Pub Date : 2022-08-01DOI: 10.33929/sherm.2022.vol4.no1.06
D. Johnson
In this paper, I ask whether the occurrence of the Holocaust is good reason to doubt the existence of God. To do so, I will explore different varieties of the problem of evil to determine exactly what kind of argument the problem of the Holocaust is. I will then explore proposed solutions to the relevant varieties of the problem of evil to see if they can solve the problem of the Holocaust. The logical problem of the Holocaust, I will argue, can only be solved at the cost of embracing an unorthodox (heretical?) “open” view of God. The evidential problem of the Holocaust can be solved, but only at the cost of embracing a deistic view of God that would entail that he might as well not exist. What’s more, both solutions are rooted in the idea of free will. Consequently, either the theist will have to answer the myriad of arguments which suggest that libertarian free will doesn’t exist, or embrace a compatibilist notion of free will which renders the above solutions moot and turns the problem of the Holocaust into a version of the logical problem of natural evil—a problem which has not yet been satisfactorily solved.
{"title":"Free Will, the Holocaust, and The Problem of Evil","authors":"D. Johnson","doi":"10.33929/sherm.2022.vol4.no1.06","DOIUrl":"https://doi.org/10.33929/sherm.2022.vol4.no1.06","url":null,"abstract":"In this paper, I ask whether the occurrence of the Holocaust is good reason to doubt the existence of God. To do so, I will explore different varieties of the problem of evil to determine exactly what kind of argument the problem of the Holocaust is. I will then explore proposed solutions to the relevant varieties of the problem of evil to see if they can solve the problem of the Holocaust. The logical problem of the Holocaust, I will argue, can only be solved at the cost of embracing an unorthodox (heretical?) “open” view of God. The evidential problem of the Holocaust can be solved, but only at the cost of embracing a deistic view of God that would entail that he might as well not exist. What’s more, both solutions are rooted in the idea of free will. Consequently, either the theist will have to answer the myriad of arguments which suggest that libertarian free will doesn’t exist, or embrace a compatibilist notion of free will which renders the above solutions moot and turns the problem of the Holocaust into a version of the logical problem of natural evil—a problem which has not yet been satisfactorily solved.","PeriodicalId":23712,"journal":{"name":"Volume 4 Issue 1","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84798198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.33929/sherm.2022.vol4.no1.09
Tommaso Manzon
This paper seeks to examine the relationship between kerygma and dialogue, arguing that the proclamation of the Christian message can take the form of a dialogical practice, and indeed of an interreligious dialogical practice. There seems to be an underlying assumption that “dialoguing” necessarily requires the weakening of one’s religious convictions, insofar as to express these in their full-blown form would lead necessarily to conflict and/or the shutting down of the conversation. However, I shall argue that this conclusion is not demanded by the nature of dialogue per se but rather from a particular understanding of what dialoguing means. The latter is underpinned by the assumption that in the realm of religion and spirituality we have no objective access to truth. I shall then hark back to a different understanding of dialogue rooted in Socrates’ philosophizing by making reference to the episode of the Apostle Paul’s kerygmatic preaching of the Gospel in Athens. I will read such a scene as one where kerigma and interreligious dialogue intertwine. The Socratic model off dialogical practice makes room for truth and allows interreligious dialogue to take place without the need to set aside one’s own religious beliefs.
