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2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)最新文献

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Direct Digital Wavelet Synthesis for Embedded Biomedical Microsystems 嵌入式生物医学微系统的直接数字小波合成
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584787
Lieuwe B. Leene, T. Constandinou
This paper presents a compact direct digital wavelet synthesizer for extracting phase and amplitude data from cortical recordings using a feed-forward recurrent digital oscillator. These measurements are essential for accurately decoding local-field - potentials in selected frequency bands. Current systems extensively to rely large digital cores to efficiently perform Fourier or wavelet transforms which is not viable for many implants. The proposed system dynamically controls oscillation to generate frequency selective quadrature wavelets instead of using memory intensive sinusoid/cordic look-up-tables while retaining robust digital operation. A MachXO3LF Lattice FPGA is used to present the results for a 16 bit implementation. This configuration requires 401 registers combined with 283 logic elements and also accommodates real-time reconfigurability to allow ultra-low-power sensors to perform spectroscopy with high-fidelity.
本文提出了一种紧凑的直接数字小波合成器,用于使用前馈循环数字振荡器从皮质记录中提取相位和幅度数据。这些测量对于准确解码选定频段的局部场电位是必不可少的。目前的系统广泛依赖大型数字核来有效地执行傅里叶或小波变换,这对于许多植入物来说是不可行的。该系统动态控制振荡产生频率选择性正交小波,而不是使用内存密集型的正弦/正弦查找表,同时保持稳健的数字操作。一个MachXO3LF晶格FPGA被用来呈现16位实现的结果。这种配置需要401个寄存器与283个逻辑元件相结合,并且还适应实时可重构性,以允许超低功耗传感器以高保真度执行光谱。
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引用次数: 0
Flex Force Smart Glove Prototype for Physical Therapy Rehabilitation 用于物理治疗康复的Flex Force智能手套原型
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584774
Lloyd E. Emokpae, Roland N. Emokpae, Brady. Emokpae
A nonintrusive and noninvasive Flex Force Smart Glove (FFSG) design is presented that allows for acquisition and processing of sensorimotor information obtained from the human hand. The novel FFSG design is powered by the Intel FPGA system on chip and incorporates all the sensors needed to measure the force and rotation of the human wrist and fingers. Quaternion-based Kalman filters are used to fuse the raw sensor data from five finger joints and one wrist joint to provide detailed orientation information. In addition, feed forward neural network filters are used to classify possible hand exercises that can be further used facilitate rehabilitation through exercise sessions. The novel design will allow for a unified way to quantify the effectiveness of both conventional and robotic-assisted rehabilitation.
提出了一种非侵入性和非侵入性的柔性力智能手套(FFSG)设计,允许从人手获得的感觉运动信息的获取和处理。新颖的FFSG设计由英特尔FPGA系统驱动,集成了测量人类手腕和手指的力和旋转所需的所有传感器。采用基于四元数的卡尔曼滤波,融合来自五个手指关节和一个手腕关节的原始传感器数据,提供详细的方向信息。此外,前馈神经网络过滤器用于分类可能的手部运动,这些运动可以进一步用于通过锻炼促进康复。这种新颖的设计将允许一种统一的方法来量化传统和机器人辅助康复的有效性。
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引用次数: 2
Live Demonstration: An Open-Source Test-Bench for Autonomous Ultrasound Imaging 现场演示:自主超声成像的开源试验台
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584728
V. Pashaei, Alex Roman, S. Mandal
A complete low-cost open-source portable ultrasound test bench will be demonstrated for a variety of biomedical imaging applications. The test bench is a programmable 64-channel system with a modular design that can be easily updated with improved hardware and software for research on wearable and implantable medical ultrasound. Initial imaging results on tissue phantoms will be shown. Moreover, a rigid prototype of a novel wearable conformal ultrasound array with integrated imaging and modulation capabilities will be demonstrated. Preliminary measurement and characterization results of the prototype show promising results with ~2.4 MHz bandwidth.
