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INFLUENCE OF HOMOCYSTEINE AND VERTEBRAL FRACTURES ON PREVALENT ABDOMINAL AORTIC CALCIFICATION IN POSTMENOPAUSAL WOMEN - A MULTICENTRIC CROSS-SECTIONAL STUDY 同型半胱氨酸和椎体骨折对绝经后妇女腹主动脉钙化的影响——一项多中心横断面研究
Pub Date : 2017-06-30 DOI: 10.15342/IJMS.V4IR.125
I. Ghozlani, A. Maataoui, A. Mounach, M. Ghazi, A. Kherrab, Z. Ouzzif, R. Niamane, A. Maghraoui
The main of this study was to examine the relationship between plasma homocysteine (Hcy), asymptomatic osteoporotic vertebral fractures (VFs) using vertebral fracture assessment (VFA) and prevalent abdominal aortic calcification (AAC) in Moroccan postmenopausal women. The study cohort consisted of 188 consecutive postmenopausal women with no prior known diagnosis of osteoporosis or taking medication interfering with bone metabolism. Mean age, weight, height, body mass index and plasma homocysteine were determined. Lateral VFA images and scans of the lumbar spine and proximal femur were obtained using a Lunar Prodigy Vision densitometer (GE Healthcare Inc., Waukesha, WI). VFs were defined using a combination of Genant’s semiquantitative approach and morphometry. VFA images were also scored for prevalent AAC using a validated 24 point scale. Fifty-eight (30.9%) patients had densitometric osteoporosis. VFs were identified using VFA in 76 (40.4%) patients: 61 women had grade 1 VFs and 15 had grade 2 or 3 VFs. One hundred twenty nine women (68.6%) did not have any detectable AAC, whereas the prevalence of significant atherosclerotic burden defined as AAC score of 5 or higher, was 13.8%. A significant positive correlation between AAC score and homocysteine was observed. Women with extended AAC, were older, had a lower weight, BMI and BMD, higher homocysteine levels and more prevalent VFs than women without extended AAC. Multiple regression analysis showed that the presence of extended AAC was significantly associated with Age and grade 2/3 VFs and not independently associated with homocysteine levels. This study did not confirm that homocysteine is important determinant of extended AAC in postmenopausal women. However, this significant atherosclerotic marker is independently associated with VFs regardless of age.
本研究的主要目的是研究摩洛哥绝经后妇女血浆同型半胱氨酸(Hcy)、无症状骨质疏松性椎体骨折(VFs)和普遍腹主动脉钙化(AAC)之间的关系。研究对象包括188年连续绝经后妇女没有事先已知的诊断骨质疏松症或服药干扰骨代谢。测定平均年龄、体重、身高、体重指数和血浆同型半胱氨酸。使用Lunar Prodigy Vision密度计(GE Healthcare Inc., Waukesha, WI)获得腰椎和股骨近端侧位VFA图像和扫描。使用Genant的半定量方法和形态计量学相结合来定义VFs。VFA图像也使用经过验证的24分制对常见AAC进行评分。58例(30.9%)患者有骨质疏松症。76例(40.4%)患者使用VFA诊断出室性颤动:61例女性为1级室性颤动,15例为2级或3级室性颤动。129名女性(68.6%)没有任何可检测到的AAC,而AAC评分为5分或更高的显著动脉粥样硬化负担的患病率为13.8%。AAC评分与同型半胱氨酸呈显著正相关。AAC延长的女性年龄较大,体重、BMI和BMD较低,同型半胱氨酸水平较高,与无AAC延长的女性相比,VFs更普遍。多元回归分析显示,AAC延长与年龄和2/3级VFs显著相关,与同型半胱氨酸水平无独立相关性。本研究未证实同型半胱氨酸是绝经后妇女AAC延长的重要决定因素。然而,这一重要的动脉粥样硬化标志物与VFs独立相关,与年龄无关。
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引用次数: 0
Unusual tufted hair folliculitis 不寻常的簇状毛囊炎
Pub Date : 2016-12-24 DOI: 10.15342/IJMS.V3I2.116
Majda Askour
Tufted hair folliculitis was first described by Smith and Sanderson in 1978. This is a rare progressive pattern of scarring alopecia that affects the scalp. The cause of this disorder is unknown. Staphylococcal organisms are frequently found in the lesion, although their role in the pathogenesis is still unclear. No widely accepted treatment regimen exists. Tufted hair folliculitis in locations other than the scalp, and bilaterally on the cheeks, is an unusual presentation.
