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[Analysis of symptomatic differences in 391 patients with Brucella infections in different age groups]. 391例不同年龄组布鲁氏菌感染患者症状差异分析
Q3 Medicine Pub Date : 2024-12-06 DOI: 10.3760/cma.j.cn112150-20240527-00426
L P Zhang, R F He, F Q Ding, T T Sun, W W Pu, T Wu
<p><p>In order to investigate the clinical manifestations and laboratory findings associated with brucellosis for the purpose of facilitating prompt clinical diagnosis and effective treatment, as well as to offer a laboratory reference for the prevention of brucellosis outbreaks. In this study, a retrospective cohort design was employed to gather epidemiological characteristics, clinical symptoms, and associated laboratory data from 391 patients diagnosed with bacterial culture-positive brucellosis at the People's Hospital of Ningxia Hui Autonomous Region between 2019 and 2023. The patients were categorized into four age groups, with each group representing a 20 years age interval. Statistical analyses were conducted to examine the differences between these age groups using R version 4.3.2 and SPSS version 24.0 software. The results showed that among the 391 cases of brucellosis patients, fever (241 cases, 61.64%), lumbar and leg joint pain (225 cases, 57.54%), abnormal liver function (124 cases, 31.71%), spleen enlargement (78 cases, 19.95%), and cholecystitis (75 cases, 19.18%) were identified as the most prevalent clinical symptoms. Furthermore, the presence of clinical symptoms such as fever, lumbar and leg joint pain, abdominal pain and distension, headache, dizziness, rash, and complications including abnormal liver function, cholecystitis, spleen enlargement, exhibited statistical significance across four distinct age groups (<i>P</i><0.05). The initial presentation of acute fever and rash was more pronounced in the pediatric cohort. In contrast, the youth group exhibited a higher prevalence of acute fever, liver function abnormalities, dizziness, headache, and splenomegaly. Furthermore, the strong-age group and the older age group more frequently experienced lumbar and leg joint pain, and symptoms related to the liver, gallbladder, spleen, and digestive system. In terms of laboratory examination, the rates of decreased white blood cell count (WBC), red blood cell count (RBC) and platelet count (PLT) were 18.91% (73 cases), 28.94% (112 cases) and 22.34% (86 cases), respectively. C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total biluric acid (TBA), adenosine deaminase (ADA), alkaline phosphatase (ALP), glutamyl transpeptidase (GGT), procalcitonin (PCT), and D-Dimer (D-Dimer). The proportion of patients with elevated quantitative test results was 88.56% (271 cases), 50.90% (197 cases), 52.20% (202 cases), 23.82% (91 cases), 75.72% (290 cases), 23.06% (89 cases), 40.89% (157 cases), 68.34% (218 cases) and 73.33% (209 cases), respectively. Among them, the quantitative detection results of CPR, ALP and D-Dimer had statistical significance among the 4 age groups (<i>χ</i><sup>2</sup>=16.366,28.089,7.880,<i>P<</i>0.05). Abnormally elevated laboratory parameters, including C-reactive protein (CRP), alkaline phosphatase (ALP), and D-dimer, were more pronounced in middle-aged and older cohorts, with a
调查与布鲁氏菌病相关的临床表现和实验室结果,促进临床及时诊断和有效治疗,并为预防布鲁氏菌病暴发提供实验室参考。本研究采用回顾性队列设计,收集2019 - 2023年宁夏回族自治区人民医院391例细菌培养阳性布鲁氏菌病患者的流行病学特征、临床症状及相关实验室数据。患者被分为四个年龄组,每组代表20岁的年龄间隔。采用R 4.3.2版和SPSS 24.0版软件对各年龄组间的差异进行统计分析。结果391例布鲁氏菌病患者中,以发热241例(61.64%)、腰腿关节痛225例(57.54%)、肝功能异常124例(31.71%)、脾肿大78例(19.95%)、胆囊炎75例(19.18%)为最常见的临床症状。发热、腰腿关节痛、腹痛及腹胀、头痛、头晕、皮疹等临床症状,以及肝功能异常、胆囊炎、脾肿大等并发症的出现,在4个不同年龄组间均有统计学意义(Pχ2=16.366、28.089、7.880,P0.05)。异常升高的实验室参数,包括c反应蛋白(CRP)、碱性磷酸酶(ALP)和d -二聚体,在中老年人群中更为明显,与年龄增长呈正相关。在391份布鲁氏菌培养阳性标本中,分离数量最多的科室为感染性科(52.4%,204例)、急诊科(9.5%,37例)和骨科(8.4%,33例)。总之,布鲁氏菌病的临床表现是多方面和异质性的,经常涉及多个器官系统,实验室检测结果表现出相当大的变异性。这些发现表明,临床医生应考虑患者的年龄组,将布鲁氏菌病的临床特征与实验室检测结果结合起来,以提高疑似病例的诊断准确性和分诊效率。因此,改进相关的诊断检查有助于有效地控制和预防该病。
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引用次数: 0
[Production of recombinant protein of Tyr p 32 from Tyrophagus putrescentiae and identifying its immunoreactivity]. 腐酪菌tyrp32重组蛋白的制备及其免疫反应性鉴定。
Q3 Medicine Pub Date : 2024-12-06 DOI: 10.3760/cma.j.cn112150-20231225-00485
D M Zhou, Y N Ren, Y F Liao, Y Zhou, Y B Cui

The present study was aimed to produce the recombinant protein of Tyrophagus putrescentiae allergen component 32 (Tyr p 32) and to identify its immunoreactivity. The cDNA encoding Tyr p 32 was amplified from total RNA of T. putrescentiae and inserted into pET-28a (+) vector. The constructed plasmid pET-28a (+)-Tyr p 32 was transformed into BL21 (DE3) receptor cells. After being induced with IPTG, the recombinant protein was purified with Ni column, and then identified on SDS-PAGE and Western blotting. Serum of children with allergic asthma and(or) rhinitis was collected, IgE-ELISA and IgE-Western blotting were used to detect the binding rate of rTyr p 32 to human T.putrescentiae-positive serum. After human bronchial epithelial cells BEAS-2B being cultured with rTyr p 32, the expression levels of IL-6 and IL-8 cytokines was detected by ELISA and qRT-PCR, t-test was used for pairwise comparison between groups. The results showed that the cDNA length of Tyr p 32 was 885 bp. The sequence identity between Tyr p 32 and Der p 32, Der f 32 was 70.21% and 68.03%, respectively. According to SDS-PAGE and Western blotting, the molecular weight of rTyr p 32 was about 35 000 Da, which was consistent with the theoretical value. IgE-ELISA results showed that the positive rate of rTyr p 32 was 41.38% (12/29) against T. putrescentiae-positive serum. When BEAS-2B cells were cultured with rTyr p 32, the expression of IL-6 and IL-8 increased in the cell supernatant in a dose-dependent manner (t=-29.10,P=0.001 2;t=-33.69,P=0.000 9), which also significantly increased the mRNA expression levels of IL-6 and IL-8 (t=-9.15,P=0.011 7;t=-17.16,P=0.003 4). In conclusion, the recombinant protein rTyr p 32 was successfully prepared, which provides raw materials for component diagnosis and specific immunotherapy of allergic diseases.

