Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100404
Rakhi Sahu, Anurag Pandey, M. Tiwari, N. Mishra, A. Varshney
The genus Citrus contains a vast range of antioxidant metabolites, dietary metabolites and antioxidant polyphenols that protect plants from unfavourable environmental conditions, enhance their tolerance to abiotic and biotic stresses and possess multiple health-promoting effects in humans along with specifically Immunity boosting. Immunity is described as a condition of being able to resist a particular disease especially through preventing the development of a pathogenic microorganism or by counteracting the effects of its products. The immune system is a bodily system that produces the immune response to defend your body from foreign substances, cells and tissues. The immune system includes various parts of the body including the thymus, spleen, lymph nodes, special deposits of lymphoid tissue (such as those in the gastrointestinal tract and bone marrow), macrophages, lymphocytes including the B cells and T cells and antibodies. This review summarizes various citrus fruit and their bioactive components having a positive effect to promote immunity responses in humans body. Additionally, we highlight the health-promoting properties along with Pharmacodynamic and Phytochemical properties of Citrus fruit described in Ayurveda and their potential usage.
{"title":"Effects of citrus fruit and their bioactive components on immunity","authors":"Rakhi Sahu, Anurag Pandey, M. Tiwari, N. Mishra, A. Varshney","doi":"10.54037/wjps.2022.100404","DOIUrl":"https://doi.org/10.54037/wjps.2022.100404","url":null,"abstract":"The genus Citrus contains a vast range of antioxidant metabolites, dietary metabolites and antioxidant polyphenols that protect plants from unfavourable environmental conditions, enhance their tolerance to abiotic and biotic stresses and possess multiple health-promoting effects in humans along with specifically Immunity boosting. Immunity is described as a condition of being able to resist a particular disease especially through preventing the development of a pathogenic microorganism or by counteracting the effects of its products. The immune system is a bodily system that produces the immune response to defend your body from foreign substances, cells and tissues. The immune system includes various parts of the body including the thymus, spleen, lymph nodes, special deposits of lymphoid tissue (such as those in the gastrointestinal tract and bone marrow), macrophages, lymphocytes including the B cells and T cells and antibodies. This review summarizes various citrus fruit and their bioactive components having a positive effect to promote immunity responses in humans body. Additionally, we highlight the health-promoting properties along with Pharmacodynamic and Phytochemical properties of Citrus fruit described in Ayurveda and their potential usage.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89912417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100104
Uma Maheswari Katari, M. Ajitha
A Simple, Accurate and Precise method was developed for the simultaneous estimation of Daunorubicin and Cytarabine in bulk and pharmaceutical dosage form by RPHPLC technique. Chromatogram was run through standard Zorbax C18 (150mm x 4.6 mm, 5μ particle size). Mobile phase containing buffer 0.01N KH2PO4: Acetonitrile taken in the ratio of 60:40 was pumped through column at a flow rate of 1.0 ml/min. Buffer used in this method was 0.01N KH2PO4 buffer. Temperature was set to 30C. Optimized wavelength selected was 240.0 nm. Retention time of Cytarabine and Daunorubicin were found to be 2.325 min and 3.208 nm. % RSD of Daunorubicin and Cytarabine were found to be 0.6 and 0.6 respectively. %Recovery was obtained as 100.30% and 100.33% for Daunorubicin and Cytarabine respectively. LOD, LOQ values obtained from regression equation of Daunorubicin and Cytarabine were 0.09, 0.28 and 0.32, 0.97 respectively. The regression equation of Daunorubicin and Cytarabine is y=39589X+28710 and y=32928X+12457 respectively Retention times were decreased and that run was decreased, so the method was simple and economical that can be adopted in regular Quality control test in Industries.
