Background: Gall Bladder cancer ranks as sixth most common digestive tract cancer with very poor survival rate. The data from India shows a very wide variation in incidence. The purpose of this study is to determine the Demographic and Clinico- pathological Profile of Gall Bladder carcinoma patients in a tertiary care hospital in Odisha. Methods: We retrospectively analyzed 103 patients of gall bladder carcinoma from our Hospital database between 2016 and 2019. The demographic and epidemiological characteristics were analyzed. Socioeconomic status was determined by the modified Kuppuswamy’s socioeconomic scale. The clinical features were analyzed as documented by history, physical examination, and imaging features. Results: Out of 103 patients, 44 (42.7%) were males and 59 (57.3%) were females. The largest numbers of patients were seen in the age group more than 40 years of age. 46.4% of patients were in low socioeconomic status. Pain abdomen was the most common symptom in 58(56.3%) patients. There was no statistically significant association of cancer with gall stone disease. In Odisha, more gall bladder cancer was seen in females. Due to lack of awareness & poor socioeconomic status maximum patients present in advanced stage with common symptom as pain abdomen. Conclusion: Most of the patients in this study belong to lower socioeconomic classes. Females were more commonly affected from gall bladder cancer and presented at an advanced stage. In our study 37.9% Gall bladder cancer were associated with gall stone disease, though it was not statistically significant.
{"title":"Demographic and Clinico-Pathological Profile of Gall Bladder Carcinoma Patients in a Tertiary Care Hospital in Odisha","authors":"A. S","doi":"10.23880/hij-16000194","DOIUrl":"https://doi.org/10.23880/hij-16000194","url":null,"abstract":"Background: Gall Bladder cancer ranks as sixth most common digestive tract cancer with very poor survival rate. The data from India shows a very wide variation in incidence. The purpose of this study is to determine the Demographic and Clinico- pathological Profile of Gall Bladder carcinoma patients in a tertiary care hospital in Odisha. Methods: We retrospectively analyzed 103 patients of gall bladder carcinoma from our Hospital database between 2016 and 2019. The demographic and epidemiological characteristics were analyzed. Socioeconomic status was determined by the modified Kuppuswamy’s socioeconomic scale. The clinical features were analyzed as documented by history, physical examination, and imaging features. Results: Out of 103 patients, 44 (42.7%) were males and 59 (57.3%) were females. The largest numbers of patients were seen in the age group more than 40 years of age. 46.4% of patients were in low socioeconomic status. Pain abdomen was the most common symptom in 58(56.3%) patients. There was no statistically significant association of cancer with gall stone disease. In Odisha, more gall bladder cancer was seen in females. Due to lack of awareness & poor socioeconomic status maximum patients present in advanced stage with common symptom as pain abdomen. Conclusion: Most of the patients in this study belong to lower socioeconomic classes. Females were more commonly affected from gall bladder cancer and presented at an advanced stage. In our study 37.9% Gall bladder cancer were associated with gall stone disease, though it was not statistically significant.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"107 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117220217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acute Myeloid Leukemia with BCR-ABL1 Translocation: A Rare Entity","authors":"J. I.","doi":"10.23880/hij-16000186","DOIUrl":"https://doi.org/10.23880/hij-16000186","url":null,"abstract":"","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134346988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Myelomatosis accounts for about 10% of haematological malignancies according to previous studies in different climes. The impact of some complications on treatment choice as well as survival outcomes is significant and worthy of study. Aims: To describe complications observed at presentation in this cohort of myeloma patients and to assess the associations of these complications with certain laboratory and clinical parameters. Results: There were 37 males and 29 females, median age 61 years (Range 37-85). Median values at presentation was Hb - 8g/dL, serum albumin 37 mg/dL and calcium 2.5 mmol/L. Bence Jones proteinuria was present in 50% (17/34), majority (78.8% -26/33) had IgG myeloma and 7 (21.2%) IgA. They had nephropathy 19% (4/21), osteolytic lesions 34.7% (17/49), pathological fractures 56.1% (23/41), anaemia 91.4% (53/58) and hypercalcaemia 42% (21/50). commonest presenting symptom was bone pain in 87.2% (48/55). There was significant correlation between hypercalcaemia and haematocrit (r=0.338, p=0.039) and platelet count (r= 0.331, p= 0.029). No relationship was found between hypercalcaemia and beta -2 microglobulin (r= 0.046, p= 0.0834) or serum immunoglobulin (r= -0.071, p= 0.745). Pathological fractures showed no significant association with haematocrit (r= -0.137, p= 0.453), platelet (r= -0.097, p= 0.642), beta -2 microglobulin (r= -0.037, p= 0.865) and serum immunoglobulin (r= -0.132, p= 0.545). Chi square value for the occurrence of renal Impairment and hypercalcaemia was found to be significant r= 8.048, p= 0.007 as well as pathological fractures (r=8.048, p=0.005). Conclusions: Myeloma is prevalent in males 1.5:1. Bone pain and anaemia are the commonest features at presentation. Bence Jones proteinuria is only seen in about half of the patients and lytic lesions in about a third. Pathological fractures, anaemia or hypercalcaemia at presentation, were not associated with tumor stage (β-2 microglobulin and albumin levels). Significant association exists between the occurrence of renal impairment and pathological fractures.