簇状毛囊炎最早由史密斯和桑德森于1978年描述。这是一种罕见的进行性瘢痕性脱发,影响头皮。这种疾病的病因尚不清楚。葡萄球菌生物经常在病变中发现,尽管它们在发病机制中的作用尚不清楚。目前还没有被广泛接受的治疗方案。在头皮以外的部位和双侧脸颊的毛囊炎是一种不寻常的表现。
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引用次数: 0
Erosive adenomatosis of the nipple 乳头糜烂性腺瘤病
Pub Date : 2016-12-24 DOI: 10.15342/IJMS.V3I2.71
H. Atarguine, S. Amal
Erosive adenomatosis of the nipple is a rare benign neoplasm caused by a complex proliferation of the lactiferous ducts that affects primarily middle-aged women . Clinically, the differential diagnosis is breast carcinoma, Paget disease and galactophoric dilatation. A correct diagnosis is fundamental to avoid unnecessary major surgery, which can increase treatment morbidity and harm the patient.
摘要乳头糜烂性腺瘤病是一种罕见的良性肿瘤,主要发生于中年妇女,由乳管的复杂增生引起。临床鉴别诊断为乳腺癌、佩吉特病及乳腺增生性扩张。正确的诊断是避免不必要的大手术的基础,大手术会增加治疗的发病率和伤害患者。
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引用次数: 0
Breast Cancer Molecular Subtypes Among Moroccan Women 摩洛哥妇女乳腺癌分子亚型
Pub Date : 2016-12-24 DOI: 10.15342/IJMS.V3I2.97
W. Mahir, L. Rouas, D. Ferhati, B. Rhrab, Z. Alhamany, N. Cherradi
Introduction: Breast cancer remains despite the therapeutic progress, the leading cause of death by cancer among women. It represents a group of very heterogeneous clinical, histopathological and molecular diseases. Molecular heterogeneity has been demonstrated by genomic analysis, even for similar histology cancers. Four subgroups of breast carcinomas are distinguished: Luminal A, Luminal B, HER2 over expression and Basal - like. The Immuno-histo-chemical analysis useip (estrogen receptors) RE, the PR (progesterone receptors), the ((Human Epidermal Growth Factor Receptor-2), the Ki67 (proliferation marker) HER2, CK5/6) has shown a subdivision into subgroups similar to those found by genomic analysis. These subgroups are different from the point of view of clinical course and response to adjuvant treatment. Objectives: The aim of this work is to study the molecular profile of the breast cancers by immunostaining on Moroccan series to a classification with a prognostic value allowing a treatment tailored to each group of patients. Furthermore, the molecular subgroups were correlated to other clinical and histological factors. Material and methods: It is a prospective study of the laboratory of Anatomy and Pathologic cytology of the children's Hospital, the service I of the maternity hospital in Rabat and in cooperation with the United Nations Centre of pathological anatomy. To do this, 88 cases of breast cancer together were diagnosed between January 1, 2010 and December 31, 2014, taking a period of five years. All tissue samples made subject study of Immuno-histo-chemistry with the following markers: RE, PR, HER2 and Ki67. Only negative triple cases (HR and HER2 negative) benefited from an additional marking with CK5/6 and EGFR to set the basal profile. Results: Series of 88 cases of mammary carcinomas observed on operating parts, ranged in age between 28 and 84 years old, with an average of 51 ± 12, 8. Carcinoma infiltrating non-specific (DOCTORS) was the most frequent (87.5%). Ranks histo-prognostic Scarff Bloom and Richardson (SBR) 2 and 3 respectively accounted for 45.5 and 51.1% of cases and only 2, 3% of the DOCTORS were grade 1. The Luminal B (53.4%) was under the most common molecular group, followed by Luminal A (23.9%), HER2 + (15.9%) and triple negative (6.8%). The correlation of molecular type of tumors with different prognostic factors showed only one significant connection with the SBR grade.
