Pub Date : 2022-04-29DOI: 10.29235/1818-9857-2022-3-77-83
K. Seńko, A. Fedulov
The article analyzes the clinical, laboratory and neuroimaging predictors of a three-month functional outcome of systemic thrombolytic therapy in patients with cerebral infarction is presented. Recently, techniques for the diagnosis and treatment of cerebral infarction have been actively developed, which has led to a decrease in mortality and a significant improvement in the functional outcome in some patients. The therapeutic response to ongoing therapy cannot be accurately predicted prior to its initiation, which makes it difficult to make the right decision regarding treatment tactics. The main focus is on the search and evaluation of the degree of determination in the outcome of thrombolytic therapy of the most significant predictors, as well as their mutual potentiation. Identification of factors associated with an unfavorable outcome of systemic thrombolysis can contribute to a safer, more effective and more widespread use of this treatment method in the shortest possible time.
{"title":"Three-month functional outcome predictors of systemic thrombolytic therapy in cerebral infarction","authors":"K. Seńko, A. Fedulov","doi":"10.29235/1818-9857-2022-3-77-83","DOIUrl":"https://doi.org/10.29235/1818-9857-2022-3-77-83","url":null,"abstract":"The article analyzes the clinical, laboratory and neuroimaging predictors of a three-month functional outcome of systemic thrombolytic therapy in patients with cerebral infarction is presented. Recently, techniques for the diagnosis and treatment of cerebral infarction have been actively developed, which has led to a decrease in mortality and a significant improvement in the functional outcome in some patients. The therapeutic response to ongoing therapy cannot be accurately predicted prior to its initiation, which makes it difficult to make the right decision regarding treatment tactics. The main focus is on the search and evaluation of the degree of determination in the outcome of thrombolytic therapy of the most significant predictors, as well as their mutual potentiation. Identification of factors associated with an unfavorable outcome of systemic thrombolysis can contribute to a safer, more effective and more widespread use of this treatment method in the shortest possible time.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"161 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115747661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-29DOI: 10.29235/1818-9857-2022-3-71-76
L. Rubanik, N. Poleshchuk
The problems of diagnosis and significance of the Chlamydia-like bacterium Waddlia chondrophila in the development of human reproductive disorders are highlighted. In-house PCR aimed to detection the 16S rRNA gene fragment of the pathogen was tested. A pilot study was carried out that allowed to detect positive cases in the group of women with miscarriage (2/49, 4.08%). The attention of biomedical specialists is focused on the need for cooperation of efforts in order to develop and implement approaches to the indication and identification of this emerging microorganism, to expand knowledge about its prevalence and etiopathogenetic mechanisms of pathological conditions caused by it.
{"title":"A new pathogen Waddlia chondrophila: the relevance of detection and study","authors":"L. Rubanik, N. Poleshchuk","doi":"10.29235/1818-9857-2022-3-71-76","DOIUrl":"https://doi.org/10.29235/1818-9857-2022-3-71-76","url":null,"abstract":"The problems of diagnosis and significance of the Chlamydia-like bacterium Waddlia chondrophila in the development of human reproductive disorders are highlighted. In-house PCR aimed to detection the 16S rRNA gene fragment of the pathogen was tested. A pilot study was carried out that allowed to detect positive cases in the group of women with miscarriage (2/49, 4.08%). The attention of biomedical specialists is focused on the need for cooperation of efforts in order to develop and implement approaches to the indication and identification of this emerging microorganism, to expand knowledge about its prevalence and etiopathogenetic mechanisms of pathological conditions caused by it.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131804298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-29DOI: 10.29235/1818-9857-2022-3-66-70
V. Padutov
The data of the is presented. The technology allows to identify the entire spectrum of organisms in an experimental sample per one cycle, while separate study for each potentially contained component previously was required. An integrated approach is submitted as a method for early diagnosis of causative agents of the main fungal diseases during of silver birch (Betula pendula Roth) and downy birch (Betula pubescens Ehrh.) plants. It based on an estimation of the size of internal transcribed spacers (ITS1 and ITS2) in the 18S-5.8S-28S rDNA gene cluster. Identification of the dominant fungi species phytopathogenic for birch under in planta conditions is possible because of the the specificity of size of the rDNA operon internal transcribed spacers, which is constant for most micromycete species, as well as the possibility of electrophoretic analysis of the ITS1 and ITS2 loci.