{"title":"In the Synagogue, in the Streets, on the Aeropagus: Kerygma and Dialogue with Reference to Acts 17","authors":"Tommaso Manzon","doi":"10.33929/sherm.2022.vol4.no1.09","DOIUrl":"https://doi.org/10.33929/sherm.2022.vol4.no1.09","url":null,"abstract":"This paper seeks to examine the relationship between kerygma and dialogue, arguing that the proclamation of the Christian message can take the form of a dialogical practice, and indeed of an interreligious dialogical practice. There seems to be an underlying assumption that “dialoguing” necessarily requires the weakening of one’s religious convictions, insofar as to express these in their full-blown form would lead necessarily to conflict and/or the shutting down of the conversation. However, I shall argue that this conclusion is not demanded by the nature of dialogue per se but rather from a particular understanding of what dialoguing means. The latter is underpinned by the assumption that in the realm of religion and spirituality we have no objective access to truth. I shall then hark back to a different understanding of dialogue rooted in Socrates’ philosophizing by making reference to the episode of the Apostle Paul’s kerygmatic preaching of the Gospel in Athens. I will read such a scene as one where kerigma and interreligious dialogue intertwine. The Socratic model off dialogical practice makes room for truth and allows interreligious dialogue to take place without the need to set aside one’s own religious beliefs.","PeriodicalId":23712,"journal":{"name":"Volume 4 Issue 1","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86889379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.33929/sherm.2022.vol4.no1.08
Frank R. Zindler
This article argues that the dendritic (tree-like) or traditional model of Christian origins must be replaced with a plectic (braid-like) model. The dendritic model assumes that Christianity began at a specific point in both time and space—in the person of “Jesus of Nazareth”—and then branched out to form the various ancient sects of Christianity. This article asks: What if the numerous forms of “Christianity” did not all derive from a single historical figure? What if these earliest “Christianities” arose in the same way that the different forms and varieties of Egyptian, Indic, and Greco-Roman religions evolved? A new paradigm is proposed where the various forms of Christianity can be envisioned as forming by the coalescence of various threads (or trajectories) of religious tradition. Some of the threads may trace back into the mists of prehistory, others may trace to the turn of the current era, and still others may have begun in the second or third centuries CE. Not all early forms of Christianity contained the same threads. Not all threads stayed in the braid for long, and still others continued into the present. After entering the braid, threads of tradition evolved, bifurcated, branched off, or were absorbed into other traditions. Clearly, this is what we see happening today as multitudinous sects, cults, and denominations continue to arise and go extinct. As in historical geology, so too in religious history: The present is the key to the past.
{"title":"A New Paradigm for the Study of Christian Origins: Replacing the Dendritic Model","authors":"Frank R. Zindler","doi":"10.33929/sherm.2022.vol4.no1.08","DOIUrl":"https://doi.org/10.33929/sherm.2022.vol4.no1.08","url":null,"abstract":"This article argues that the dendritic (tree-like) or traditional model of Christian origins must be replaced with a plectic (braid-like) model. The dendritic model assumes that Christianity began at a specific point in both time and space—in the person of “Jesus of Nazareth”—and then branched out to form the various ancient sects of Christianity. This article asks: What if the numerous forms of “Christianity” did not all derive from a single historical figure? What if these earliest “Christianities” arose in the same way that the different forms and varieties of Egyptian, Indic, and Greco-Roman religions evolved? A new paradigm is proposed where the various forms of Christianity can be envisioned as forming by the coalescence of various threads (or trajectories) of religious tradition. Some of the threads may trace back into the mists of prehistory, others may trace to the turn of the current era, and still others may have begun in the second or third centuries CE. Not all early forms of Christianity contained the same threads. Not all threads stayed in the braid for long, and still others continued into the present. After entering the braid, threads of tradition evolved, bifurcated, branched off, or were absorbed into other traditions. Clearly, this is what we see happening today as multitudinous sects, cults, and denominations continue to arise and go extinct. As in historical geology, so too in religious history: The present is the key to the past.","PeriodicalId":23712,"journal":{"name":"Volume 4 Issue 1","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85689964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.33929/sherm.2022.vol4.no1.07
Morgan Rempel
While religious belief is not a dominant theme in Levi’s Holocaust writing, over the course of a forty-year writing career this longstanding nonbeliever offers a number of thoughtful reflections on God, faith, and the Holocaust. The first half of my paper examines the Jewish identity of the young Levi, as well as the isolated thoughts on God, faith, and religion found in Survival in Auschwitz (1947). While that early work deliberately focuses on day-to-day exigencies amidst the unrelenting struggle for existence at Auschwitz-Monovitz, it still raises provocative questions about prayer and belief in the context of the Holocaust. In his later writing and interviews, Levi digs deeper and with greater frequency into matters concerning God and the Holocaust. From the recurring charge of “blasphemy” to his career-long characterization of his unlikely survival as a matter of simple luck rather than Divine Providence, my paper goes on to examine the later Levi’s increasingly subtle reflections on matters related to God and the Holocaust. Finally, I look at the later Levi’s repeated insistence that the years of persecution brought with them a newfound understanding of himself as a Jew. By examining his thoughts on how his Auschwitz imprisonment simultaneously confirmed his nonbelief and inaugurated his self-conception as a Jew, my paper demonstrates that Levi’s scattered reflections on God, faith, and the Holocaust are both challenging and well worth our careful, continued study.
