Thalassemia is the most common single gene disorder in the world found at high frequencies in many populations worldwide. Beta thalassemia presents with extremely diverse phenotypes within the homozygous and compound heterozygote states. The term “ β -thalassemia intermedia” (TI) was first suggested to describe patients who had clinical manifestations that are not as mild as β -thalassemia minor and not as severe as β -thalassemia major” (TM). Patients with TI usually present to medical attention in later childhood or even adulthood. Diagnosis of thalassemia intermedia relies on clinical presentation more than the molecular characterization. In this study clinical features of the patients having thalassemia intermedia were observed. The study was carried out on 100 known thalassemic intermedia patients. All of the patients were diagnosed clinically and confirmed with molecular analysis. The clinical features observed age at the time of examination, age at the start of transfusion, interval between transfusion, facial changes, spleen and liver. Presence of jaundice in the patients was also noted. The ages of the patients were between 2 to 34 years. The age at commencement of transfusion was between 1 year to 32 years. 21 patients had severe facial changes, 48 with mild facial changes while 31 had no facial changes. Only 6 patients had enlarged spleen. Six of the patients had their spleen removed. 5 patients showed up with significant jaundice and 38 patients had enlarged liver. Patients presented with broad spectrum of clinical features. Majority of the patient had mild changes in liver and spleen, having mild facial changes and less sever jaundice. While others represented with sever hemolysis , enlarged spleen and liver accompanied with significant facial changes and yellow coloration of skin representing jaundice. Thus it is difficult a draw a definite line between thalassemia intermedia and thalassemia major. A careful observation of physical presentation and molecular analysis support is required to claim the diagnosis of thalassemia intermedia
{"title":"Diversity of Clinical Features of Patients with Thalassemia Intermedia","authors":"A. S","doi":"10.23880/hij-16000169","DOIUrl":"https://doi.org/10.23880/hij-16000169","url":null,"abstract":"Thalassemia is the most common single gene disorder in the world found at high frequencies in many populations worldwide. Beta thalassemia presents with extremely diverse phenotypes within the homozygous and compound heterozygote states. The term “ β -thalassemia intermedia” (TI) was first suggested to describe patients who had clinical manifestations that are not as mild as β -thalassemia minor and not as severe as β -thalassemia major” (TM). Patients with TI usually present to medical attention in later childhood or even adulthood. Diagnosis of thalassemia intermedia relies on clinical presentation more than the molecular characterization. In this study clinical features of the patients having thalassemia intermedia were observed. The study was carried out on 100 known thalassemic intermedia patients. All of the patients were diagnosed clinically and confirmed with molecular analysis. The clinical features observed age at the time of examination, age at the start of transfusion, interval between transfusion, facial changes, spleen and liver. Presence of jaundice in the patients was also noted. The ages of the patients were between 2 to 34 years. The age at commencement of transfusion was between 1 year to 32 years. 21 patients had severe facial changes, 48 with mild facial changes while 31 had no facial changes. Only 6 patients had enlarged spleen. Six of the patients had their spleen removed. 5 patients showed up with significant jaundice and 38 patients had enlarged liver. Patients presented with broad spectrum of clinical features. Majority of the patient had mild changes in liver and spleen, having mild facial changes and less sever jaundice. While others represented with sever hemolysis , enlarged spleen and liver accompanied with significant facial changes and yellow coloration of skin representing jaundice. Thus it is difficult a draw a definite line between thalassemia intermedia and thalassemia major. A careful observation of physical presentation and molecular analysis support is required to claim the diagnosis of thalassemia intermedia","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127734787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aseptic necrosis is a commonly discerned degenerative condition of the bone characteristically constituted of deteriorated cellular components. Generally, the condition arises secondary to discontinuity of subchondral vascular effusion. The disorder is additionally designated as avascular necrosis, osteonecrosis or ischemic bone necrosis and no bone is exempt. Specific sites incriminated are the tibial tuberosity as encountered in Osgood-Schlatter’s disease or proximal femoral epiphysis as denominated in Legg-Calve’-Perthes disease.