一个完整的低成本开源便携式超声试验台将展示各种生物医学成像应用。试验台是一个可编程的64通道系统,采用模块化设计,可以通过改进的硬件和软件轻松更新,用于可穿戴和植入式医学超声的研究。将显示组织幻象的初步成像结果。此外,还将展示一种具有集成成像和调制能力的新型可穿戴适形超声阵列的刚性原型。原型机的初步测量和表征结果表明,在~2.4 MHz带宽下取得了良好的效果。
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引用次数: 2
Efficient implementation and stability analysis of a HV-CMOS current/voltage mode stimulator 高压cmos电流/电压模式刺激器的高效实现和稳定性分析
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584804
Michael Haas, M. Ortmanns
This paper presents an improved version of a reconfigurable current/voltage mode neural stimulator, which can be integrated in multichannel, bidirectional neural interfaces. The current mode stimulator consists of two high voltage (HV) current sources, which provide biphasic stimulation currents of up to 10.2 mA from a ± 9 V supply voltage. In voltage mode, the stimulator has an output range of ±8 V with a resolution of 6 bit. In order to allow voltage mode simulation, a semi-digital feedback loop is used which controls the output current required to achieve the desired stimulation voltage. This allows to fully re-use the HV current sources from the current stimulator and results in class-B operation. Therefore, the power consumption is dominated by the output current and additionally the feedback requires only very little area overhead. Compared to the prior implementation in this work the voltage mode digital to analog converter (DAC) for waveform generation is avoided, by implementing a binary scaled, capacitive level shifter. This reduces the quiescent power by 26 % and reduces the overhead area by 22 %. Additionally, a complete stability analysis based on ΔΣ modulator theory is presented for the first time. The complete frontend including the neural recorder has been layouted for manufacturing in a 180 nm HV CMOS technology.
本文提出了一种改进的可重构电流/电压模式神经刺激器,它可以集成在多通道、双向神经接口中。电流模式刺激器由两个高压(HV)电流源组成,在±9 V的电源电压下提供高达10.2 mA的双相刺激电流。在电压模式下,刺激器的输出范围为±8 V,分辨率为6位。为了允许电压模式仿真,使用半数字反馈回路来控制所需的输出电流以达到所需的刺激电压。这允许充分重用来自电流刺激器的高压电流源,并导致b级操作。因此,功耗主要由输出电流决定,另外,反馈只需要很小的面积开销。与此工作的先前实现相比,通过实现二进制缩放的电容电平移位器,避免了用于波形生成的电压模式数模转换器(DAC)。这减少了26%的静态功率,减少了22%的开销面积。此外,本文还首次给出了基于ΔΣ调制器理论的完整稳定性分析。包括神经记录仪在内的整个前端已经采用180nm高压CMOS技术进行制造。
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引用次数: 5
StethoVest: A simultaneous multichannel wearable system for cardiac acoustic mapping StethoVest:一种用于心脏声学测绘的多通道可穿戴系统
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584742
Christos Sapsanis, Nathaniel Welsh, Michael Pozin, Guillaume Garreau, Gaspar Tognetti, Hani Bakhshaee, P. Pouliquen, R. Mittal, W. R. Thompson, A. Andreou
Cardiac acoustic mapping remains a highly unexplored area, likely due in part to a decline in research into heart auscultation over the past several decades. However, because the stethoscope remains an integral part of clinical care, novel approaches to improve the accuracy and scope of auscultation are now being explored. The current work introduces an innovative design for heart acoustic mapping based on a microphone array embedded in a wearable vest. The system incorporates a customized design of a front-end readout channel with discrete components paired with analog to digital converter DAQ modules. The main scope is to provide simultaneous recordings of heart sounds to generate spatiotemporal images. This noninvasive and time efficient technique will assist in the exploration of normal and pathological heart activity propagation patterns, providing new knowledge to the current understanding of the cardiac acousteome.
心脏声学测绘仍然是一个高度未开发的领域,部分原因可能是过去几十年来对心脏听诊的研究有所减少。然而,由于听诊器仍然是临床护理的一个组成部分,目前正在探索新的方法来提高听诊的准确性和范围。目前的工作介绍了一种基于嵌入可穿戴背心的麦克风阵列的心脏声学测绘的创新设计。该系统结合了一个定制设计的前端读出通道与离散元件配对模拟到数字转换器DAQ模块。主要范围是提供心音的同时记录,以产生时空图像。这种无创和省时的技术将有助于探索正常和病理心脏活动的传播模式,为目前对心脏听体的理解提供新的知识。
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引用次数: 8
A Low-Power Low-Noise Biomedical Instrumentation Amplifier Using Novel Ripple-Reduction Technique 一种采用新型纹波降频技术的低功耗低噪声生物医学仪器放大器
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584744
Yizhao Zhou, Menglian Zhao, Yangtao Dong, Xiaobo Wu, Lihan Tang
This paper presents a low-power low-noise capacitively-coupled chopper instrumentation amplifier (CCIA), which is suitable for biomedical applications such as EEG, ECG and neural recoding. A novel ripple-reduction technique combined with ping-pong auto-zeroing is employed to suppress the ripple at the output of the instrumentation amplifier (IA) by the up-modulated amplifier offset and flicker noise. By using a positive feedback loop in the IA, the IA's input impedance is increased. The complete CCIA is simulated in a standard 0.18 μm CMOS process. The simulated result shows the IA consumes several µA current at 1.8 V supply. The equivalent input noise power spectrum density (PSD) is 54 nV/√Hz and the noise efficiency factor (NEF) achieves 4.05 within 1 kHz, while the equivalent input noise PSD is 55.4 nV/√Hz and NEF is 4.15 within 10 kHz. And the input impedance is about 100MΩ.
