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Curviflorside and curviflorin, new naphthalene glycoside and flavanol from Plicosepalus curviflorus 曲桦中的曲桦苷、曲桦苷、新萘苷和黄烷醇
Pub Date : 2016-11-15 DOI: 10.1515/znc-2016-0180
N. A. Al Musayeib, S. Ibrahim, M. Amina, Gadah A Al Hamoud, G. Mohamed
Abstract The naphthalene glycosidecurviflorside [1,5-dihydroxy-8-methoxynaphthalene-2-O-β-D-xylopyranoside] (3) and the flavanol curviflorin [(+)-catechin-7-O-3″,4″-dihydroxybenzoate] (4), along with two known flavonoids: (+)-catechin (1) and quercetin (2) were isolated from the shoots of Plicosepalu scurviflorus Benth. (Loranthaceae) growing in Saudi Arabia and the chemical structures were elucidated by 2D-NMR spectroscopy.
摘要从苦参(Plicosepalu scurviflorus Benth)茎中分离得到萘糖苷曲维flor苷[1,5-二羟基-8-甲氧基萘萘-2- o -β- d -木pyranoside](3)和黄烷醇曲维florin[(+)-儿茶素-7- o -3″,4″-二羟基苯甲酸酯](4),以及已知的两种黄酮类化合物(+)-儿茶素(1)和槲皮素(2)。利用二维核磁共振光谱对产自沙特阿拉伯的Loranthaceae植物及其化学结构进行了鉴定。
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引用次数: 5
Virus inactivation under the photodynamic effect of phthalocyanine zinc(II) complexes 酞菁锌(II)配合物光动力作用下的病毒灭活
Pub Date : 2016-11-15 DOI: 10.1515/znc-2016-0119
M. Remichkova, L. Mukova, L. Nikolaeva-Glomb, N. Nikolova, L. Doumanova, V. Mantareva, I. Angelov, V. Kussovski, A. Galabov
Abstract Various metal phthalocyanines have been studied for their capacity for photodynamic effects on viruses. Two newly synthesized water-soluble phthalocyanine Zn(II) complexes with different charges, cationic methylpyridyloxy-substituted Zn(II)- phthalocyanine (ZnPcMe) and anionic sulfophenoxy-substituted Zn(II)-phthalocyanine (ZnPcS), were used for photoinactivation of two DNA-containing enveloped viruses (herpes simplex virus type 1 and vaccinia virus), two RNA-containing enveloped viruses (bovine viral diarrhea virus and Newcastle disease virus) and two nude viruses (the enterovirus Coxsackie B1, a RNA-containing virus, and human adenovirus 5, a DNA virus). These two differently charged phthalocyanine complexes showed an identical marked virucidal effect against herpes simplex virus type 1, which was one and the same at an irradiation lasting 5 or 20 min (Δlog=3.0 and 4.0, respectively). Towards vaccinia virus this effect was lower, Δlog=1.8 under the effect of ZnPcMe and 2.0 for ZnPcS. Bovine viral diarrhea virus manifested a moderate sensitivity to ZnPcMe (Δlog=1.8) and a pronounced one to ZnPcS at 5- and 20-min irradiation (Δlog=5.8 and 5.3, respectively). The complexes were unable to inactivate Newcastle disease virus, Coxsackievirus B1 and human adenovirus type 5.
