Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100205
Muni Raja LakshmiK, N. Priya, G. Asuntha
{"title":"Formulation and Evaluation of Sitagliptin Liposomes","authors":"Muni Raja LakshmiK, N. Priya, G. Asuntha","doi":"10.54037/wjps.2022.100205","DOIUrl":"https://doi.org/10.54037/wjps.2022.100205","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88531320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100209
Amra Bratovcic
This review mainly focuses on nanoparticle-based drug delivery systems fabricated from plants (starch, cellulose, pectin), animals (chitosan, gelatin) and microorganisms (dextran). Herein, the focus is on the physical-chemical properties of biopolymers and its derivatives and the mechanism of action in the treatments of cancer. Nanoparticle-based drug delivery systems improved efficacy by: increasing half-life of vulnerable drugs and proteins, improving the solubility of hydrophobic drugs, and allowing controlled and targeted release of drugs in diseased site. Of all the mentioned biopolymers, only dextran and pure pectin are problematic. Some clinical studies have shown unexpected side effects caused by dextran such as thrombocytopenia and hepatotoxicity and, pure pectin-based materials, undesirable swelling and corrosion properties. Doxorubicin has been used in combination with almost all of these biopolymers because it is widely used as an effective chemotherapeutic agent in the treatment of many types of solid tumors of the breast, lung, colon, ovary, prostate and bladder.
{"title":"Application of Natural Biopolymersand its Derivatives as Nano -Drug Delivery Systems in Cancer Treatment","authors":"Amra Bratovcic","doi":"10.54037/wjps.2022.100209","DOIUrl":"https://doi.org/10.54037/wjps.2022.100209","url":null,"abstract":"This review mainly focuses on nanoparticle-based drug delivery systems fabricated from plants (starch, cellulose, pectin), animals (chitosan, gelatin) and microorganisms (dextran). Herein, the focus is on the physical-chemical properties of biopolymers and its derivatives and the mechanism of action in the treatments of cancer. Nanoparticle-based drug delivery systems improved efficacy by: increasing half-life of vulnerable drugs and proteins, improving the solubility of hydrophobic drugs, and allowing controlled and targeted release of drugs in diseased site. Of all the mentioned biopolymers, only dextran and pure pectin are problematic. Some clinical studies have shown unexpected side effects caused by dextran such as thrombocytopenia and hepatotoxicity and, pure pectin-based materials, undesirable swelling and corrosion properties. Doxorubicin has been used in combination with almost all of these biopolymers because it is widely used as an effective chemotherapeutic agent in the treatment of many types of solid tumors of the breast, lung, colon, ovary, prostate and bladder.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79332055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100111
P. Sharanya, S. Rani
A simple, Accurate, Precise method was developed for the simultaneous estimation of the Netarsudil and Latanoprost in opthalmic solution dosage form. Chromatogram was run through Zodiacsil C18 150 x 4.6 mm, 5μ. Mobile phase containing 0.01N Ammonium acetate: Methanol taken with in the ratio 55:45 was pumped through column on a flow rate at 1.0ml/min. Buffer used in this method was Ammonium acetate. Temperature was maintained at 30C. Optimized wavelength selected was 225nm. Retention time of Netarsudil and Latanoprost were found to be 2.222 min and 2.706 min. %RSD of the Netarsudil and Latanoprost were and found to be 0.5 and 0.8 respectively. %Recovery was obtained as 100.09% and 100.5% for Netarsudil and Latanoprost respectively. LOD, LOQ values obtained from regression equations of Netarsudil and Latanoprost were 0.07, 0.22 and 0.03, 0.09 respectively. Regression equation of Netarsudil y = 33253x +578.8 and y =45497x + 399.2 of Latanoprost. Retention times were decreased and that runtime was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.
