Pub Date : 2024-01-01DOI: 10.21608/smj.2023.225197.1403
B. Atta, Mohamed Abdel Aal, S. Mahmoud
Background: Heart rate monitoring is usually used in pediatric early warning scores; primary bradycardia may cause high morbidity and rarely sudden cardiac death. Objective: Good assessment of primary bradycardia in children to allow proper management of critically ill child to prevent sudden death. Patients and methods: The study was prepared in Pediatric Arrhythmia Clinic, Emergency room department and outpatient clinic from March 2020 to August 2021. Children aged from 1day to 14 years presenting with 1ry bradycardia were enrolled in our study. Pre-death bradycardia was excluded. Full medical history, physical examination, basic investigations, 12 leads ECG and echocardiography were done to all included patients in this study. Holter monitoring was done while indicated. Results: 30 patients were included in the study. Heart rate ranged from 46 to 90 beat/minute with mean 67.44 bpm. 50 % of them had Syncopal attacks and another 50 % was diagnosed during routine examination. ASD detected in 20% of them, 20% had CHB; the remaining 60% were Idiopathic. Sinus bradycardia was present in 18 children, CHB was present in 6 patients while 1 st and 2 nd degree AV block were presenting in 6 children. Conclusion: Primary bradycardia in children needs early, good assessment and well management to decrease the need of acute intervention and preventing sudden death.
{"title":"Primary bradycardia in children at Sohag University hospital: A single center experience","authors":"B. Atta, Mohamed Abdel Aal, S. Mahmoud","doi":"10.21608/smj.2023.225197.1403","DOIUrl":"https://doi.org/10.21608/smj.2023.225197.1403","url":null,"abstract":"Background: Heart rate monitoring is usually used in pediatric early warning scores; primary bradycardia may cause high morbidity and rarely sudden cardiac death. Objective: Good assessment of primary bradycardia in children to allow proper management of critically ill child to prevent sudden death. Patients and methods: The study was prepared in Pediatric Arrhythmia Clinic, Emergency room department and outpatient clinic from March 2020 to August 2021. Children aged from 1day to 14 years presenting with 1ry bradycardia were enrolled in our study. Pre-death bradycardia was excluded. Full medical history, physical examination, basic investigations, 12 leads ECG and echocardiography were done to all included patients in this study. Holter monitoring was done while indicated. Results: 30 patients were included in the study. Heart rate ranged from 46 to 90 beat/minute with mean 67.44 bpm. 50 % of them had Syncopal attacks and another 50 % was diagnosed during routine examination. ASD detected in 20% of them, 20% had CHB; the remaining 60% were Idiopathic. Sinus bradycardia was present in 18 children, CHB was present in 6 patients while 1 st and 2 nd degree AV block were presenting in 6 children. Conclusion: Primary bradycardia in children needs early, good assessment and well management to decrease the need of acute intervention and preventing sudden death.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"125 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139128424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.21608/smj.2023.238315.1416
Hassan Elnady
. Abstract The model of the physician who uses research to try to solve the mystery of the disease has existed throughout the ages, starting from the era of Hippocrates, through the Middle Ages, and up to the present day. The terms "physician-scientist," "clinical-scientist," and "clinician-scientist" have all been used to refer to medical practitioner who works in a position between clinical practice and research. Due to their knowledge of both science and medicine, physician-scientists are able to pose clinically pertinent research questions and integrate scientific inquiry into patient care. They provide a distinct viewpoint to biomedical research. Basic science principles are a prerequisite for physician-scientists. Translational medicine is a two-way concept that includes both bench-to-bedside factors, which work to improve the speed at which new therapeutic strategies developed through basic research are tested in clinical settings, and bedside-to-bench factors, which offer feedback on how new treatments are being used and how they can be made better. The institutional divide between the clinic and the lab is where physician-scientists are expected to stand, with one foot in each. They serve as a bridge between the two different worlds, where differences in language and training can make communication challenging. Physician-scientists act as catalysts for translational research. Physician-scientists collaborations enhance patient care, advance medical education, and improve the biomedical industry's profitability.