{"title":"Stability Indicating Method Development and Validation for Determination of Daunorubicin and Cytarabine in Bulk and Pharmaceutical Dosage Form by RP-HPLC","authors":"Uma Maheswari Katari, M. Ajitha","doi":"10.54037/wjps.2022.100104","DOIUrl":"https://doi.org/10.54037/wjps.2022.100104","url":null,"abstract":"A Simple, Accurate and Precise method was developed for the simultaneous estimation of Daunorubicin and Cytarabine in bulk and pharmaceutical dosage form by RPHPLC technique. Chromatogram was run through standard Zorbax C18 (150mm x 4.6 mm, 5μ particle size). Mobile phase containing buffer 0.01N KH2PO4: Acetonitrile taken in the ratio of 60:40 was pumped through column at a flow rate of 1.0 ml/min. Buffer used in this method was 0.01N KH2PO4 buffer. Temperature was set to 30C. Optimized wavelength selected was 240.0 nm. Retention time of Cytarabine and Daunorubicin were found to be 2.325 min and 3.208 nm. % RSD of Daunorubicin and Cytarabine were found to be 0.6 and 0.6 respectively. %Recovery was obtained as 100.30% and 100.33% for Daunorubicin and Cytarabine respectively. LOD, LOQ values obtained from regression equation of Daunorubicin and Cytarabine were 0.09, 0.28 and 0.32, 0.97 respectively. The regression equation of Daunorubicin and Cytarabine is y=39589X+28710 and y=32928X+12457 respectively Retention times were decreased and that run was decreased, so the method was simple and economical that can be adopted in regular Quality control test in Industries.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"140 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78537662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100207
Kanikella Sivaji, A. Sai, M. Prasad, Sundaresh Ram, N. Vamsi, N. Rahul
{"title":"A Case Report of Pyrogenic Meningitis","authors":"Kanikella Sivaji, A. Sai, M. Prasad, Sundaresh Ram, N. Vamsi, N. Rahul","doi":"10.54037/wjps.2022.100207","DOIUrl":"https://doi.org/10.54037/wjps.2022.100207","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89580419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100302
L. S.
Sauropus androgynus (L.) Merr., known traditionally as a multivitamin plant being cultivated in kitchen garden throughout south Indian region. Different organic solvents such as Ethyl acetate, hexane, and methanol were used to extract the bioactive compounds from the fresh air dried plant leaves. Among which ethyl acetate extracted most of the bioactive compounds efficiently. The compounds like tannins, flavonoids, proteins, terpenoids, coumarins and steroids were extracted at varied concentration remain parallel with their bioactive principles. Test organisms used were Escherichia coli, Staphylococcus aureus and Bacillus subtilis showed their sensitiveness with the ethyl acetate extract in vitro. The percentage scavenging activity was also observed to be more with ethyl acetate extract, which was found to increase with concentration.
{"title":"Variation in the efficacy of organic extrants for the phytochemical validation of Sauropus androgynus – a multivitamin plant","authors":"L. S.","doi":"10.54037/wjps.2022.100302","DOIUrl":"https://doi.org/10.54037/wjps.2022.100302","url":null,"abstract":"Sauropus androgynus (L.) Merr., known traditionally as a multivitamin plant being cultivated in kitchen garden throughout south Indian region. Different organic solvents such as Ethyl acetate, hexane, and methanol were used to extract the bioactive compounds from the fresh air dried plant leaves. Among which ethyl acetate extracted most of the bioactive compounds efficiently. The compounds like tannins, flavonoids, proteins, terpenoids, coumarins and steroids were extracted at varied concentration remain parallel with their bioactive principles. Test organisms used were Escherichia coli, Staphylococcus aureus and Bacillus subtilis showed their sensitiveness with the ethyl acetate extract in vitro. The percentage scavenging activity was also observed to be more with ethyl acetate extract, which was found to increase with concentration.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89736695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100702
Saurabh Saklani, Shivam Bisht, Yogesh Joshi
COPDisone of acommonprogressive diseasecharacterized by persistent airflow limitations in the lungs with symptoms of breathlessness, excessive sputum production and chronic cough. This was a prospective, observational study carried out among patients of COPD in a tertiary care hospital to evaluate demographic, etiologicandco-morbidity status.Study was carried out by reviewing prescription of 120 COPD patients,out of which 67.5% were malesand 32.5% were females. The majority of the patients were in age group of 56-60 years (34.16%). Among 120 patients, 65.83% were smokersand48.33% were alcoholics. Etiologic assessment reflected that 68.33% patientbelongs to low socioeconomic status followed by exposure to biomass smoker 8.33%. Out of 120 patients, 53.33% were not havingany other co-morbid condition and the most common co-morbidity found in remaining patients was hypertension 17.5%. This study was concluded to state that such studies were found helpful for existing patient population, publicsand also for scientific researchers.