{"title":"Development and Validation of Stability Indicating Analytical Method for the Simultaneous Estimation of Netarsudil and Latanoprost by RP-HPLC","authors":"P. Sharanya, S. Rani","doi":"10.54037/wjps.2022.100111","DOIUrl":"https://doi.org/10.54037/wjps.2022.100111","url":null,"abstract":"A simple, Accurate, Precise method was developed for the simultaneous estimation of the Netarsudil and Latanoprost in opthalmic solution dosage form. Chromatogram was run through Zodiacsil C18 150 x 4.6 mm, 5μ. Mobile phase containing 0.01N Ammonium acetate: Methanol taken with in the ratio 55:45 was pumped through column on a flow rate at 1.0ml/min. Buffer used in this method was Ammonium acetate. Temperature was maintained at 30C. Optimized wavelength selected was 225nm. Retention time of Netarsudil and Latanoprost were found to be 2.222 min and 2.706 min. %RSD of the Netarsudil and Latanoprost were and found to be 0.5 and 0.8 respectively. %Recovery was obtained as 100.09% and 100.5% for Netarsudil and Latanoprost respectively. LOD, LOQ values obtained from regression equations of Netarsudil and Latanoprost were 0.07, 0.22 and 0.03, 0.09 respectively. Regression equation of Netarsudil y = 33253x +578.8 and y =45497x + 399.2 of Latanoprost. Retention times were decreased and that runtime was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73957991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100301
L. S.
Sauropus androgynus (L.) Merr., known traditionally as a multivitamin plant being cultivated in kitchen garden throughout south Indian region. Different organic solvents such as Ethyl acetate, hexane, and methanol were used to extract the bioactive compounds from the fresh air dried plant leaves. Among which ethyl acetate extracted most of the bioactive compounds efficiently. The compounds like tannins, flavonoids, proteins, terpenoids, coumarins and steroids were extracted at varied concentration remain parallel with their bioactive principles. Test organisms used were Escherichia coli, Staphylococcus aureus and Bacillus subtilis showed their sensitiveness with the ethyl acetate extract in vitro. The percentage scavenging activity was also observed to be more with ethyl acetate extract, which was found to increase with concentration.
{"title":"Variation in the efficacy of organic extrants for the phytochemical validation of Sauropus androgynus –a multivitamin plant","authors":"L. S.","doi":"10.54037/wjps.2022.100301","DOIUrl":"https://doi.org/10.54037/wjps.2022.100301","url":null,"abstract":"Sauropus androgynus (L.) Merr., known traditionally as a multivitamin plant being cultivated in kitchen garden throughout south Indian region. Different organic solvents such as Ethyl acetate, hexane, and methanol were used to extract the bioactive compounds from the fresh air dried plant leaves. Among which ethyl acetate extracted most of the bioactive compounds efficiently. The compounds like tannins, flavonoids, proteins, terpenoids, coumarins and steroids were extracted at varied concentration remain parallel with their bioactive principles. Test organisms used were Escherichia coli, Staphylococcus aureus and Bacillus subtilis showed their sensitiveness with the ethyl acetate extract in vitro. The percentage scavenging activity was also observed to be more with ethyl acetate extract, which was found to increase with concentration.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86965475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aselin Puthenpurail, Hinal Rathi, Surya M Nauli, Ahmmed Ally
Monoclonal antibodies (mAbs) are increasingly being prescribed to patients and investigated in the field of medicine and research. This class of medication is unique due to its ability to be engineered into targeting a specific receptor. Numerous studies and reviews have reported the efficacy, potency, and clinical usage of mAbs in the treatment of a variety of diseases ranging from autoimmune disorders to malignant cancers. However, very few publications classify and provide a brief synopsis of mAbs that includes their pharmacological profiles. mechanisms of action, uses, and side effects in a concise manner. Therefore, this review aims to classify the current mAbs drugs used in clinical practice according to system diseases by providing a brief summary for each of them. For example, regarding cardiovascular disorders, mAbs such as Abciximab, Bevacizumab, and Digoxin Immune Fab will be reviewed. Denosumab, used to treat musculoskeletal disorders, will be also discussed. In addition, mAbs such as Adalimumab, Eculizumab, Natalizumab used in autoimmune disorders and Alemtuzumab, Trastuzumab, Cetuximab, and Rituximab that are prescribed for tumors will be reviewed. Finally, we shall discuss two mAbs that are IL-6 antagonists, Tocilizumab and Siltuximab, which are in ongoing clinical trials as potential treatments of COVID-19. The mAbs have profound benefits against chronic and malignant conditions, and the overall purpose of this review is to illustrate the basic pharmacological profiles of mAbs that physicians may find useful in establishing their management protocols.
