Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100201
D. S. Kumar, Dr. Sujata Yadav, D. Dipti
{"title":"Clinical Efficacy of Simhyadi Kwathalong with Shati Churnain Tamaka Shwasa (Bronchial Asthma)","authors":"D. S. Kumar, Dr. Sujata Yadav, D. Dipti","doi":"10.54037/wjps.2022.100201","DOIUrl":"https://doi.org/10.54037/wjps.2022.100201","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73567877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100103
Pasala Lydia Grace, C. Parthiban
A simple, Accurate, precise method was developed for the simultaneous estimation of the Darunavir and Ritonavir in tablet dosage form. Chromatogram was run through standard symmetry C18 (4.6 x 150 mm, 5m). Mobile phase containing Buffer 0.01N KH2PO4: Acetonitrile taken in the ratio 45:55%v/v was pumped through column at a flow rate of 1ml/min. Optimized wavelength selected was 290 nm. Retention time of Darunavir and Ritonavir were found to be 2.131 min and 2.593 min. %RSD of the Darunavir and Ritonavir were and found to be 0.8 and 0.6 respectively. %Recovery was obtained as 99.59% and 99.94% for Darunavir and Ritonavir respectively. LOD, LOQ values obtained from regression equations of Darunavir and Ritonavir were 0.86, 2.60 and 0.09, 0.29 respectively. Regression equation of Darunavir is y = 12533x + 10387 and y = 9061x + 183.8 of Ritonavir. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.
建立了一种简便、准确、精确的同时测定片剂中达那韦和利托那韦含量的方法。通过标准对称C18 (4.6 x 150 mm, 5m)运行色谱图。流动相含缓冲液0.01N KH2PO4:乙腈，比例为45:55%v/v，以1ml/min的流速泵入柱中。优选波长为290 nm。达那韦和利托那韦的滞留时间分别为2.131 min和2.593 min, RSD分别为0.8和0.6。达那韦和利托那韦的回收率分别为99.59%和99.94%。达若那韦和利托那韦的LOD、LOQ分别为0.86、2.60和0.09、0.29。达那韦的回归方程为y = 12533x + 10387，利托那韦的回归方程为y = 9061x + 183.8。该方法减少了滞留时间，缩短了运行时间，简便、经济，可用于工业中常规的质量控制试验。
{"title":"Analytical method development and validation for the simultaneous estimation of Darunavir and Ritonavir by RP-HPLC method","authors":"Pasala Lydia Grace, C. Parthiban","doi":"10.54037/wjps.2022.100103","DOIUrl":"https://doi.org/10.54037/wjps.2022.100103","url":null,"abstract":"A simple, Accurate, precise method was developed for the simultaneous estimation of the Darunavir and Ritonavir in tablet dosage form. Chromatogram was run through standard symmetry C18 (4.6 x 150 mm, 5m). Mobile phase containing Buffer 0.01N KH2PO4: Acetonitrile taken in the ratio 45:55%v/v was pumped through column at a flow rate of 1ml/min. Optimized wavelength selected was 290 nm. Retention time of Darunavir and Ritonavir were found to be 2.131 min and 2.593 min. %RSD of the Darunavir and Ritonavir were and found to be 0.8 and 0.6 respectively. %Recovery was obtained as 99.59% and 99.94% for Darunavir and Ritonavir respectively. LOD, LOQ values obtained from regression equations of Darunavir and Ritonavir were 0.86, 2.60 and 0.09, 0.29 respectively. Regression equation of Darunavir is y = 12533x + 10387 and y = 9061x + 183.8 of Ritonavir. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81712910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100503
Sonu Kanaujiya, Sunil Kumar
Natural super disintegrants have been used for fast dissolving tablets because they are biodegradable, chemically inert, non-harmful, more affordable and widely available. The natural polymer improves the properties of the tablet as it is commonly used as diluents and binders. Super explosives are those substances that promote rapid decomposition in a lesser amount compared to explosives. Super disintegrants are the vehicles added to the tablet formulation to promote the breakdown of tablets and capsules into small microparticles in aqueous media, leading to an increase in surface area and promoting rapid drug release. Some research is going to develop safe and effective medication with super disintegrating agents that can be dissolved rapidly to treat the disease.