本研究旨在制备腐噬菌变应原32 (tyrp32)重组蛋白,并对其免疫反应性进行鉴定。从腐尸t总RNA中扩增编码tyrp32的cDNA,并插入pET-28a(+)载体中。将构建的质粒pET-28a (+)-Tyr p32转化到BL21 (DE3)受体细胞中。IPTG诱导后,用Ni柱纯化重组蛋白,SDS-PAGE和Western blotting鉴定重组蛋白。收集变应性哮喘和(或)鼻炎患儿血清,采用IgE-ELISA和IgE-Western blotting检测rtyrp32与人腐链球菌阳性血清的结合率。rtyrp32培养人支气管上皮细胞BEAS-2B后,采用ELISA和qRT-PCR检测IL-6、IL-8细胞因子的表达水平,组间两两比较采用t检验。结果表明,Tyr p32 cDNA长度为885 bp。Tyr p32与Der p32、Der f32的序列一致性分别为70.21%和68.03%。根据SDS-PAGE和Western blotting, rtyrp32的分子量约为35 000 Da,与理论值一致。IgE-ELISA结果显示,rtyrp32对腐链球菌阳性血清的阳性率为41.38%(12/29)。当BEAS-2B细胞被培养rTyr p 32岁的表达细胞上清液中il - 6和引发增加剂量依赖性的方式(t = -29.10, p = 0.001 2; t = -33.69, p = 0.000),也显著增加mRNA表达水平的il - 6和引发(t = -9.15, p = 0.011 7; t = -17.16, p = 0.003 4)。总之,重组蛋白rTyr p 32成功做好准备,为组件提供原材料过敏疾病的诊断和特定的免疫疗法。
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引用次数: 0
[Clinical features and prognosis of children with multiple Takayasu's arteritis complicated with carotid artery occlusion]. 【小儿多发性高松动脉炎合并颈动脉闭塞的临床特点及预后分析】。
Q3 Medicine Pub Date : 2024-12-06 DOI: 10.3760/cma.j.cn112150-20240602-00444
B P He, J M Lai

This study aimed to analyze the clinical characteristics and prognosis of Takayasu's arteritis (TA) with carotid artery occlusion in children. This study collected clinical data and follow-up information on the first diagnosis and treatment of c-TA combined with carotid artery occlusion in pediatric patients at the Children's Hospital affiliated with the Capital Institute of Pediatrics and Inner Mongolia Medical University Affiliated Hospital from 2013 to 2023. This study included four female patients with a mean age of (13.25±1.71) years old. The time from onset to diagnosis was (8.14±11.19) months. Their main clinical symptoms and signs were dizziness, headache, chest discomfort, aphasia, dyskinesia, impaired mobility of the limbs, hypertension, asymmetry of blood pressure in the limbs, vascular murmurs or tremors, weakened radial artery pulsation, and decreased muscle strength. All four children showed elevated levels of C-reactive protein and erythrocyte sedimentation rate. The medical imaging results showed that among the four patients, three had bilateral carotid artery occlusion, and one had unilateral carotid artery occlusion. There were three cases of cerebrovascular involvement, accompanied by arterial involvement in multiple parts of the body, mainly involving bilateral subclavian arteries, cephalic trunk arteries, bilateral renal arteries, bilateral iliac arteries, and middle cerebral arteries. Four children were effectively treated with glucocorticoids and immunosuppressants. These children were followed up for a period of (42.25±52.54) months, which showed that the original affected artery still had varying degrees of occlusion, with no progression from the pre-treatment period and no new arterial involvement. The condition of three children with pre-existing physical and language disorders gradually improved. In summary, children with c-TA combined with carotid artery occlusion can cause involvement of multiple blood vessels. Their clinical manifestations are mostly systemic symptoms and ischemia of corresponding supply organs caused by vascular lesions, which are prone to be combined with cerebral infarction, and their occluded blood vessels are difficult to recover.

本研究旨在分析儿童颈动脉闭塞性高松动脉炎(Takayasu’s arteritis, TA)的临床特点及预后。本研究收集了首都儿科研究所附属儿童医院和内蒙古医科大学附属医院2013 - 2023年首次诊断和治疗c-TA合并颈动脉闭塞儿科患者的临床资料和随访资料。本研究纳入4例女性患者,平均年龄(13.25±1.71)岁。发病至确诊时间为(8.14±11.19)个月。其主要临床症状和体征为头晕、头痛、胸部不适、失语、运动障碍、四肢活动障碍、高血压、四肢血压不对称、血管杂音或震颤、桡动脉搏动减弱、肌力下降。所有四名儿童均显示c反应蛋白和红细胞沉降率升高。医学影像学结果显示,4例患者中,3例双侧颈动脉闭塞,1例单侧颈动脉闭塞。脑血管受累3例,伴多部位动脉受累,主要累及双侧锁骨下动脉、头干动脉、双侧肾动脉、双侧髂动脉、大脑中动脉。4例患儿经糖皮质激素和免疫抑制剂有效治疗。随访时间为(42.25±52.54)个月,原患动脉仍有不同程度的闭塞,与治疗前相比无进展,无新的动脉受累。三名先前存在身体和语言障碍的儿童的状况逐渐改善。综上所述,儿童c-TA合并颈动脉闭塞可累及多根血管。其临床表现多为血管病变引起的全身性症状及相应供血器官缺血,易合并脑梗死,其闭塞的血管难以恢复。
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引用次数: 0
[Epidemiological characteristics and influencing factors of public health emergency events of varicella in the Beijing-Tianjin-Hebei region, 2006-2021]. 2006-2021年京津冀地区水痘突发公共卫生事件流行病学特征及影响因素分析
Q3 Medicine Pub Date : 2024-12-06 DOI: 10.3760/cma.j.cn112150-20240301-00171
X Y Liu, M M Wang, M Y You, P H Wang, T Q Wang, X M Chen, C D Xu, X D Li, L Wang, Y H Hu, D P Yin

To explore the epidemiological characteristics of public health emergency events (PHEE) of varicella in the Beijing-Tianjin-Hebei region and analyze its related influencing factors. Excel was used to organize the varicella data in the Beijing-Tianjin-Hebei region from 2006 to 2021, reported by the management information system of PHEE, to describe the epidemiological characteristics of varicella events. Spatial autocorrelation and spatial scanning methods were used to test and determine its spatial clusters. Geographic detectors were used to analyze the impact of socio-economic factors. From 2006 to 2021, there were 644 reported varicella events in the Beijing-Tianjin-Hebei region, with a total of 18 052 cases and an incidence rate of 2.78%. The number, duration and response time M (Q1, Q3) of each reported event were 22 (15, 35) cases, 19 (7, 34) days and 7 (4, 17) days, respectively. Hebei Province had a shorter response time and duration of events compared to Beijing and Tianjin. The most reported varicella events were in 2006 and 2007, with 112 and 106 events, respectively. By 2014, the number of events had decreased yearly, and there was a small peak from 2017 to 2019 between 2014 and 2021. From 2006 to 2021, the PHEE of varicella showed a seasonal bimodal distribution from March to June and from October to January of the following year, with peaks in May and December. There was a total of 500 reported varicella events in primary schools, including 218 events in rural primary schools (34%), 142 events in county and town primary schools (22%) and 140 events in urban primary schools (22%). The distribution of varicella events showed a positive spatial autocorrelation and strong spatial clustering, with Moran's I of 0.31. The Class 1 clustering area was centered in Kuancheng Manchu Autonomous County, Chengde City, with a radius of 207 km and included 58 districts (LLR=3 550.23, RR=3.78). The most explanatory factor among socio-economic factors was the proportion of the population aged 0-24 years old (q=0.22), and the interaction effect between each factor was stronger than the independent effect. Overall, there are differences in the level of handling varicella events across Beijing, Tianjin and Hebei. The main occurrence of varicella events is in primary schools, especially in rural areas. Varicella events exhibit spatial clustering. Population structure-related factors have a strong impact on the risk of the incidence of varicella events.

