Pub Date : 2024-01-26DOI: 10.15625/2525-2518/17325
Ngo Thu Huong, Hoang Thi Huyen, T. Q. Phong
Tetracycline (TC) is a broad-spectrum antibiotic used in the treatment of several infectious diseases. The excessive use of tetracycline antibiotics, especially tetracyclines in livestock, has raised concerns about residues of tetracycline antibiotics in food that may affect consumers' health. It is necessary to develop a rapid test strip for detecting tetracycline antibiotic residues in food and animal feed. This paper presents the suitable conditions for the conjugation of tetracycline to BSA or KLH: molar ratio of TC:BSA/KLH was 25:1, formaldehyde concentration of 5 %, temperature of 4oC and reaction time of 4 hours. The KLH-TC conjugate was used to successfully raise polyclonal antibodies against TC in rabbits. The anti-TC polyclonal antibodies were purified and could be used for the development of the lateral flow immunoassay test strip for the detection of tetracycline.
{"title":"Conjugation of tetracycline with carrier proteins and production of its polyclonal antibody for the development of rapid test","authors":"Ngo Thu Huong, Hoang Thi Huyen, T. Q. Phong","doi":"10.15625/2525-2518/17325","DOIUrl":"https://doi.org/10.15625/2525-2518/17325","url":null,"abstract":"Tetracycline (TC) is a broad-spectrum antibiotic used in the treatment of several infectious diseases. The excessive use of tetracycline antibiotics, especially tetracyclines in livestock, has raised concerns about residues of tetracycline antibiotics in food that may affect consumers' health. It is necessary to develop a rapid test strip for detecting tetracycline antibiotic residues in food and animal feed. This paper presents the suitable conditions for the conjugation of tetracycline to BSA or KLH: molar ratio of TC:BSA/KLH was 25:1, formaldehyde concentration of 5 %, temperature of 4oC and reaction time of 4 hours. The KLH-TC conjugate was used to successfully raise polyclonal antibodies against TC in rabbits. The anti-TC polyclonal antibodies were purified and could be used for the development of the lateral flow immunoassay test strip for the detection of tetracycline.","PeriodicalId":23553,"journal":{"name":"Vietnam Journal of Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140494468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.15625/2525-2518/17077
Nguyen Duy Tuan, Denisuyk A. P., Doan Minh Khai, Sizov V. A.
In this article effect of some additives on combustion behaviour of high energetic compositions based on KNO3 was studied. The KNO3-based samples were made by mixing, rolling, and pressing. Investigated additives were: copper salicylate, nickel salicylate, copper-lead phthalate, nickel-lead phthalate, soot and carbon nanotubes. Burning rate was determined by the pressure increasing by using modification of the corner point method. It is shown that individual additives insignificantly effect on the burning rate of studied samples. The carbon nanotubes brand TMD with specific surface area ~270 m2/g and copper salicylate are the most effective additives on the burning rate. It should be noted that copper salicylate with carbon nanotubes have a significantly greater effect on the burning rate than individual additives or the catalyst with soot.
{"title":"Influence of some additives on burning rate of KNO3-based compositions","authors":"Nguyen Duy Tuan, Denisuyk A. P., Doan Minh Khai, Sizov V. A.","doi":"10.15625/2525-2518/17077","DOIUrl":"https://doi.org/10.15625/2525-2518/17077","url":null,"abstract":"In this article effect of some additives on combustion behaviour of high energetic compositions based on KNO3 was studied. The KNO3-based samples were made by mixing, rolling, and pressing. Investigated additives were: copper salicylate, nickel salicylate, copper-lead phthalate, nickel-lead phthalate, soot and carbon nanotubes. Burning rate was determined by the pressure increasing by using modification of the corner point method. It is shown that individual additives insignificantly effect on the burning rate of studied samples. The carbon nanotubes brand TMD with specific surface area ~270 m2/g and copper salicylate are the most effective additives on the burning rate. It should be noted that copper salicylate with carbon nanotubes have a significantly greater effect on the burning rate than individual additives or the catalyst with soot.","PeriodicalId":23553,"journal":{"name":"Vietnam Journal of Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.15625/2525-2518/18233
Hoang Trong, Vu Nhu Lan, Nguyen Nam Hoang
In recent years, we have experienced IoT solutions' rapid and beneficial development throughout all aspects of life. In addition to the apparent advantages, the increased number and variety of devices have resulted in more security issues. The DDOS attack, which originates from a broad range of sources and is a significant challenge for IoT systems, is one of the most prevalent but devastating attacks. IoT devices are typically simple and have few computing resources, which puts them at risk of being infected and attackers. IDS intrusion detection systems are considered superior protection against DDOS attacks. Therefore, the IDS system attracts many researchers and implements intelligent techniques such as machine learning and fuzzy logic to detect these DDOS attacks quickly and precisely. Along with the approach of intelligent computation, this study presents a novel technique for detecting DDOS attacks based on hedge algebra, which has never been implemented on IDS systems. We use the PSO swarm optimization algorithm to optimize the proposed model's parameters for optimized performance. Our experiment on the IoT-23 dataset shows that the proposed model's accuracy and performance metrics for DDOS attack detection are better than those proposed by other previous authors.