{"title":"The Central Role of the Physician-Scientist in Translational Medicine. An Overview.","authors":"Hassan Elnady","doi":"10.21608/smj.2023.238315.1416","DOIUrl":"https://doi.org/10.21608/smj.2023.238315.1416","url":null,"abstract":". Abstract The model of the physician who uses research to try to solve the mystery of the disease has existed throughout the ages, starting from the era of Hippocrates, through the Middle Ages, and up to the present day. The terms \"physician-scientist,\" \"clinical-scientist,\" and \"clinician-scientist\" have all been used to refer to medical practitioner who works in a position between clinical practice and research. Due to their knowledge of both science and medicine, physician-scientists are able to pose clinically pertinent research questions and integrate scientific inquiry into patient care. They provide a distinct viewpoint to biomedical research. Basic science principles are a prerequisite for physician-scientists. Translational medicine is a two-way concept that includes both bench-to-bedside factors, which work to improve the speed at which new therapeutic strategies developed through basic research are tested in clinical settings, and bedside-to-bench factors, which offer feedback on how new treatments are being used and how they can be made better. The institutional divide between the clinic and the lab is where physician-scientists are expected to stand, with one foot in each. They serve as a bridge between the two different worlds, where differences in language and training can make communication challenging. Physician-scientists act as catalysts for translational research. Physician-scientists collaborations enhance patient care, advance medical education, and improve the biomedical industry's profitability.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139127462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.21608/smj.2023.238926.1417
E. Fadel, Hanaa EL hady, Amal Ahmed, M. Tolba
Background and Aim: Human toxoplasmosis is caused by the ubiquitous intracellular apicomplexan pathogen, Toxoplasma gondii (T. gondii) . It has been acclaimed as the most successful parasite ever, infecting up to one-third of the global population. The objective of this study was to evaluate the seroprevalence of T. gondii in individuals with different types of malignancies in comparison to a control group of healthy individuals. Patients and Methods: A case-control study was conducted from March 2022 to June 2023. Sera of 50 patients with different cancer types and 50 healthy individuals were analyzed for Toxoplasma gondii IgG and IgM using indirect ELISA. Results : A total of 100 individuals were evaluated, and it was found that 67 of them (67%) tested positive for Toxoplasma IgG antibodies. Seroprevalence was significantly higher (p=0.016) in cancer patients (64%) than in controls. Moreover, 15% were positive for Toxoplasma IgM. Notably, the prevalence was found to be greater among cancer patients compared to the control group, with (18% vs 12%), respectively. Patients with hematological malignancies exhibited a slightly greater rate of IgG seropositivity compared to those with solid organ tumors (85% and 77% respectively). A similar trend of Toxoplasma IgM, with a prevalence of 25% in hematological malignancies and 9.1% in solid organ tumors. Conclusion : T. gondii infection was shown to be substantially more common in cancer patients. Seropositive patients are at a high risk for reactivation, whereas seronegative patients are at risk for infection. Our research shows that toxoplasmosis screening must be promoted in these settings.