摘要:人们研究了各种金属酞菁对病毒的光动力作用。新合成的两种不同电荷的水溶性酞菁锌(II)配合物,阳离子甲基吡啶氧基取代锌(II)-酞菁(ZnPcMe)和阴离子磺胺氧基取代锌(II)-酞菁(ZnPcS),用于两种含dna的包膜病毒(单纯疱疹病毒1型和牛痘病毒)、两种含rna的包膜病毒(牛病毒性腹泻病毒和新城疫病毒)和两种裸病毒(柯萨奇B1肠病毒、一种含rna的病毒和人类腺病毒5,一种DNA病毒)。这两种带不同电荷的酞菁复合物对1型单纯疱疹病毒具有相同的显著杀病毒作用,在持续5或20分钟的照射下,1型单纯疱疹病毒是相同的(Δlog分别=3.0和4.0)。ZnPcMe对牛痘病毒的影响较低,Δlog=1.8, ZnPcS为2.0。牛病毒性腹泻病毒对ZnPcMe具有中等敏感性(Δlog=1.8),对ZnPcS具有显著敏感性(Δlog=5.8和5.3)。该复合物不能灭活新城疫病毒、柯萨奇病毒B1和人腺病毒5型。
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引用次数: 16
A comparative proteomic analysis for adventitious root formation in lotus root (Nelumbo nucifera Gaertn) 莲藕不定根形成的比较蛋白质组学分析
Pub Date : 2016-11-10 DOI: 10.1515/znc-2016-0170
Cheng Libao, J. Runzhi, Yang Mengli, Li Liangjun, Liu Shuyan
Abstract Adventitious roots (ARs) directly affect lotus seedling growth and product quality because principal root is not well developed. However, the details of AR formation at the molecular level have not been determined in lotus. Therefore, three stages were chosen to identify the change of proteins abundant during rhizome formation, using isobaric tags for relative and absolute quantization coupled with liquid chromatography–tandem mass spectrometry to gain insight into the molecular mechanisms involved in AR formation. We totally obtained 323,375 spectra during AR formation. After filtering to eliminate low-scoring spectra, 66,943 spectra, including 53,106 unique spectra, were identified. These unique spectra matched 28,905 peptides, including 24,992 unique peptides, which were assembled into 6686 proteins. In the C0/C1 and C1/C2 stages, 66 and 32 proteins showed enhanced abundance, and 173 and 73 proteins showed decreased abundance, respectively. Seventeen important AR formation-related proteins from the three stages were identified, and the expressions of nine genes from the above-identified proteins were assessed by qRT-PCR. This article provides a comprehensive understanding of the changes in metabolism during AR formation, and is helpful to accelerate the progress of breeding in fulture in lotus root.
摘要由于主根发育不良,不定根直接影响莲苗的生长和产品质量。然而,在莲藕中AR在分子水平上形成的细节尚未确定。因此,我们选择了三个阶段来鉴定根茎形成过程中丰富蛋白的变化,利用等压标签进行相对定量和绝对定量,结合液相色谱-串联质谱分析来深入了解AR形成的分子机制。在AR形成过程中,我们总共获得了323375个光谱。经滤波剔除低评分光谱后,共识别出66,943个光谱,其中唯一光谱53,106个。这些独特的光谱匹配了28,905条肽,其中包括24,992条独特的肽,这些肽被组装成6686种蛋白质。在C0/C1和C1/C2阶段,分别有66个和32个蛋白丰度增强,173个和73个蛋白丰度降低。鉴定了三个阶段的17个重要的AR形成相关蛋白,并利用qRT-PCR技术对上述蛋白中9个基因的表达进行了评估。本文为全面了解AR形成过程中代谢的变化提供了依据,有助于加快今后莲藕育种的进展。
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引用次数: 2
Synthesis, in-vitro cytotoxicity of 1H-benzo[f]chromene derivatives and structure–activity relationships of the 1-aryl group and 9-position h -苯并[f]铬衍生物的合成、体外细胞毒性及1-芳基和9位的构效关系
Pub Date : 2016-11-10 DOI: 10.1515/znc-2016-0139
H. M. Mohamed, A. Fouda, E. Khattab, Ahmed M El- Agrody, T. H. Afifi
Abstract A series of 1H-benzo[f]chromene-2-carbonitriles was synthesized and evaluated for their cytotoxic activities against MCF-7, HCT-116, and HepG-2 cancer cells. The SAR studies reported that the substitution in the phenyl ring at 1-position of 1H-benzo[f]chromene nucleus with the specific group, H atom, or methoxy group at 9-position increases the ability of the molecule against the different cell lines.