{"title":"A Novel IDS System based on Hedge Algebras to Detect DDOS Attack in IoT Systems","authors":"Hoang Trong, Vu Nhu Lan, Nguyen Nam Hoang","doi":"10.15625/2525-2518/18233","DOIUrl":"https://doi.org/10.15625/2525-2518/18233","url":null,"abstract":"In recent years, we have experienced IoT solutions' rapid and beneficial development throughout all aspects of life. In addition to the apparent advantages, the increased number and variety of devices have resulted in more security issues. The DDOS attack, which originates from a broad range of sources and is a significant challenge for IoT systems, is one of the most prevalent but devastating attacks. IoT devices are typically simple and have few computing resources, which puts them at risk of being infected and attackers. IDS intrusion detection systems are considered superior protection against DDOS attacks. Therefore, the IDS system attracts many researchers and implements intelligent techniques such as machine learning and fuzzy logic to detect these DDOS attacks quickly and precisely. Along with the approach of intelligent computation, this study presents a novel technique for detecting DDOS attacks based on hedge algebra, which has never been implemented on IDS systems. We use the PSO swarm optimization algorithm to optimize the proposed model's parameters for optimized performance. Our experiment on the IoT-23 dataset shows that the proposed model's accuracy and performance metrics for DDOS attack detection are better than those proposed by other previous authors.","PeriodicalId":23553,"journal":{"name":"Vietnam Journal of Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138970569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.15625/2525-2518/18029
Hoang Gia Phuc, Dinh Kim Ngan, Dang Ngoc Quan, Tran Le Dang Khoa, T. T. Khôi, N. Huy, Hoang Phi Hung, Nguyen Huynh Bao Chau, Nguyen Thi Thuy
This study applied ferrate in aquaculture wastewater treatment as a multi-purpose agent for pollutants’ oxidation, coagulation, and disinfection. Pangasius catfish aquaculture wastewater samples were collected from three sources and their characteristics were analyzed. Face Centered Composite Central (FCCC) design was utilized for designing the experiments with two independent factors (i.e., pH and ferrate dose) and 6 responses (i.e., effluent concentrations of COD, turbidity, PO43-, TKN, NH4+, and log reduction of coliform). The effects of the two factors on the responses were evaluated and the optimum conditions for each response and also for all responses were discussed. The results showed that the wastewater with low frequencies of water renewing required treatment before discharging or recirculating. pH, ferrate dose, and their interaction affected differently on the responses. The treatment was preferred at the acidic conditions for COD, turbidity, and TKN removals, but the basic environments for coliform, NH4+, and phosphate removals. However, the effect of pH on the treatment depended on the ferrate dose. The optimum working condition for all responses was suggested at pH 3 and 20 mg/L of ferrate dose by which the treatment efficiencies reached 99.985 % (log reduction of 3.826), 96.8 %, 93.0 %, 85.7 %, 61.7 %, and 50.0 %, for coliform, PO43-, turbidity, COD, NH4+, and TKN, respectively. These pollutants’ effluent concentrations met well the allowable values for discharging while the pH value required adjustment post - treatment. A further study focusing on pH and NH4+ treatment is suggested for the recirculation purpose of the treated water.