{"title":"Current Trend of Toxoplasmosis in Cancer Patients, Sohag University Hospitals, Sohag, Egypt","authors":"E. Fadel, Hanaa EL hady, Amal Ahmed, M. Tolba","doi":"10.21608/smj.2023.238926.1417","DOIUrl":"https://doi.org/10.21608/smj.2023.238926.1417","url":null,"abstract":"Background and Aim: Human toxoplasmosis is caused by the ubiquitous intracellular apicomplexan pathogen, Toxoplasma gondii (T. gondii) . It has been acclaimed as the most successful parasite ever, infecting up to one-third of the global population. The objective of this study was to evaluate the seroprevalence of T. gondii in individuals with different types of malignancies in comparison to a control group of healthy individuals. Patients and Methods: A case-control study was conducted from March 2022 to June 2023. Sera of 50 patients with different cancer types and 50 healthy individuals were analyzed for Toxoplasma gondii IgG and IgM using indirect ELISA. Results : A total of 100 individuals were evaluated, and it was found that 67 of them (67%) tested positive for Toxoplasma IgG antibodies. Seroprevalence was significantly higher (p=0.016) in cancer patients (64%) than in controls. Moreover, 15% were positive for Toxoplasma IgM. Notably, the prevalence was found to be greater among cancer patients compared to the control group, with (18% vs 12%), respectively. Patients with hematological malignancies exhibited a slightly greater rate of IgG seropositivity compared to those with solid organ tumors (85% and 77% respectively). A similar trend of Toxoplasma IgM, with a prevalence of 25% in hematological malignancies and 9.1% in solid organ tumors. Conclusion : T. gondii infection was shown to be substantially more common in cancer patients. Seropositive patients are at a high risk for reactivation, whereas seronegative patients are at risk for infection. Our research shows that toxoplasmosis screening must be promoted in these settings.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"143 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139128316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-19DOI: 10.21608/smj.2023.247638.1428
Marwa Mohamed, Doaa Gamal, Hanan Metwally Assaf
: Background: Patients with vitiligo may be more susceptible to cardiovascular disease, atherosclerosis, metabolic syndrome, and other disorders since it is seen as a systemic disorder rather than a skin condition. Patients and methods: 44 non-segmental vitiligo patients and 41 healthy controls participated in this study. Vitiligo Area Scoring Index (VASI) Score was used in patient evaluation to determine the severity of vitiligo. With vitiligo patients, the Reynolds Risk Score (RRS) was used to assess cardiovascular risk. Serum levels of glycosylated hemoglobin (HbA1c), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), high sensitivity C-reactive protein (hs-CRP), and neutrophil gelatinase-associated lipocalin (NGAL) were measured for each participant using biochemical analyses. Results: In this study we found that Cases of vitiligo had higher median RRs score (1 (0.2-13.6) than control (0.9 (0.2-3) but this was statistically insignificant. Also, there was significant (p=0.008) association between disease status and RRs categories i.e., all control group had low risk of cardiac disease while 80% of vitiligo patients group had low risk, about 13% had medium risk and 7% had high risk. Vitiligo cases had insignificantly (p = 0.136) lower median serum NGAL level (246 (104 - 775 ng/ml) compared with control (276 (122 - 783 ng/ml) but this was within normal range of this marker (10ng/ml→3000ng/ml). Non-significant minimal positive correlation between serum NGAL level and RRs score was found (r=0.086, p=0.287). Conclusion: Vitiligo patients are more susceptible for cardiovascular diseases and assessment of serum NGAL level had no role in early detection of these disorders.
{"title":"Assessment of Serum Neutrophil Gelatinase-associated Lipocalin in early detection of cardiovascular risk in patients with Vitiligo","authors":"Marwa Mohamed, Doaa Gamal, Hanan Metwally Assaf","doi":"10.21608/smj.2023.247638.1428","DOIUrl":"https://doi.org/10.21608/smj.2023.247638.1428","url":null,"abstract":": Background: Patients with vitiligo may be more susceptible to cardiovascular disease, atherosclerosis, metabolic syndrome, and other disorders since it is seen as a systemic disorder rather than a skin condition. Patients and methods: 44 non-segmental vitiligo patients and 41 healthy controls participated in this study. Vitiligo Area Scoring Index (VASI) Score was used in patient evaluation to determine the severity of vitiligo. With vitiligo patients, the Reynolds Risk Score (RRS) was used to assess cardiovascular risk. Serum levels of glycosylated hemoglobin (HbA1c), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), high sensitivity C-reactive protein (hs-CRP), and neutrophil gelatinase-associated lipocalin (NGAL) were measured for each participant using biochemical analyses. Results: In this study we found that Cases of vitiligo had higher median RRs score (1 (0.2-13.6) than control (0.9 (0.2-3) but this was statistically insignificant. Also, there was significant (p=0.008) association between disease status and RRs categories i.e., all control group had low risk of cardiac disease while 80% of vitiligo patients group had low risk, about 13% had medium risk and 7% had high risk. Vitiligo cases had insignificantly (p = 0.136) lower median serum NGAL level (246 (104 - 775 ng/ml) compared with control (276 (122 - 783 ng/ml) but this was within normal range of this marker (10ng/ml→3000ng/ml). Non-significant minimal positive correlation between serum NGAL level and RRs score was found (r=0.086, p=0.287). Conclusion: Vitiligo patients are more susceptible for cardiovascular diseases and assessment of serum NGAL level had no role in early detection of these disorders.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"57 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139171819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-17DOI: 10.21608/smj.2023.246235.1426