提出了一种低功耗、低噪声的电容耦合斩波仪器放大器(CCIA),它适用于脑电图、心电和神经编码等生物医学应用。提出了一种结合乒乓自动调零的新型纹波抑制技术,通过上调放大器偏置和闪烁噪声抑制仪表放大器输出端的纹波。通过在IA中使用正反馈回路,增加了IA的输入阻抗。在标准的0.18 μm CMOS工艺中模拟了完整的CCIA。仿真结果表明,在1.8 V电源下,IA消耗了几µA的电流。等效输入噪声功率谱密度(PSD)为54 nV/√Hz,在1khz范围内噪声效率因子(NEF)为4.05;等效输入噪声PSD为55.4 nV/√Hz,在10khz范围内NEF为4.15。输入阻抗大约是100MΩ。
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引用次数: 9
Enabling Communication for Locked-in Syndrome Patients using Deep Learning and an Emoji-based Brain Computer Interface 使用深度学习和基于表情符号的脑机接口为闭锁综合征患者提供交流
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584821
A. Comaniciu, L. Najafizadeh
Locked-in syndrome describes a condition in which patients are incapable of speaking or moving, although they do retain their cognitive capabilities. In this paper, we propose a novel Brain Computer Interface design using a versatile emoji-based symbol display and a deep learning solution to enable these patients to communicate using recordings obtained through electroencephalography (EEG). EEG signals are converted into images representing their spatiotemporal characteristics. Images are then classified using a deep convolutional neural network (CNN) to recognize the intended emoji symbol. A prototype of the proposed system was tested on five healthy volunteers, showing significant improvement in the recognition rate when compared to the classic LDA classifier.
闭锁综合症描述的是一种患者无法说话或移动的状况,尽管他们的认知能力仍然存在。在本文中,我们提出了一种新颖的脑机接口设计,使用基于表情符号的多功能符号显示和深度学习解决方案,使这些患者能够使用脑电图(EEG)获得的记录进行交流。脑电信号被转换成代表其时空特征的图像。然后使用深度卷积神经网络(CNN)对图像进行分类,以识别预期的表情符号。该系统的原型在5名健康志愿者身上进行了测试,与经典的LDA分类器相比,识别率有了显著提高。
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引用次数: 9
A 120 dB, Asynchronous, Time-Domain, Multispectral Imager for Near-Infrared Fluorescence Image-Guided Surgery 用于近红外荧光成像引导手术的120 dB,异步,时域,多光谱成像仪
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584782
S. Blair, Missael Garcia, Nan Cui, V. Gruev
As surgery has become the standard-of-care for cancer, surgeons have been left underequipped to identify tumors in the operating room, causing many operations to end in positive margins and necessitating secondary treatments to remove remaining tumor tissue. Near-infrared fluorescence image-guided surgery utilizes near-infrared fluorescent markers and near-infrared sensitive cameras to highlight cancerous tissues. Unfortunately, state-of-the-art imaging systems are unable to handle the high dynamic range between strong surgical lighting and weak fluorescent emission and suffer from temperature-dependent co-registration error. To provide a cost-effective and space-efficient imaging system with sufficient dynamic range and no co-registration error, we have developed a single-chip snapshot multispectral imaging system that provides four channels across the visible and near-infrared spectra. By monolithically integrating an asynchronous time-domain image sensor and pixelated interference filters, we have achieved a dynamic range of 120 dB without co-registration error. The imager can detect less than 100 nM of the FDA-approved fluorescent dye indocyanine green under surgical lighting conditions, making it a promising candidate for image-guided surgery clinical trials.