{"title":"Metagenomic analysis of fungal phytopathogens in birch planting material","authors":"V. Padutov","doi":"10.29235/1818-9857-2022-3-66-70","DOIUrl":"https://doi.org/10.29235/1818-9857-2022-3-66-70","url":null,"abstract":"The data of the is presented. The technology allows to identify the entire spectrum of organisms in an experimental sample per one cycle, while separate study for each potentially contained component previously was required. An integrated approach is submitted as a method for early diagnosis of causative agents of the main fungal diseases during of silver birch (Betula pendula Roth) and downy birch (Betula pubescens Ehrh.) plants. It based on an estimation of the size of internal transcribed spacers (ITS1 and ITS2) in the 18S-5.8S-28S rDNA gene cluster. Identification of the dominant fungi species phytopathogenic for birch under in planta conditions is possible because of the the specificity of size of the rDNA operon internal transcribed spacers, which is constant for most micromycete species, as well as the possibility of electrophoretic analysis of the ITS1 and ITS2 loci.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132102233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-27DOI: 10.29235/1818-9857-2022-1-50-55
C. Gospodarik, M. Kovalev
The article analyzes the current state of the economies of the EAEU member countries and proposes a new innovative development scenario until 2030. The results of the implementation of the proposed scenario are predicted using a built hybrid model of economic growth.
{"title":"The EAEU unified innovation space as a foundation of sustainable economic growth","authors":"C. Gospodarik, M. Kovalev","doi":"10.29235/1818-9857-2022-1-50-55","DOIUrl":"https://doi.org/10.29235/1818-9857-2022-1-50-55","url":null,"abstract":"The article analyzes the current state of the economies of the EAEU member countries and proposes a new innovative development scenario until 2030. The results of the implementation of the proposed scenario are predicted using a built hybrid model of economic growth.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128531023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-20DOI: 10.29235/1818-9857-2022-4-79-83
E. Gusakovskaya, N. Maksimovich
The article presents the results of research to study the course of experimental peritonitis in rats under administration of non-selective NO-synthase inhibitor, Nώ-nitro-L-arginine methyl ester (L-NAME). It has been shown that administration of L-NAME results in increase in the severity of in-toxication, reaction of leukocytes of blood and peritoneal exudate with inhibi-tion of phagocytic activity of neutrophils, enhance of oxidative stress, damage to the endothelium of blood vessels and peritoneum.
{"title":"The L-NAME effects in acute experimental peritonitis","authors":"E. Gusakovskaya, N. Maksimovich","doi":"10.29235/1818-9857-2022-4-79-83","DOIUrl":"https://doi.org/10.29235/1818-9857-2022-4-79-83","url":null,"abstract":"The article presents the results of research to study the course of experimental peritonitis in rats under administration of non-selective NO-synthase inhibitor, Nώ-nitro-L-arginine methyl ester (L-NAME). It has been shown that administration of L-NAME results in increase in the severity of in-toxication, reaction of leukocytes of blood and peritoneal exudate with inhibi-tion of phagocytic activity of neutrophils, enhance of oxidative stress, damage to the endothelium of blood vessels and peritoneum. ","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129650916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-20DOI: 10.29235/1818-9857-2022-4-52-58
Y. Nechepurenko
As part of the implementation of the state policy in the field of innovation, the system of intellectual property management in the National Academy of Sciences of Belarus is described. It allowed subordinate organizations to become one of the leaders in our country in terms of creating inventions, utility models, plant varieties and know-how, as well as licensing industrial property in the territory of the Republic of Belarus and the Russian Federation. The main directions for further improvement of work in the field of intellectual property in the Academy of Sciences are determined.
{"title":"Intellectual property management system in the NAS of Belarus","authors":"Y. Nechepurenko","doi":"10.29235/1818-9857-2022-4-52-58","DOIUrl":"https://doi.org/10.29235/1818-9857-2022-4-52-58","url":null,"abstract":"As part of the implementation of the state policy in the field of innovation, the system of intellectual property management in the National Academy of Sciences of Belarus is described. It allowed subordinate organizations to become one of the leaders in our country in terms of creating inventions, utility models, plant varieties and know-how, as well as licensing industrial property in the territory of the Republic of Belarus and the Russian Federation. The main directions for further improvement of work in the field of intellectual property in the Academy of Sciences are determined. ","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"1032 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127427237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-20DOI: 10.29235/1818-9857-2022-4-26-31
V. Kalesnikovich
The article presents an approach aimed at combining descriptive information about the "project object" on a common platform, focused on effective information support for research, environmental and nature conservation tasks. The aim of the study is to reduce the negative consequences of recreational loads by increasing the recreational stability of territories by creating "project objects".