sara mahmoud ali, Adham Salah El-din Mohamed Saro
{"title":"Importance of peripapillary retinal nerve fiber layer, Ganglion cell complex and visual field severity indices in primary open angle glaucoma","authors":"sara mahmoud ali, Adham Salah El-din Mohamed Saro","doi":"10.21608/smj.2023.246235.1426","DOIUrl":"https://doi.org/10.21608/smj.2023.246235.1426","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"403 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139176805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/smj.2023.196963.1374
Esraa Abo El-Hassan, Asmaa Thabet, M. Fattouh, U. Arafa
: The 1989-discovered hepatitis virus type C (HCV) is a single-stranded RNA (of 9.6 kb) genome coding for about 3010 amino acid types. HCV infection is a significant health burden. Most often (55–85%), acute HCV infection progresses to chronic disease. Little RNAs called micro-RNAs (miRNAs) are part of nearly every developmental or disease process, and in immunological and inflammatory responses as they control messenger RNA (mRNA) translation and mRNA stability. The aberrant regulation of miRNA is significantly linked to the occurrence and progression of numerous diseases. MicroRNA-122 or ―MiR-122‖, is a miRNA exclusive to liver. According to several studies, genome stability, translation, and even replication of HCV have all been linked to it.
{"title":"MicroRNA-122: A Key Factor in Chronic HCV infection","authors":"Esraa Abo El-Hassan, Asmaa Thabet, M. Fattouh, U. Arafa","doi":"10.21608/smj.2023.196963.1374","DOIUrl":"https://doi.org/10.21608/smj.2023.196963.1374","url":null,"abstract":": The 1989-discovered hepatitis virus type C (HCV) is a single-stranded RNA (of 9.6 kb) genome coding for about 3010 amino acid types. HCV infection is a significant health burden. Most often (55–85%), acute HCV infection progresses to chronic disease. Little RNAs called micro-RNAs (miRNAs) are part of nearly every developmental or disease process, and in immunological and inflammatory responses as they control messenger RNA (mRNA) translation and mRNA stability. The aberrant regulation of miRNA is significantly linked to the occurrence and progression of numerous diseases. MicroRNA-122 or ―MiR-122‖, is a miRNA exclusive to liver. According to several studies, genome stability, translation, and even replication of HCV have all been linked to it.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125112034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/smj.2023.213644.1394
E. Fadel, Hanaa Ahmed El Hady, Aml Ahmed, M. Tolba
{"title":"Toxoplasma and Cancer: Friends or Faux? Uncorking the Paradox","authors":"E. Fadel, Hanaa Ahmed El Hady, Aml Ahmed, M. Tolba","doi":"10.21608/smj.2023.213644.1394","DOIUrl":"https://doi.org/10.21608/smj.2023.213644.1394","url":null,"abstract":"","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"No. 67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127954107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/smj.2023.218719.1396
Hazem Elmoghazy, M. Wasel, A. Hammady, M. Mostafa
Purpose : The one-stage repair offers the benefit of utilizing skin that prior surgical operations have not damaged, has an intact blood supply and requires fewer hospitalization days, but it also depends on the surgeon's "expertise" and the family's preferences. Two-stage surgery is frequently preferred in severe primary proximal hypospadias or revision hypospadias. This study aimed to compare the surgical and functional outcomes of one-stage vs. two-stage hypospadias chordal repair. Methods : We conducted a comparative, non-randomized, prospective study on 60 patients with hypospadias with any degree of marked chordae. Patients were allocated to receive either one-stage or two-stage repair using onlay grafts and flaps. All patients were followed for one year postoperatively. The repair was completed six months later using the standard Thiersch–Duplay technique in those with a two-stage repair. Results : Thirty patients were managed in a two-stage procedure (28 with onlay preputial flap and two with buccal mucosal graft), while the remaining 30 patients were managed with a single-stage hypospadias repair with preputial skin flap (tabularized or onlay). The blood loss and operative time were significantly higher in the two-stage procedure group (p <0.05). The success rate of surgery in the one-stage group was 80%, while the two-stage group had a success rate of 83%, indicating a statistically insignificant difference between the two groups. The postoperative complication rate was 20% and 17% in the one-stage and two-stage groups, respectively. Conclusion : The one-stage correction is an effective surgical procedure for treating this condition, with short operative time and less blood loss without the need for a second stage.