导言:尽管治疗取得了进展,但乳腺癌仍然是妇女癌症死亡的主要原因。它代表了一组非常异质性的临床、组织病理学和分子疾病。分子异质性已被基因组分析证明,即使是相似的组织学癌症。乳腺癌可分为四个亚组:腔内A、腔内B、HER2过表达和基底样。免疫组织化学分析使用(雌激素受体)RE, PR(孕激素受体),(人表皮生长因子受体-2),Ki67(增殖标志物)HER2, CK5/6)显示亚群的细分与基因组分析发现的亚群相似。这些亚组从临床病程和对辅助治疗的反应的角度来看是不同的。目的:这项工作的目的是通过对摩洛哥系列的免疫染色来研究乳腺癌的分子特征,以分类具有预后价值,从而为每组患者量身定制治疗。此外,分子亚群与其他临床和组织学因素相关。材料和方法:这是儿童医院解剖学和病理细胞学实验室的一项前瞻性研究,是拉巴特妇产医院的一项服务,并与联合国病理解剖学中心合作进行的。为此,在2010年1月1日至2014年12月31日期间,共诊断出88例乳腺癌,耗时5年。所有组织标本进行免疫组化研究,标记物为RE、PR、HER2、Ki67。只有三阴性病例(HR和HER2阴性)受益于CK5/6和EGFR的额外标记,以确定基础概况。结果:本组共88例手术部位乳腺癌,年龄28 ~ 84岁,平均51±12.8例。浸润性非特异性癌(DOCTORS)发生率最高(87.5%)。历史预后等级Scarff Bloom和Richardson (SBR) 2级和3级分别占45.5%和51.1%,仅2.3%的医生为1级。最常见的分子群是Luminal B(53.4%),其次是Luminal A(23.9%)、HER2 +(15.9%)和三阴性(6.8%)。肿瘤分子类型与不同预后因素的相关性仅与SBR分级有显著相关性。
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引用次数: 0
Neuroblastoma: Incidental Craniocerebral Metastasis - A Case Report 神经母细胞瘤:偶发颅脑转移1例
Pub Date : 2016-12-24 DOI: 10.15342/IJMS.V3I2.124
P. Jain, Sahil Singlab
Neuroblastoma has been attributed the term “the great imitator” due to its varied spectrum of presentations. Although neuroblastoma is a common childhood malignancy, which frequently metastasizes, involvement of the Central nervous system is rarely reported in the literature. It commonly metastasizes to the base of the skull and orbits late in the disease. Early detection and aggressive treatment of this complication may allow some patients to live longer than they would have otherwise.
神经母细胞瘤由于其表现多样,被称为“伟大的模仿者”。虽然神经母细胞瘤是一种常见的儿童恶性肿瘤,它经常转移,累及中枢神经系统在文献中很少报道。它通常在疾病晚期转移到颅底和眼眶。这种并发症的早期发现和积极治疗可能会使一些患者活得更长。
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引用次数: 1
Cellulitis Developing After Intramuscular Metamizole Injection 肌内注射安咪唑后蜂窝织炎的发生
Pub Date : 2016-12-24 DOI: 10.15342/IJMS.V3I2.105
O. Öztürk, E. Dost, B. Yazıcıoğlu
If the suitable technique is not used in intramuscular injection applications and the injection area is not detected correctly, complications may be observed. Our patient was given intramuscular Metamizole in his house and then he had cellulitis with necrosis area. Following an antibiotic treatment, tissue defect was primarily covered with gluteal muscle skin flap. Cellulitis development after metamizole injection is not common still potential side effects should be considered before prescription.
如果在肌内注射应用中没有使用合适的技术,并且没有正确检测注射区域,可能会观察到并发症。我们的病人在他的房子里给肌肉注射了Metamizole,然后他得了蜂窝织炎和坏死区域。在抗生素治疗后,组织缺损主要由臀肌皮瓣覆盖。注射安美唑后蜂窝织炎的发展并不常见,但在处方前应考虑潜在的副作用。
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引用次数: 1
IMMEDIATE REACTIONS TO MONOCLONAL ANTIBODIES IN CLINICAL HEMATOLOGY 临床血液学中对单克隆抗体的即时反应
Pub Date : 2016-12-24 DOI: 10.15342/IJMS.V3I2.102
Vasiliki Kyriazi
Monoclonal antibodies (MoAbs) have been widely used in clinical hematology. As foreign macro-molecules, they can cause infusional reactions during the administration or within 24 hours after the infusion, which encompass a spectrum of mechanisms. Although most of these reactions are non-allergic, are often indistinguishable from true allergic reactions mediated by IgE immunoglobulins. The diagnosis is often challenging and relies mainly on clinical criteria. They occur during the first doses, soon after the initiation of treatment. The symptoms are usually well controlled by the immediate drug discontinuation or reduction of the infusion rate. The management remains largely supportive, consisting of oxygen, intravenous fluids, bronchodilators, antihistamines and steroids. Most of MoAb protocols recommend premedication with steroids and antihistamines and gradually escalating infusion rates. Increased medical and nursing vigilance is required and resuscitative equipment should always be readily available. These events affect patients' quality of life, leading to treatment delay or discontinuation and series of tests. The decision to rechallenge the treatment depends on severity grading, clinical parameters and treatment goals. This article provides an update of MoAbs used in clinical hematology. It summarizes the pathophysiology, the diagnostic approach, the preventive measures and treatment of MoAb-related reactions.