{"title":"Application of face centered composite central for optimization of pangasius catfish aquaculture wastewater treatment using potassium ferrate","authors":"Hoang Gia Phuc, Dinh Kim Ngan, Dang Ngoc Quan, Tran Le Dang Khoa, T. T. Khôi, N. Huy, Hoang Phi Hung, Nguyen Huynh Bao Chau, Nguyen Thi Thuy","doi":"10.15625/2525-2518/18029","DOIUrl":"https://doi.org/10.15625/2525-2518/18029","url":null,"abstract":"This study applied ferrate in aquaculture wastewater treatment as a multi-purpose agent for pollutants’ oxidation, coagulation, and disinfection. Pangasius catfish aquaculture wastewater samples were collected from three sources and their characteristics were analyzed. Face Centered Composite Central (FCCC) design was utilized for designing the experiments with two independent factors (i.e., pH and ferrate dose) and 6 responses (i.e., effluent concentrations of COD, turbidity, PO43-, TKN, NH4+, and log reduction of coliform). The effects of the two factors on the responses were evaluated and the optimum conditions for each response and also for all responses were discussed. The results showed that the wastewater with low frequencies of water renewing required treatment before discharging or recirculating. pH, ferrate dose, and their interaction affected differently on the responses. The treatment was preferred at the acidic conditions for COD, turbidity, and TKN removals, but the basic environments for coliform, NH4+, and phosphate removals. However, the effect of pH on the treatment depended on the ferrate dose. The optimum working condition for all responses was suggested at pH 3 and 20 mg/L of ferrate dose by which the treatment efficiencies reached 99.985 % (log reduction of 3.826), 96.8 %, 93.0 %, 85.7 %, 61.7 %, and 50.0 %, for coliform, PO43-, turbidity, COD, NH4+, and TKN, respectively. These pollutants’ effluent concentrations met well the allowable values for discharging while the pH value required adjustment post - treatment. A further study focusing on pH and NH4+ treatment is suggested for the recirculation purpose of the treated water.","PeriodicalId":23553,"journal":{"name":"Vietnam Journal of Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.15625/2525-2518/16725
Nguyen Trong Nghia, Duc Trung Nguyen, Pham Van Tien, Nguyen Thi Minh, Hue
CH radicals play an important role in the combustion of hydrocarbon. The insertion mechanism of a CH radical into the O-H bond of n-C4H9OH is investigated theoretically by a detailed potential energy surface calculation at the BHandHLYP/6-311++G(3df,2p) and CCSD(T)/6-311++G(d,p) (single-point) levels. Our results show that the CH radical attacks into the oxygen atom in n-C4H9OH to form a prereaction complex (COMP) to be followed by an insertion of the CH radical into the O-H bond of the n-C4H9OH molecule to form the low-lying intermediate IS1 (CH2OCH2CH2CH2CH3). This intermediate can isomerize to form IS2 (CH3OCH2CHCH2CH3), IS3 (CH3CH2CH2CH2CH2O), and IS4 (CH3CH2CH2CH2CHOH). These intermediates can decompose to yield 9 products (PR1-PR9) in which major ones are PR1 (CH2CH2CH2CH3 + CH2O), PR2 (CH2CHCH2CH3 + CH3O) and PR3 (CH2CHCH2OCH3 + CH3).
{"title":"Theoretical study on the insertion reaction of CH(X2) into the oh bond in n-C4H9OH","authors":"Nguyen Trong Nghia, Duc Trung Nguyen, Pham Van Tien, Nguyen Thi Minh, Hue","doi":"10.15625/2525-2518/16725","DOIUrl":"https://doi.org/10.15625/2525-2518/16725","url":null,"abstract":"CH radicals play an important role in the combustion of hydrocarbon. The insertion mechanism of a CH radical into the O-H bond of n-C4H9OH is investigated theoretically by a detailed potential energy surface calculation at the BHandHLYP/6-311++G(3df,2p) and CCSD(T)/6-311++G(d,p) (single-point) levels. Our results show that the CH radical attacks into the oxygen atom in n-C4H9OH to form a prereaction complex (COMP) to be followed by an insertion of the CH radical into the O-H bond of the n-C4H9OH molecule to form the low-lying intermediate IS1 (CH2OCH2CH2CH2CH3). This intermediate can isomerize to form IS2 (CH3OCH2CHCH2CH3), IS3 (CH3CH2CH2CH2CH2O), and IS4 (CH3CH2CH2CH2CHOH). These intermediates can decompose to yield 9 products (PR1-PR9) in which major ones are PR1 (CH2CH2CH2CH3 + CH2O), PR2 (CH2CHCH2CH3 + CH3O) and PR3 (CH2CHCH2OCH3 + CH3).","PeriodicalId":23553,"journal":{"name":"Vietnam Journal of Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.15625/2525-2518/17497
Nguyen Ha Thanh, H. T. Phuong, Le Nhat Thuy Giang, Nguyen Thi Quynh Giang, Nguyen Tuan Anh, Dang Thi Tuyet Anh, N. Tuyen
Chromene is a significant class of heterocyclic compounds prossessing a simple structure as well as important biological activities. Many studies have been done to find new approaches for the preparation of chromene derivatives. Notably, the introduction of fluorine into heterocyclic molecules resulted in a significant improvement of their biological activities. In this study, a simple, straightforward, and highly efficient microwave-assisted three-component synthesis of novel 2-amino-4H-benzo[g]chromene-5,10-dione-3-carbonitrile derivatives bearing fluorine atoms has been developed using 1,4-diazabicyclo[2.2.2]octane (DABCO) as an eco-friendly catalyst, and acetonitrile as a solvent. Starting from 2-hydroxy-1,4-dihydronaphthalene-1,4-dione, malononitrile, and fluorinated aromatic aldehyde, 2-amino-4H-benzo[g]chromene-5,10-dione-3-carbonitrile derivatives have been afforded in good yields (71 – 76 %). The plausible reaction mechanism was described. Products were synthesized through a sequential Knoevenagel condensation, Michael addition, intramolecular cyclization, and [1,3]-hydrogen shift step. The structure of products was completely elucidated by 1H NMR, 13C NMR, and mass spectra. The particularly valuable feature of this process is mild reaction conditions, short reaction times, and good yields.
