Pub Date : 2023-08-22DOI: 10.21608/smj.2023.225427.1401
Usama M. Abdelaal, A. Ali, A. Osman, Mohamed M. Malak
{"title":"Elevated liver enzymes as a predictor of acute kidney injury in hospitalized patients with COVID-19","authors":"Usama M. Abdelaal, A. Ali, A. Osman, Mohamed M. Malak","doi":"10.21608/smj.2023.225427.1401","DOIUrl":"https://doi.org/10.21608/smj.2023.225427.1401","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126522788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-21DOI: 10.21608/smj.2023.226275.1400
Usama M. Abdelaal, Heba allah Abd El-rahman, lotfy abo-dahab, M. Elbadry
Background: It is well known that acid-base imbalances and low serum bicarbonate are linked to increased illness severity. Aim: To examine the prognostic significance of information obtained from arterial blood gas (ABG)-related parameters and serum electrolytes at the time of hospital admission on adverse clinical outcomes, the length of LOS, and other factors. Methods: A total of 357 candidate individuals with liver cirrhosis were screened for enrollment in this prospective study. 329 patients agreed to participate who had evidence of liver cirrhosis or presented with signs and symptoms suggesting decompensated liver cirrhosis. Individuals with diabetes ketoacidosis, acute coronary syndrome, fulminant liver failure, preexisting end-stage renal disease, or chronic obstructive pulmonary disease (a total of 208) weren't involved in the research. Then, 121 patients who were hospitalized in the Internal Medicine department or treated in ICU with a confirmed diagnosis of decompensated cirrhosis (age ≥ 18 years) were prospectively recruited and monitored throughout the research period. Results: This research involved 121 cases with a confirmed diagnosis of cirrhosis. Regarding the PH, normal PH were 76 (62.8%) patients, acidemia 22 (18.2%), alkalemia 23 (18.2). There were 73 (60.4%) patients were child C score at time of admission. The mean MELD score was 19.26± 9.01. The mean MELD-PaCO2-HCO3 was 23.79 ± 7.45 while the mean MELD-bicarbonate was 16.35±7.22 . As a regimen of management, serum electrolyte acid base correction was used in 33 (27.3%) cases, while endoscopy or band ligation was performed in 40 (33.1%) cases. Medication for Na and K correction were used in 6 (5%) and 17 (14%) cases respectively. Vasopressors were used in 12 (9.9%) cases who were admitted to the ICU. None of the cases underwent renal replacement therapy. Conclusion: The high incidence of metabolic acidosis and the frequency of organ failures are strong predictors of death in critically ill individuals with cirrhosis, leading to a poor prognosis and a high mortality rate.
{"title":"Impact of Serum levels of Bicarbonate and Electrolytes on Adverse Clinical Outcomes in Cirrhotics","authors":"Usama M. Abdelaal, Heba allah Abd El-rahman, lotfy abo-dahab, M. Elbadry","doi":"10.21608/smj.2023.226275.1400","DOIUrl":"https://doi.org/10.21608/smj.2023.226275.1400","url":null,"abstract":"Background: It is well known that acid-base imbalances and low serum bicarbonate are linked to increased illness severity. Aim: To examine the prognostic significance of information obtained from arterial blood gas (ABG)-related parameters and serum electrolytes at the time of hospital admission on adverse clinical outcomes, the length of LOS, and other factors. Methods: A total of 357 candidate individuals with liver cirrhosis were screened for enrollment in this prospective study. 