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Imaging diagnosis: Disseminated hemangiosarcoma in a Welsh pony. 影像诊断:一匹威尔士小马患上了播散性血管肉瘤。
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-09-01 Epub Date: 2024-05-24 DOI: 10.1111/vru.13386
Brianna Farber, Rebecca Urion, Eric T Hostnik

A 16-year-old pony gelding presented with epistaxis and a head tilt. Referral skull radiographs suggested an ethmoid hematoma. Concurrent neurologic abnormalities prompted contrast-enhanced CT of the head and cranial neck, revealing numerous hyperattenuating masses throughout the brain and paranasal sinuses, along with a large osteolytic mass in the second cervical vertebra. The vertebral mass extended into the vertebral canal, causing focal extradural compressive myelopathy. These findings were inconsistent with ethmoid hematoma and metastatic hemangiosarcoma or malignant melanoma were prioritized as potential causes for the clinical signs. Postmortem examination confirmed the sinonasal, intracranial, and vertebral masses as hemangiosarcoma, and additionally revealed innumerable thoracoabdominal metastatic lesions and hemorrhagic foci. A final diagnosis of disseminated hemangiosarcoma was made. In this study, CT proved invaluable for evaluating the severity and characterizing regional disease and neural involvement, directly affecting case management decisions.

一匹 16 岁的小马出现鼻衄和头部倾斜。转诊时头颅X光片显示为乙状结肠血肿。同时出现的神经系统异常促使对头部和颅颈部进行造影剂增强 CT 检查,结果发现整个大脑和副鼻窦内有许多高强度肿块,第二颈椎内有一个巨大的溶骨性肿块。椎体肿块伸入椎管,导致局灶性硬膜外压迫性脊髓病。这些发现与乙状结肠血肿不符,转移性血管肉瘤或恶性黑色素瘤被认为是导致临床症状的潜在原因。尸检证实鼻窦、颅内和椎体肿块为血管肉瘤,此外还发现了无数胸腹转移灶和出血灶。最终诊断为播散性血管肉瘤。在这项研究中,CT 被证明在评估区域性疾病和神经受累的严重程度和特征方面非常有价值,直接影响了病例管理决策。
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引用次数: 0
Effect of gadolinium contrast medium administration on susceptibility-weighted imaging of the canine brain. 使用钆造影剂对犬大脑感度加权成像的影响
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-09-01 Epub Date: 2024-06-17 DOI: 10.1111/vru.13395
Martina Mugnai, Edoardo Auriemma, Barbara Contiero, Delia Franchini, Eric Zini, Federica Tirrito

Susceptibility-weighted imaging (SWI) is a gradient echo (GE) MRI sequence. Intravenous administration of gadolinium (Gd) may affect GE images, but its effect on SWI has not been investigated in veterinary medicine. This cross-sectional prospective study evaluated the effects of Gd on SWI. Seventy-one dogs that underwent brain MRI were included and distributed in two groups. Susceptibility-weighted imaging was performed pre- and postcontrast, obtained immediately after Gd administration (Group A: n = 35) or delayed (Group B: n = 36; median delay 19.9 min). Pre- and post-Gd SWI were analyzed for signal intensity changes in the lentiform nuclei of gray matter (GM), in the centrum semiovale of white matter (WM), and in brain lesions. No difference in GM signal intensity was identified in either group between pre- and postcontrast images (Group A, P = .395; Group B, P = .895). In group A, WM signal intensity was lower in pre- than post-Gd sequences (P = .019). Brain lesions were identified in 30/71 (41%) cases; the signal intensity of intracranial lesions was significantly lower in pre- than post-Gd images in both groups (P < .001); the number of lesions influenced the difference in signal intensity in group B (P = .043). Susceptibility artifacts did not change in appearance between pre- and postcontrast images in either the normal brain or in parenchymal lesions. In conclusion, Gd may modify the signal intensity of WM and brain lesions but does not affect the susceptibility artifacts and does not interfere with SWI interpretation.