{"title":"The Cadaverous Carnage- Aseptic Bone Necrosis","authors":"B. A","doi":"10.23880/hij-16000182","DOIUrl":"https://doi.org/10.23880/hij-16000182","url":null,"abstract":"Aseptic necrosis is a commonly discerned degenerative condition of the bone characteristically constituted of deteriorated cellular components. Generally, the condition arises secondary to discontinuity of subchondral vascular effusion. The disorder is additionally designated as avascular necrosis, osteonecrosis or ischemic bone necrosis and no bone is exempt. Specific sites incriminated are the tibial tuberosity as encountered in Osgood-Schlatter’s disease or proximal femoral epiphysis as denominated in Legg-Calve’-Perthes disease.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"1 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122315875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The assessment of haematological parameters is very necessary because, they are important proxy indicators useful in the assessment of immune status, therapeutic purposes and monitoring of disease progression and treatment outcome for proper patient management. This study was aimed at determining some haematological parameters in apparently healthy elderly persons living in Sokoto, Nigeria. This was a cross-sectional study involving a total of 105 apparently healthy elderly persons living in Sokoto. Elderly persons aged 60years and above were recruited for the study. Full blood counts (FBC) were determined using five part haematological analyser by Mindray, Germany. Data were analysed using Statistical Package of Social Sciences (SPSS) version 25. Haematological parameters showed distinct differences with some local reference ranges. This study found out that the values of WBC, Lymphocyte, Neutrophil, Eosinophil, Monocyte, RDW-CV, Platelet Count, MPV, PDW and Plateletcrit were within the normal range in according to reference ranges used in Sokoto. While the values of RBC, HCT, MCHC, MCH and MCV were lower based on reference values used in Sokoto. However, RDW-CV was raised. There were statistical significant increases in mean values of Hb, HCT and MCV among male than females in Sokoto metropolis (p<0.05). There was statistical significant increases in mean values of PLT count among females than males in (p<0.05). There were statistical differences in mean values of Neutrophil, RBC, HCT, PLT and PCT among different age groups in Sokoto metropolis (p<0.05). There were statistical differences in mean values of WBC, Lymphocyte, Neutrophil, Eosinophil, RDW-CV, PLT, PDW and PCT among different groups of BMI in Sokoto metropolis (p<0.05). It was observed that monocyte increased significantly with BMI from normal weight to obesity (p<0.05). In conclusion, this study established a baseline data for FBC in elderly in Sokoto. Some of the parameters under study vary with local reference range. Elderly have lower haemoglobin and HCT. There is age, gender and BMI variation in the parameters studied. There is need to establish a different reference ranges for elderly in a given location for proper understanding and management of elderly population in our society.
{"title":"Some Haematological Parameters of the Elderly in Sokoto, Nigeria","authors":"Amilo Gi","doi":"10.23880/hij-16000185","DOIUrl":"https://doi.org/10.23880/hij-16000185","url":null,"abstract":"The assessment of haematological parameters is very necessary because, they are important proxy indicators useful in the assessment of immune status, therapeutic purposes and monitoring of disease progression and treatment outcome for proper patient management. This study was aimed at determining some haematological parameters in apparently healthy elderly persons living in Sokoto, Nigeria. This was a cross-sectional study involving a total of 105 apparently healthy elderly persons living in Sokoto. Elderly persons aged 60years and above were recruited for the study. Full blood counts (FBC) were determined using five part haematological analyser by Mindray, Germany. Data were analysed using Statistical Package of Social Sciences (SPSS) version 25. Haematological parameters showed distinct differences with some local reference ranges. This study found out that the values of WBC, Lymphocyte, Neutrophil, Eosinophil, Monocyte, RDW-CV, Platelet Count, MPV, PDW and Plateletcrit were within the normal range in according to reference ranges used in Sokoto. While the values of RBC, HCT, MCHC, MCH and MCV were lower based on reference values used in Sokoto. However, RDW-CV was raised. There were statistical significant increases in mean values of Hb, HCT and MCV among male than females in Sokoto metropolis (p<0.05). There was statistical significant increases in mean values of PLT count among females than males in (p<0.05). There were statistical differences in mean values of Neutrophil, RBC, HCT, PLT and PCT among different age groups in Sokoto metropolis (p<0.05). There were statistical differences in mean values of WBC, Lymphocyte, Neutrophil, Eosinophil, RDW-CV, PLT, PDW and PCT among different groups of BMI in Sokoto metropolis (p<0.05). It was observed that monocyte increased significantly with BMI from normal weight to obesity (p<0.05). In conclusion, this study established a baseline data for FBC in elderly in Sokoto. Some of the parameters under study vary with local reference range. Elderly have lower haemoglobin and HCT. There is age, gender and BMI variation in the parameters studied. There is need to establish a different reference ranges for elderly in a given location for proper understanding and management of elderly population in our society.