{"title":"Analysis of the natural resource complex «Ruzhanskaya pushcha»","authors":"V. Kalesnikovich","doi":"10.29235/1818-9857-2022-4-26-31","DOIUrl":"https://doi.org/10.29235/1818-9857-2022-4-26-31","url":null,"abstract":"The article presents an approach aimed at combining descriptive information about the \"project object\" on a common platform, focused on effective information support for research, environmental and nature conservation tasks. The aim of the study is to reduce the negative consequences of recreational loads by increasing the recreational stability of territories by creating \"project objects\". ","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131465950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-20DOI: 10.29235/1818-9857-2022-4-71-78
A. Goncharov
The review presents the basic information about the method of imaging flow cytometry and the main differences from traditional flow cytometry and fluorescence microscopy. The principles of the method, the design of instruments, the process of data collection and analysis are described in detail. The fields of application of the method and its possibilities in the analysis of cells, microorganisms and microparticles are described.
{"title":"Imaging flow cytometry for life sciences","authors":"A. Goncharov","doi":"10.29235/1818-9857-2022-4-71-78","DOIUrl":"https://doi.org/10.29235/1818-9857-2022-4-71-78","url":null,"abstract":"The review presents the basic information about the method of imaging flow cytometry and the main differences from traditional flow cytometry and fluorescence microscopy. The principles of the method, the design of instruments, the process of data collection and analysis are described in detail. The fields of application of the method and its possibilities in the analysis of cells, microorganisms and microparticles are described. ","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133561481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-20DOI: 10.29235/1818-9857-2022-4-45-49
A. Aksenevich
During the analysis of the key legal act regulating distribution channels abroad, namely Resolution №183, it was revealed that the specified indicators need to be adjusted and clarified, since do not fully take into account generally accepted methodological approaches to assessing effectiveness and are focused more on quantitative rather than qualitative aspects. Also, given the active participation of the state in the regulation of foreign entities of enterprises’ distribution network, it is important to analyze state regulation influence on exporters’ foreign trade activities. This necessitates the development of a methodological approach that would allow for a comprehensive analysis of the channels for selling products to foreign markets in order to determine an effective export strategy by business entities.
{"title":"Key performance indicators of foreign entities of commodity distribution networks","authors":"A. Aksenevich","doi":"10.29235/1818-9857-2022-4-45-49","DOIUrl":"https://doi.org/10.29235/1818-9857-2022-4-45-49","url":null,"abstract":"During the analysis of the key legal act regulating distribution channels abroad, namely Resolution №183, it was revealed that the specified indicators need to be adjusted and clarified, since do not fully take into account generally accepted methodological approaches to assessing effectiveness and are focused more on quantitative rather than qualitative aspects. Also, given the active participation of the state in the regulation of foreign entities of enterprises’ distribution network, it is important to analyze state regulation influence on exporters’ foreign trade activities. This necessitates the development of a methodological approach that would allow for a comprehensive analysis of the channels for selling products to foreign markets in order to determine an effective export strategy by business entities. ","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128168100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-01DOI: 10.29235/1818-9857-2022-2-24-35
Daria Bobrukevich, N. Antonevich, A. Hancharou, E. Rynda, O. Timokhina, Y. Minich, E. Golovach, M. Dotsenko, E. Dotsenko
The advanced analysis of immune parameters describing differentiation profile, activation and exhaustion of lymphocytes, monocytes and granulocytes of patients with moderate and severe/critical COVID-19 pneumonia was performed.
{"title":"Characteristics of the immunity system in patients with pneumonia associated with COVID-19","authors":"Daria Bobrukevich, N. Antonevich, A. Hancharou, E. Rynda, O. Timokhina, Y. Minich, E. Golovach, M. Dotsenko, E. Dotsenko","doi":"10.29235/1818-9857-2022-2-24-35","DOIUrl":"https://doi.org/10.29235/1818-9857-2022-2-24-35","url":null,"abstract":"The advanced analysis of immune parameters describing differentiation profile, activation and exhaustion of lymphocytes, monocytes and granulocytes of patients with moderate and severe/critical COVID-19 pneumonia was performed.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133004773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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