{"title":"An “Italian Citizen of Jewish Race”: Primo Levi on Belief, Blasphemy and Becoming a Jew","authors":"Morgan Rempel","doi":"10.33929/sherm.2022.vol4.no1.07","DOIUrl":"https://doi.org/10.33929/sherm.2022.vol4.no1.07","url":null,"abstract":"While religious belief is not a dominant theme in Levi’s Holocaust writing, over the course of a forty-year writing career this longstanding nonbeliever offers a number of thoughtful reflections on God, faith, and the Holocaust. The first half of my paper examines the Jewish identity of the young Levi, as well as the isolated thoughts on God, faith, and religion found in Survival in Auschwitz (1947). While that early work deliberately focuses on day-to-day exigencies amidst the unrelenting struggle for existence at Auschwitz-Monovitz, it still raises provocative questions about prayer and belief in the context of the Holocaust. In his later writing and interviews, Levi digs deeper and with greater frequency into matters concerning God and the Holocaust. From the recurring charge of “blasphemy” to his career-long characterization of his unlikely survival as a matter of simple luck rather than Divine Providence, my paper goes on to examine the later Levi’s increasingly subtle reflections on matters related to God and the Holocaust. Finally, I look at the later Levi’s repeated insistence that the years of persecution brought with them a newfound understanding of himself as a Jew. By examining his thoughts on how his Auschwitz imprisonment simultaneously confirmed his nonbelief and inaugurated his self-conception as a Jew, my paper demonstrates that Levi’s scattered reflections on God, faith, and the Holocaust are both challenging and well worth our careful, continued study.","PeriodicalId":23712,"journal":{"name":"Volume 4 Issue 1","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77497750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.33929/sherm.2022.vol4.no1.02
Elyse Pierce
International genocide intervention strategies that involve the extended evacuation and/or displacement of refugees often save the physical lives of would-be victims at the expense of psychological and social trauma and cultural erasure. Through a comparison of the international rescue efforts of the Kindertransport program in Great Britain prior to and during the Second World War and the refugee caravans organized by La Benevolencija in Sarajevo during the Bosnian Civil War, the benefits and dangers of inter-ethnic, inter-religious rescue in times of mass violence are examined, along with how the social dynamics of racialized religious identification influenced the occurrence of these intervention strategies. The implications gleaned from this comparison offer guidance for current and future genocide intervention programs, where great care should be taken, whenever possible, to keep family groups intact and together, provide necessary psychological and social services for refugees, and allow for the continued practice of communal cultural and religious traditions without forced assimilation. The moment of physical rescue is only the initial component of a successful intervention into religio-ethnic violence; to truly prevent the genocidal destruction of a people and culture, those people’s ability to identify with their traditions and maintain their way of life is of equal and vital importance.
{"title":"The Danger of Cultural Erasure in Inter-Ethnic, Inter-Religious, Trans-National Rescue During Genocide: A Comparison of the Shoah and the Bosnian Civil War","authors":"Elyse Pierce","doi":"10.33929/sherm.2022.vol4.no1.02","DOIUrl":"https://doi.org/10.33929/sherm.2022.vol4.no1.02","url":null,"abstract":"International genocide intervention strategies that involve the extended evacuation and/or displacement of refugees often save the physical lives of would-be victims at the expense of psychological and social trauma and cultural erasure. Through a comparison of the international rescue efforts of the Kindertransport program in Great Britain prior to and during the Second World War and the refugee caravans organized by La Benevolencija in Sarajevo during the Bosnian Civil War, the benefits and dangers of inter-ethnic, inter-religious rescue in times of mass violence are examined, along with how the social dynamics of racialized religious identification influenced the occurrence of these intervention strategies. The implications gleaned from this comparison offer guidance for current and future genocide intervention programs, where great care should be taken, whenever possible, to keep family groups intact and together, provide necessary psychological and social services for refugees, and allow for the continued practice of communal cultural and religious traditions without forced assimilation. The moment of physical rescue is only the initial component of a successful intervention into religio-ethnic violence; to truly prevent the genocidal destruction of a people and culture, those people’s ability to identify with their traditions and maintain their way of life is of equal and vital importance.","PeriodicalId":23712,"journal":{"name":"Volume 4 Issue 1","volume":"os-12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87192488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.33929/sherm.2022.vol4.no1.01
K. Hanson
There has understandably been a good deal of emphasis on how Jewish faith has been affected in the wake of the genocidal catastrophe of the Shoah. Much less attention has been devoted, however, to how observant Jews were impacted, with regard to their faith, in the midst of the tragedy. Elie Wiesel, for his part, was said to have put God on trial at Auschwitz. It will also be instructive to consider two Jewish leaders, both ultra-orthodox rabbis, who were victims of the Nazi genocide. Their perspectives (unlike post-Holocaust theology) provide a window on Jewish thought while events were unfolding. The reflections of Rabbi Kalonymus Kalman Shapira, who was residing in Warsaw at the outbreak of the war, were published in Israel in 1960 under the title Esh Kodesh. The work elucidates what may be viewed as a normative theology of suffering. Another ultra-orthodox rabbi, Yissachar Teichtal, was living in Budapest during the Nazi era. His theology is even more dramatic, rejecting all exilic philosophies, and developing a religious Zionist philosophy. If there is a to be found a merging of the two approaches, it is in the idea of “reconstruction,” on the one hand of the individual, and on the other, of the Jewish nation – the uniquely Jewish concept of tikkun.