摘要合成了一系列1h -苯并[f]铬-2-碳腈,并对其对MCF-7、HCT-116和HepG-2癌细胞的细胞毒活性进行了评价。SAR研究报道了H-苯并[f]铬核1位苯基环被9位的特定基团、H原子或甲氧基取代,增加了分子对不同细胞系的能力。
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引用次数: 12
Biodegradation of micropollutant naproxen with a selected fungal strain and identification of metabolites 微污染物萘普生的生物降解及代谢物鉴定
Pub Date : 2016-11-10 DOI: 10.1515/znc-2016-0162
Y. D. Aracagök, H. Göker, N. Cihangir
Abstract Pharmaceuticals are widely used for treating human and animal diseases. Naproxen [(S) 6-methoxy-α-methyl-2-naphthalene acetic acid] and its sodium salt are members of the α-arylpropionic acid group of nonsteroidal anti-inflammatory drugs. Due to excessive usage of naproxen, this drug has been determined even in drinking water. In this study, four fungal strains Phanerochaete chrysosporium, Funalia trogii, Aspergillus niger, and Yarrowia lipolytica were investigated in terms of naproxen removal abilities. According to LC/MS data, A. niger was found the most efficient strain with 98% removal rate. Two main by-products of fungal transformation, O-desmethylnaproxen and 7-hydroxynaproxen, were identified by using LC/MS, 1HNMR, and 13CNMR. Our results showed that O-demethylation and hydroxylation of naproxen is catalyzed by cytochrome P450 enzyme system.
药物广泛用于治疗人类和动物疾病。萘普生[(S) 6-甲氧基-α-甲基-2-萘乙酸]及其钠盐是非甾体类抗炎药中α-芳基丙酸基团的成员。由于过度使用萘普生,甚至在饮用水中也发现了这种药物。在本研究中,研究了四种真菌菌株黄孢平革菌、trogii Funalia、黑曲霉和多脂耶氏菌对萘普生的去除能力。LC/MS数据显示,黑曲霉的去除率最高,达98%。通过LC/MS、1HNMR和13CNMR鉴定了真菌转化的两种主要副产物o -去甲基萘普生和7-羟基萘普生。结果表明,萘普生的o -去甲基化和羟基化是由细胞色素P450酶系统催化的。
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引用次数: 16
Anti-inflammatory activity of highly oxygenated terpenoids from Achillea biebersteinii Afan 水蛭高氧萜类化合物的抗炎活性
Pub Date : 2016-11-01 DOI: 10.1515/znc-2016-0098
A. H. Mohamed, N. S. Mohamed, A. Hamed, M. Hegazy
Abstract In continuation of our chemical investigation on some medicinal plants of the genus Achillea, chromatographic investigation of the methylene chloride/methanol (1:1) extract of the air-dried aerial part of Achillea biebersteinii Afan. (family Asteraceae) afforded a new natural monoterpene (2), in addition to two known sesquiterpenes (3 and 4). Compound 1 was isolated as light needle crystals. Structures were established on the basis of MS and NMR spectroscopic (1H, 13C, 1H-1H correlation spectroscopy, heteronuclear multiple-quantum coherence and heteronuclear multiple-bond correlation) data and in case of compound 1 were confirmed by X-ray analysis. All isolated compounds were examined for their anti-inflammatory activity to inhibit lipopolysaccharide-induced NO production in RAW264.7 macrophage cells. Compounds 3 and 4 produced a promising anti-inflammatory effect (76% and 80% inhibition, respectively). However, compounds 1 and 2 produced moderate inhibition of NO release recording a 41% and 36% inhibition of NO production, respectively.