329 patients agreed to participate who had evidence of liver cirrhosis or presented with signs and symptoms suggesting decompensated liver cirrhosis. Individuals with diabetes ketoacidosis, acute coronary syndrome, fulminant liver failure, preexisting end-stage renal disease, or chronic obstructive pulmonary disease (a total of 208) weren't involved in the research. Then, 121 patients who were hospitalized in the Internal Medicine department or treated in ICU with a confirmed diagnosis of decompensated cirrhosis (age ≥ 18 years) were prospectively recruited and monitored throughout the research period. Results: This research involved 121 cases with a confirmed diagnosis of cirrhosis. Regarding the PH, normal PH were 76 (62.8%) patients, acidemia 22 (18.2%), alkalemia 23 (18.2). There were 73 (60.4%) patients were child C score at time of admission. The mean MELD score was 19.26± 9.01. The mean MELD-PaCO2-HCO3 was 23.79 ± 7.45 while the mean MELD-bicarbonate was 16.35±7.22 . As a regimen of management, serum electrolyte acid base correction was used in 33 (27.3%) cases, while endoscopy or band ligation was performed in 40 (33.1%) cases. Medication for Na and K correction were used in 6 (5%) and 17 (14%) cases respectively. Vasopressors were used in 12 (9.9%) cases who were admitted to the ICU. None of the cases underwent renal replacement therapy. Conclusion: The high incidence of metabolic acidosis and the frequency of organ failures are strong predictors of death in critically ill individuals with cirrhosis, leading to a poor prognosis and a high mortality rate.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127297737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.21608/smj.2023.223456.1397
Asmaa Hassan, Nagwa Abd Mohamed, A. Abdelhamid, H. Ahmed, Nasreen Abdelhaliem
{"title":"Management and interplay of Type 2 Diabetes Mellitus with obesity","authors":"Asmaa Hassan, Nagwa Abd Mohamed, A. Abdelhamid, H. Ahmed, Nasreen Abdelhaliem","doi":"10.21608/smj.2023.223456.1397","DOIUrl":"https://doi.org/10.21608/smj.2023.223456.1397","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130102559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-11DOI: 10.21608/smj.2023.213662.1395
R. Abdelatif, M. Mohamed, R. Mahmoud, Mohamed A. Bakheet
{"title":"Pediatric critical care services in resource-limited settings; a current state and approaches to improvement.","authors":"R. Abdelatif, M. Mohamed, R. Mahmoud, Mohamed A. Bakheet","doi":"10.21608/smj.2023.213662.1395","DOIUrl":"https://doi.org/10.21608/smj.2023.213662.1395","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134577841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-08DOI: 10.21608/smj.2023.206040.1383
M. Mohamed, R. Abdelatif, Mohamed A. Bakheet, R. Mahmoud
: Introduction: Severity of illness (SOI) scores have been developed to predict the outcome and to provide a better quality of care with available resources. Objective of the study : was to evaluate the predictive ability of pediatric index of mortality-2 (PIM-2), pediatric index of mortality-3(PIM-3) and pediatric risk of mortality IV (PRISM IV) in a resource-limited pediatric intensive care unit (PICU). Materials and methods : We conducted a prospective cohort study in PICU in Sohag University Hospital in the period from March 2018 to June 2020. We recorded the baseline patient characteristics, admission diagnoses, variables of PIM-2, PIM-3 and PRISM IV models and outcomes of children admitted to the PICU. We utilized area under receiver operating characteristics (AU-ROC) curves and Goodness-of-fit (GOF) test to evaluate the discrimination and calibration of the three models. Results: Of 451 patients enrolled, 171 (37.9%) died. Sepsis was the major admission diagnosis. The discrimination was acceptable for PRISM IV, while it was poor for both PIM-2 and PIM-3 as indicated by the AU-ROC which was (0.74; 95%CI: 0.62- 0.86 for PRISM IV) vs (0.69; 95% CI: 0.58- 0.81 for PIM-2) and (0.69; 95% CI: 0.57-0.81for PIM-3) ( p < 0.0001). The calibration was poor for all scores as the p -value of GOF test for was < 0.0001 for all scores. Conclusion: The discrimination of PRISM IV was acceptable and the best among the three models. All scores had poor calibration and under-predict mortality in our setting. We suggest utilizing them as quality indicators rather than in mortality prediction.