{"title":"The Shoah and Jewish Faith: Voices from the Midst of Tragedy","authors":"K. Hanson","doi":"10.33929/sherm.2022.vol4.no1.01","DOIUrl":"https://doi.org/10.33929/sherm.2022.vol4.no1.01","url":null,"abstract":"There has understandably been a good deal of emphasis on how Jewish faith has been affected in the wake of the genocidal catastrophe of the Shoah. Much less attention has been devoted, however, to how observant Jews were impacted, with regard to their faith, in the midst of the tragedy. Elie Wiesel, for his part, was said to have put God on trial at Auschwitz. It will also be instructive to consider two Jewish leaders, both ultra-orthodox rabbis, who were victims of the Nazi genocide. Their perspectives (unlike post-Holocaust theology) provide a window on Jewish thought while events were unfolding. The reflections of Rabbi Kalonymus Kalman Shapira, who was residing in Warsaw at the outbreak of the war, were published in Israel in 1960 under the title Esh Kodesh. The work elucidates what may be viewed as a normative theology of suffering. Another ultra-orthodox rabbi, Yissachar Teichtal, was living in Budapest during the Nazi era. His theology is even more dramatic, rejecting all exilic philosophies, and developing a religious Zionist philosophy. If there is a to be found a merging of the two approaches, it is in the idea of “reconstruction,” on the one hand of the individual, and on the other, of the Jewish nation – the uniquely Jewish concept of tikkun.","PeriodicalId":23712,"journal":{"name":"Volume 4 Issue 1","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84469758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.33929/sherm.2022.vol4.no1.10
Richard Carrier
The edited volume, Varieties of Jesus Mythicism, aims to present diverse approaches and theories to the debate on Jesus’ historical existence. While it includes several enlightening and worthwhile contributions, there are too many amateur contributions employing dubious claims and methodologies. The result is that, apart from the few worthy contributions, the book as a whole is only useful for comparing poor with genuine scholarship. And some advice on how to make such a comparison, so as to distinguish the one from the other, is here provided.
{"title":"Book Review: Varieties of Jesus Mythicism","authors":"Richard Carrier","doi":"10.33929/sherm.2022.vol4.no1.10","DOIUrl":"https://doi.org/10.33929/sherm.2022.vol4.no1.10","url":null,"abstract":"The edited volume, Varieties of Jesus Mythicism, aims to present diverse approaches and theories to the debate on Jesus’ historical existence. While it includes several enlightening and worthwhile contributions, there are too many amateur contributions employing dubious claims and methodologies. The result is that, apart from the few worthy contributions, the book as a whole is only useful for comparing poor with genuine scholarship. And some advice on how to make such a comparison, so as to distinguish the one from the other, is here provided.","PeriodicalId":23712,"journal":{"name":"Volume 4 Issue 1","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74231571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.33929/sherm.2022.vol4.no1.05
D. Patterson
This article examines Haj Amin al-Husseini’s involvement in the Holocaust, his ties to the Muslim Brotherhood, and the Brotherhood’s post-Holocaust influence on the spread of exterminationist Jew hatred. The article examines the connection between the Nazis and the Muslim Brotherhood facilitated by al-Husseini, showing the pivotal nature of the Arab Revolt of 1936 – 1939 in these relationships. By then the Brotherhood was sending delegations to the Nuremberg rallies and distributing the Protocols of the Elders of Zion and Arabic-language selections from Mein Kampf. The article then explores al-Husseini’s direct collaboration with the Nazis and participation in the Holocaust. This begins with his instigation of a Nazi-backed coup in Iraq in April 1941, which was followed by the slaughter of hundreds of Jews in Baghdad. From there we go to al-Husseini’s first meeting with Hitler in November 1941 and his work with Himmler in organizing Muslim SS killing units in the Balkans. This section ends with al-Husseini’s hero’s welcome as a Nazi war criminal in July 1946, when he was once again embraced by the Muslim Brotherhood. Finally, the article moves to the post-war years, with al-Husseini’s recruitment and indoctrination of Yasser Arafat in the Brotherhood. This article considers the Brotherhood’s influence on the Palestinian Liberation Organization and Hamas in the spread of an exterminationist agenda inspired by the Nazis.