{"title":"Assessment of Demographic, EtiologicandCo-morbidity Status AmongCOPD Patients","authors":"Saurabh Saklani, Shivam Bisht, Yogesh Joshi","doi":"10.54037/wjps.2022.100702","DOIUrl":"https://doi.org/10.54037/wjps.2022.100702","url":null,"abstract":"COPDisone of acommonprogressive diseasecharacterized by persistent airflow limitations in the lungs with symptoms of breathlessness, excessive sputum production and chronic cough. This was a prospective, observational study carried out among patients of COPD in a tertiary care hospital to evaluate demographic, etiologicandco-morbidity status.Study was carried out by reviewing prescription of 120 COPD patients,out of which 67.5% were malesand 32.5% were females. The majority of the patients were in age group of 56-60 years (34.16%). Among 120 patients, 65.83% were smokersand48.33% were alcoholics. Etiologic assessment reflected that 68.33% patientbelongs to low socioeconomic status followed by exposure to biomass smoker 8.33%. Out of 120 patients, 53.33% were not havingany other co-morbid condition and the most common co-morbidity found in remaining patients was hypertension 17.5%. This study was concluded to state that such studies were found helpful for existing patient population, publicsand also for scientific researchers.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"40 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89500552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100204
Sweta Sharma, P. Patel, A. Yadav
{"title":"Nutraceuticals aid in managing COVID-19","authors":"Sweta Sharma, P. Patel, A. Yadav","doi":"10.54037/wjps.2022.100204","DOIUrl":"https://doi.org/10.54037/wjps.2022.100204","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72647366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100209
Amra Bratovcic
This review mainly focuses on nanoparticle-based drug delivery systems fabricated from plants (starch, cellulose, pectin), animals (chitosan, gelatin) and microorganisms (dextran). Herein, the focus is on the physical-chemical properties of biopolymers and its derivatives and the mechanism of action in the treatments of cancer. Nanoparticle-based drug delivery systems improved efficacy by: increasing half-life of vulnerable drugs and proteins, improving the solubility of hydrophobic drugs, and allowing controlled and targeted release of drugs in diseased site. Of all the mentioned biopolymers, only dextran and pure pectin are problematic. Some clinical studies have shown unexpected side effects caused by dextran such as thrombocytopenia and hepatotoxicity and, pure pectin-based materials, undesirable swelling and corrosion properties. Doxorubicin has been used in combination with almost all of these biopolymers because it is widely used as an effective chemotherapeutic agent in the treatment of many types of solid tumors of the breast, lung, colon, ovary, prostate and bladder.