{"title":"Comparative study of natural disintegrants, selection criteria for superdisintegrants","authors":"Sonu Kanaujiya, Sunil Kumar","doi":"10.54037/wjps.2022.100503","DOIUrl":"https://doi.org/10.54037/wjps.2022.100503","url":null,"abstract":"Natural super disintegrants have been used for fast dissolving tablets because they are biodegradable, chemically inert, non-harmful, more affordable and widely available. The natural polymer improves the properties of the tablet as it is commonly used as diluents and binders. Super explosives are those substances that promote rapid decomposition in a lesser amount compared to explosives. Super disintegrants are the vehicles added to the tablet formulation to promote the breakdown of tablets and capsules into small microparticles in aqueous media, leading to an increase in surface area and promoting rapid drug release. Some research is going to develop safe and effective medication with super disintegrating agents that can be dissolved rapidly to treat the disease.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80286239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the present work is to formulate and evaluate a bilayered tablet (BT) ofMetformin HCl as Sustained release and Gliclazide as Immediate release (IR). The polymer usedin sustained release is HMPC K100M and the super disintegrate used in immediate release inproportion of Gum Karaka & Croscarmellose sodium by direct compression method. In thisstudy, a bilayered tablet containing Gliclazide in IRL and Metformin in SRL was made using thewet granulation method, with the goal of making the formulations IRL as small as possible, Willrelease Gliclazide as soon as possible to combat postprandial hyperglycemic level, followed bysteady-state plasma glucose management by Metformin with along-termrelease. The hardnessof the different formulations ranged from 7.5-8.5 kg/cm. All the formulations exhibited less than1% friability. The drug content analysis of Metformin and Gliclazide in all formulations wasfound within the IP limits (±5%) which indicate that the drug was uniformly distributed in thetablets. The inviter dissolution study was performed for layer I (Metformin) up to 12 hrs (afterevery 1hour intervals) and for layer II (Gliclazide) up to 40 min (after every 5 min interval). Thebilayered tablet contributing initial loading dose and dissolves rapidly, the remainder of the drugin the extended release was constant rate till the end of the dissolution process. The I.R spectraprovedthattherewasno interactionbetweenthepolymer,Excipients andMetformin,Gliclazide.
{"title":"Formulation and evaluation of bilayered tablets of sustained release metformin HCl and gliclazide","authors":"K.Manga, M.Sudhakar, K.Meghana, K.Avanthi, G.Swathi","doi":"10.54037/wjps.2022.100310","DOIUrl":"https://doi.org/10.54037/wjps.2022.100310","url":null,"abstract":"The aim of the present work is to formulate and evaluate a bilayered tablet (BT) ofMetformin HCl as Sustained release and Gliclazide as Immediate release (IR). The polymer usedin sustained release is HMPC K100M and the super disintegrate used in immediate release inproportion of Gum Karaka & Croscarmellose sodium by direct compression method. In thisstudy, a bilayered tablet containing Gliclazide in IRL and Metformin in SRL was made using thewet granulation method, with the goal of making the formulations IRL as small as possible, Willrelease Gliclazide as soon as possible to combat postprandial hyperglycemic level, followed bysteady-state plasma glucose management by Metformin with along-termrelease. The hardnessof the different formulations ranged from 7.5-8.5 kg/cm. All the formulations exhibited less than1% friability. The drug content analysis of Metformin and Gliclazide in all formulations wasfound within the IP limits (±5%) which indicate that the drug was uniformly distributed in thetablets. The inviter dissolution study was performed for layer I (Metformin) up to 12 hrs (afterevery 1hour intervals) and for layer II (Gliclazide) up to 40 min (after every 5 min interval). Thebilayered tablet contributing initial loading dose and dissolves rapidly, the remainder of the drugin the extended release was constant rate till the end of the dissolution process. The I.R spectraprovedthattherewasno interactionbetweenthepolymer,Excipients andMetformin,Gliclazide.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81387902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100106
Sravya V, S. P, Jagannath Patro V, S. Ch
Nizatidine is a gastroprotective drug with a short biological half-life and narrow absorption window. This study aimed at developing floating tablets of nizatidine using various HPMC viscosity grades, namely K4M, K15M, Carbopol 934P, Sodium alginate and sodium carboxy methyl cellulose. Directly compressed tablets revealed an excellent uniformity in hardness, thickness and weight and nizatidine was evenly distributed within the matrix floating tablets. Buoyancy study revealed the tablets remain buoyant for more than 12 h. Among all the formulations, F12 formulation containing 3:1 ratio of HPMC K15M and Carbopol 934P was found to be promising, which showed a floating lag time less than 5min and floating duration of more than 12 hours. It showed constant drug release up to 12 hours and good bio adhesion strength. All the designed formulations displayed zero order release kinetics and drug release follows non-Fickian diffusion mechanism.