感度加权成像(SWI)是一种梯度回波(GE)磁共振成像序列。静脉注射钆(Gd)可能会影响 GE 图像,但其对 SWI 的影响尚未在兽医学中进行过研究。这项横断面前瞻性研究评估了钆对 SWI 的影响。71只接受脑部核磁共振成像的狗被分为两组。在注射钆后立即(A 组:n = 35)或延迟(B 组:n = 36;中位延迟 19.9 分钟)进行对比前后的感度加权成像。钆前和钆后 SWI 分析了灰质(GM)透镜状核、白质(WM)半卵圆中心和脑损伤的信号强度变化。两组对比前和对比后图像中的 GM 信号强度均无差异(A 组,P = 0.395;B 组,P = 0.895)。在 A 组中,钆前序列的 WM 信号强度低于钆后序列(P = .019)。在 30/71 例(41%)病例中发现了脑部病变;在两组病例中,颅内病变的信号强度在钆对比前图像中均明显低于钆对比后图像(P = 0.019)。
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引用次数: 0
Computed tomographic anatomic variations of the phrenicoabdominal veins in cats. 猫膈腹静脉的计算机断层扫描解剖变异。
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-09-01 Epub Date: 2024-07-09 DOI: 10.1111/vru.13408
Dario Nappo, Chiara Massarenti, Maria Elena Andreis, Eric Zini, Giuseppe Lacava, Silvia Rabba, Edoardo Auriemma

There are no published reports describing the anatomic variations of the phrenicoabdominal (PhAbd) veins in cats. The aim of this study was to evaluate the anatomic variations of the PhAbd veins in cats without adrenal disease. This is an anatomic study. Abdominal CT images of cats acquired from January 2021 to February 2023 were retrospectively reviewed. Inclusion criteria were the presence of pre- and postcontrast CT images of the abdomen and the absence of any abdominal diseases that compromise the left and right PhAbd veins visualization. A total of 128 cats were included. Three different vascular anatomic variations were found in the distal pericaval segment of the left phrenicoabdominal (LPhAbd) vein. In the first type, found in 65 cases (50.8%), the LPhAbd vein drained directly into the caudal vena cava. In the second type defined IIa, found in 25 cases (19.5%), the LPhAbd vein drained into the distal third of the left renal vein, less than 5 mm from its opening into the caudal vena cava. In the third type defined IIb, found in 38 cases (29.7%), the LPhAbd vein drained into the distal third of the left renal vein, more than 5 mm from its opening into the caudal vena cava. The right phrenicoabdominal vein had a consistent path and drained into the caudal vena cava in all cases. The knowledge of these vascular variations is expected to help the surgeon during adrenalectomy due to masses with vascular invasion in cats.

目前还没有关于猫膈腹静脉(PhAbd)解剖结构变化的公开报道。本研究旨在评估无肾上腺疾病猫的膈腹静脉解剖学变化。这是一项解剖学研究。研究人员回顾性审查了 2021 年 1 月至 2023 年 2 月期间采集的猫腹部 CT 图像。纳入标准是腹部对比前和对比后的 CT 图像,以及没有任何影响左右 PhAbd 静脉显像的腹部疾病。共纳入 128 只猫。在左膈腹静脉(LPhAbd)远端腔周段发现了三种不同的血管解剖变异。第一种是 65 例(50.8%),LPhAbd 静脉直接排入尾腔静脉。在定义为 IIa 的第二种类型中,有 25 例(19.5%)患者的 LPhAbd 静脉排入左肾静脉的远端三分之一处,距离其开口进入腔尾静脉的位置不到 5 毫米。在第三种定义为 IIb 的类型中,有 38 例(29.7%)患者的 LPhAbd 静脉引流至左肾静脉远端三分之一处,距离其开口进入腔尾静脉的距离超过 5 毫米。右膈腹静脉的路径一致,在所有病例中均排入尾腔静脉。对这些血管变化的了解有望帮助外科医生对猫体内有血管侵犯的肿块进行肾上腺切除术。
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引用次数: 0
Calendar of Important Dates. 重要日期日历。
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-07-14 DOI: 10.1111/vru.13407
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引用次数: 0
Comparison of a new immobilization method using a reusable 3-point fixation cylinder system and bite-block type immobilization methods in veterinary radiotherapy. 在兽医放射治疗中使用可重复使用的三点固定圆筒系统的新型固定方法与咬合块式固定方法的比较。
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-07-01 Epub Date: 2024-03-30 DOI: 10.1111/vru.13364
Shinichiro Yoda, Takuya Maruo, Haruka Arai, Rihoko Takahashi, Takuya Kusaka, Yuta Nishiyama, Hideki Kayanuma

In veterinary radiotherapy, highly reproducible immobilization is important for accurate irradiation. Consequently, we developed a new reusable head-immobilization method for dogs using cylinders. This study aimed to compare the accuracy of our novel immobilization method using cylinders with that of bite-block type immobilization methods. Three immobilization methods were compared: bite-block only, bite-block combined with torso immobilization, and immobilization using cylinders. Five beagles with canine teeth underwent CT five times for each of the three immobilization methods. One beagle without canine teeth underwent CT 15 times using each method. Three maxillary landmarks (maxillary incisor, frontal sinus, and occipital bone) and one mandibular landmark (mandibular incisor) were established, and the errors in each immobilization method were measured. For all head landmarks, the error in the immobilization method using cylinders was the most reproducible, with the smallest errors. No significant differences were observed in the time required for immobilization. Although there were limitations (such as the use of dogs from a single breed, a single episode of anesthesia, no disassembly of the immobilization system between scans, and the same person performing the positioning on the same day), we found our new reusable immobilization method using cylinders was the most accurate among the three compared methods. This was a proof-of-principle study to evaluate head immobilization using cylinders, and further investigations are needed to confirm its clinical utility.

