bugde , Yoichi Furuya , Venkata Sayoji Rao Dukkipati","doi":"10.1016/j.tube.2025.102721","DOIUrl":"10.1016/j.tube.2025.102721","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"156 ","pages":"Article 102721"},"PeriodicalIF":2.9,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comments on “A comparative study between milk- and serum-based antibody detection assays for Johne's disease in New Zealand dairy cattle”","authors":"Arun Kumar, Ankur Sharma, Saumya Das, Preeti Dnyandeo Sonje, Dhanya Dedeepya","doi":"10.1016/j.tube.2025.102719","DOIUrl":"10.1016/j.tube.2025.102719","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"156 ","pages":"Article 102719"},"PeriodicalIF":2.9,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1016/j.tube.2025.102718
Uzair Abbas , Kiran Iqbal Masood , Tulaib Iqbal , Shama Qaiser , Martin Rottenberg , Bushra Jamil , Rabia Hussain , Zahra Hasan
SARS-CoV-2 infection modulates innate and adaptive immunity and likely impacts outcomes of infections such as Mycobacterium tuberculosis (MTB). We investigated the association between COVID-19 and latent tuberculosis infection (LTBi), studying viral and mycobacterial antigen-stimulated responses in those with and without a history of COVID-19.
We studied healthy Controls and COVID-19 convalescent subjects. Participants were screened for LTBi using an interferon-gamma release assay (IGRA). SARS-CoV-2 Spike- and MTB H37Rv-sonicate -stimulated cytokines from peripheral blood mononuclear cells (PBMCs) were measured.
Spike-induced IFN-γ (p = 0.03), IL-6 (p = 0.018) and IL-2 (p = 0.04) levels were reduced in COVID-19 as compared with Controls. Within Controls, Spike induced higher cytokine levels in IGRA positive participants (p < 0.05). MTB-induced IFN-γ (0.003), IL-2 (p = 0.0021), IL-6 (p = 0.002), TNF-α (p = 0.02), and IL-10 (p = 0.04) levels were lowered in COVID-19. MTB- stimulated higher levels of proinflammatory cytokines were found in IGRA-positive Controls. Between IGRA positive participants, the COVID-19 group displayed lower Spike and MTB induced IFN-γ (0.003), IL-6 (0.0037), IL-2 (0.001), and TNF-α (0.005) levels. Further, MTB-induced IL-6/IL-10 and TNF-α/IL-10 ratios were higher in COVID-IGRA positive participants.
Reduced SARS-CoV-2 and MTB activation of inflammatory cytokines reflects downregulated immunity after COVID-19. Further studies are required to assess whether LTBi and COVID-19 increase the risk of progression to tuberculosis.
{"title":"Dysregulated IFN-γ, IL-6 and TNF-α after COVID-19 is suggestive of lowered innate immune responses to SARS-CoV-2 and MTB","authors":"Uzair Abbas , Kiran Iqbal Masood , Tulaib Iqbal , Shama Qaiser , Martin Rottenberg , Bushra Jamil , Rabia Hussain , Zahra Hasan","doi":"10.1016/j.tube.2025.102718","DOIUrl":"10.1016/j.tube.2025.102718","url":null,"abstract":"<div><div>SARS-CoV-2 infection modulates innate and adaptive immunity and likely impacts outcomes of infections such as <em>Mycobacterium tuberculosis</em> (MTB). We investigated the association between COVID-19 and latent tuberculosis infection (LTBi), studying viral and mycobacterial antigen-stimulated responses in those with and without a history of COVID-19.</div><div>We studied healthy Controls and COVID-19 convalescent subjects. Participants were screened for LTBi using an interferon-gamma release assay (IGRA). SARS-CoV-2 Spike- and MTB H37Rv-sonicate -stimulated cytokines from peripheral blood mononuclear cells (PBMCs) were measured.</div><div>Spike-induced IFN-γ (p = 0.03), IL-6 (p = 0.018) and IL-2 (p = 0.04) levels were reduced in COVID-19 as compared with Controls. Within Controls, Spike induced higher cytokine levels in IGRA positive participants (p < 0.05). MTB-induced IFN-γ (0.003), IL-2 (p = 0.0021), IL-6 (p = 0.002), TNF-α (p = 0.02), and IL-10 (p = 0.04) levels were lowered in COVID-19. MTB- stimulated higher levels of proinflammatory cytokines were found in IGRA-positive Controls. Between IGRA positive participants, the COVID-19 group displayed lower Spike and MTB induced IFN-γ (0.003), IL-6 (0.0037), IL-2 (0.001), and TNF-α (0.005) levels. Further, MTB-induced IL-6/IL-10 and TNF-α/IL-10 ratios were higher in COVID-IGRA positive participants.</div><div>Reduced SARS-CoV-2 and MTB activation of inflammatory cytokines reflects downregulated immunity after COVID-19. Further studies are required to assess whether LTBi and COVID-19 increase the risk of progression to tuberculosis.</div></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"156 ","pages":"Article 102718"},"PeriodicalIF":2.9,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145683684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to “Correspondence on ‘Utility of pleural fluid-derived extracellular vesicles as a source of Mycobacterium tuberculosis antigens MPT51 and MPT64 for pleural TB diagnosis: a proof-of-concept study”","authors":"Neha Jindal, Manisha Dass, Pratibha Sharma, Sagarika Haldar","doi":"10.1016/j.tube.2025.102699","DOIUrl":"10.1016/j.tube.2025.102699","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"155 ","pages":"Article 102699"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145535028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.tube.2025.102706
Safiya Mehraj , Shazia Ali , Chetan Kumar , Asif Ali , Zahoor Ahmad
Background
Chronic inflammation fuels tissue damage and morbidity in numerous diseases, including Tuberculosis, underscoring the vital need for Host-Directed Therapies to safely modulate the exaggerated host response. We investigated the immunomodulatory potential of Sofalcone and Rebamipide alongside a novel Diaryl Ether derivative of Dehydrozingerone DHZ (6), hypothesizing that they exert therapeutic effects by targeting the central inflammatory driver, the NF-κB pathway.