目的探讨京津冀地区水痘突发公共卫生事件的流行病学特征,并分析其相关影响因素。采用Excel软件对2006 - 2021年京津冀地区公共卫生系统管理信息系统报告的水痘数据进行整理,描述水痘事件的流行病学特征。采用空间自相关和空间扫描的方法对其空间簇进行检验和确定。使用地理探测器分析社会经济因素的影响。2006 - 2021年,京津冀地区共报告水痘病例644例,共18052例,发病率为2.78%。每个报告事件的数量、持续时间和反应时间M (Q1、Q3)分别为22(15,35)例、19(7,34)天和7(4,17)天。与北京和天津相比,河北省的事件响应时间和持续时间较短。报告最多的水痘事件发生在2006年和2007年,分别有112例和106例。到2014年,事件数量逐年减少,2014年至2021年期间,2017年至2019年出现小高峰。2006 - 2021年水痘PHEE呈3 - 6月和次年10 - 1月的季节性双峰分布,5月和12月为高峰。共报告小学水痘病例500例,其中农村小学218例(34%),县镇小学142例(22%),城市小学140例(22%)。水痘事件的空间分布表现出正的空间自相关性和较强的空间聚类性,其Moran’s I为0.31。1类集聚区以承德市宽城满族自治县为中心,半径207 km,包括58个区(LLR=3 550.23, RR=3.78)。社会经济因素中最具解释性的因子是0-24岁人口比例(q=0.22),且各因子之间的交互效应强于独立效应。总体而言,北京、天津和河北对水痘事件的处理水平存在差异。水痘事件主要发生在小学,特别是在农村地区。水痘事件呈现空间聚集性。人口结构相关因素对水痘事件发生的风险有很大影响。
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引用次数: 0
[Analysis of the distribution characteristics of allergen sIgE detection in patients with respiratory and skin mucosal diseases in a hospital in Shanghai City from 2022 to 2023]. [2022 - 2023年上海市某医院呼吸道及皮肤粘膜疾病患者过敏原sIgE检测分布特征分析]。
Q3 Medicine Pub Date : 2024-12-06 DOI: 10.3760/cma.j.cn112150-20240325-00247
B B Xuan, M Y Tan, H X Sun, J J Chen, L D Zhou, H H Zhang, J M Yao, Y J Wang, J P Lin, H M Sheng
<p><p>Analyzing the distribution characteristics of allergen sIgE in the serum of patients with respiratory and skin mucosal diseases in Shanghai City, and to provide epidemiological characteristics and diagnostic basis for the prevention and treatment of allergic respiratory and dermo-mucous diseases in Shanghai City. Adopting cross-sectional research, a total of 3 822 patients who received treatment in Tongren Hospital, Shanghai Jiao Tong University School of Medicine from July 2022 to July 2023 due to respiratory diseases or skin and dermo-mucous symptoms were included. Among them, there were 1 456 males and 2 366 females, with an age range of 1-97 years old. The median age (interquartile range) was 33 (27, 44) years old. The sIgE was detected by using immunoblotting. Statistical analysis was conducted using SPSS 22.0 software, and the comparison of count data (rates) between groups was conducted using <i>χ<sup>2</sup></i> test. The results showed that a total of 3 377 (88.4%) cases among 3 822 patients were at least one allergen sIgE positive, and 72.9% (2 788/3 822) of them were multiple allergies sIgE positive. The top five allergen sIgE positive rates were Dermatophagoides pteronyssinus (37.9%, 1 447/3 822), Dermatophagoides farinae (32.1%, 1 225/3 822), milk (31.7%, 1 211/3 822), fungi (28.3%, 1 080/3 822), and Blomia tropicdis (23.8%, 909/3 822), with only milk was a kind of food allergen. The highest positive rates within the respiratory system disease group or dermo-mucous disease group were also these five allergens, without any difference in disease categories. The positive rates of cat dandruff, Humulusscandens, and juniper/birch in the respiratory system disease group were significantly higher than those in the skin and mucous membrane disease group, while the positive rates of shrimp/crab were relatively low (11.3% <i>vs</i> 14.9%, <i>χ<sup>2</sup></i>=9.616,<i>P</i>=0.002). Whether in the respiratory system disease group or the dermo-mucous disease group, the positive rates of Dermatophagoides pteronyssinus in male patients were significantly higher than those of females(42.6% <i>vs</i> 35.7%,41.0% <i>vs</i> 34.4%), with statistical significance (<i>χ<sup>2</sup></i>=12.515, <i>P</i><0.001; <i>χ<sup>2</sup></i>=5.143, <i>P</i>=0.023), And the three allergens, Dermatophagoides farinae, cat dander, and egg white allergens are also characterized by this feature.In addition, the positive rates of milk(33.8% <i>vs</i> 30.1%, <i>χ<sup>2</sup></i>=3.911, <i>P</i>=0.048), shrimp/crab(13.2% <i>vs</i> 10.0%, <i>χ<sup>2</sup></i>=6.423, <i>P</i>=0.014) in the respiratory system disease group were higher in males than in females, while in the dermo-mucous disease group, dog dander(20.5% <i>vs</i> 14.6%, <i>χ<sup>2</sup></i>=6.726, <i>P</i>=0.010) and peanuts/soybeans(10.5% <i>vs</i> 6.9%, <i>χ<sup>2</sup></i>=4.698, <i>P</i>=0.030) showed this phenomenon. In both the respiratory system disease group and the dermo-mucous disease group, there
分析上海市呼吸道及皮肤粘膜疾病患者血清中变应原sIgE的分布特征,为上海市呼吸道及皮肤粘膜变应性疾病的防治提供流行病学特征和诊断依据。采用横断面研究方法,纳入2022年7月至2023年7月在上海交通大学医学院同仁医院因呼吸系统疾病或皮肤及真皮粘膜症状就诊的患者3 822例。其中男性1 456例,女性2 366例,年龄1 ~ 97岁。年龄中位数(四分位数间距)为33岁(27岁,44岁)。免疫印迹法检测sIgE。采用SPSS 22.0软件进行统计学分析,组间计数资料(率)比较采用χ2检验。结果显示,3 822例患者中至少有一种过敏原sIgE阳性的有3 377例(88.4%),其中多重过敏原sIgE阳性的有72.9%(2 788/3 822)。sIgE阳性率居前5位的过敏原依次为:鸡翅棘球蚴(37.9%,1 447/3 822)、粉状棘球蚴(32.1%,1 225/3 822)、牛奶(31.7%,1 221 /3 822)、真菌(28.3%,1 080/3 822)、热带布洛米原虫(23.8%,909/3 822),其中牛奶是唯一一种食物过敏原。呼吸系统疾病组和皮肤粘膜疾病组中,这五种过敏原的阳性率最高,在疾病类别上无差异。呼吸系统疾病组猫头皮屑、葎草、刺柏/桦木的阳性率显著高于皮肤粘膜疾病组,而虾/蟹的阳性率相对较低(11.3% vs 14.9%, χ2=9.616,P=0.002)。无论是呼吸系统疾病组还是皮肤-粘膜疾病组,男性患者翼状棘球蚴阳性率均显著高于女性(42.6% vs 35.7%,41.0% vs 34.4%),差异均有统计学意义(χ2=12.515, χ2=5.143, P=0.023),且3种过敏原、粉状棘球蚴、猫皮屑、蛋清过敏原均具有这一特征。另外,呼吸系统疾病组的乳汁(33.8%比30.1%,χ2=3.911, P=0.048)、虾/蟹(13.2%比10.0%,χ2=6.423, P=0.014)阳性率男性高于女性,而皮肤-粘膜疾病组的狗皮屑(20.5%比14.6%,χ2=6.726, P=0.010)和花生/大豆(10.5%比6.9%,χ2=4.698, P=0.030)阳性率均高于女性。呼吸系统疾病组和皮肤-粘膜疾病组均有6种吸入性过敏原(鸡翅类皮屑、粉状皮屑、热带褐皮虫、猫头皮屑、狗皮屑、真菌)和4种食物过敏原(蛋黄、蛋清过敏原、牛奶、虾/蟹)。未成年人呼吸道疾病组烟曲霉阳性率(7.2% vs 9.3% vs 10.5% vs 15.7%, χ2=10.996, P=0.012)和皮肤粘膜疾病组蟑螂阳性率(4.2% vs 11.3% vs 9.6% vs 16.4%, χ2=10.237, P=0.017)最低。过敏原阳性率存在季节差异,大多数过敏原在夏季和秋季的阳性率明显较高。综上所述,上海市呼吸道和皮肤粘膜疾病患者sIgE阳性的过敏原以翼状棘球蚴、粉状棘球蚴、乳汁、真菌和热带布洛米菌最为常见。过敏原sIgE在两大类疾病中的流行趋势基本一致。过敏原sIgE在不同性别、年龄、季节的患者人群中分布不同,临床可根据血清过敏原检测结果进行预防和治疗。