{"title":"Formulate gastroretentive floating bioadhesive drug delivery system of nizatidine by direct compression technique","authors":"Sravya V, S. P, Jagannath Patro V, S. Ch","doi":"10.54037/wjps.2022.100106","DOIUrl":"https://doi.org/10.54037/wjps.2022.100106","url":null,"abstract":"Nizatidine is a gastroprotective drug with a short biological half-life and narrow absorption window. This study aimed at developing floating tablets of nizatidine using various HPMC viscosity grades, namely K4M, K15M, Carbopol 934P, Sodium alginate and sodium carboxy methyl cellulose. Directly compressed tablets revealed an excellent uniformity in hardness, thickness and weight and nizatidine was evenly distributed within the matrix floating tablets. Buoyancy study revealed the tablets remain buoyant for more than 12 h. Among all the formulations, F12 formulation containing 3:1 ratio of HPMC K15M and Carbopol 934P was found to be promising, which showed a floating lag time less than 5min and floating duration of more than 12 hours. It showed constant drug release up to 12 hours and good bio adhesion strength. All the designed formulations displayed zero order release kinetics and drug release follows non-Fickian diffusion mechanism.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"55 23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80705688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100107
Navya Vutukuri, M. Ajitha
{"title":"Stability Indicating RP-HPLC Method Development and Validation for simultaneous estimation of Indacaterol and Glycopyrrolate and in Bulk and Pharmaceutical Dosage Form","authors":"Navya Vutukuri, M. Ajitha","doi":"10.54037/wjps.2022.100107","DOIUrl":"https://doi.org/10.54037/wjps.2022.100107","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77610045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100801
Surendra Kumar, G. Mangal
Avascular necrosis (AVN), is a condition that occurs when there is loss of blood supply to the bone, also known as osteonecrosis, bone infarction, aseptic necrosis, or ischemic bone necrosis. Based on pathogenesis and clinical sign and symptoms, it can be compared with AsthimajjagataVata. One of the popular and frequently used medications in the Ayurvedic medical systemis PanchatiktaGugguluGhrita. Panchatikta Guggulu Ghritahas been described in AstangahrudyamVatavyadiChikitsaAdhayayamwhich is indicated in Asthimajjagata Vata. Here is an attempt made on pharmacodynamics of Panchatikta Guggulu Ghrita in respect ofAsthimajjagataVata.
{"title":"Pharmacodynamics of PanchatiktaGugguluGhritain AsthimajjagataVatawith special reference to avascular necrosis of femoral head","authors":"Surendra Kumar, G. Mangal","doi":"10.54037/wjps.2022.100801","DOIUrl":"https://doi.org/10.54037/wjps.2022.100801","url":null,"abstract":"Avascular necrosis (AVN), is a condition that occurs when there is loss of blood supply to the bone, also known as osteonecrosis, bone infarction, aseptic necrosis, or ischemic bone necrosis. Based on pathogenesis and clinical sign and symptoms, it can be compared with AsthimajjagataVata. One of the popular and frequently used medications in the Ayurvedic medical systemis PanchatiktaGugguluGhrita. Panchatikta Guggulu Ghritahas been described in AstangahrudyamVatavyadiChikitsaAdhayayamwhich is indicated in Asthimajjagata Vata. Here is an attempt made on pharmacodynamics of Panchatikta Guggulu Ghrita in respect ofAsthimajjagataVata.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75785384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100308
Hrushikesh Reddy, G. Jyothi, Maheshwari, D.Prasad, M.Sudhakar
Nanoliposome, or submicron bilayer lipid vesicle, is a new technology for the encapsulation and delivery of bioactive agents. The list of bioactive material that can be incorporated tonanoliposomes is huge, ranging from pharmaceuticals to cosmetics and nutraceuticals. Nanoliposomes have been used to improve the therapeutic index of new or established drugs by modifying drug absorption, reducing metabolism, prolonging biological half-life and reducing toxicity. The sole characteristic of nanoliposomes is their ability to compartmentalize and solubilize both hydrophilic and hydrophobic materials. This sole characteristic, coupled with biocompatibility and biodegradability make nanoliposomes very attractive as drug delivery vehicles. This review article intends to provide an overview of liposomes and nanoliposomes their properties, preparation methods and evaluation parameters. Also it explains various applications of nanoliposomes in nanotherapy including diagnostics, targeted cancer, gene therapy, cosmetics and nutraceuticals.