摘要/ Abstract摘要:在对一些药用植物阿喀那属进行化学研究的基础上,对阿喀那属风干部分的二氯甲烷/甲醇(1:1)提取物进行了色谱分析。在已知的两种倍半萜类化合物(3和4)之外,还发现了一种新的天然单萜类化合物(2)。化合物1为轻针状晶体。根据质谱和核磁共振谱(1H、13C、1H-1H相关谱、异核多量子相干和异核多键相关)数据建立了结构,对化合物1进行了x射线分析。所有分离的化合物均检测其抗炎活性,以抑制脂多糖诱导的RAW264.7巨噬细胞NO的产生。化合物3和4具有良好的抗炎作用(分别抑制76%和80%)。然而,化合物1和2对NO释放有中等抑制作用,分别抑制41%和36%的NO生成。
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引用次数: 8
Antiproliferative effect of synthetic cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against human cancer cell lines 合成环酰亚胺(甲基酞酰亚胺、羧酸酞酰亚胺和伊塔康酰亚胺)对人癌细胞系的抗增殖作用
Pub Date : 2016-11-01 DOI: 10.1515/znc-2016-0067
D. Stiz, Adriana Campos, Ana Lúcia Tasca Gois Ruiz, João Ernesto de Carvalho, R. Corrêa, V. Cechinel-Filho
Abstract This work describes the antiproliferative potential of 14 cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against several human cancer cell lines. The antiproliferative effect was evaluated using the sulforhodamine B assay. Although some compounds from methylphtalimide and carboxylic acid phtalimide classes exhibited a selective antiproliferative activity, the itaconimides (11–14) exhibited the best results, especially compound 14, which presented a TGI (concentration that produces total growth inhibition) value of 0.0043 μM against glioma (U251), being inactive against the non-tumor cell line (HaCat). Absorption, distribution, metabolism and excretion in silico evaluations suggest that these compounds are promising candidates.
摘要:本文描述了14种环亚胺(甲基酞酰亚胺、羧酸酞酰亚胺和伊塔康酰亚胺)对几种人类癌细胞系的抗增殖潜力。采用硫代丹胺B法评价其抗增殖作用。虽然甲基酞酰亚胺类化合物和羧酸酞酰亚胺类化合物具有选择性的抗增殖活性,但伊塔康酰亚胺类化合物(11-14)表现出最好的效果,特别是化合物14,其对胶质瘤(U251)的TGI(产生总生长抑制的浓度)值为0.0043 μM,对非肿瘤细胞系(HaCat)无活性。吸收,分布,代谢和排泄在硅评价表明,这些化合物是有希望的候选者。
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引用次数: 4
The chemical composition, antimicrobial, and antioxidant activities of Pycnocycla spinosa and Pycnocyla flabellifolia essential oils 碧萝芷和碧萝芷精油的化学成分、抑菌活性和抗氧化活性
Pub Date : 2016-11-01 DOI: 10.1515/znc-2016-0038
M. Mahboubi, E. Mahdizadeh, Rezvan Heidary Tabar
Abstract The purpose of our study was to compare the chemical compositions and antimicrobial and antioxidant activities of Pycnocycla spinosa and Pycnocycla flabellifolia essential oils. cis-Asarone (62.5%) and widdra-2,4(14)-diene (9%) were the main components of P. spinosa aerial part essential oil, while elemicin (60.1%) and caryophyllene oxide (9.8%) were the main components of P. spinosa seed essential oil. α-Phellandrene (25.5%), p-cymene (15.3%), and limonene (13.3%) were found in P. flabellifolia essential oil. The inhibition zone diameters for P. flabellifolia essential oil were significantly higher than for the two other essential oils from P. spinosa (p<0.05). In broth dilution assay (µL/mL), the sensitive microorganism to Pycnocycla sp. (P. spinosa, P. flabellifolia) was Aspergillus niger, followed by Candida albicans. In 2,2-diphenyl-1-picrylhydrazyl (DPPH) system, P. spinosa aerial parts essential oil (IC50=548 µg/mL) had higher antioxidant activity than that of two other essential oils.