{"title":"[Analysis of the distribution characteristics of allergen sIgE detection in patients with respiratory and skin mucosal diseases in a hospital in Shanghai City from 2022 to 2023].","authors":"B B Xuan, M Y Tan, H X Sun, J J Chen, L D Zhou, H H Zhang, J M Yao, Y J Wang, J P Lin, H M Sheng","doi":"10.3760/cma.j.cn112150-20240325-00247","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20240325-00247","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Analyzing the distribution characteristics of allergen sIgE in the serum of patients with respiratory and skin mucosal diseases in Shanghai City, and to provide epidemiological characteristics and diagnostic basis for the prevention and treatment of allergic respiratory and dermo-mucous diseases in Shanghai City. Adopting cross-sectional research, a total of 3 822 patients who received treatment in Tongren Hospital, Shanghai Jiao Tong University School of Medicine from July 2022 to July 2023 due to respiratory diseases or skin and dermo-mucous symptoms were included. Among them, there were 1 456 males and 2 366 females, with an age range of 1-97 years old. The median age (interquartile range) was 33 (27, 44) years old. The sIgE was detected by using immunoblotting. Statistical analysis was conducted using SPSS 22.0 software, and the comparison of count data (rates) between groups was conducted using &lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;&lt;/i&gt; test. The results showed that a total of 3 377 (88.4%) cases among 3 822 patients were at least one allergen sIgE positive, and 72.9% (2 788/3 822) of them were multiple allergies sIgE positive. The top five allergen sIgE positive rates were Dermatophagoides pteronyssinus (37.9%, 1 447/3 822), Dermatophagoides farinae (32.1%, 1 225/3 822), milk (31.7%, 1 211/3 822), fungi (28.3%, 1 080/3 822), and Blomia tropicdis (23.8%, 909/3 822), with only milk was a kind of food allergen. The highest positive rates within the respiratory system disease group or dermo-mucous disease group were also these five allergens, without any difference in disease categories. The positive rates of cat dandruff, Humulusscandens, and juniper/birch in the respiratory system disease group were significantly higher than those in the skin and mucous membrane disease group, while the positive rates of shrimp/crab were relatively low (11.3% &lt;i&gt;vs&lt;/i&gt; 14.9%, &lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;&lt;/i&gt;=9.616,&lt;i&gt;P&lt;/i&gt;=0.002). Whether in the respiratory system disease group or the dermo-mucous disease group, the positive rates of Dermatophagoides pteronyssinus in male patients were significantly higher than those of females(42.6% &lt;i&gt;vs&lt;/i&gt; 35.7%,41.0% &lt;i&gt;vs&lt;/i&gt; 34.4%), with statistical significance (&lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;&lt;/i&gt;=12.515, &lt;i&gt;P&lt;/i&gt;&lt;0.001; &lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;&lt;/i&gt;=5.143, &lt;i&gt;P&lt;/i&gt;=0.023), And the three allergens, Dermatophagoides farinae, cat dander, and egg white allergens are also characterized by this feature.In addition, the positive rates of milk(33.8% &lt;i&gt;vs&lt;/i&gt; 30.1%, &lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;&lt;/i&gt;=3.911, &lt;i&gt;P&lt;/i&gt;=0.048), shrimp/crab(13.2% &lt;i&gt;vs&lt;/i&gt; 10.0%, &lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;&lt;/i&gt;=6.423, &lt;i&gt;P&lt;/i&gt;=0.014) in the respiratory system disease group were higher in males than in females, while in the dermo-mucous disease group, dog dander(20.5% &lt;i&gt;vs&lt;/i&gt; 14.6%, &lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;&lt;/i&gt;=6.726, &lt;i&gt;P&lt;/i&gt;=0.010) and peanuts/soybeans(10.5% &lt;i&gt;vs&lt;/i&gt; 6.9%, &lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;&lt;/i&gt;=4.698, &lt;i&gt;P&lt;/i&gt;=0.030) showed this phenomenon. In both the respiratory system disease group and the dermo-mucous disease group, there ","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"58 12","pages":"1902-1911"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Expert consensus on the passive immunization prevention of infant respiratory syncytial virus infection in China]. [中国婴儿呼吸道合胞病毒感染被动免疫预防专家共识]。
Q3 Medicine Pub Date : 2024-12-06 DOI: 10.3760/cma.j.cn112150-20240826-00684

Respiratory syncytial virus (RSV) infection, which has the very heavy disease burdens, is the most common viral pathogen that seriously threatens the health of infants and young children. In order to better guide and standardize the clinical diagnosis, treatment, monitoring and immunization prevention and control of RSV infection in China, the Chinese Preventive Medicine Association jointly organized multidisciplinary experts to form a special working group, drawing on the implementation experience of foreign passive immunization prevention of RSV, integrating the existing evidence and the latest progress as a problem oriented, and putting forward the expert consensus on the passive immunization prevention of infant RSV infection in China in the future. The aim is to answer some professional questions about RSV infection and its immunoprophylaxis, especially passive immunoprophylaxis, in order to provide reference for the practice of immunoprophylaxis for professionals in medical institutions, disease prevention and control institutions and community health service centers at all levels.