{"title":"Performance of pediatric index of mortality-2, pediatric index of mortality-3 and pediatric risk of mortality IV in an Egyptian pediatric intensive care unit.","authors":"M. Mohamed, R. Abdelatif, Mohamed A. Bakheet, R. Mahmoud","doi":"10.21608/smj.2023.206040.1383","DOIUrl":"https://doi.org/10.21608/smj.2023.206040.1383","url":null,"abstract":": Introduction: Severity of illness (SOI) scores have been developed to predict the outcome and to provide a better quality of care with available resources. Objective of the study : was to evaluate the predictive ability of pediatric index of mortality-2 (PIM-2), pediatric index of mortality-3(PIM-3) and pediatric risk of mortality IV (PRISM IV) in a resource-limited pediatric intensive care unit (PICU). Materials and methods : We conducted a prospective cohort study in PICU in Sohag University Hospital in the period from March 2018 to June 2020. We recorded the baseline patient characteristics, admission diagnoses, variables of PIM-2, PIM-3 and PRISM IV models and outcomes of children admitted to the PICU. We utilized area under receiver operating characteristics (AU-ROC) curves and Goodness-of-fit (GOF) test to evaluate the discrimination and calibration of the three models. Results: Of 451 patients enrolled, 171 (37.9%) died. Sepsis was the major admission diagnosis. The discrimination was acceptable for PRISM IV, while it was poor for both PIM-2 and PIM-3 as indicated by the AU-ROC which was (0.74; 95%CI: 0.62- 0.86 for PRISM IV) vs (0.69; 95% CI: 0.58- 0.81 for PIM-2) and (0.69; 95% CI: 0.57-0.81for PIM-3) ( p < 0.0001). The calibration was poor for all scores as the p -value of GOF test for was < 0.0001 for all scores. Conclusion: The discrimination of PRISM IV was acceptable and the best among the three models. All scores had poor calibration and under-predict mortality in our setting. We suggest utilizing them as quality indicators rather than in mortality prediction.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124621882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.21608/smj.2023.211392.1392
S. Ali, H. Shehata, Hesham Hefney, M. Ezzat
{"title":"Study of Interleukin-17 and Fc Gamma Receptor in SLE Patients and Its Relation to Disease Activity and Clinical Presentation","authors":"S. Ali, H. Shehata, Hesham Hefney, M. Ezzat","doi":"10.21608/smj.2023.211392.1392","DOIUrl":"https://doi.org/10.21608/smj.2023.211392.1392","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132063219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-21DOI: 10.21608/smj.2023.202649.1377
yasmein Aly
{"title":"The promising role of different imaging diagnostic modalities for percutaneous transcatheter device closure of secundum atrial septal defect in pediatrics in sohag university hospital","authors":"yasmein Aly","doi":"10.21608/smj.2023.202649.1377","DOIUrl":"https://doi.org/10.21608/smj.2023.202649.1377","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122935371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-17DOI: 10.21608/smj.2023.206496.1390
Mohamed Eid, Mahmoud B. Ahmed, Y. Kamal, A. Kassem
{"title":"Study of Pulmonary Hypertension in Patients with Primary Myelofibrosis in Sohag University Hospital","authors":"Mohamed Eid, Mahmoud B. Ahmed, Y. Kamal, A. Kassem","doi":"10.21608/smj.2023.206496.1390","DOIUrl":"https://doi.org/10.21608/smj.2023.206496.1390","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134279775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-16DOI: 10.21608/smj.2023.210990.1391
M. Eid, Mahmoud B. Ahmed, Y. Kamal, A. Kassem
{"title":"Pathophysiology of Pulmonary Hypertension in Patients with Myeloproliferative Neoplasms","authors":"M. Eid, Mahmoud B. Ahmed, Y. Kamal, A. Kassem","doi":"10.21608/smj.2023.210990.1391","DOIUrl":"https://doi.org/10.21608/smj.2023.210990.1391","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117328161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-15DOI: 10.21608/smj.2023.199323.1376
S. Hammam
{"title":"Antibody drug conjugate ,historical and future overview","authors":"S. Hammam","doi":"10.21608/smj.2023.199323.1376","DOIUrl":"https://doi.org/10.21608/smj.2023.199323.1376","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122924899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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