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2018 IEEE Life Sciences Conference (LSC)最新文献

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Aptamers-Based Gold-Micro-Array for High-Selective Detection of Bacteria Using Fluorescence Microscopy 基于适体体的金微阵列用于高选择性荧光显微镜细菌检测
Pub Date : 2018-10-01 DOI: 10.1109/LSC.2018.8572150
M. Salami, M. Abadi, Kh. Nejad Shahrokh Abadi, M. Sawan
The monitoring of Escherichia coli (E. coli) bacteria in food and water is an effective preventive measure in controlling the outbreaks of serious food-related diseases. Moreover, the accurate detection of its early stage of the bacteria can ensure the public health and safety. In this study, a target-selective aptamer-based platform is proposed as a reliable procedure for the detection of the E. coli in Phosphate-buffered saline (PBS) using fluorescent microscopy. The results show that the aptamer sequences, immobilized on an array of Au-micro-squares, are very high selective towards the target bacteria cells. This platform, presented for the first time, can be potentially used to detect different kinds of cells simultaneously. Also, an important cell-counting application, based on Neubauer Lam high accuracy method, is proposed and implemented and validated by experimental results.
对食品和水中的大肠杆菌进行监测是控制严重食源性疾病暴发的有效预防措施。而且,对其早期细菌的准确检测可以保证公众的健康和安全。在本研究中,提出了一种基于靶标选择性适配体的平台,作为使用荧光显微镜检测磷酸盐缓冲盐水(PBS)中大肠杆菌的可靠方法。结果表明,固定在au微方阵上的适体序列对目标细菌细胞具有很高的选择性。这是首次提出的平台,可以潜在地用于同时检测不同种类的细胞。提出了一种重要的基于Neubauer Lam高精度方法的细胞计数应用,并通过实验结果进行了验证。
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引用次数: 0
Countermeasure Data Integration within Autonomous Space Medicine: An Extension to Artemis in Space 自主空间医学中的对策数据集成:空间阿尔忒弥斯的延伸
Pub Date : 2018-10-01 DOI: 10.1109/LSC.2018.8572188
Jennifer Yeung, C. McGregor
Health effects of space mission crewmembers due to microgravity have historically been acceptable and reversible, yet the effect of longer duration missions remain largely unknown. Expected communication blocks between the spacecraft and Mission Control on Earth preventing crew members from consulting with Earth-based doctors immediately should a medical problem arise onboard presents the potential to integrate a health analytics platform for real-time physiological monitoring. This paper proposes a design for the data integration of current medical support and countermeasure equipment that collect physiological data from astronauts onboard the ISS with an existing platform to enable predictive and diagnostic analytic provisions.
在历史上,由于微重力对空间飞行任务机组人员的健康造成的影响是可以接受和可逆的,但较长时间飞行任务的影响在很大程度上仍然是未知的。航天器与地球上的任务控制中心之间预期的通信障碍,使机组人员在出现医疗问题时无法立即咨询地球上的医生,这就有可能整合一个健康分析平台,用于实时生理监测。本文提出了一种现有医疗支持和对策设备的数据集成设计,这些设备从国际空间站上的宇航员那里收集生理数据,并利用现有平台实现预测和诊断分析。
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引用次数: 1
Neural Excitations by the Current Injected Through the Carbon Nanotube Surface of an Intracortical Electrode in Vivo 体内皮层内电极碳纳米管表面注入的电流对神经系统的刺激作用
Pub Date : 2018-10-01 DOI: 10.1109/LSC.2018.8572216
R. Ota, Shohei Suga, Y. Hayashida
We fabricated carbon-nanotube-coated neural electrodes that can be inserted into the cerebral cortex in vivo. Using the fast voltage-sensitive dye imaging technique, we visualized spatio-temporal neural responses in the mouse cortex to microstimulation delivered through these electrodes. The experimental results showed the usability of the electrodes for inducing spatially confined neural excitations in vivo. This type of stimulation electrode is expected to have higher charge conductivity and cell membrane affinity at the electrode-tissue interface as the coating layer of the carbon nanotube becomes thicker while maintaining the geometric cross-sectional area. This might offer an advantage over the conventional metal-surface electrode.