呼吸道合胞病毒(RSV)感染疾病负担极重,是严重威胁婴幼儿健康的最常见病毒性病原体。为了更好地指导和规范我国RSV感染的临床诊断、治疗、监测和免疫防控工作,中华预防医学会联合多学科专家组成专项工作组,借鉴国外RSV被动免疫预防的实施经验,以问题为导向,整合现有证据和最新进展,提出了未来我国婴幼儿RSV感染被动免疫预防的专家共识。旨在解答有关RSV感染及其免疫预防,尤其是被动免疫预防的一些专业问题,为各级医疗机构、疾病预防控制机构和社区卫生服务中心的专业人员提供免疫预防的实践参考。
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引用次数: 0
[Changes and correlation between serum β-amyloid 1-42 and total bilirubin in patients with Alzheimer's disease]. [阿尔茨海默病患者血清β-淀粉样蛋白1-42和总胆红素的变化及其相关性]。
Q3 Medicine Pub Date : 2024-12-06 DOI: 10.3760/cma.j.cn112150-20240813-00652
X Y Wang, H Deng, W Li, Y F Zhou, S J Pan
<p><p><b>Objective:</b> To investigate the levels of β-amyloid 1-42 (Aβ1-42) and total bilirubin (TBIL) in serum of patients with Alzheimer 's disease (AD) and the relationship between them. <b>Methods:</b> A case-control study was conducted to select 73 patients with AD who were hospitalized in Beijing Huilongguan Hospital from November 2023 to February 2024 as AD group, and 70 healthy controls (HC) were selected as HC group. The basic information of all subjects and the clinical information of AD patients were collected, and the levels of Aβ1-42 and TBIL were detected and compared between the two groups. The effects of Aβ1-42 and TBIL on AD were analyzed by binary logistic regression. Correlation analysis was used to analyze the relationship between TBIL and Aβ1-42 in AD group and HC group. According to the level of Aβ1-42 in AD patients, they were divided into Aβ1-42 elevated group and Aβ1-42 normal group. The differences of clinical data and TBIL levels between the two groups were compared. According to the quartile of TBIL in AD patients, they were divided into Q1 group, Q2 group, Q3 group and Q4 group. The correlation between TBIL and the risk of Aβ1-42 elevation was analyzed by binary logistic regression. The receiver operating characteristic (ROC) curve was drawn to analyze the ability of TBIL level to predict the increase of Aβ1-42 in AD patients. <b>Results:</b> There was no significant difference in gender, marital status, education level, smoking and drinking between AD group and HC group (<i>P></i>0.05), while the levels of Aβ1-42 and TBIL and age in AD group were significantly higher than those in HC group [101.10(71.20, 128.60) pg/ml/22.40(10.00, 39.60) pg/ml<i>, Z</i>=-8.714, <i>P</i><0.001;(11.00±3.22/8.07±3.00) μmol/L<i>, t</i>=5.621, <i>P</i><0.001;(77.14±8.20/68.30±10.27) years, <i>t</i>=5.672, <i>P</i><0.001]. For AD patients, the TBIL level in the Aβ1-42 elevated group was lower than that in the Aβ1-42 normal group [(10.05±2.94/11.66±3.28) μmol/L<i>, t</i>=-2.148, <i>P</i>=0.035], while there was no significant difference in other demographic and clinical data between the two groups (<i>P</i>>0.05). Binary logistic regression analysis showed that higher levels of Aβ1-42 (<i>OR</i>=1.021, 95%<i>CI</i>:1.010-1.032) and TBIL (<i>OR</i>=1.505, 95%<i>CI</i>:1.249-1.814), older age (<i>OR</i>=1.083, 95%<i>CI</i>:1.020-1.150) and female (<i>OR</i>=4.348, 95%<i>CI</i>:1.253-15.094) were risk factors for AD. Correlation analysis showed that TBIL was negatively correlated with Aβ1-42 in AD patients (<i>r=</i>-0.322, <i>P</i>=0.006). After adjusting the relevant covariates, binary logistic regression showed that compared with AD patients in Q1 group, the risk of Aβ1-42 elevation in AD patients in Q4 group was lower (<i>OR</i>=0.052, 95%<i>CI</i>:0.005-0.535, <i>P</i><0.05), and TBIL was negatively correlated with the risk of Aβ1-42 elevation (<i>P</i> trend<0.05). ROC curve showed that the area under the curve (AUC) of TBIL in predicti
目的:探讨阿尔茨海默病(AD)患者血清β-淀粉样蛋白1-42 (a - β1-42)和总胆红素(TBIL)水平及其相关性。方法:选取2023年11月至2024年2月在北京回龙观医院住院的73例AD患者作为AD组,健康对照(HC) 70例作为HC组。收集所有受试者的基本信息和AD患者的临床信息,检测两组间Aβ1-42和TBIL的水平并进行比较。采用二元logistic回归分析a - β1-42和TBIL对AD的影响。采用相关分析分析AD组和HC组TBIL与a - β1-42的关系。根据AD患者Aβ1-42水平分为Aβ1-42升高组和Aβ1-42正常组。比较两组患者临床资料及TBIL水平的差异。根据AD患者TBIL的四分位数分为Q1组、Q2组、Q3组和Q4组。采用二元logistic回归分析TBIL与Aβ1-42升高风险的相关性。绘制受试者工作特征(ROC)曲线,分析TBIL水平对AD患者a - β1-42升高的预测能力。结果:AD组与HC组在性别、婚姻状况、文化程度、吸烟、饮酒等方面差异无统计学意义(P>0.05), AD组Aβ1-42、TBIL水平及年龄均显著高于HC组[101.10(71.20,128.60)pg/ml/22.40(10.00, 39.60) pg/ml, Z=-8.714, P, t=5.621, Pt=5.672, P, t=-2.148, P=0.035],其他人口统计学及临床资料两组间差异无统计学意义(P>0.05)。二元logistic回归分析显示,较高水平的Aβ1-42 (OR=1.021, 95%CI:1.010 ~ 1.032)和TBIL (OR=1.505, 95%CI:1.249 ~ 1.814)、年龄(OR=1.083, 95%CI:1.020 ~ 1.150)和女性(OR=4.348, 95%CI:1.253 ~ 15.094)是AD的危险因素。相关分析显示,AD患者TBIL与a - β1-42呈负相关(r=-0.322, P=0.006)。调整相关协变量后,二元logistic回归显示,与Q1组AD患者相比,Q4组AD患者Aβ1-42升高的风险较低(OR=0.052, 95%CI:0.005 ~ 0.535, PP趋势)。结论:AD患者Aβ1-42和TBIL水平较高,且TBIL水平与Aβ1-42升高的风险呈负相关。
{"title":"[Changes and correlation between serum β-amyloid 1-42 and total bilirubin in patients with Alzheimer's disease].","authors":"X Y Wang, H Deng, W Li, Y F Zhou, S J Pan","doi":"10.3760/cma.j.cn112150-20240813-00652","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20240813-00652","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the levels of β-amyloid 1-42 (Aβ1-42) and total bilirubin (TBIL) in serum of patients with Alzheimer 's disease (AD) and the relationship between them. &lt;b&gt;Methods:&lt;/b&gt; A case-control study was conducted to select 73 patients with AD who were hospitalized in Beijing Huilongguan Hospital from November 2023 to February 2024 as AD group, and 70 healthy controls (HC) were selected as HC group. The basic information of all subjects and the clinical information of AD patients were collected, and the levels of Aβ1-42 and TBIL were detected and compared between the two groups. The effects of Aβ1-42 and TBIL on AD were analyzed by binary logistic regression. Correlation analysis was used to analyze the relationship between TBIL and Aβ1-42 in AD group and HC group. According to the level of Aβ1-42 in AD patients, they were divided into Aβ1-42 elevated group and Aβ1-42 normal group. The differences of clinical data and TBIL levels between the two groups were compared. According to the quartile of TBIL in AD patients, they were divided into Q1 group, Q2 group, Q3 group and Q4 group. The