{"title":"One stage versus two stage repair of hypospadias with marked chordae: a non randomized comparative study.","authors":"Hazem Elmoghazy, M. Wasel, A. Hammady, M. Mostafa","doi":"10.21608/smj.2023.218719.1396","DOIUrl":"https://doi.org/10.21608/smj.2023.218719.1396","url":null,"abstract":"Purpose : The one-stage repair offers the benefit of utilizing skin that prior surgical operations have not damaged, has an intact blood supply and requires fewer hospitalization days, but it also depends on the surgeon's \"expertise\" and the family's preferences. Two-stage surgery is frequently preferred in severe primary proximal hypospadias or revision hypospadias. This study aimed to compare the surgical and functional outcomes of one-stage vs. two-stage hypospadias chordal repair. Methods : We conducted a comparative, non-randomized, prospective study on 60 patients with hypospadias with any degree of marked chordae. Patients were allocated to receive either one-stage or two-stage repair using onlay grafts and flaps. All patients were followed for one year postoperatively. The repair was completed six months later using the standard Thiersch–Duplay technique in those with a two-stage repair. Results : Thirty patients were managed in a two-stage procedure (28 with onlay preputial flap and two with buccal mucosal graft), while the remaining 30 patients were managed with a single-stage hypospadias repair with preputial skin flap (tabularized or onlay). The blood loss and operative time were significantly higher in the two-stage procedure group (p <0.05). The success rate of surgery in the one-stage group was 80%, while the two-stage group had a success rate of 83%, indicating a statistically insignificant difference between the two groups. The postoperative complication rate was 20% and 17% in the one-stage and two-stage groups, respectively. Conclusion : The one-stage correction is an effective surgical procedure for treating this condition, with short operative time and less blood loss without the need for a second stage.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"431 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132298781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21608/smj.2023.213198.1393
A. Aggag, S. Saied, K. Allam, R. Hossameldin
: Background: Temporomandibular disorder (TMD) is a description of temporomandibular joint (TMJ) dysfunction and pain with variable degrees of severity, aim of our study is to evaluate the prevalence of TMD among Sohag University medical students. Methods: An online Google form questionnaire of two parts was used for the collection and evaluation of demographic data in the first part and Fonseca’s Anamnestic ten questions in the second part, the link to the questionnaire was sent to students through social media including WhatsApp, Facebook, Telegram groups. A sample of 1130 medical students, including all academic grades with ages ranging from 17 to 32 years responded to the link. Fonseca’s Anamnestic Index (FAI) and its questionnaire were used for the evaluation of the prevalence and degree of severity of TMD. Results: The interpretation of the resulting data showed that a total of 746 students (66%) had TMD of which 422 (56.6%) were females and 324 (43.4%) were males. The FAI was used to classify participants according to severity, the results were categorized as follows; 384 (34%) with no TMD, 508 (45%) with mild degree, 198(17.5%) moderate degree, 40 (3.5%) severe degree of TMD. Females were generally more affected than males. There was a statistically significant difference between categories of TMD across gender. Conclusion: TMD has a high prevalence among asymptomatic medical students, with the mild TMD category representing the highest prevalence among volunteers. Prevalence among females was significantly higher than for males. Our results were consistent with similar studies in the literature.