摘要本研究的目的是比较碧萝芷和碧萝芷精油的化学成分及抑菌和抗氧化活性。菝葜地上部位精油的主要成分为顺式asarone(62.5%)和widdra2,4(14)-二烯(9%),菝葜种子精油的主要成分为榄香素(60.1%)和石竹烯氧化物(9.8%)。其中含有α-费蓝烯(25.5%)、对伞花烯(15.3%)和柠檬烯(13.3%)。松柏挥发油的抑菌带直径显著高于其他两种松柏挥发油(p<0.05)。肉汤稀释试验(µL/mL)中,对棘圆霉属(P. spinosa, P. flabellifolia)敏感的微生物为黑曲霉,其次为白色念珠菌。在2,2-二苯基-1-苦味酰肼(DPPH)体系中,刺骨草挥发油(IC50=548µg/mL)的抗氧化活性高于其他两种挥发油。
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引用次数: 4
Seasonal variation of gastroprotective terpenoids in Maytenus robusta (Celastraceae) quantified by gas chromatography-flame ionization detection (GC-FID) 气相色谱-火焰离子化检测法(GC-FID)定量测定毛藤中胃保护萜类化合物的季节变化
Pub Date : 2016-11-01 DOI: 10.1515/znc-2015-0185
T. Zermiani, A. A. Junior, Rene A. Ferreira, T. Wagner, M. S. Machado, V. Cechinel-Filho, R. Niero
Abstract The triterpenes friedelin (1), β-friedelinol (2) and 3,15-dioxo-21α-hydroxyfriedelane (3) in the aerial parts of Maytenus robusta, a Brazilian medicinal plant with antiulcer potential, were seasonally quantified by gas chromatography flame-ionization detection (GC-FID) using an external standard. The method was found to be linear, precise and sensitive. Compounds 1 and 2 were found in M. robusta leaves and branches, with highest concentrations in the leaves collected in autumn, i.e. 3.21 ± 0.16 and 12.60 ± 1.49 mg g−1 dry weight of 1 and 2, respectively. On the other hand, compound 3 was found only in the branches, with the highest concentrations in winter and autumn (0.21 ± 0.01 and 0.20 ± 0.02 mg g−1). The results allow to define the optimal season and plant parts for the collection of M. robusta as a phytotherapeutic drug.
摘要采用气相色谱火焰离子化法(GC-FID),季节性定量分析了巴西抗溃疡药用植物马梅藤(Maytenus robusta)气相部位中三萜毛豆素(1)、β-毛豆烯醇(2)和3,15-二氧o-21α-羟基毛豆烯(3)的含量。结果表明,该方法线性好,精度高,灵敏度高。化合物1和2分别存在于罗布塔叶和枝中,秋季叶中含量最高,分别为干重3.21±0.16和12.60±1.49 mg g−1。化合物3仅存在于树枝中,冬季和秋季浓度最高,分别为0.21±0.01和0.20±0.02 mg g−1。研究结果为确定罗布斯塔作为植物治疗药物的最佳季节和植物部位提供了依据。
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引用次数: 6
New lupan-type triterpenoids 新的羽扇豆型三萜
Pub Date : 2016-11-01 DOI: 10.1515/znc-2015-0235
P. Mkounga, H. L. Maza, B. M. Ouahouo, Lydie N Tyon, H. Ishikawa, H. Nishino, A. Nkengfack
Abstract Three new lupan-type triterpernoid derivatives, namely globimetulin A (1), B (2) and C (3), were isolated from the shoot of Globimetula dinklagei (Loranthaceae), a hemiparasitic plant growing on Manihot esculenta, along with five known compounds: friedelin (4), friedelan-3-ol (5), 28-hydroxyfriedelin (6), 4-hydroxy-3,5-dimethoxybenzoic acid (7) and (1R,5S,7S)-7-[2-(4-hydroxyphenyl)ethyl]-2,6-dioxabicyclo[3.3.1]nonan-3-one (8). The structures of the new compounds were elucidated by detailed analyses of their MS, IR, 1D and 2D NMR spectral data and chemical evidence. Some of these compounds were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms, but none of them exhibited noticeable activity.
摘要/ Abstract摘要:从生长在manhot esculenta上的半寄生植物globimetulei (Loranthaceae)的茎中分离得到了3个新的羽豆型三萜衍生物globimetulin A(1)、B(2)和C(3),以及5个已知化合物。通过质谱、红外光谱、一维和二维核磁共振数据和化学证据对新化合物的结构进行了详细的分析,并对化合物的结构进行了鉴定。其中一些化合物在体外对多种微生物的抑菌活性进行了评估,但没有一种化合物表现出明显的活性。
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引用次数: 6
期刊
Zeitschrift für Naturforschung C
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