在兽医放射治疗中,高重复性的固定对于精确照射非常重要。因此,我们为狗开发了一种使用圆筒的可重复使用的头部固定新方法。本研究旨在比较我们使用圆柱体的新型固定方法与咬合块式固定方法的准确性。我们对三种固定方法进行了比较:仅咬合块固定法、咬合块与躯干固定相结合的固定法以及使用圆柱体的固定法。五只长有犬齿的小猎犬在三种固定方法中分别接受了五次 CT 检查。一只没有犬齿的猎兔犬接受了每种方法 15 次的 CT 检查。建立了三个上颌地标(上颌切牙、额窦和枕骨)和一个下颌地标(下颌切牙),并测量了每种固定方法的误差。在所有头部地标中,使用圆柱体固定法的误差重复性最好,误差最小。在固定所需的时间方面没有观察到明显的差异。虽然存在一些限制(如使用单一品种的狗,一次麻醉,扫描之间不拆卸固定系统,同一天由同一人进行定位),但我们发现使用圆柱体的新型可重复使用固定方法是三种比较方法中最准确的。这是一项评估使用圆柱体进行头部固定的原理验证研究,还需要进一步的研究来确认其临床实用性。
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引用次数: 0
Calendar of Important Dates. 重要日期日历。
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-07-01 Epub Date: 2024-07-08 DOI: 10.1111/vru.13404
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引用次数: 0
AWARDS AND AUTHOR INSTRUCTIONS. 奖项和作者说明。
IF 1.3 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-07-01 DOI: 10.1111/vru.13117
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引用次数: 0
Prevalence of presumed endplate junction failure at the lumbosacral intervertebral junction in dogs on computed tomography 通过计算机断层扫描推测狗腰骶椎椎间关节内板连接失败的发生率
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-22 DOI: 10.1111/vru.13398
Anna R. Tellegen, Martijn Beukers, Björn P. Meij, Marianna A. Tryfonidou, Stefanie Veraa
Lumbosacral intervertebral disc herniation (IVDH) is a common cause of lower back pain in dogs and humans. In humans, the vertebral endplate to annulus fibrosus (AF) attachment was implicated as an alternative failure site besides rupture through the dorsal AF (AFF). Endplate junction failure (EPJF) is characterized by IVDH, accompanied by endplate irregularities (type A), rim avulsions (type B), or larger bony avulsions on one (type C) or both endplates (type D), associated with an adjacent endplate defect. This retrospective study reports the CT prevalence of presumed EPJF in dogs and its associations with signalment and other lumbosacral CT abnormalities. CT scans, including the lumbosacral spine of dogs obtained at two institutions, were assessed, yielding 324 scans. Presumed EPJF was found in 69 dogs (21%) and AFF in 68 dogs (21%), commonly at the caudal endplate of the last lumbar vertebra (71%). The remaining 187 dogs did not show presumed EPJF or AFF. Presumed EPJF type A occurred in 49/69, type B in 19/69, and type C in 1/69 dogs. Univariable logistic regression showed that presumed EPJF was associated with significantly higher IVDH grades than AFF. In the multiple regression model, presumed EPJF and AFF remained associated with increasing age and spondylosis deformans. Presumed EPJF was associated with vertebral endplate sclerosis and AFF with zygapophyseal joint osteoarthritis. In conclusion, presumed EPJF was observed on CT in 21% of dogs with lumbosacral IVDH. Prospective studies correlating EPJF on CT with clinical, surgical, and histopathological findings are needed for a better understanding of the underlying pathology and clinical relevance.
