Evan’s syndrome is a rare and chronic autoimmune disease characterised by autoimmune hemolytic anemia and immune thrombocytopenic purpura with a positive Coomb’s test in the absence of an underlying etiology. Majority of the patients with this syndrome have a chronic relapsing course and significant morbidity and mortality despite treatment. We present a case of a 22 year old female, in which, based on the clinical features, Coombs test, hemolytic anemia and thrombocytopenia, a diagnosis of Evans syndrome was made.
{"title":"Evan’s Syndrome - A Case Report","authors":"B. N","doi":"10.23880/hij-16000174","DOIUrl":"https://doi.org/10.23880/hij-16000174","url":null,"abstract":"Evan’s syndrome is a rare and chronic autoimmune disease characterised by autoimmune hemolytic anemia and immune thrombocytopenic purpura with a positive Coomb’s test in the absence of an underlying etiology. Majority of the patients with this syndrome have a chronic relapsing course and significant morbidity and mortality despite treatment. We present a case of a 22 year old female, in which, based on the clinical features, Coombs test, hemolytic anemia and thrombocytopenia, a diagnosis of Evans syndrome was made.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134185062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several studies in Malaria endemic areas have reported conflicting observations on Blood Group ABO association with placental Malaria and pregnancy outcome. The purpose of this study is to determine the association between Placental Malaria and Blood Group O in the Munuki Primary Health Care Centre in South Sudan. Material and Methods: This was a prospective study. Each pregnant lady was enrolled after signing of informed consent and meeting study entry criteria. In all 589 pregnant women were evaluated. For each done were; ABO phenotype ones, at the enrolment and testing for malaria in and twice in the cause of pregnancy. Peripheral blood malaria parasites testing were by using RDT test to describe the type of plasmodium species. Results: The 589 enrolled were as follows; 154 (32.6%), 124 (26.3%) and 182 (38.6%) primigravidae, secundigravidae and multigravidae, respectively. The ABO distribution was; 124 (A), 59 (B), 14 (AB) and 257 (O). Negative peripheral Malaria parasites for pregnant women at ANC have higher positive Peripheral Malaria at DR with OR 2.93 CI (1.78__4.88) and ANC positive Malaria cases had higher chances of become positive during delivery OR 0.43 CI (0.30___0.62). Blood group O and peripheral malaria at DR with OR 1.17 CI (0.92___1.48) and Other Blood group at DR with OR 0.84 CI (0.67___1.06). Blood group O participants had higher P. Falciparum 60 /106 accounts for 56.6%. These results revealed significance interaction effect of Placental Malaria Parasites in Blood group O in Munuki Primary Health Center in Juba-South Sudan. This study recommends usage of protective measures against malaria during pregnancy.
{"title":"Blood Group ABO, Placental Malaria Parasitization and Pregnancy Outcome in Munuki Primary health Centre in South Sudan","authors":"Kueil Bg","doi":"10.23880/hij-16000199","DOIUrl":"https://doi.org/10.23880/hij-16000199","url":null,"abstract":"Several studies in Malaria endemic areas have reported conflicting observations on Blood Group ABO association with placental Malaria and pregnancy outcome. The purpose of this study is to determine the association between Placental Malaria and Blood Group O in the Munuki Primary Health Care Centre in South Sudan. Material and Methods: This was a prospective study. Each pregnant lady was enrolled after signing of informed consent and meeting study entry criteria. In all 589 pregnant women were evaluated. For each done were; ABO phenotype ones, at the enrolment and testing for malaria in and twice in the cause of pregnancy. Peripheral blood malaria parasites testing were by using RDT test to describe the type of plasmodium species. Results: The 589 enrolled were as follows; 154 (32.6%), 124 (26.3%) and 182 (38.6%) primigravidae, secundigravidae and multigravidae, respectively. The ABO distribution was; 124 (A), 59 (B), 14 (AB) and 257 (O). Negative peripheral Malaria parasites for pregnant women at ANC have higher positive Peripheral Malaria at DR with OR 2.93 CI (1.78__4.88) and ANC positive Malaria cases had higher chances of become positive during delivery OR 0.43 CI (0.30___0.62). Blood group O and peripheral malaria at DR with OR 1.17 CI (0.92___1.48) and Other Blood group at DR with OR 0.84 CI (0.67___1.06). Blood group O participants had higher P. Falciparum 60 /106 accounts for 56.6%. These results revealed significance interaction effect of Placental Malaria Parasites in Blood group O in Munuki Primary Health Center in Juba-South Sudan. This study recommends usage of protective measures against malaria during pregnancy.