correlation between TBIL and the risk of Aβ1-42 elevation was analyzed by binary logistic regression. The receiver operating characteristic (ROC) curve was drawn to analyze the ability of TBIL level to predict the increase of Aβ1-42 in AD patients. &lt;b&gt;Results:&lt;/b&gt; There was no significant difference in gender, marital status, education level, smoking and drinking between AD group and HC group (&lt;i&gt;P&gt;&lt;/i&gt;0.05), while the levels of Aβ1-42 and TBIL and age in AD group were significantly higher than those in HC group [101.10(71.20, 128.60) pg/ml/22.40(10.00, 39.60) pg/ml&lt;i&gt;, Z&lt;/i&gt;=-8.714, &lt;i&gt;P&lt;/i&gt;&lt;0.001;(11.00±3.22/8.07±3.00) μmol/L&lt;i&gt;, t&lt;/i&gt;=5.621, &lt;i&gt;P&lt;/i&gt;&lt;0.001;(77.14±8.20/68.30±10.27) years, &lt;i&gt;t&lt;/i&gt;=5.672, &lt;i&gt;P&lt;/i&gt;&lt;0.001]. For AD patients, the TBIL level in the Aβ1-42 elevated group was lower than that in the Aβ1-42 normal group [(10.05±2.94/11.66±3.28) μmol/L&lt;i&gt;, t&lt;/i&gt;=-2.148, &lt;i&gt;P&lt;/i&gt;=0.035], while there was no significant difference in other demographic and clinical data between the two groups (&lt;i&gt;P&lt;/i&gt;&gt;0.05). Binary logistic regression analysis showed that higher levels of Aβ1-42 (&lt;i&gt;OR&lt;/i&gt;=1.021, 95%&lt;i&gt;CI&lt;/i&gt;:1.010-1.032) and TBIL (&lt;i&gt;OR&lt;/i&gt;=1.505, 95%&lt;i&gt;CI&lt;/i&gt;:1.249-1.814), older age (&lt;i&gt;OR&lt;/i&gt;=1.083, 95%&lt;i&gt;CI&lt;/i&gt;:1.020-1.150) and female (&lt;i&gt;OR&lt;/i&gt;=4.348, 95%&lt;i&gt;CI&lt;/i&gt;:1.253-15.094) were risk factors for AD. Correlation analysis showed that TBIL was negatively correlated with Aβ1-42 in AD patients (&lt;i&gt;r=&lt;/i&gt;-0.322, &lt;i&gt;P&lt;/i&gt;=0.006). After adjusting the relevant covariates, binary logistic regression showed that compared with AD patients in Q1 group, the risk of Aβ1-42 elevation in AD patients in Q4 group was lower (&lt;i&gt;OR&lt;/i&gt;=0.052, 95%&lt;i&gt;CI&lt;/i&gt;:0.005-0.535, &lt;i&gt;P&lt;/i&gt;&lt;0.05), and TBIL was negatively correlated with the risk of Aβ1-42 elevation (&lt;i&gt;P&lt;/i&gt; trend&lt;0.05). ROC curve showed that the area under the curve (AUC) of TBIL in predicti","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"58 12","pages":"1987-1993"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Current situation and demand for specialized development of allergy nursing in eighty-eight hospitals in Guangdong Province]. [广东省88家医院过敏护理专科发展现状及需求]。
Q3 Medicine Pub Date : 2024-12-06 DOI: 10.3760/cma.j.cn112150-20240125-00084
C Dai, J Su, Y L Xu, Q P Chen, X X Lin, Y N Xu, X L Liu, S Chen, Y X Xu, A Z Yan, Y Y Hu, L Wang, F F Yan, Q L Zhou
<p><p>To investigate the current situation and demand for specialized development of allergy nursing in 88 hospitals in Guangdong Province, as well as to provide evidence for the management of allergy nursing. From August to December 2023, a cross-sectional study was conducted to analyze the core managers of allergy nursing-related work in eighty-eight hospitals in Guangdong Province supported by the Allergy Nursing Branch of the Guangdong Nurses Association and the Nursing Group of the Allergy Branch of the Guangdong Medical Association. An online survey was conducted using the Delphi method to compile a questionnaire on the current status and demand for specialized development of allergy nursing in Guangdong Province. Chi-square tests and Fisher's exact probability method were used to analyze the differences in the current status of specialty technology applications and the development and demand of specialized nursing between hospitals with or without allergy specialty departments. The results showed that among the eighty-eight hospitals in the nineteen prefecture-level cities surveyed in Guangdong Province, 17 hospitals (19%) had established allergy specialty departments, all of which were top-tier tertiary hospitals. The establishment duration [<i>M</i> (<i>Q</i><sub>1</sub>, <i>Q</i><sub>3</sub>)] was 3 (1, 10) years. The implementation rates of skin prick test (94%, 16/17), in-vitro examination (82%, 14/17), nasal endoscopy (82%, 14/17), subcutaneous specific immunotherapy (82%, 14/17), multidisciplinary consultation (65%, 11/17), fractional exhaled nitric oxide detection (47%, 8/17), skin patch test (41%, 7/17), and autologous serum skin test (35%, 6/17) in hospitals with allergy department were higher than those in hospitals without allergy department [59%, 42/71 (<i>χ<sup>2</sup>=</i>7.462, <i>P=</i>0.006)], [54%, 38/71 (<i>χ<sup>2</sup>=</i>4.717, <i>P</i>=0.030)], [51%, 36/71 (<i>χ<sup>2</sup>=</i>5.599, <i>P</i>=0.018)], [34%, 24/71 (<i>χ<sup>2</sup>=</i>13.177, <i>P</i><0.001)], [24%, 17/71 (<i>χ<sup>2</sup>=</i>10.505, <i>P</i>=0.001)], [24%, 17/71 (<i>χ<sup>2</sup>=</i>5.540, <i>P</i>=0.019)], [11%, 8/71 (Fisher's exact test, <i>P</i>=0.008)], [11%, 8/71 (Fisher's exact test, <i>P</i>=0.025)]. In the development plan of allergy nursing in the next two years, hospitals that had set up allergy departments had a higher proportion in adding nurses (82%, 14/17, <i>χ<sup>2</sup>=</i>13.177, <i>P</i><0.001), formulating specialized nurse training plans (71%, 12/17, <i>χ<sup>2</sup>=</i>3.980, <i>P</i>=0.046), formulating group standards or clinical guidelines (41%, 7/17, Fisher's exact test, <i>P</i>=0.046), and formulating assessment standards (53%, 9/17, Fisher's exact test, <i>P</i>=0.002). The demand for all aspects of allergy specialty nursing knowledge and skills accounted for more than 50%, and it was not related to whether the hospital set up an allergy department. In conclusion, the specialized development of allergy nursing in