{"title":"Complications and Associations in a Multiple Myeloma Cohort at Presentation","authors":"A. Madu","doi":"10.23880/hij-16000213","DOIUrl":"https://doi.org/10.23880/hij-16000213","url":null,"abstract":"Background: Myelomatosis accounts for about 10% of haematological malignancies according to previous studies in different climes. The impact of some complications on treatment choice as well as survival outcomes is significant and worthy of study. Aims: To describe complications observed at presentation in this cohort of myeloma patients and to assess the associations of these complications with certain laboratory and clinical parameters. Results: There were 37 males and 29 females, median age 61 years (Range 37-85). Median values at presentation was Hb - 8g/dL, serum albumin 37 mg/dL and calcium 2.5 mmol/L. Bence Jones proteinuria was present in 50% (17/34), majority (78.8% -26/33) had IgG myeloma and 7 (21.2%) IgA. They had nephropathy 19% (4/21), osteolytic lesions 34.7% (17/49), pathological fractures 56.1% (23/41), anaemia 91.4% (53/58) and hypercalcaemia 42% (21/50). commonest presenting symptom was bone pain in 87.2% (48/55). There was significant correlation between hypercalcaemia and haematocrit (r=0.338, p=0.039) and platelet count (r= 0.331, p= 0.029). No relationship was found between hypercalcaemia and beta -2 microglobulin (r= 0.046, p= 0.0834) or serum immunoglobulin (r= -0.071, p= 0.745). Pathological fractures showed no significant association with haematocrit (r= -0.137, p= 0.453), platelet (r= -0.097, p= 0.642), beta -2 microglobulin (r= -0.037, p= 0.865) and serum immunoglobulin (r= -0.132, p= 0.545). Chi square value for the occurrence of renal Impairment and hypercalcaemia was found to be significant r= 8.048, p= 0.007 as well as pathological fractures (r=8.048, p=0.005). Conclusions: Myeloma is prevalent in males 1.5:1. Bone pain and anaemia are the commonest features at presentation. Bence Jones proteinuria is only seen in about half of the patients and lytic lesions in about a third. Pathological fractures, anaemia or hypercalcaemia at presentation, were not associated with tumor stage (β-2 microglobulin and albumin levels). Significant association exists between the occurrence of renal impairment and pathological fractures.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121763262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Malignant hematologic diseases may present with rare features. One of these is the first manifestation as a central airway lesion whose symptoms could be mistaken for asthma, chronic obstructive pulmonary disease, non-resolving or recurrent pneumonia, foreign body inhalation or both acute and chronic heart failure. The age of onset of the symptoms does not help in the differential diagnosis, leaving the clinician with a diagnostic dilemma, frequently clarified by invasive sampling. Current evidence of this group of entities is based predominantly on case reports. The aim of this work is to report a non-systematic review of haematological pathologies that can present themselves as an obstruction of the central airways, the possible ways in which it is possible to diagnose and treat them locally. Methodology: This revision work is the result of a critical analysis of the existing literature, carried out by collecting the main bibliographic entries in different languages present in international scientific databases relative to the topic of interest. All the arguments have been elaborated by the authors and critically re-proposed, in a non-systematic way (narrative revision).