{"title":"Islamic Jihad and the Holocaust: From Hitler to Hamas","authors":"D. Patterson","doi":"10.33929/sherm.2022.vol4.no1.05","DOIUrl":"https://doi.org/10.33929/sherm.2022.vol4.no1.05","url":null,"abstract":"This article examines Haj Amin al-Husseini’s involvement in the Holocaust, his ties to the Muslim Brotherhood, and the Brotherhood’s post-Holocaust influence on the spread of exterminationist Jew hatred. The article examines the connection between the Nazis and the Muslim Brotherhood facilitated by al-Husseini, showing the pivotal nature of the Arab Revolt of 1936 – 1939 in these relationships. By then the Brotherhood was sending delegations to the Nuremberg rallies and distributing the Protocols of the Elders of Zion and Arabic-language selections from Mein Kampf. The article then explores al-Husseini’s direct collaboration with the Nazis and participation in the Holocaust. This begins with his instigation of a Nazi-backed coup in Iraq in April 1941, which was followed by the slaughter of hundreds of Jews in Baghdad. From there we go to al-Husseini’s first meeting with Hitler in November 1941 and his work with Himmler in organizing Muslim SS killing units in the Balkans. This section ends with al-Husseini’s hero’s welcome as a Nazi war criminal in July 1946, when he was once again embraced by the Muslim Brotherhood. Finally, the article moves to the post-war years, with al-Husseini’s recruitment and indoctrination of Yasser Arafat in the Brotherhood. This article considers the Brotherhood’s influence on the Palestinian Liberation Organization and Hamas in the spread of an exterminationist agenda inspired by the Nazis.","PeriodicalId":23712,"journal":{"name":"Volume 4 Issue 1","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87382763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atif Kamil, A. Zeb, Farooq Hussain, M. Jamal, Azmat Ali, Muhammad A Shah, Ayaz Ahmad, J. Khan, F. Anwar, Nabila
Hepatitis C virus is known to be major public health issue around the globe. The aim was to investigate the treatment and detection of HCV infection in general population of District Mardan. Presently no standard treatment is available for the cure of Hepatitis C viral infection, attributed possibly to the hyper variations in HCV genome, expressing several distinct HCV genotypes. For a period of 5 months (June 2016 - November 2016), 270 suspected individuals visited the main hospital of Mardan Medical complex (MMC), were interviewed. Among them 100 individuals were diagnosed by ELISA and PCR for HCV detection at the diagnostic laboratory of MMC. A total of 170 HCV patients were treated at the MMC, with oral medicine or interferon vaccines and the response were monitored by PCR after treatments. Our result showed that high sensitivity for genome-based PCR detection of HCV in comparison to viral coat protein detection by ELISA. The assessment of treatment strategies for HCV showed high response for presently available medicines i.e., Sovaldi, Sofiget, Sofohil, Ocvir and sofosbuvir in comparison to interferon and pig interferon. The accurate and early diagnosis of the HCV infection is crucial for effective treatment strategies. Thereby PCR detection should be the proffered method for specific and accurate detection of HCV infection. The standard medicine available presently proved better treatment method for HCV infection in comparison to interferon vaccination. Keywords: Vaccine, Medication, Sovaldi, Mardan, Interferon, Sofohil, HCV.