目的了解广东省88家医院变态反应护理专业化发展的现状及需求,为变态反应护理管理提供依据。本研究于2023年8 - 12月,在广东省护士协会变态反应护理分会和广东省医学会变态反应分会护理组的支持下,对广东省88家医院变态反应护理相关工作的核心管理人员进行了横断面研究。采用德尔菲法进行网上调查,编制广东省变态反应护理专科发展现状及需求调查问卷。采用卡方检验和Fisher精确概率法分析有无过敏专科医院在专科技术应用现状、专科护理发展及需求方面的差异。结果显示,广东省调查的19个地级市的88家医院中,17家(19%)医院设立了过敏专科,且均为三级甲等医院。建立期限[M (Q1, Q3)]为3(1,10)年。有过敏科医院皮肤点刺试验(94%,16/17)、体外检查(82%,14/17)、鼻内窥镜检查(82%,14/17)、皮下特异性免疫治疗(82%,14/17)、多学科会诊(65%,11/17)、呼气一氧化氮分式检测(47%,8/17)、皮肤贴试验(41%,7/17)、自体血清皮肤试验(35%,6/17)的实施率均高于无过敏科医院[59%,42/71],[χ2=7.462, P=0.006], [54%,38/71(χ2 = 4.717,P = 0.030)],[51%, 36/71(χ2 = 5.599,P = 0.018)],[34%, 24/71(χ2 = 13.177,Pχ2 = 10.505,P = 0.001)],[24%, 17/71(χ2 = 5.540,P = 0.019)],[11%, 8/71(确切概率法,P = 0.008)],[11%, 8/71(确切概率法,P = 0.025)]。在未来两年的过敏护理发展规划中,设立过敏科的医院增加护士(82%,14/17,χ2=13.177, Pχ2=3.980, P=0.046)、制定团体标准或临床指南(41%,7/17,Fisher精确检验,P=0.046)、制定评估标准(53%,9/17,Fisher精确检验,P=0.002)的比例较高。对过敏专科各方面护理知识和技能的需求占50%以上,与医院是否设立过敏科无关。综上所述,广东省变态反应专科护理发展尚处于起步阶段,对变态反应相关知识和技能的提升需求较大。需要进一步规范专业建设,同时对过敏护士进行培训,促进过敏反应护理专业从点到区全面发展。
{"title":"[Current situation and demand for specialized development of allergy nursing in eighty-eight hospitals in Guangdong Province].","authors":"C Dai, J Su, Y L Xu, Q P Chen, X X Lin, Y N Xu, X L Liu, S Chen, Y X Xu, A Z Yan, Y Y Hu, L Wang, F F Yan, Q L Zhou","doi":"10.3760/cma.j.cn112150-20240125-00084","DOIUrl":"https://doi.org/10.3760/cma.j.cn112150-20240125-00084","url":null,"abstract":"&lt;p&gt;&lt;p&gt;To investigate the current situation and demand for specialized development of allergy nursing in 88 hospitals in Guangdong Province, as well as to provide evidence for the management of allergy nursing. From August to December 2023, a cross-sectional study was conducted to analyze the core managers of allergy nursing-related work in eighty-eight hospitals in Guangdong Province supported by the Allergy Nursing Branch of the Guangdong Nurses Association and the Nursing Group of the Allergy Branch of the Guangdong Medical Association. An online survey was conducted using the Delphi method to compile a questionnaire on the current status and demand for specialized development of allergy nursing in Guangdong Province. Chi-square tests and Fisher's exact probability method were used to analyze the differences in the current status of specialty technology applications and the development and demand of specialized nursing between hospitals with or without allergy specialty departments. The results showed that among the eighty-eight hospitals in the nineteen prefecture-level cities surveyed in Guangdong Province, 17 hospitals (19%) had established allergy specialty departments, all of which were top-tier tertiary hospitals. The establishment duration [&lt;i&gt;M&lt;/i&gt; (&lt;i&gt;Q&lt;/i&gt;&lt;sub&gt;1&lt;/sub&gt;, &lt;i&gt;Q&lt;/i&gt;&lt;sub&gt;3&lt;/sub&gt;)] was 3 (1, 10) years. The implementation rates of skin prick test (94%, 16/17), in-vitro examination (82%, 14/17), nasal endoscopy (82%, 14/17), subcutaneous specific immunotherapy (82%, 14/17), multidisciplinary consultation (65%, 11/17), fractional exhaled nitric oxide detection (47%, 8/17), skin patch test (41%, 7/17), and autologous serum skin test (35%, 6/17) in hospitals with allergy department were higher than those in hospitals without allergy department [59%, 42/71 (&lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;=&lt;/i&gt;7.462, &lt;i&gt;P=&lt;/i&gt;0.006)], [54%, 38/71 (&lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;=&lt;/i&gt;4.717, &lt;i&gt;P&lt;/i&gt;=0.030)], [51%, 36/71 (&lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;=&lt;/i&gt;5.599, &lt;i&gt;P&lt;/i&gt;=0.018)], [34%, 24/71 (&lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;=&lt;/i&gt;13.177, &lt;i&gt;P&lt;/i&gt;&lt;0.001)], [24%, 17/71 (&lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;=&lt;/i&gt;10.505, &lt;i&gt;P&lt;/i&gt;=0.001)], [24%, 17/71 (&lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;=&lt;/i&gt;5.540, &lt;i&gt;P&lt;/i&gt;=0.019)], [11%, 8/71 (Fisher's exact test, &lt;i&gt;P&lt;/i&gt;=0.008)], [11%, 8/71 (Fisher's exact test, &lt;i&gt;P&lt;/i&gt;=0.025)]. In the development plan of allergy nursing in the next two years, hospitals that had set up allergy departments had a higher proportion in adding nurses (82%, 14/17, &lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;=&lt;/i&gt;13.177, &lt;i&gt;P&lt;/i&gt;&lt;0.001), formulating specialized nurse training plans (71%, 12/17, &lt;i&gt;χ&lt;sup&gt;2&lt;/sup&gt;=&lt;/i&gt;3.980, &lt;i&gt;P&lt;/i&gt;=0.046), formulating group standards or clinical guidelines (41%, 7/17, Fisher's exact test, &lt;i&gt;P&lt;/i&gt;=0.046), and formulating assessment standards (53%, 9/17, Fisher's exact test, &lt;i&gt;P&lt;/i&gt;=0.002). The demand for all aspects of allergy specialty nursing knowledge and skills accounted for more than 50%, and it was not related to whether the hospital set up an allergy department. In conclusion, the specialized development of allergy nursing in ","PeriodicalId":24033,"journal":{"name":"中华预防医学杂志","volume":"58 12","pages":"1926-1932"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A clinical analysis on the distribution characteristics of dermatophagoides pteronyssinus allergen components among children with allergic rhinitis and asthma in a hospital of pediatric in Shenzhen City from 2021 to 2024]. [深圳市某儿科医院2021 - 2024年变应性鼻炎、哮喘患儿翼状窦类皮螨过敏原成分分布特征的临床分析]。
Q3 Medicine Pub Date : 2024-12-06 DOI: 10.3760/cma.j.cn112150-20240708-00545
S J Zhuang, T T Fan, X Y Ruan, R L Lai, W J Yan, C Y Liu, Z W Lu, M F Huang, F H Yang, Y M Bao