{"title":"Multicomponent reaction for the synthesis of novel fluorinated 2-amino-4H-benzo[g]chromene-5,10-dione-3-carbonitriles","authors":"Nguyen Ha Thanh, H. T. Phuong, Le Nhat Thuy Giang, Nguyen Thi Quynh Giang, Nguyen Tuan Anh, Dang Thi Tuyet Anh, N. Tuyen","doi":"10.15625/2525-2518/17497","DOIUrl":"https://doi.org/10.15625/2525-2518/17497","url":null,"abstract":"Chromene is a significant class of heterocyclic compounds prossessing a simple structure as well as important biological activities. Many studies have been done to find new approaches for the preparation of chromene derivatives. Notably, the introduction of fluorine into heterocyclic molecules resulted in a significant improvement of their biological activities. In this study, a simple, straightforward, and highly efficient microwave-assisted three-component synthesis of novel 2-amino-4H-benzo[g]chromene-5,10-dione-3-carbonitrile derivatives bearing fluorine atoms has been developed using 1,4-diazabicyclo[2.2.2]octane (DABCO) as an eco-friendly catalyst, and acetonitrile as a solvent. Starting from 2-hydroxy-1,4-dihydronaphthalene-1,4-dione, malononitrile, and fluorinated aromatic aldehyde, 2-amino-4H-benzo[g]chromene-5,10-dione-3-carbonitrile derivatives have been afforded in good yields (71 – 76 %). The plausible reaction mechanism was described. Products were synthesized through a sequential Knoevenagel condensation, Michael addition, intramolecular cyclization, and [1,3]-hydrogen shift step. The structure of products was completely elucidated by 1H NMR, 13C NMR, and mass spectra. The particularly valuable feature of this process is mild reaction conditions, short reaction times, and good yields.","PeriodicalId":23553,"journal":{"name":"Vietnam Journal of Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138999147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.15625/2525-2518/17593
Nguyễn Quốc Vượng, Nguyen Thi Hue, Pham Thi Hang, Nguyen Hoang Nam, N. Tuấn, Le Thanh, Pham Van Cuong, Duong Thi Hai Yen, N. X. Nhiem, B. H. Tai, P. Kiem
Six urs-ketone triterpenes (1 - 6) and two flavonoids (7, 8) from the leaves of Sarcosperma kontumense Gagnep. ex Aubrév., were isolated. Their chemical structures were elucidated as 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid (1), rotundic acid (2), euscaphic acid (3), ursolic acid (4), pomolic acid (5), jacoumaric acid (6), (+)-catechin (7), and (-)-epi-catechin (8), by spectroscopic analyses including ESI-MS, 1D and 2D NMR spectra and comparison with those reported in the literatures. In which, compounds 1, 2, 4, 6, and 8 were firstly isolated from the genus Sarcosperma.