{"title":"A BRIEF SYNOPSIS OF MONOCLONAL ANTIBODY FOR THE TREATMENT OF VARIOUS GROUPS OF DISEASES.","authors":"Aselin Puthenpurail, Hinal Rathi, Surya M Nauli, Ahmmed Ally","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Monoclonal antibodies (mAbs) are increasingly being prescribed to patients and investigated in the field of medicine and research. This class of medication is unique due to its ability to be engineered into targeting a specific receptor. Numerous studies and reviews have reported the efficacy, potency, and clinical usage of mAbs in the treatment of a variety of diseases ranging from autoimmune disorders to malignant cancers. However, very few publications classify and provide a brief synopsis of mAbs that includes their pharmacological profiles. mechanisms of action, uses, and side effects in a concise manner. Therefore, this review aims to classify the current mAbs drugs used in clinical practice according to system diseases by providing a brief summary for each of them. For example, regarding cardiovascular disorders, mAbs such as Abciximab, Bevacizumab, and Digoxin Immune Fab will be reviewed. Denosumab, used to treat musculoskeletal disorders, will be also discussed. In addition, mAbs such as Adalimumab, Eculizumab, Natalizumab used in autoimmune disorders and Alemtuzumab, Trastuzumab, Cetuximab, and Rituximab that are prescribed for tumors will be reviewed. Finally, we shall discuss two mAbs that are IL-6 antagonists, Tocilizumab and Siltuximab, which are in ongoing clinical trials as potential treatments of COVID-19. The mAbs have profound benefits against chronic and malignant conditions, and the overall purpose of this review is to illustrate the basic pharmacological profiles of mAbs that physicians may find useful in establishing their management protocols.</p>","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"10 11","pages":"14-22"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775886/pdf/nihms-1770850.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39962856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.54037/wjps.2021.91102
Aleti Rajareddy, A. Divya
{"title":"Stability Indicating RP -HPLC Method Development and validation for the simultaneous estimation of Ertugliflozin and Sitagliptin in Bulk and Pharmaceutical Dosage form","authors":"Aleti Rajareddy, A. Divya","doi":"10.54037/wjps.2021.91102","DOIUrl":"https://doi.org/10.54037/wjps.2021.91102","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81565773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.54037/wjps.2021.91005
Shubham A. Khadse, M. Mohite
{"title":"Formulation and evaluation of transdermal patch of stiripentol for treatment of seizures","authors":"Shubham A. Khadse, M. Mohite","doi":"10.54037/wjps.2021.91005","DOIUrl":"https://doi.org/10.54037/wjps.2021.91005","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80582568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sachin Nivrutti Gadekar, Jeevan R. Rajguru, Dr. Subhash V. Deshmane, Dr. K. R. Biyani
{"title":"Review on solid dispersion for suitable drug","authors":"Sachin Nivrutti Gadekar, Jeevan R. Rajguru, Dr. Subhash V. Deshmane, Dr. K. R. Biyani","doi":"10.54037/wjps.2021.9911","DOIUrl":"https://doi.org/10.54037/wjps.2021.9911","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79217987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gomathi Murugan, J. Chennakesavalu, Kalaiselvi Chinnamuthu, Soundharya Kaveri
{"title":"Formulation and evaluation of Mefenamic acid solid dispersions","authors":"Gomathi Murugan, J. Chennakesavalu, Kalaiselvi Chinnamuthu, Soundharya Kaveri","doi":"10.54037/wjps.2021.9902","DOIUrl":"https://doi.org/10.54037/wjps.2021.9902","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77885565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.54037/wjps.2021.91107
Kushal Nandi, Rimum Ghosh, S. Mondal, D. Sen, D. Saha
{"title":"Source, isolation & impact of glycone and aglycone in human body","authors":"Kushal Nandi, Rimum Ghosh, S. Mondal, D. Sen, D. Saha","doi":"10.54037/wjps.2021.91107","DOIUrl":"https://doi.org/10.54037/wjps.2021.91107","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"238 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75765274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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