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133735977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To identify some common chromosomal mutation in patients with Multiple myeloma (MM) at Bach Mai hospital, from June 2016 to June 2021. Methods: We reviewed the cytogenetic results from 363 patients who were diagnosed with MM by IMWG diagnostic criteria 2014 at Bach Mai hospital. Results: Chromosomal abnormalities were detected in 35,3% (128/363) of the patients. Among these results, 128 cases (82,8%) had both numerical and structural chromosome abnormalities. Hyperdiploidy with structural cytogenetic aberrations was the most common finding (42,19%), followed by hypodiploidy with structural aberrations (23,44%). Amplification of the long arm of chromosome 1, loss 13/ del(13q) and abnormality involving 14q32 were the most frequent abnormalities which were observed in 39,84%, 24,2% and 21,9%. The most common numerical abnormalities were gains of chromosomes 9 with 28,57%.
{"title":"Abnormal Chromosome in Patients with Multiple Myeloma: A Cohor Study in Vietnam","authors":"Tung Nguyen Tuan","doi":"10.23880/hij-16000212","DOIUrl":"https://doi.org/10.23880/hij-16000212","url":null,"abstract":"Objective: To identify some common chromosomal mutation in patients with Multiple myeloma (MM) at Bach Mai hospital, from June 2016 to June 2021. Methods: We reviewed the cytogenetic results from 363 patients who were diagnosed with MM by IMWG diagnostic criteria 2014 at Bach Mai hospital. Results: Chromosomal abnormalities were detected in 35,3% (128/363) of the patients. Among these results, 128 cases (82,8%) had both numerical and structural chromosome abnormalities. Hyperdiploidy with structural cytogenetic aberrations was the most common finding (42,19%), followed by hypodiploidy with structural aberrations (23,44%). Amplification of the long arm of chromosome 1, loss 13/ del(13q) and abnormality involving 14q32 were the most frequent abnormalities which were observed in 39,84%, 24,2% and 21,9%. The most common numerical abnormalities were gains of chromosomes 9 with 28,57%.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134298241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In COVID-19 transitory and reversible perturbation of myelopoeisis and granulopoiesis is disordered. Characteristic changes on peripheral blood smear can help in diagnosis, may be in prognosis and treatment protocols. Decrease in lymphocyte count and increase in the neutrophilic lymphocytic ratio (NLR ratio) are the obvious abnormalities detected. Coronovirus mainly affects lungs as most of the ACE-2 receptors are present in lung. Corona has S spikes which helps in attaching it to the ACE -2 Receptor mainly affecting the type II pneumocytes causing capillary leakage and alveolar edema leading to breathing difficulty. COVID-19 is a global pandemic more research is required for prognostication, treatment and diagnostic protocols as disease was an unknown entity before its occurrence.
{"title":"Haematological Profile in COVID-19 Infection","authors":"D. S.","doi":"10.23880/hij-16000173","DOIUrl":"https://doi.org/10.23880/hij-16000173","url":null,"abstract":"In COVID-19 transitory and reversible perturbation of myelopoeisis and granulopoiesis is disordered. Characteristic changes on peripheral blood smear can help in diagnosis, may be in prognosis and treatment protocols. Decrease in lymphocyte count and increase in the neutrophilic lymphocytic ratio (NLR ratio) are the obvious abnormalities detected. Coronovirus mainly affects lungs as most of the ACE-2 receptors are present in lung. Corona has S spikes which helps in attaching it to the ACE -2 Receptor mainly affecting the type II pneumocytes causing capillary leakage and alveolar edema leading to breathing difficulty. COVID-19 is a global pandemic more research is required for prognostication, treatment and diagnostic protocols as disease was an unknown entity before its occurrence.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134404839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Procalcitonin Elevation without Sepsis: Can it be a Tumor Marker? A Case Report and Literature Review","authors":"O. Keskin","doi":"10.23880/hij-16000141","DOIUrl":"https://doi.org/10.23880/hij-16000141","url":null,"abstract":"","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"516 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133234423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transfusion Medicine has come a long way and has for long been regarded a Cinderella in medicine and medical science. Since the discovery around 1900 by Karl Landsteiner [1] of the ABO blood groups as principle elements for compatibility, the science has been dominated by the laboratory research for immunohematology, microbiology and virology, focused on the test tube and not so much the patient. Over the 20st century several development eras are to be recognized that contributed to the maturation of transfusion medicine as a bridging science. Twenty Nobel laureates contributed to this development.