{"title":"Secondary metabolites from Sarcosperma kontumense","authors":"Nguyễn Quốc Vượng, Nguyen Thi Hue, Pham Thi Hang, Nguyen Hoang Nam, N. Tuấn, Le Thanh, Pham Van Cuong, Duong Thi Hai Yen, N. X. Nhiem, B. H. Tai, P. Kiem","doi":"10.15625/2525-2518/17593","DOIUrl":"https://doi.org/10.15625/2525-2518/17593","url":null,"abstract":"Six urs-ketone triterpenes (1 - 6) and two flavonoids (7, 8) from the leaves of Sarcosperma kontumense Gagnep. ex Aubrév., were isolated. Their chemical structures were elucidated as 2α,3α,19α,23-tetrahydroxy-13,27-cyclours-11-en-28-oic acid (1), rotundic acid (2), euscaphic acid (3), ursolic acid (4), pomolic acid (5), jacoumaric acid (6), (+)-catechin (7), and (-)-epi-catechin (8), by spectroscopic analyses including ESI-MS, 1D and 2D NMR spectra and comparison with those reported in the literatures. In which, compounds 1, 2, 4, 6, and 8 were firstly isolated from the genus Sarcosperma.","PeriodicalId":23553,"journal":{"name":"Vietnam Journal of Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
α-mangostin is a natural product isolated from the mangosteen pericarps with diverse biological activities, including cytotoxicity against cancer cells. However, the application of α-mangostin in cancer treatment is limited due to the high cytotoxicity and poor solubility in water. In this research, we fabricated α-mangostin-loaded liposomes from soybean lecithin and cholesterol to enhance the solubility in water of α-mangostin and reduce side effects in the treatment of cancer. The liposomal membrane uses Soybean Lecithin (SBL) as a phospholipid and Tocopherol (Toc) as a stabilizer, at 4 ratios of SBL/Toc are 1/1, 2/1, 4/1, 8/1. Experimental results showed that liposomes with SBL/Toc molar ratio of 4/1 had a mean size value of 105.8 ± 3.9 nm, and a polydispersity index (PDI) of 0.149. The encapsulation efficiency was 51.3 %. We believe that this formulation has the potential to be developed into an improved drug delivery system for α-mangostin. The lung carcinoma epithelial cells (A549) were cultured in microwell for 14 days to form spheroids. Then, spheroids were probed with a concentration of α-mangostin-loaded liposomes of 10 µM. The results showed the ability to significantly reduce cell viability after 36 hours of testing.
{"title":"Fabrication of α-mangostin – loaded liposomes for cytotoxic-activity against A549 lung-cancer spheroids","authors":"Tran Dinh Thiet, Phạm Thu Uyên, Nguyen Thanh Duong","doi":"10.15625/2525-2518/17524","DOIUrl":"https://doi.org/10.15625/2525-2518/17524","url":null,"abstract":"α-mangostin is a natural product isolated from the mangosteen pericarps with diverse biological activities, including cytotoxicity against cancer cells. However, the application of α-mangostin in cancer treatment is limited due to the high cytotoxicity and poor solubility in water. In this research, we fabricated α-mangostin-loaded liposomes from soybean lecithin and cholesterol to enhance the solubility in water of α-mangostin and reduce side effects in the treatment of cancer. The liposomal membrane uses Soybean Lecithin (SBL) as a phospholipid and Tocopherol (Toc) as a stabilizer, at 4 ratios of SBL/Toc are 1/1, 2/1, 4/1, 8/1. Experimental results showed that liposomes with SBL/Toc molar ratio of 4/1 had a mean size value of 105.8 ± 3.9 nm, and a polydispersity index (PDI) of 0.149. The encapsulation efficiency was 51.3 %. We believe that this formulation has the potential to be developed into an improved drug delivery system for α-mangostin. The lung carcinoma epithelial cells (A549) were cultured in microwell for 14 days to form spheroids. Then, spheroids were probed with a concentration of α-mangostin-loaded liposomes of 10 µM. The results showed the ability to significantly reduce cell viability after 36 hours of testing.","PeriodicalId":23553,"journal":{"name":"Vietnam Journal of Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139000240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.15625/2525-2518/16454
Hoang Nguyen Ho, H. T. Trinh, Manh Duy Tran, H. Duong, C. T. Dinh
In the several decades, although neonicotinoids insecticides (typically imidacloprid and thiamethoxam) are widely used and account for 24 % of the total global pesticide production, they still have negative impacts on natural enemies such as kinds of bees as well as adversely affect human health. However, there are only a few studies evaluating the levels of imidacloprid and thiamethoxam in airborne environments including indoor dust. Therefore, the aim of this study was to investigate the distribution, concentration and health risk to human of imidacloprid and thiamethoxam in indoor dust samples collected from 6 inner districts of Hanoi. Imidacloprid was found in indoor dust samples at all samples with an average concentration of 0.079 µg/g (ranging from 0.028 to 0.216 µg/g, the detection frequency of 100 %). Meanwhile, the mean concentration of thiamethoxam was revealed lower than imidacloprid at 0.013 µg/g (ranging from 0.01 to 0.027 µg/g, the detection frequency of 60 %). In high-end exposure, based on the measured concentrations, daily intake doses (IDs) of imidacloprid and thiamethoxam were calculated to be 9.96 × 10-1 and 1.10 × 10-2 ng/kg-bw/day for adults, and 1.78 and 1.98 × 10-1 ng/kg-bw/day for children, respectively. The estimated values of hazard quotient (HQ) of imidacloprid and thiamethoxam were 1.75 × 10-6 and 9.20 × 10-7 ng/kg-bw/day for adults, and 3.13 × 10-5 and 1.65 × 10-5 ng/kg-bw/day for children, respectively. All HQ and HI values of the insecticides were less than 1 for both of adults and children, indicating the potential adverse effects to human health are negligible.