腰骶椎间盘突出症(IVDH)是导致狗和人类下背部疼痛的常见原因。在人类中,椎体终板与纤维环(AF)的连接被认为是背侧 AF(AFF)破裂以外的另一个失效部位。椎体终板连接失败(EPJF)的特征是IVDH,伴有终板不规则(A型)、边缘撕脱(B型)或一个(C型)或两个终板(D型)较大的骨性撕脱,并伴有邻近终板缺损。这项回顾性研究报告了推测的 EPJF 在犬中的 CT 患病率及其与信号和其他腰骶部 CT 异常的关联。研究人员评估了在两家机构获得的包括犬腰骶椎在内的 324 份 CT 扫描结果。在 69 只狗(21%)中发现了推测的 EPJF,在 68 只狗(21%)中发现了 AFF,常见于最后一节腰椎的尾椎终板(71%)。其余 187 只狗没有出现推测的 EPJF 或 AFF。推测的 EPJF A 型发生在 49/69 只犬中,B 型发生在 19/69 只犬中,C 型发生在 1/69 只犬中。单变量逻辑回归显示,推定 EPJF 与 IVDH 分级明显高于 AFF 相关。在多元回归模型中,推测的 EPJF 和 AFF 仍与年龄增长和脊柱畸形有关。假定的EPJF与椎体终板硬化有关,而AFF与颧骨关节骨关节炎有关。总之,21% 的腰骶部 IVDH 患犬可在 CT 上观察到假定的 EPJF。需要进行前瞻性研究,将 CT 上的 EPJF 与临床、手术和组织病理学结果联系起来,以便更好地了解潜在的病理和临床意义。
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引用次数: 0
The vertebral right heart index: A new radiographic method to assess right heart enlargement in dogs 脊椎右心指数:评估犬右心室肥大的新放射学方法
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-21 DOI: 10.1111/vru.13402
Caterina Puccinelli, Tommaso Vezzosi, Giovanni Grosso, Rosalba Tognetti, Edoardo Auriemma, Oriol Domenech, Simonetta Citi
In veterinary medicine, the radiographic assessment of right heart enlargement (RHE) is essentially subjective. The aim of this study was to evaluate the vertebral right heart index (VRHi) as a new quantitative radiographic method to detect RHE in dogs. This was a multicenter, retrospective, observational study, including dogs with RHE and control dogs. All dogs had to have a thoracic radiographic study and a complete echocardiography on the same day. Right heart enlargement was defined as the presence of right atrial enlargement, right ventricular enlargement, and/or hypertrophy based on echocardiography. For the radiographic study, all the radiographic views available for each case were considered for measurement: right lateral (RL), left lateral (LL), ventrodorsal (VD), and dorsoventral (DV). The VRHi was measured using LL, RL, VD, and DV views. A total of 204 dogs were included: 91 dogs with RHE and 113 control dogs. The VRHi (RL), the VRHi (LL), and the VRHi (VD) were significantly greater in dogs with RHE compared with controls (P < .0001). The best diagnostic accuracy was observed for VRHi (LL) (area under the curve [AUC] 0.86, P < .0001; cutoff ≥ 3.5 vertebrae, sensitivity [Se] 71%, specificity [Sp] 89%), followed by VRHi (RL) (AUC 0.85, P < .0001; cutoff ≥ 3.5 vertebrae, Se 68%, Sp 86%) and VRHi (VD) (AUC 0.80, P = .0004; cutoff ≥ 3.0 vertebrae, Se 57%, Sp 95%). In conclusion, the lateral VRHi in LL and RL and the VD VRHi could represent useful radiological tools for the detection of RHE in dogs.