由于手术已经成为癌症治疗的标准,外科医生在手术室里没有足够的设备来识别肿瘤,导致许多手术以阳性边缘结束,需要二次治疗来切除剩余的肿瘤组织。近红外荧光图像引导手术利用近红外荧光标记物和近红外敏感相机来突出癌组织。不幸的是,最先进的成像系统无法处理强手术照明和弱荧光发射之间的高动态范围,并遭受温度依赖的共配准误差。为了提供具有足够动态范围且无共配准误差的经济高效的成像系统,我们开发了一种单芯片快照多光谱成像系统,该系统提供了跨越可见和近红外光谱的四个通道。通过单片集成异步时域图像传感器和像素化干扰滤波器,我们实现了120 dB的动态范围,没有共配准误差。该成像仪可以在手术照明条件下检测到小于100 nM的fda批准的荧光染料吲哚菁绿,使其成为图像引导手术临床试验的有希望的候选者。
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引用次数: 4
ECG Arrhythmia Classification Using Transfer Learning from 2- Dimensional Deep CNN Features 基于2维深度CNN特征迁移学习的心电心律失常分类
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584808
M. Salem, S. Taheri, Jiann-Shiun Yuan
Due to the recent advances in the area of deep learning, it has been demonstrated that a deep neural network, trained on a huge amount of data, can recognize cardiac arrhythmias better than cardiologists. Moreover, traditionally feature extraction was considered an integral part of ECG pattern recognition; however, recent findings have shown that deep neural networks can carry out the task of feature extraction directly from the data itself. In order to use deep neural networks for their accuracy and feature extraction, high volume of training data is required, which in the case of independent studies is not pragmatic. To arise to this challenge, in this work, the identification and classification of four ECG patterns are studied from a transfer learning perspective, transferring knowledge learned from the image classification domain to the ECG signal classification domain. It is demonstrated that feature maps learned in a deep neural network trained on great amounts of generic input images can be used as general descriptors for the ECG signal spectrograms and result in features that enable classification of arrhythmias. Overall, an accuracy of 97.23 percent is achieved in classifying near 7000 instances by ten-fold cross validation.
由于深度学习领域的最新进展,已经证明,经过大量数据训练的深度神经网络可以比心脏病专家更好地识别心律失常。此外,传统上认为特征提取是心电模式识别的重要组成部分;然而,最近的研究结果表明,深度神经网络可以直接从数据本身进行特征提取。为了利用深度神经网络的准确性和特征提取,需要大量的训练数据,这在独立研究的情况下是不实用的。为了应对这一挑战,本工作从迁移学习的角度研究了四种心电模式的识别和分类,将从图像分类领域学习到的知识转移到心电信号分类领域。研究表明,在大量通用输入图像上训练的深度神经网络中学习到的特征映射可以用作心电信号谱图的一般描述符,并产生能够对心律失常进行分类的特征。总体而言,通过10倍交叉验证对近7000个实例进行分类,准确率达到97.23%。
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引用次数: 109
Energy Efficient Convolutional Neural Networks for EEG Artifact Detection 高效卷积神经网络用于脑电信号伪影检测
Pub Date : 2018-10-01 DOI: 10.1109/BIOCAS.2018.8584791
Mohit Khatwani, M. Hosseini, Hirenkumar Paneliya, T. Mohsenin, W. Hairston, Nicholas R. Waytowich
This paper proposes an energy efficient Convolutional Neural Network based architecture for detecting different types of artifacts in multi-channel EEG signals. Our method achieves an average artifact detection accuracy of 74% and precision of 92% across seven different artifact types which outperforms existing techniques in terms of classification accuracy as well as the more common ICA based solution in terms of computational complexity and memory requirements. We designed a minimal neural network processor whose Verilog HDL is configurable for implementing 2n processing engines (PEs). We deployed our CNN on the processor, placed and routed on Artix-7 FPGA and examined different number of PEs at different operating frequencies. Our experiments indicate that utilizing 4 PEs operating at a clock frequency of 11.1 MHz is the optimal configuration for our hardware to yield the least classification energy consumption of 32 mJ accomplished in the maximum allowed prediction time of 1 Sec. We also implemented our CNN on TX2 NVIDIA platform and, by tweaking the CPU and the GPU frequencies, explored a least power configuration and another least energy consuming configuration. Our FPGA results indicate that the 4-PE implementation outperforms the low power config. of TX2 by 65× in terms of power, and the low energy config. of TX2 by 2× in terms of energy per classification. Our CNN-based FPGA implementation method also outperforms the ICA method by 11× in terms of energy consumption per classification.
针对多通道脑电信号中不同类型伪影的检测问题,提出了一种基于卷积神经网络的高能效结构。我们的方法在七种不同的工件类型中实现了74%的平均工件检测准确率和92%的精度,在分类精度方面优于现有技术,在计算复杂性和内存要求方面优于更常见的基于ICA的解决方案。我们设计了一个最小的神经网络处理器,其Verilog HDL可配置用于实现2n处理引擎(pe)。我们将CNN部署在处理器上,在Artix-7 FPGA上放置和路由,并在不同的工作频率下检查不同数量的pe。我们的实验表明,使用4个以11.1 MHz时钟频率工作的pe是我们硬件的最佳配置,可以在1秒的最大允许预测时间内产生最小的分类能耗32 mJ。我们还在TX2 NVIDIA平台上实现了我们的CNN,并通过调整CPU和GPU频率,探索了最低功耗配置和另一种最低能耗配置。我们的FPGA结果表明,4-PE实现优于低功耗配置。TX2的功率降低了65倍,低能耗配置。将TX2的能量除以2倍。我们基于cnn的FPGA实现方法在每个分类的能耗方面也优于ICA方法11倍。
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引用次数: 16
期刊
2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)
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