{"title":"Current situation and health risk assessment of neonicotinoids insecticides in urban indoor dust from Ha Noi, Viet Nam","authors":"Hoang Nguyen Ho, H. T. Trinh, Manh Duy Tran, H. Duong, C. T. Dinh","doi":"10.15625/2525-2518/16454","DOIUrl":"https://doi.org/10.15625/2525-2518/16454","url":null,"abstract":"In the several decades, although neonicotinoids insecticides (typically imidacloprid and thiamethoxam) are widely used and account for 24 % of the total global pesticide production, they still have negative impacts on natural enemies such as kinds of bees as well as adversely affect human health. However, there are only a few studies evaluating the levels of imidacloprid and thiamethoxam in airborne environments including indoor dust. Therefore, the aim of this study was to investigate the distribution, concentration and health risk to human of imidacloprid and thiamethoxam in indoor dust samples collected from 6 inner districts of Hanoi. Imidacloprid was found in indoor dust samples at all samples with an average concentration of 0.079 µg/g (ranging from 0.028 to 0.216 µg/g, the detection frequency of 100 %). Meanwhile, the mean concentration of thiamethoxam was revealed lower than imidacloprid at 0.013 µg/g (ranging from 0.01 to 0.027 µg/g, the detection frequency of 60 %). In high-end exposure, based on the measured concentrations, daily intake doses (IDs) of imidacloprid and thiamethoxam were calculated to be 9.96 × 10-1 and 1.10 × 10-2 ng/kg-bw/day for adults, and 1.78 and 1.98 × 10-1 ng/kg-bw/day for children, respectively. The estimated values of hazard quotient (HQ) of imidacloprid and thiamethoxam were 1.75 × 10-6 and 9.20 × 10-7 ng/kg-bw/day for adults, and 3.13 × 10-5 and 1.65 × 10-5 ng/kg-bw/day for children, respectively. All HQ and HI values of the insecticides were less than 1 for both of adults and children, indicating the potential adverse effects to human health are negligible.","PeriodicalId":23553,"journal":{"name":"Vietnam Journal of Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.15625/2525-2518/17261
Huong Thu Dang, Huy Son Dinh, Tu Anh Loc, La Anh Nguyen
Antibiotic-resistant bacteria are increasingly common and threaten human health. Recently, antibiotic resistance in food associated bacteria become an emerging threat to this state. These bacteria may act as reservoirs of antibiotic resistance genes and transfer to commensal or pathogenic bacteria in the human intestines. Therefore, either probiotics or starter cultures have to be evaluated for antibiotic interaction. In this study, the antibiotic susceptibility of seven Lactobacillus strains was determined. The MIC values revealed that all strains were resistant to tetracycline, ciprofloxacin, vancomycin and aminoglycoside antibiotics group (gentamicin, neomycin, kanamycin and streptomycin). However, the results from PCR analysis showed that parC gene for ciprofloxacin resistance was only present in Lb. fermentum SMC2; vanX gene, responsible for the vancomycin resistance, was found in two strains Lb. plantarum AS34 and TJ26. Most strains showed susceptibilityto at least one type of protein synthesis inhibit antibiotics: chloramphenicol, erythromycin and clindamycin. Four strains Lb. brevis NCTH24, Lb. casei PK2, Lb. fermentum SBV2, and Lb. plantarum NCDC3 did not carry any antibiotic resistance genes which indicates these antibiotic resistances are intrinsic and nontransmissible.
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