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"295 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132716447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The International Society on Thrombosis and Haemostasis (ISTH) published guidelines for the diagnosis and treatment on Vaccine-Induced Thrombotic Thrombocytopenia (VITT) in April of 2021. Guidelines were inclusive of those persons at risk for VITT, screening, initial evaluation, and treatment. A study was conducted to evaluate case reports of patients with VITT in regard to diagnostic testing and treatment options as recommended by the ISTH. Ten case reports were identified employing the PubMed database where VITT was diagnosed in patients who received the Astra Zeneca vaccine. The average fibrinogen level was 166.9 mg/dL, the average platelet count was 47.2 x 10 9 /L, and the average D-Dimer level was 39.3 mg/L. All cases of VITT exhibited a positive anti-PF4 assay. Anticoagulants administered to patients varied across cases however all patients received IVIG to increase platelet counts in patients. A one sample t test was performed to ascertain if statistical significance was present comparing average fibrinogen, platelet count, and D-Dimer levels to normal values. Statistical significance was found with platelet count and D- Dimer parameters. Organizations like the ISTH has provided timely therapeutic information and guidance to clinicians in combating SARS-CoV2 related clinical manifestations. These findings serve to illuminate the nexus between ISTH VITT guidelines and clinical adaptation.
{"title":"Adaptation of ISTH Guidelines on Vaccine Induced Thrombocytopenic Thrombosis to Clinical Practice and Analysis of Patient Cases","authors":"H. V","doi":"10.23880/hij-16000197","DOIUrl":"https://doi.org/10.23880/hij-16000197","url":null,"abstract":"The International Society on Thrombosis and Haemostasis (ISTH) published guidelines for the diagnosis and treatment on Vaccine-Induced Thrombotic Thrombocytopenia (VITT) in April of 2021. Guidelines were inclusive of those persons at risk for VITT, screening, initial evaluation, and treatment. A study was conducted to evaluate case reports of patients with VITT in regard to diagnostic testing and treatment options as recommended by the ISTH. Ten case reports were identified employing the PubMed database where VITT was diagnosed in patients who received the Astra Zeneca vaccine. The average fibrinogen level was 166.9 mg/dL, the average platelet count was 47.2 x 10 9 /L, and the average D-Dimer level was 39.3 mg/L. All cases of VITT exhibited a positive anti-PF4 assay. Anticoagulants administered to patients varied across cases however all patients received IVIG to increase platelet counts in patients. A one sample t test was performed to ascertain if statistical significance was present comparing average fibrinogen, platelet count, and D-Dimer levels to normal values. Statistical significance was found with platelet count and D- Dimer parameters. Organizations like the ISTH has provided timely therapeutic information and guidance to clinicians in combating SARS-CoV2 related clinical manifestations. These findings serve to illuminate the nexus between ISTH VITT guidelines and clinical adaptation.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130956548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Compound Heterozygous Sickle Cell and Beta Thalessemia Trait with High Hb F: A Rare Case from India","authors":"Mayank Jain","doi":"10.23880/hij-16000160","DOIUrl":"https://doi.org/10.23880/hij-16000160","url":null,"abstract":"","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133501619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of Red Cell Alloantibodies in Pregnant Women","authors":"Smita Mahapatra","doi":"10.23880/hij-16000154","DOIUrl":"https://doi.org/10.23880/hij-16000154","url":null,"abstract":"","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133510897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of Platelet Refractoriness in a Tertiary Care Hospital","authors":"D. Sahoo","doi":"10.23880/hij-16000158","DOIUrl":"https://doi.org/10.23880/hij-16000158","url":null,"abstract":"","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125393250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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