{"title":"Where do we Position Transfusion Medicine in the Family of Sciences?","authors":"C. S. Sibinga","doi":"10.23880/hij-16000137","DOIUrl":"https://doi.org/10.23880/hij-16000137","url":null,"abstract":"Transfusion Medicine has come a long way and has for long been regarded a Cinderella in medicine and medical science. Since the discovery around 1900 by Karl Landsteiner [1] of the ABO blood groups as principle elements for compatibility, the science has been dominated by the laboratory research for immunohematology, microbiology and virology, focused on the test tube and not so much the patient. Over the 20st century several development eras are to be recognized that contributed to the maturation of transfusion medicine as a bridging science. Twenty Nobel laureates contributed to this development.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132356088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Long non-coding RNAs are non-coding RNAs, which contribute to different biological processes. The expression of these RNAs alters in various diseases. This study aimed to compare the expression of long non-coding RNA genes in newly diagnosed patients with de novo acute myeloid leukemia and to evaluate their response to cytarabine-based treatment. In this cross-sectional study, approved by the Ethics Committee of Shiraz University of Medical Sciences (Shiraz, Iran), the expression of LOC285758, IRAIN, and HOTAIR was examined in de novo AML patients at Namazi Teaching Hospital during 2019-2020. The patients, treated with standard regimens, were compared with the controls, using quantitative real time- polymerase chain reaction assay. After whole blood samples were collected from the subjects, total RNA was extracted by Trizol reagent from whole blood. Next, cDNA was synthesized, and the expression levels of LOC285758, HOTAIR, and IRAIN were analyzed by RT-PCR assay, using SYBER Green Master Mix and 2 -ΔΔCt method. The results showed that the expression of LOC285758 was significantly upregulated in AML patients, compared to the controls (P< 0.001). After complete remission, the expression of LOC285758 was re-evaluated in patients. It was found that LOC285758 was significantly downregulated in de novo AML patients (P=0.001). The expression of HOTAIR, similar to IRAIN, did not change in de novo AML patients, whereas it was downregulated in patients with complete remission, compared to the controls. The present findings indicated that LOC285758 could discriminate AML patients from the healthy controls and indicate the patients’ response to treatment.
长链非编码rna是非编码rna，参与不同的生物过程。这些rna的表达在各种疾病中发生变化。本研究旨在比较新诊断的急性髓系白血病患者长链非编码RNA基因的表达，并评估他们对阿糖胞苷治疗的反应。在这项横断面研究中，由设拉子医学科学大学(设拉子，伊朗)伦理委员会批准，在Namazi教学医院2019-2020年期间检测了LOC285758、IRAIN和HOTAIR在新发AML患者中的表达。采用标准方案治疗的患者与对照组进行实时定量聚合酶链反应测定。采集全血标本后，用Trizol试剂从全血中提取总RNA。下一步，合成cDNA，采用SYBER Green Master Mix和2 -ΔΔCt方法，RT-PCR检测LOC285758、HOTAIR和IRAIN的表达水平。结果显示，与对照组相比，AML患者中LOC285758的表达显著上调(P< 0.001)。完全缓解后，在患者中重新评估LOC285758的表达。发现LOC285758在新发AML患者中显著下调(P=0.001)。HOTAIR的表达与IRAIN相似，在新发AML患者中没有变化，而在完全缓解的患者中，与对照组相比，HOTAIR的表达下调。本研究结果表明，LOC285758可以区分AML患者和健康对照，并指示患者对治疗的反应。
{"title":"Changes in Loc285758 Expression in Response to Cytarabine- Based Treatment in Patients with Acute Myeloid Leukemia","authors":"T. G","doi":"10.23880/hij-16000200","DOIUrl":"https://doi.org/10.23880/hij-16000200","url":null,"abstract":"Long non-coding RNAs are non-coding RNAs, which contribute to different biological processes. The expression of these RNAs alters in various diseases. This study aimed to compare the expression of long non-coding RNA genes in newly diagnosed patients with de novo acute myeloid leukemia and to evaluate their response to cytarabine-based treatment. In this cross-sectional study, approved by the Ethics Committee of Shiraz University of Medical Sciences (Shiraz, Iran), the expression of LOC285758, IRAIN, and HOTAIR was examined in de novo AML patients at Namazi Teaching Hospital during 2019-2020. The patients, treated with standard regimens, were compared with the controls, using quantitative real time- polymerase chain reaction assay. After whole blood samples were collected from the subjects, total RNA was extracted by