<p><p><b>Objective:</b> To investigate the distribution characteristics and analyze the clinical significance of dermatophagoides pteronyssinus allergen components in children with allergic rhinitis and asthma in Shenzhen. <b>Methods:</b> This study was a cross-sectional study. The clinical data of children with allergic rhinitis and asthma induced by dust mites admitted to the allergy clinic of Shenzhen Children's Hospital from 2021 to 2024 were collected and the serum sIgE levels of dermatophagoides pteronyssinus, dermatophagoides farinae (Der p, Der f) and dermatophagoides pteronyssinus components (Der p 1, Der p 2, Der p 10, Der p 23) were detected by magnetic bead chemiluminescence method. The correlation between dermatophagoides pteronyssinus allergen components and clinical data of children was analyzed. According to the diagnosis, the children were divided into allergic rhinitis (AR) group and AR with asthma (ARAS) group. According to the age, the children were divided into preschool age (5 years ≤age<7 years), school age (7 years ≤age<10 years) and adolescence (10 years ≤age≤15 years). The expression differences of dermatophagoides pteronyssinus components among AR group and ARAS group and different age groups were compared. <b>Results:</b> A total of 314 children with allergic rhinitis and asthma caused by dust mites were included in the study, of whom 112 were male and 202 were female. There were 188 cases of AR and 126 cases of ARAS, aged 5-15 years, with a median age of 7.54 years and an average age of (8.02±2.24) years. BMI was 13.89-31.76 kg/m<sup>2</sup>,the median BMI was 15.87 kg/m² and average BMI was (16.55±3.05) kg/m². There was not statistically significant difference in gender, age, BMI, blood eosinophils, blood basophils, FeNO, FVC and FEV1 between the AR group and the ARAS group (<i>P</i>>0.05). There was significant difference in FEV1/FVC and small airway function indexes MMEF, MEF75%, MEF50% and MEF25% between the AR group and the ARAS group (<i>P</i><0.05). In the 314 children, the dermatophagoides pteronyssinus allergen components sensitization rates were in the order of Der p 1 (97.1%), Der p 2 (89.8%), Der p 23 (55.1%), Der p 10 (8.6%), and the difference in the positive rate was statistically significant (χ<sup>2</sup>=658.31, <i>P</i><0.001). There was not significant difference in Der p 1, Der p 2 and Der p 10 among children of different ages (<i>P</i>>0.05). There was significant difference in Der p 23 among children of different ages (χ<sup>2</sup>=7.29, <i>P</i>=0.03). A correlation analysis showed that Der p, Der f, Der p 1 and Der p 2 had a high positive correlation (<i>P</i><0.001). Eosinophils are positively correlated with Der p, Der f, Der p 1, Der p 2, Der p 10 and Der p 23 (<i>P</i><0.001). FeNO is positively correlated with Der p, Der f, and Der p 23 (<i>P</i><0.05). Small airway function indicators MMEF, MEF50% and MEF25% are negatively correlated with Der p, Der f and Der p 1 (<i>P</i><0.05). The sI
目的:了解深圳市儿童变应性鼻炎、哮喘患者翼状窦类皮螨原成分的分布特点,分析其临床意义。方法:本研究为横断面研究。收集2021 ~ 2024年深圳儿童医院变态反应症门诊收治的尘螨致变应性鼻炎、哮喘患儿的临床资料,采用磁珠化学发光法检测血清中翼螨类、粉螨类(Der p、Der f)及翼螨类成分(Der p 1、Der p 2、Der p 10、Der p 23)的sIgE水平。分析蝶翼窦类皮肤过敏原成分与患儿临床资料的相关性。根据诊断将患儿分为变应性鼻炎(AR)组和AR合并哮喘(ARAS)组。根据年龄将患儿分为学龄前(5岁≤年龄)。结果:共有314例由尘螨引起的变应性鼻炎和哮喘患儿纳入研究,其中男性112例,女性202例。AR 188例,ARAS 126例,年龄5 ~ 15岁,中位年龄7.54岁,平均年龄(8.02±2.24)岁。BMI为13.89 ~ 31.76 kg/m2,中位BMI为15.87 kg/m²,平均BMI为(16.55±3.05)kg/m²。AR组与ARAS组在性别、年龄、BMI、血嗜酸性粒细胞、血嗜碱性粒细胞、FeNO、FVC、FEV1差异均无统计学意义(P < 0.05)。AR组与ARAS组FEV1/FVC及小气道功能指标MMEF、MEF75%、MEF50%、MEF25%差异有统计学意义(P2=658.31, PP = 0.05)。不同年龄段儿童Der p23差异有统计学意义(χ2=7.29, p =0.03)。相关分析显示,Der p、Der f、Der p1、Der p2呈高度正相关(PPPPP0.05)。在ARAS组中,120例(95.24%)检出至少2种类皮蚁翼窦成分阳性,71例(56.35%)检出至少3种类皮蚁翼窦成分阳性。AR组至少2种类皮药翼窦成分阳性171例(90.96%),至少3种类皮药翼窦成分阳性94例(50.00%)。结论:Der p1、Der p2和Der p23可能是深圳市致变应性鼻炎和哮喘的主要类皮螨类翼鼻窦变应原成分。翼状窦成分sIgE水平升高可加重下气道嗜酸性粒细胞炎症和气道阻塞的严重程度。对尘螨过敏原特异性免疫治疗反应不佳的患儿应注意检出类皮肤药翼窦成分。
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引用次数: 0
[A preliminary study on the short-term effectiveness and safety of sublingual immunotherapy-spray for patients with respiratory allergy]. [舌下免疫治疗喷雾剂对呼吸道过敏患者短期疗效及安全性的初步研究]。
Q3 Medicine Pub Date : 2024-12-06 DOI: 10.3760/cma.j.cn112150-20240921-00761
X Y Dai, H D Lou, X Y Wang, S Chen, J Zhang, H B Ding, J Li, L Cheng

To investigate the short-term effectiveness and safety of sublingual allergen immunotherapy with allergen sprays (SLIT-sprays) in Chinese patients with allergic rhinitis (AR) with or without asthma using real-world data. The retrospective cohort study included 100 patients who received SLIT-sprays in the ENT departments in Hainan Shulan (Boao) Hospital and Boao Super Hospital between October 2023 and August 2024. A questionnaire survey was conducted to collect clinical data on the effectiveness and safety of SLIT-sprays, examining the types and incidence of adverse events (AEs) during treatment, treatments after the occurrence of AEs, and changes in Visual Analog Scale (VAS) scores before and after SLIT-sprays. Self-reports from 100 patients were collected. The results showed that the average treatment duration for the 100 patients was (90.7±58.9) days, median 78.5 days. Using changes in VAS scores as the effectiveness assessment, the average VAS score increased by 4.2 (95%CI: 4.06-4.34). The incidence of AEs during the SLIT-sprays was 17.0% (17/100), all of which were mild to moderate local reactions, with no serious AEs reported. There were no significant differences in AE incidence among patients with different diseases (AR or AR with asthma and asthma alone) (χ2=1.831,P>0.05), different age group (χ2=1.477,P>0.05), different types of allergen extracts (χ2=1.613,P>0.05), or the number of allergen extracts used (patients using one or two allergen extracts) (Fisher's exact test,P>0.05). In conclusion, Chinese patients showed good safety and tolerability to SLIT-sprays, with all AEs being mild to moderate local reactions and no serious or systemic AEs occurring. Patients reported positive subjective evaluations of the early treatment effects.

目的:探讨舌下过敏原喷雾剂(SLIT-sprays)对伴有或不伴有哮喘的中国变应性鼻炎(AR)患者的短期有效性和安全性。该回顾性队列研究纳入了2023年10月至2024年8月在海南舒兰(博鳌)医院和博鳌超级医院耳鼻喉科接受裂隙喷雾剂治疗的100例患者。通过问卷调查收集sslit喷雾剂的有效性和安全性的临床资料,检查治疗过程中不良事件(ae)的类型和发生率,ae发生后的治疗情况,以及sslit喷雾剂前后视觉模拟评分(VAS)的变化。收集了100例患者的自我报告。结果显示,100例患者的平均治疗时间为(90.7±58.9)d,中位治疗时间为78.5 d。以VAS评分变化作为疗效评价,VAS评分平均提高4.2分(95%CI: 4.06-4.34)。喷施过程中不良反应发生率为17.0%(17/100),均为轻度至中度局部反应,无严重不良反应报告。不同疾病(AR、AR合并哮喘和单独哮喘)、不同年龄组(χ2=1.477,P>0.05)、不同过敏原提取物类型(χ2=1.613,P>0.05)、不同过敏原提取物使用次数(使用一种或两种过敏原提取物)患者的AE发病率差异无统计学意义(Fisher精确检验,P>0.05)。综上所述,中国患者对slit喷雾剂表现出良好的安全性和耐受性,所有不良反应均为轻度至中度局部反应,未发生严重或全身性不良反应。患者报告了对早期治疗效果的积极主观评价。
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引用次数: 0
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中华预防医学杂志
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