{"title":"Application of Natural Biopolymersand its Derivatives as Nano -Drug Delivery Systems in Cancer Treatment","authors":"Amra Bratovcic","doi":"10.54037/wjps.2022.100209","DOIUrl":"https://doi.org/10.54037/wjps.2022.100209","url":null,"abstract":"This review mainly focuses on nanoparticle-based drug delivery systems fabricated from plants (starch, cellulose, pectin), animals (chitosan, gelatin) and microorganisms (dextran). Herein, the focus is on the physical-chemical properties of biopolymers and its derivatives and the mechanism of action in the treatments of cancer. Nanoparticle-based drug delivery systems improved efficacy by: increasing half-life of vulnerable drugs and proteins, improving the solubility of hydrophobic drugs, and allowing controlled and targeted release of drugs in diseased site. Of all the mentioned biopolymers, only dextran and pure pectin are problematic. Some clinical studies have shown unexpected side effects caused by dextran such as thrombocytopenia and hepatotoxicity and, pure pectin-based materials, undesirable swelling and corrosion properties. Doxorubicin has been used in combination with almost all of these biopolymers because it is widely used as an effective chemotherapeutic agent in the treatment of many types of solid tumors of the breast, lung, colon, ovary, prostate and bladder.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79332055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100205
Muni Raja LakshmiK, N. Priya, G. Asuntha
{"title":"Formulation and Evaluation of Sitagliptin Liposomes","authors":"Muni Raja LakshmiK, N. Priya, G. Asuntha","doi":"10.54037/wjps.2022.100205","DOIUrl":"https://doi.org/10.54037/wjps.2022.100205","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88531320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100701
Sankari M, Thamizharasi S, Mariyammal A, Meghana K, Parvatha Raja Kumaran V.S, Chetan A
Rheumatoid arthritis is a chronic systemic inflammation of the synovial joint and progressive destruction of cartilage and bone that may affect many tissues and organs-skin, blood vessels, heart, lungs and muscles but principally attacks the joints, producing a non-suppurative proliferative andinflammatory synovitis that often progresses to destruction of the articular cartilage and ankylosis of the joints. Angiogenesis and microvascular lesions are common features of RA inflammation, which leads to abnormal serum protein infiltration into the synovium. The objective of the study was to determine the preliminary phytochemical constituents, to evaluate acute toxicity studies, In-vitroanti-oxidant studies, In vitroand In-vivoanti-arthritic activity of theroot bark of Spathodea campanulata.. Paw edema was induced in rats by intra plantar injection of 0.1ml of Complete Freund’s Adjuvant (CFA) in left hind paw. The ethanolic extract of Spathodea campanulata (150mg/Kg & 300mg/Kg) and Diclofenac Sodium were orally administered for 28 consecutive days.Percentage inhibition was determined by Protein denaturation method and Membrane Stabilizing Activity Hematological, Histopathology, Radiological Analysis of CFA-induced arthritis in rat was performed. Statisticalsignificant was analyzed by one-way ANOVA followed by Tukey test. Our study concluded that ethanolic extract at the dose of 300 mg/kg showed significant anti-arthritic activity when compared to Diclofenac sodium
{"title":"Evaluation of anti-arthritic activity of Spathodea Campanulata of root bark extract on freund’s adjuvant induced arthritis in rats models","authors":"Sankari M, Thamizharasi S, Mariyammal A, Meghana K, Parvatha Raja Kumaran V.S, Chetan A","doi":"10.54037/wjps.2022.100701","DOIUrl":"https://doi.org/10.54037/wjps.2022.100701","url":null,"abstract":"Rheumatoid arthritis is a chronic systemic inflammation of the synovial joint and progressive destruction of cartilage and bone that may affect many tissues and organs-skin, blood vessels, heart, lungs and muscles but principally attacks the joints, producing a non-suppurative proliferative andinflammatory synovitis that often progresses to destruction of the articular cartilage and ankylosis of the joints. Angiogenesis and microvascular lesions are common features of RA inflammation, which leads to abnormal serum protein infiltration into the synovium. The objective of the study was to determine the preliminary phytochemical constituents, to evaluate acute toxicity studies, In-vitroanti-oxidant studies, In vitroand In-vivoanti-arthritic activity of theroot bark of Spathodea campanulata.. Paw edema was induced in rats by intra plantar injection of 0.1ml of Complete Freund’s Adjuvant (CFA) in left hind paw. The ethanolic extract of Spathodea campanulata (150mg/Kg & 300mg/Kg) and Diclofenac Sodium were orally administered for 28 consecutive days.Percentage inhibition was determined by Protein denaturation method and Membrane Stabilizing Activity Hematological, Histopathology, Radiological Analysis of CFA-induced arthritis in rat was performed. Statisticalsignificant was analyzed by one-way ANOVA followed by Tukey test. Our study concluded that ethanolic extract at the dose of 300 mg/kg showed significant anti-arthritic activity when compared to Diclofenac sodium","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88078440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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