我们制造了碳纳米管包覆的神经电极,可以在体内插入大脑皮层。使用快速电压敏感染料成像技术,我们可视化了小鼠皮层对通过这些电极传递的微刺激的时空神经反应。实验结果表明,电极在体内诱导空间受限的神经兴奋是可行的。随着碳纳米管的涂层变得更厚,同时保持几何截面积,这种类型的刺激电极有望在电极-组织界面具有更高的电荷导电性和细胞膜亲和力。这可能比传统的金属表面电极有优势。
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引用次数: 0
Preprocessing and Normalization of 3D-Skeleton-Data for Human Motion Recognition 用于人体运动识别的3d骨骼数据预处理与归一化
Pub Date : 2018-10-01 DOI: 10.1109/LSC.2018.8572153
Jan P. Vox, F. Wallhoff
One key task for motion recognition using machine learning algorithms is the preprocessing of the input data. In this work 3D-skeleton-data is used to classify 19 motion exercises. Due to different body shapes and deviations in the movements from different subjects it becomes necessary to normalize the data. This work addresses the normalization of 3D-skeletoD-data by indicating body joint angles and normalization to an independent coordinate system. The recogntion is based on a Support Vector Machine (SVM) and is evaluated on a dataset containing examples from 21 subjects. The recognition accuracies using different normalized feature combinations are examined. The authors conclude that joint angles are best suitable for the recognition of motion exercises.
使用机器学习算法进行运动识别的一个关键任务是对输入数据进行预处理。在这项工作中,3d骨骼数据被用于分类19种运动练习。由于不同受试者的身体形状和运动偏差不同,有必要对数据进行规范化。这项工作通过指示身体关节角度和归一化到独立的坐标系来解决3d - skeleton -data的归一化问题。该识别基于支持向量机(SVM),并在包含21个主题的示例的数据集上进行评估。研究了不同归一化特征组合的识别精度。作者得出结论,关节角度最适合运动识别练习。
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引用次数: 6
Considering Skin Inhomogeneity in Photoplethysmography-Based Local Pulse Transit Time Measurement 考虑皮肤不均匀性的光容积描记局部脉冲传递时间测量
Pub Date : 2018-10-01 DOI: 10.1109/LSC.2018.8572210
Nils Beckrnann, R. Viga, A. Doğangün, A. Grabmaier
The local measurement of pulse transit time in blood vessels can be implemented using photoplethysmography-based sensors. Therefore, at least two sensors must be placed such that the measured signals originate from the same artery. However, results from our previous research suggest that this kind of measurement does not always provide reliable results. We assumed that the inhomogeneous structure of the skin causes this behavior. Based on this theoretical background related experiments $(mathbf{n}=mathbf{8})$ were executed. The results suggest a signal distortion that strongly depends on the mounting position of the sensors. It can be shown that this distortion is presumably responsible for erroneous calculations of pulse transit time.
脉搏在血管中传递时间的局部测量可以使用基于光容积描记的传感器来实现。因此,必须放置至少两个传感器,使所测量的信号来自同一动脉。然而,我们之前的研究结果表明,这种测量并不总是提供可靠的结果。我们假设皮肤的不均匀结构导致了这种行为。在此理论背景下,执行了相关实验$(mathbf{n}=mathbf{8})$。结果表明,信号失真很大程度上取决于传感器的安装位置。可以证明,这种畸变可能是导致脉冲传递时间计算错误的原因。
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引用次数: 2
High-Rate Ultrasonic Link for Data Telemetry to Implantable Biomedical Microsystems Using Pulse Excitation 利用脉冲激励的高速率超声链路用于植入式生物医学微系统的数据遥测
Pub Date : 2018-10-01 DOI: 10.1109/LSC.2018.8572111
Keivan Keramatzadeh, A. M. Sodagar
This paper reports on the design, simulation, and test of an ultrasonic data telemetry link. A pulse-based data telemetry technique is suggested in this paper, which aims at the suppression of the residual tail of oscillations that naturally follows the response of an ultrasonic transducer to a rectangular pulse. This is made possible by the introduction of a line encoding scheme that suggests the use of an excitatory/inhibitory complex rather than a single excitatory pulse. Efficacy of the technique suggested in this paper was verified through modeling and testing a complete ultrasonic data telemetry link including the transmitting and receiving transducers, as well as the signal conditioning and data recovery blocks on the receiver side. According to the results for transducers with the resonance frequency of 1MHz and saline as the communication channel, a maximum bit rate of 350kbps was achieved.