Methods
We evaluated the safety and efficacy of the compounds in THP-1 macrophages infected with M. smegmatis. Mechanistic studies utilized Western blotting, immunofluorescence, and ELISA to track NF-κB activation. MMP activity was assessed by gelatin zymography, and ROS production was quantified using the DCFH-DA assay.
Results
All compounds exhibited low cytotoxicity and significantly reduced intracellular bacterial survival. Agents potently and consistently inhibited the NF-κB cascade, evidenced by ≈ 83 % suppression of upstream P-IKKα/IKKβ and up to ≈89 % reduction in p65 phosphorylation. This molecular blockade prevented p65 nuclear translocation and resulted in a downstream functional benefit: near total abolition of MMP-2/9 activity and ≈71 % mitigation of ROS production.
Conclusion
Our results unequivocally validate NF-κB inhibition by DHZ (6), Sofalcone, and Rebamipide as a powerful strategy for HDT. These compounds are promising adjunct therapies to suppress host inflammation and limit tissue damage.
{"title":"Inhibition of mycobacteria proliferation in macrophages by diaryl ether derivatives of Dehydrozingerone compound and repurposed drugs (Rebamipide, Sofalcone) via NF-κB pathway inhibition","authors":"Safiya Mehraj , Shazia Ali , Chetan Kumar , Asif Ali , Zahoor Ahmad","doi":"10.1016/j.tube.2025.102706","DOIUrl":"10.1016/j.tube.2025.102706","url":null,"abstract":"<div><h3>Background</h3><div>Chronic inflammation fuels tissue damage and morbidity in numerous diseases, including Tuberculosis, underscoring the vital need for Host-Directed Therapies to safely modulate the exaggerated host response. We investigated the immunomodulatory potential of Sofalcone and Rebamipide alongside a novel Diaryl Ether derivative of Dehydrozingerone DHZ (6), hypothesizing that they exert therapeutic effects by targeting the central inflammatory driver, the NF-κB pathway.</div></div><div><h3>Methods</h3><div>We evaluated the safety and efficacy of the compounds in THP-1 macrophages infected with <em>M. smegmatis.</em> Mechanistic studies utilized Western blotting, immunofluorescence, and ELISA to track NF-κB activation. MMP activity was assessed by gelatin zymography, and ROS production was quantified using the DCFH-DA assay.</div></div><div><h3>Results</h3><div>All compounds exhibited low cytotoxicity and significantly reduced intracellular bacterial survival. Agents potently and consistently inhibited the NF-κB cascade, evidenced by ≈ 83 % suppression of upstream P-IKKα/IKKβ and up to ≈89 % reduction in p65 phosphorylation. This molecular blockade prevented p65 nuclear translocation and resulted in a downstream functional benefit: near total abolition of MMP-2/9 activity and ≈71 % mitigation of ROS production.</div></div><div><h3>Conclusion</h3><div>Our results unequivocally validate NF-κB inhibition by DHZ (6), Sofalcone, and Rebamipide as a powerful strategy for HDT. These compounds are promising adjunct therapies to suppress host inflammation and limit tissue damage.</div></div>","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"155 ","pages":"Article 102706"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.tube.2025.102695
Promod K. Mehta
{"title":"Letter to Editor: manuscript entitled “Utility of pleural fluid-derived extracellular vesicles as a source of Mycobacterium tuberculosis antigens MPT51 and MPT64 for pleural TB diagnosis: a proof-of-concept study” by Jindal et al. published in Tuberculosis150 (2025) 102578","authors":"Promod K. Mehta","doi":"10.1016/j.tube.2025.102695","DOIUrl":"10.1016/j.tube.2025.102695","url":null,"abstract":"","PeriodicalId":23383,"journal":{"name":"Tuberculosis","volume":"155 ","pages":"Article 102695"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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