Trizol reagent from whole blood. Next, cDNA was synthesized, and the expression levels of LOC285758, HOTAIR, and IRAIN were analyzed by RT-PCR assay, using SYBER Green Master Mix and 2 -ΔΔCt method. The results showed that the expression of LOC285758 was significantly upregulated in AML patients, compared to the controls (P< 0.001). After complete remission, the expression of LOC285758 was re-evaluated in patients. It was found that LOC285758 was significantly downregulated in de novo AML patients (P=0.001). The expression of HOTAIR, similar to IRAIN, did not change in de novo AML patients, whereas it was downregulated in patients with complete remission, compared to the controls. The present findings indicated that LOC285758 could discriminate AML patients from the healthy controls and indicate the patients’ response to treatment.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115217474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transfusion reactions are the untoward event towards blood products. Although majority of transfusion reactions are uneventful sometimes it may have life threatening events. This study was conducted to estimate the incidence and determine the nature of blood transfusion reactions in our hospital. It also aims to find practices which could prevention such reactions. All the Adverse transfusion reactions were investigated in detail in the blood bank for the clerical errors, immunohematology workup and classified according to their nature. A total of 38308 units of components were issued to various departments in the hospital. Total 61 transfusion reactions were reported to the blood bank following transfusion of components only (0.16%). The most common type of transfusion reaction among all the ATRs was febrile nonhemolytic transfusion reaction (44%), followed by allergic (39%). Fever and chills, rigors were the most common symptom. Other reactions were dyspnoea, rashes and tachycardia. Avoiding unnecessary transfusion, red cell modification like leukofitration for FNHTR, red cell washing for allergic reactions and anaphylactoid reactions and implementing Patient Blood Management are tools to decrease transfusion reactions.
{"title":"Incidence of Adverse Transfusion Reaction and Practices for its Prevention","authors":"Sahoo D","doi":"10.23880/hij-16000183","DOIUrl":"https://doi.org/10.23880/hij-16000183","url":null,"abstract":"Transfusion reactions are the untoward event towards blood products. Although majority of transfusion reactions are uneventful sometimes it may have life threatening events. This study was conducted to estimate the incidence and determine the nature of blood transfusion reactions in our hospital. It also aims to find practices which could prevention such reactions. All the Adverse transfusion reactions were investigated in detail in the blood bank for the clerical errors, immunohematology workup and classified according to their nature. A total of 38308 units of components were issued to various departments in the hospital. Total 61 transfusion reactions were reported to the blood bank following transfusion of components only (0.16%). The most common type of transfusion reaction among all the ATRs was febrile nonhemolytic transfusion reaction (44%), followed by allergic (39%). Fever and chills, rigors were the most common symptom. Other reactions were dyspnoea, rashes and tachycardia. Avoiding unnecessary transfusion, red cell modification like leukofitration for FNHTR, red cell washing for allergic reactions and anaphylactoid reactions and implementing Patient Blood Management are tools to decrease transfusion reactions.","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121275967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serial Assessment of Biochemical Parameters of Red Cell in the Blood Unit Segments Kept At 4","authors":"Deva Japa Ajith","doi":"10.23880/hij-16000149","DOIUrl":"https://doi.org/10.23880/hij-16000149","url":null,"abstract":"","PeriodicalId":245976,"journal":{"name":"Haematology International Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126409314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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