本文报道了一种超声波数据遥测链路的设计、仿真和测试。本文提出了一种基于脉冲的数据遥测技术,其目的是抑制超声波换能器对矩形脉冲的响应所产生的振荡残余。这是通过引入一种线编码方案来实现的,该方案建议使用兴奋/抑制复合物而不是单一的兴奋脉冲。通过对一个完整的超声波数据遥测链路的建模和测试,包括发射和接收换能器,以及接收端的信号调理和数据恢复块,验证了本文提出的技术的有效性。结果表明,共振频率为1MHz,通信通道为盐水的换能器,最大比特率可达350kbps。
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引用次数: 2
Fully-Integrated, High-Efficiency, Multi-Output Charge Pump for High-Density Microstimulators 完全集成,高效,多输出电荷泵高密度微刺激器
Pub Date : 2018-10-01 DOI: 10.1109/LSC.2018.8572121
Amin Rashidi, N. Yazdani, A. M. Sodagar
This paper proposes a high-efficiency charge pump circuit with small integrated capacitors, dedicated to high-density microstimulators. The proposed circuit offers improvement of about 35% in the charge pump efficiency over the conventional cross-coupled charge pumps. This is achieved through proper employment of two techniques: (a) omitting the undesired conductive paths that discharge the output capacitor, and (b) discounting the dynamic switching power losses by half. Moreover, a straightforward physical layout is proposed to prevent the latchup phenomenon. Occupying 0.5 mm2 of silicon area, circuits for a 4-stage (1 positive stage and 3 negative stages) charge pump were designed and simulated in transistor level in a standard $mathbf{0.18}-mu mathbf{m}$ CMOS technology. Designed for an implantable visual prosthesis, the charge pump generates output voltages of 3.48V, −1.69V, −3.38V, and −5.05V out of a 1.8V input voltage and exhibits average power efficiency of 92.8% and 86.8% for 1- and 3-stage circuits respectively, all in the case of a $mathbf{100} mu mathbf{A}$ current load. An output per stage with current sinking/sourcing ability allows different stimulation channels to be independently connected to different supply levels according their operational needs.
本文提出了一种用于高密度微刺激器的小型集成电容高效电荷泵电路。所提出的电路比传统的交叉耦合电荷泵的效率提高了约35%。这是通过适当采用两种技术来实现的:(a)省略输出电容放电的不希望的导电路径,以及(b)将动态开关功率损耗减半。此外,提出了一种直观的物理布局,以防止闭锁现象。采用标准的$mathbf{0.18}-mu mathbf{m}$ CMOS技术,设计了4级(1正级和3负级)电荷泵电路,并在晶体管级上进行了仿真。在$mathbf{100} mu mathbf{a}$电流负载情况下,电荷泵在1.8V输入电压下可产生3.48V、−1.69V、−3.38V和−5.05V的输出电压,在一级和三级电路中平均功率效率分别为92.8%和86.8%。具有当前下沉/注入能力的每级产量允许不同的增产通道根据作业需要独立连接到不同的供应层。
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引用次数: 10
Brain-Computer Interface Systems: Why a Standard Model is Essential on BCI Standards 脑机接口系统:为什么标准模型对脑机接口标准至关重要
Pub Date : 2018-10-01 DOI: 10.1109/LSC.2018.8572142
L. Bianchi
Brain-Computer Interfaces have gained a large interest in several research fields in a relatively short time. This has led to different ways to describe and analyze systems making their comparison very difficult. Moreover, sharing data, methods and tools is difficult because standard file formats are still missing. Here some of the advantages coming from the definition of a standard model are reported together with the proposal of a roadmap aimed at achieving this goal with a minimal effort from the scientific community.