{"title":"Central Airway Obstruction due to Hematologic Malignancies, Diagnosis and Local Treatment - A Narrative Review","authors":"F. A","doi":"10.23880/hij-16000176","DOIUrl":"https://doi.org/10.23880/hij-16000176","url":null,"abstract":"Background: Malignant hematologic diseases may present with rare features. One of these is the first manifestation as a central airway lesion whose symptoms could be mistaken for asthma, chronic obstructive pulmonary disease, non-resolving or recurrent pneumonia, foreign body inhalation or both acute and chronic heart failure. The age of onset of the symptoms does not help in the differential diagnosis, leaving the clinician with a diagnostic dilemma, frequently clarified by invasive sampling. Current evidence of this group of entities is based predominantly on case reports. The aim of this work is to report a non-systematic review of haematological pathologies that can present themselves as an obstruction of the central airways, the possible ways in which it is possible to diagnose and treat them locally. Methodology: This revision work is the result of a critical analysis of the existing literature, carried out by collecting the main bibliographic entries in different languages present in international scientific databases relative to the topic of interest. All the arguments have been elaborated by the authors and critically re-proposed, in a non-systematic way (narrative revision).","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130154040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Blood Donors Profile at the Blood Transfusion Regional Center Tulear, Madagascar","authors":"Andriamiarimbola Irène Rakotoniana","doi":"10.23880/hij-16000147","DOIUrl":"https://doi.org/10.23880/hij-16000147","url":null,"abstract":"","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121597663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Therapy with Plasma Growth Factors: Controversies of Key at Cellular Therapy","authors":"J. A. Rubio","doi":"10.23880/hij-16000140","DOIUrl":"https://doi.org/10.23880/hij-16000140","url":null,"abstract":"","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114766880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemorrhage in the Setting of Acute Severe Refractory Immune Thrombocytopenic Purpura: A Case Report","authors":"Emily Jane Bryer","doi":"10.23880/hij-16000143","DOIUrl":"https://doi.org/10.23880/hij-16000143","url":null,"abstract":"","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114910484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acute lymphoblastic leukemia is the most common leukemia in children, which is associated with a high relapse rate despite prevalent therapies. Ganoderic acid-A (GAA) is one of the bioactive compounds of Ganoderma lucidum, which possesses potential antileukemic properties. This study aimed to investigate the effect of the GAA extract on the expression of microRNA and the apoptosis induction in the BCP-ALL cell line. In this case-control study, NALM-6 Cells were treated with the GAA extract and L-asparaginase separately. The cell viability and apoptosis rates were examined using MTT and flow cytometry, respectively. Moreover, the effect of the GAA on the expression of miR-125b and miR-365a-3p, in comparison to L-asparaginase, was studied using RT-PCR. The GAA extract inhibited the cell growth in a dose- and time-dependent manner. Moreover, the GAA extract significantly induced apoptosis compared to L-asparaginase (P=0.0021 vs. P=0.0112). The results showed that the treatment of Nalm-6 cells with GAA significantly reduced the expression of miR-125b (P< 0.0001) and miR-365a-3p (P= 0.0001). Furthermore, it was demonstrated that the downregulation of miR-125b and miR-365a-3p was surprisingly higher in the GA-treated Nalm-6 cells than in L-asparaginase-treated Nalm-6 cells. According to the findings, the GAA extract has antileukemic effects and can be used as a promising agent with fewer side effects in all treatments.
{"title":"Apoptosis Induction of Ganoderic Acid-A by Downregulating miR- 125b and miR-365a-3p in Nalm-6 cells","authors":"T. G","doi":"10.23880/hij-16000201","DOIUrl":"https://doi.org/10.23880/hij-16000201","url":null,"abstract":"Acute lymphoblastic leukemia is the most common leukemia in children, which is associated with a high relapse rate despite prevalent therapies. Ganoderic acid-A (GAA) is one of the bioactive compounds of Ganoderma lucidum, which possesses potential antileukemic properties. This study aimed to investigate the effect of the GAA extract on the expression of microRNA and the apoptosis induction in the BCP-ALL cell line. In this case-control study, NALM-6 Cells were treated with the GAA extract and L-asparaginase separately. The cell viability and apoptosis rates were examined using MTT and flow cytometry, respectively. Moreover, the effect of the GAA on the expression of miR-125b and miR-365a-3p, in comparison to L-asparaginase, was studied using RT-PCR. The GAA extract inhibited the cell growth in a dose- and time-dependent manner. Moreover, the GAA extract significantly induced apoptosis compared to L-asparaginase (P=0.0021 vs. P=0.0112). The results showed that the treatment of Nalm-6 cells with GAA significantly reduced the expression of miR-125b (P< 0.0001) and miR-365a-3p (P= 0.0001). Furthermore, it was demonstrated that the downregulation of miR-125b and miR-365a-3p was surprisingly higher in the GA-treated Nalm-6 cells than in L-asparaginase-treated Nalm-6 cells. According to the findings, the GAA extract has antileukemic effects and can be used as a promising agent with fewer side effects in all treatments.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123482249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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