{"title":"Assessment of Detection and Treatment Response of Hepatitis C viral Infection in District Mardan Pakistan","authors":"Atif Kamil, A. Zeb, Farooq Hussain, M. Jamal, Azmat Ali, Muhammad A Shah, Ayaz Ahmad, J. Khan, F. Anwar, Nabila","doi":"10.34091/ajls.4.1.9","DOIUrl":"https://doi.org/10.34091/ajls.4.1.9","url":null,"abstract":"Hepatitis C virus is known to be major public health issue around the globe. The aim was to investigate the treatment and detection of HCV infection in general population of District Mardan. Presently no standard treatment is available for the cure of Hepatitis C viral infection, attributed possibly to the hyper variations in HCV genome, expressing several distinct HCV genotypes. For a period of 5 months (June 2016 - November 2016), 270 suspected individuals visited the main hospital of Mardan Medical complex (MMC), were interviewed. Among them 100 individuals were diagnosed by ELISA and PCR for HCV detection at the diagnostic laboratory of MMC. A total of 170 HCV patients were treated at the MMC, with oral medicine or interferon vaccines and the response were monitored by PCR after treatments. Our result showed that high sensitivity for genome-based PCR detection of HCV in comparison to viral coat protein detection by ELISA. The assessment of treatment strategies for HCV showed high response for presently available medicines i.e., Sovaldi, Sofiget, Sofohil, Ocvir and sofosbuvir in comparison to interferon and pig interferon. The accurate and early diagnosis of the HCV infection is crucial for effective treatment strategies. Thereby PCR detection should be the proffered method for specific and accurate detection of HCV infection. The standard medicine available presently proved better treatment method for HCV infection in comparison to interferon vaccination.\u0000\u0000Keywords: Vaccine, Medication, Sovaldi, Mardan, Interferon, Sofohil, HCV.","PeriodicalId":23712,"journal":{"name":"Volume 4 Issue 1","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79775524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Fatima, N. Malkani, M. Muzammal, A. Khan, M. Usama
The current study aims to produce stable liposomes from total lipid extracts from bacteria. Liposomes are the small vesicles that are made up of lipids. On their structural basis, they can be considered as simplified cell structure of cell membrane. Structure of liposomes depends on the pH of preparation buffer, method of preparation and the environmental condition in which they are prepared. Liposomes have importance in the field of medicines for diagnostic and therapeutic purposes. They mainly work as a vehicle for drug delivery. The objective of the current study was to make stable liposomes from two types of bacterial samples i.e., a Gram-positive and a Gram-negative strain. E. coli and Bacillus sp. were selected as representative of Gram-negative and Gram-positive bacteria, respectively. Lipid extraction was performed by various methods, out of which the modified Bligh and Dyer method gave most effective results. Liposomes were prepared by extrusion and their stability and efficiency was tested by fluorescence spectrophotometer using OxanolVI. Our results showed that liposomes formed by lipids extracted from E. coli were more stable than the liposomes formed by lipids extracted from Bacillus sp. Keywords: liposomes, Lipids, diagnostic, therapeutic, purposes, fluorescence, Bacillus sp.
{"title":"Stable Vesicle Production from Bacterial Total Lipid Extracts","authors":"S. Fatima, N. Malkani, M. Muzammal, A. Khan, M. Usama","doi":"10.34091/ajls.4.1.1","DOIUrl":"https://doi.org/10.34091/ajls.4.1.1","url":null,"abstract":"The current study aims to produce stable liposomes from total lipid extracts from bacteria. Liposomes are the small vesicles that are made up of lipids. On their structural basis, they can be considered as simplified cell structure of cell membrane. Structure of liposomes depends on the pH of preparation buffer, method of preparation and the environmental condition in which they are prepared. Liposomes have importance in the field of medicines for diagnostic and therapeutic purposes. They mainly work as a vehicle for drug delivery. The objective of the current study was to make stable liposomes from two types of bacterial samples i.e., a Gram-positive and a Gram-negative strain. E. coli and Bacillus sp. were selected as representative of Gram-negative and Gram-positive bacteria, respectively. Lipid extraction was performed by various methods, out of which the modified Bligh and Dyer method gave most effective results. Liposomes were prepared by extrusion and their stability and efficiency was tested by fluorescence spectrophotometer using OxanolVI. Our results showed that liposomes formed by lipids extracted from E. coli were more stable than the liposomes formed by lipids extracted from Bacillus sp.\u0000\u0000Keywords: liposomes, Lipids, diagnostic, therapeutic, purposes, fluorescence, Bacillus sp.","PeriodicalId":23712,"journal":{"name":"Volume 4 Issue 1","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82057943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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