脑机接口在较短的时间内引起了多个研究领域的极大兴趣。这导致了描述和分析系统的不同方法,使得它们的比较非常困难。此外,共享数据、方法和工具也很困难,因为标准文件格式仍然缺失。这里报告了标准模型定义带来的一些好处,并提出了一个路线图,旨在以最小的努力从科学界实现这一目标。
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引用次数: 3
Power Efficiency and Power Delivery Measurement in Inductive Links with Arbitrary Source and Load Impedance Values 具有任意源和负载阻抗值的电感链路的功率效率和功率传输测量
Pub Date : 2018-10-01 DOI: 10.1109/LSC.2018.8572077
S. Abdollah Mirbozorgi, Y. Jia, Maysam Ghovanloo
Paper describes a method for measuring power transfer efficiency (PTE) and power delivered to the load (PDL) in inductive links with desired source and load impedances using Network Analyzer (NA) and Spectrum Analyzer (SA). Characteristics of an inductive link vary by the source (input) and load (output) resistors. Although measuring the PTE and PDL using NA and SA is simple, straightforward, and accurate, the measured results are valid only for the ports' impedances at $mathbf{50} Omega$. We present a method that allows using NA and SA for measurement with any desired source and load resistances that match the actual operating conditions. For this purpose, we 1) add resistors in series or in parallel with the NA ports, 2) measure PTE by NA and PDL by SA (over $mathbf{50} Omega$), and 3) calculate the actual PTE and PDL. This method provides more flexibility in design and optimization of inductive links by finding the optimal load resistor and model from measurement of the link. We have verified the functionality of the proposed method by simulating, implementing, and measuring the performance of a prototype inductive link for energizing small implants.
本文介绍了一种利用网络分析仪(NA)和频谱分析仪(SA)测量具有期望源和负载阻抗的电感链路中功率传输效率(PTE)和向负载传递功率(PDL)的方法。电感链路的特性因源(输入)电阻和负载(输出)电阻而异。虽然使用NA和SA测量PTE和PDL简单、直接和准确,但测量结果仅适用于端口在$mathbf{50} Omega$处的阻抗。我们提出了一种方法,允许使用NA和SA测量与实际工作条件相匹配的任何所需源和负载电阻。为此,我们1)在NA端口上串联或并联电阻,2)用NA测量PTE,用SA(超过$mathbf{50} Omega$)测量PDL, 3)计算实际的PTE和PDL。该方法通过对链路的测量找到最优的负载电阻和模型,为电感链路的设计和优化提供了更大的灵活性。我们通过模拟、实现和测量用于激励小型植入物的原型电感链路的性能,验证了所提出方法的功能。
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引用次数: 4
Analog-Like Control is Possible in SSVEP Based Brain-Computer Interfaces 基于SSVEP的脑机接口可能实现类似模拟的控制
Pub Date : 2018-10-01 DOI: 10.1109/LSC.2018.8572094
L. Bianchi, R. Ferrante, Lucia Rita Ouitadamo
We investigated the possibility of realizing an analog-like control driven by SSVEPs elicited by just two LEDs flickering at different frequencies. Eight subjects participated in the study during which they had to gaze upon one among 7 locations on a 30 cm horizontal virtual line. A linear model that was able to predict the correct viewed position with a mean error of about 2cm by analyzing 4 seconds of data was built. This suggests that analog-like controls can be implemented in BCIs.
我们研究了实现由两个不同频率闪烁的led引发的ssvep驱动的类似模拟物控制的可能性。8名受试者参加了这项研究,在此期间,他们必须凝视30厘米水平虚拟线上的7个位置中的一个。建立了一个线性模型,通过分析4秒的数据,能够预测正确的观察位置,平均误差约为2cm。这表明类似模拟的控制可以在bci中实现。
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引用次数: 3
期刊
2018 IEEE Life Sciences Conference (LSC)
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