{"title":"Prevalence and Severity of Temporomandibular Joint Disorders Among Sohag University Medical Students: A Questionnaire Study","authors":"A. Aggag, S. Saied, K. Allam, R. Hossameldin","doi":"10.21608/smj.2023.213198.1393","DOIUrl":"https://doi.org/10.21608/smj.2023.213198.1393","url":null,"abstract":": Background: Temporomandibular disorder (TMD) is a description of temporomandibular joint (TMJ) dysfunction and pain with variable degrees of severity, aim of our study is to evaluate the prevalence of TMD among Sohag University medical students. Methods: An online Google form questionnaire of two parts was used for the collection and evaluation of demographic data in the first part and Fonseca’s Anamnestic ten questions in the second part, the link to the questionnaire was sent to students through social media including WhatsApp, Facebook, Telegram groups. A sample of 1130 medical students, including all academic grades with ages ranging from 17 to 32 years responded to the link. Fonseca’s Anamnestic Index (FAI) and its questionnaire were used for the evaluation of the prevalence and degree of severity of TMD. Results: The interpretation of the resulting data showed that a total of 746 students (66%) had TMD of which 422 (56.6%) were females and 324 (43.4%) were males. The FAI was used to classify participants according to severity, the results were categorized as follows; 384 (34%) with no TMD, 508 (45%) with mild degree, 198(17.5%) moderate degree, 40 (3.5%) severe degree of TMD. Females were generally more affected than males. There was a statistically significant difference between categories of TMD across gender. Conclusion: TMD has a high prevalence among asymptomatic medical students, with the mild TMD category representing the highest prevalence among volunteers. Prevalence among females was significantly higher than for males. Our results were consistent with similar studies in the literature.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126735339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-23DOI: 10.21608/smj.2023.226952.1402
S. Mohammed, Tamer H. M. Soliman, Ahmed Mahmoud, Osama Sedeek
Objective: The research attempted to assess the susceptibility of TRAIL polymorphism (rs1131580) in T2DM and its relationship with metabolic parameters in T2DM. Patients and Methods: This study was performed on 80 subjects, 60 T2DM patients and age & sex matched 20 healthy volunteers as controls, The patients had complete clinical examination and detailed history collection, and detection of TRAIL single nucleotide polymorphism rs1131580 by PCR-RFLP standing for polymerase chain reaction-restriction fragment length polymorphism.. Results: TRAIL SNP rs1131580 mutation was greatly more common in the group of diabetics. Conclusion: A homozygous variant allele (CC) genotype of the TRAIL SNP rs1131580 carries a 1.5-fold risk of DM. Also, having the C allele elevated the risk of T2DM by 1.7 times.
目的:探讨TRAIL多态性(rs1131580)在T2DM中的易感性及其与T2DM代谢参数的关系。患者和方法:本研究选取80例受试者，60例T2DM患者和年龄性别匹配的20例健康志愿者作为对照，对患者进行了完整的临床检查和详细的病史收集，采用PCR-RFLP (polymerase chain反应限制性片段长度多态性)检测TRAIL单核苷酸多态性rs1131580。结果:TRAIL SNP rs1131580突变在糖尿病患者中更为常见。结论:TRAIL SNP rs1131580的纯合子变异等位基因(CC)携带1.5倍的糖尿病风险，同时携带C等位基因使2型糖尿病风险增加1.7倍。
{"title":"TRAIL Single Nucleotide Polymorphism in Type 2 Egyptian Diabetic Patients","authors":"S. Mohammed, Tamer H. M. Soliman, Ahmed Mahmoud, Osama Sedeek","doi":"10.21608/smj.2023.226952.1402","DOIUrl":"https://doi.org/10.21608/smj.2023.226952.1402","url":null,"abstract":"Objective: The research attempted to assess the susceptibility of TRAIL polymorphism (rs1131580) in T2DM and its relationship with metabolic parameters in T2DM. Patients and Methods: This study was performed on 80 subjects, 60 T2DM patients and age & sex matched 20 healthy volunteers as controls, The patients had complete clinical examination and detailed history collection, and detection of TRAIL single nucleotide polymorphism rs1131580 by PCR-RFLP standing for polymerase chain reaction-restriction fragment length polymorphism.. Results: TRAIL SNP rs1131580 mutation was greatly more common in the group of diabetics. Conclusion: A homozygous variant allele (CC) genotype of the TRAIL SNP rs1131580 carries a 1.5-fold risk of DM. Also, having the C allele elevated the risk of T2DM by 1.7 times.","PeriodicalId":254383,"journal":{"name":"Sohag Medical Journal","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130823817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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