{"title":"Nanoliposomes-A Review","authors":"Hrushikesh Reddy, G. Jyothi, Maheshwari, D.Prasad, M.Sudhakar","doi":"10.54037/wjps.2022.100308","DOIUrl":"https://doi.org/10.54037/wjps.2022.100308","url":null,"abstract":"Nanoliposome, or submicron bilayer lipid vesicle, is a new technology for the encapsulation and delivery of bioactive agents. The list of bioactive material that can be incorporated tonanoliposomes is huge, ranging from pharmaceuticals to cosmetics and nutraceuticals. Nanoliposomes have been used to improve the therapeutic index of new or established drugs by modifying drug absorption, reducing metabolism, prolonging biological half-life and reducing toxicity. The sole characteristic of nanoliposomes is their ability to compartmentalize and solubilize both hydrophilic and hydrophobic materials. This sole characteristic, coupled with biocompatibility and biodegradability make nanoliposomes very attractive as drug delivery vehicles. This review article intends to provide an overview of liposomes and nanoliposomes their properties, preparation methods and evaluation parameters. Also it explains various applications of nanoliposomes in nanotherapy including diagnostics, targeted cancer, gene therapy, cosmetics and nutraceuticals.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86847418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100501
G. Manisha, G. Sharma, Shraddha Shekar, T. Rao
The aim of the present study was to formulate Stealth Liposomes containing Curcumin which are formulated by combinations of Cholesterol, Distearoylphosphatidylcholine, hydrogenated soyphosphotidylcholine to treat rheumatoid arthritis. Turmeric and especially its most active compound curcumin have many scientifically-proven health benefits. It's a potent anti-inflammatory and help improve symptoms of Rheumatoid arthritis. Total 8 formulations were developed using Cholesterol, Distearoylphosphatidylcholine, hydrogenated soyphosphotidylcholine in various ratios by thin film hydration method & evaluated for Entrapment Efficiency, SEM, particle size and shape, FTIR studies, invitro dissolution studies. From the invitro studies we can say that as the cholesterol ratio increases, drug release rate is increased upto particular ratio. Among all the fomulations, F7 formulation shows best drug release of 92.62% by the end of 24 hours whereas all the other formulations did not release the drug more than F7. So F7 formulation was choosen as optimized formulation.
{"title":"Design and development of stealth liposomes for oral administration of poorly bioavailable drug","authors":"G. Manisha, G. Sharma, Shraddha Shekar, T. Rao","doi":"10.54037/wjps.2022.100501","DOIUrl":"https://doi.org/10.54037/wjps.2022.100501","url":null,"abstract":"The aim of the present study was to formulate Stealth Liposomes containing Curcumin which are formulated by combinations of Cholesterol, Distearoylphosphatidylcholine, hydrogenated soyphosphotidylcholine to treat rheumatoid arthritis. Turmeric and especially its most active compound curcumin have many scientifically-proven health benefits. It's a potent anti-inflammatory and help improve symptoms of Rheumatoid arthritis. Total 8 formulations were developed using Cholesterol, Distearoylphosphatidylcholine, hydrogenated soyphosphotidylcholine in various ratios by thin film hydration method & evaluated for Entrapment Efficiency, SEM, particle size and shape, FTIR studies, invitro dissolution studies. From the invitro studies we can say that as the cholesterol ratio increases, drug release rate is increased upto particular ratio. Among all the fomulations, F7 formulation shows best drug release of 92.62% by the end of 24 hours whereas all the other formulations did not release the drug more than F7. So F7 formulation was choosen as optimized formulation.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78971136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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