在兽医学中,右心扩大(RHE)的放射学评估基本上是主观的。本研究旨在评估椎体右心指数(VRHi),将其作为检测犬 RHE 的一种新的定量放射影像学方法。这是一项多中心、回顾性、观察性研究,包括患有 RHE 的狗和对照组狗。所有犬只都必须在同一天进行胸部X光检查和完整的超声心动图检查。根据超声心动图检查结果,右心房增大、右心室增大和/或肥厚是右心增大的定义。在放射学研究中,每个病例的所有放射学切面都被考虑用于测量:右外侧(RL)、左外侧(LL)、腹背(VD)和背腹(DV)。VRHi使用LL、RL、VD和DV视图进行测量。共纳入 204 只狗:其中 91 只患有 RHE,113 只为对照组。与对照组相比,RHE 患犬的 VRHi (RL)、VRHi (LL) 和 VRHi (VD) 明显更高(P < .0001)。VRHi (LL) 的诊断准确率最高(曲线下面积 [AUC] 0.86,P < .0001;临界值≥ 3.5 个椎体,灵敏度 [Se] 71%,特异性 [Sp] 89%),其次是 VRHi (RL)(曲线下面积 [AUC] 0.85,P < .0001; 临界值≥ 3.5 个椎体,Se 68%,Sp 86%)和 VRHi (VD)(AUC 0.80,P = .0004; 临界值≥ 3.0 个椎体,Se 57%,Sp 95%)。总之,LL 和 RL 的外侧 VRHi 以及 VD VRHi 是检测犬 RHE 的有用放射学工具。
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引用次数: 0
Computed tomography‐derived structural analysis for the likelihood of pathologic fracture in canine antebrachial osteosarcoma 计算机断层扫描结构分析犬胫骨骨肉瘤发生病理性骨折的可能性
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-21 DOI: 10.1111/vru.13403
Michele A. Steffey, Tanya C. Garcia, Angela Gorney, Susan M. Stover, Allison L. Zwingenberger
Determining the risk of pathologic fracture in dogs with a primary bone tumor would aid in case selection for in‐situ treatment options. Prior research found strong relationships between in vitro strength of canine antebrachii with primary bone tumors and CT‐derived metrics. This study assesses the prognosis for pathologic fracture in dogs with distal radial bone tumors using CT‐derived structural analysis metrics. CT images of the antebrachium in dogs with aggressive osseous lesions of the radius were used to calculate structural rigidity and failure forces, including axial rigidity (AR), craniocaudal bending rigidity (BR), torsional rigidity (TR), and failure forces for a slightly‐curved/asymmetric beam (Fs) or a curved beam (Fc). Metrics were compared with the clinical outcome of radial fracture. Eight of 19 dogs with CT‐derived metrics developed a radial fracture. The prognostic potential of the metrics to discriminate fractured and nonfractured bones was analyzed using receiver operating characteristic curves (area under the curve), stepwise logistic regression, and classification regression (CART) analyses. Fc was the most sensitive and specific metric for prognosing fracture occurrence (AUC = 0.864). When dog body weight (BW) was included, all five metrics had AUC > 0.705. Fc was the best predictor of fracture using stepwise logistic regression and CART analysis, followed by BR. An indication of fracture probability can be determined by normalizing Fc or BR with dog BW or by using the logistic regression equation of either metric with dog BW. Results warrant further analysis of a larger cohort to evaluate fracture likelihood in dogs with antebrachial bone neoplasia.
确定患有原发性骨肿瘤的犬发生病理性骨折的风险将有助于选择原位治疗方案。先前的研究发现,患有原发性骨肿瘤的犬胫骨体外强度与 CT 衍生指标之间存在密切关系。本研究利用 CT 衍生结构分析指标评估了桡骨远端骨肿瘤犬病理骨折的预后。研究人员使用桡骨侵袭性骨质病变犬胫骨前端的 CT 图像计算结构刚度和破坏力,包括轴向刚度 (AR)、颅尾弯曲刚度 (BR)、扭转刚度 (TR) 以及微弯/不对称梁 (Fs) 或弯曲梁 (Fc) 的破坏力。这些指标与桡骨骨折的临床结果进行了比较。在 19 只具有 CT 指标的狗中,有 8 只发生了桡骨骨折。使用接收器操作特征曲线(曲线下面积)、逐步逻辑回归和分类回归 (CART) 分析方法分析了这些指标在区分骨折和非骨折骨骼方面的预后潜力。Fc 是预测骨折发生的最灵敏、最特异的指标(AUC = 0.864)。当包括狗的体重(BW)时,所有五个指标的 AUC 均为 0.705。通过逐步逻辑回归和 CART 分析,Fc 是预测骨折的最佳指标,其次是 BR。通过将 Fc 或 BR 与狗的体重进行归一化,或使用任一指标与狗的体重的逻辑回归方程,可以确定骨折概率。研究结果表明,有必要对更大的群组进行进一步分析,以评估肱骨前端骨瘤病犬骨折的可能性。
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引用次数: 0
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Veterinary Radiology & Ultrasound
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