单克隆抗体(MoAbs)已广泛应用于临床血液学。作为外源大分子,它们可在给药期间或给药后24小时内引起输注反应,其中包括一系列机制。虽然大多数这些反应是非过敏性的,但往往与IgE免疫球蛋白介导的真正的过敏反应难以区分。诊断通常具有挑战性,主要依赖于临床标准。它们发生在治疗开始后不久的第一次给药期间。症状通常通过立即停药或降低输注速度得到很好的控制。治疗主要是支持性的,包括输氧、静脉输液、支气管扩张剂、抗组胺药和类固醇。大多数MoAb方案建议预先使用类固醇和抗组胺药,并逐渐增加输注速率。需要提高医疗和护理的警惕性,复苏设备应随时可用。这些事件影响患者的生活质量,导致治疗延迟或中断和一系列检查。重新挑战治疗的决定取决于严重程度分级、临床参数和治疗目标。本文提供了临床血液学中使用的moab的更新。综述了moab相关反应的病理生理、诊断方法、预防措施和治疗方法。
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引用次数: 0
Multiple myeloma revealed by a sphenoid plasmocytoma: case report and literature review 多发性骨髓瘤表现为蝶骨浆细胞瘤:1例报告及文献复习
Pub Date : 2016-12-24 DOI: 10.15342/IJMS.V3I2.103
S. Kadiri
Plasma cell neoplasms can manifest as a solitary or multiple plasmocytomas and may be associated with or progressing to multiple myeloma (MM). Cranial and intracranial plasmocytomas revealing multiple myeloma are very rare and only few cases are reported in the literature. We report the case of a sphenoid plasmocytoma that revealed a multiple myeloma in a 56 year-old woman with 3 months history of temporal headache and diplopia. Magnetic resonance imaging (MRI) and computed tomography (CT) showed a sphenoid mass. An endoscopic sphenoidal biopsy was performed and the histopathological exams showed a plasmocytoma with a positive staining for CD138. Further biological studies confirmed the diagnosis of multiple myeloma with a monoclonal gamma peak of immunoglobulin (Ig) A. The patient started systemic chemotherapy and received decompressive radiation therapy on the sphenoidal sinus. She remained in remission for 8 months and died from renal dysfunction. Although the sphenoid plasmocytoma is a very rare presentation of multiple myeloma it should be considered for effective patient management and prognosis improvement.
浆细胞瘤可以表现为单个或多个浆细胞瘤,并可能与多发性骨髓瘤(MM)相关或进展。颅内浆细胞瘤显示多发性骨髓瘤是非常罕见的,只有少数病例在文献报道。我们报告的病例蝶浆细胞瘤显示多发性骨髓瘤在一个56岁的妇女3个月的颞部头痛和复视的历史。磁共振成像(MRI)和计算机断层扫描(CT)显示蝶骨肿块。内镜下蝶窦活检,组织病理学检查显示CD138染色阳性浆细胞瘤。进一步的生物学研究证实了多发性骨髓瘤的诊断,免疫球蛋白(Ig) a的单克隆γ峰。患者开始全身化疗并接受蝶窦减压放疗。患者病情持续缓解8个月后死于肾功能不全。虽然蝶骨浆细胞瘤是一种非常罕见的多发性骨髓瘤的表现,但应考虑有效的患者管理和预后改善。
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引用次数: 1
Intramuscular Benign Lipoma of the Biceps Brachii Muscle - A Case Report 肱二头肌肌内良性脂肪瘤1例报告
Pub Date : 2016-06-26 DOI: 10.15342/IJMS.V3I1.76
A. Ibrahimi, H. Boussakri, M. Elidrissi, M. Shimi, A. Elmrini
Intramuscular lipoma is an uncommon mesenchymal neoplasm that characteristically infiltrates adjacent tissues and tends to recur after excision. Only a few publications referring to the upper extremities location have been reported. We report a case of an intramuscular lipoma of the biceps brachii muscle studied with MRI. Complete excision was performed without recurrence.
肌内脂肪瘤是一种罕见的间质肿瘤,其特征是浸润邻近组织,切除后容易复发。只有少数文献报道了上肢的位置。我们报告一例肱二头肌肌肉内脂肪瘤的研究与MRI。完全切除无复发。
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引用次数: 1
Educational Use Of Digital Video In The Context Of Practical Work In Dentistry Prospective Evaluation Survey Of The Optimal Duration Of Educational Films By Second-Year Students Of Dentistry In Rabat 数字视频在牙科实际工作背景下的教学使用拉巴特牙科二年级学生对教育片最佳时长的前瞻性评价调查
Pub Date : 2016-06-26 DOI: 10.15342/IJMS.V2I2.72
A. Regragui, Ahmed Abdedine, N. Merzouk, F. Benfdil
The transmission of knowledge is a critical step that requires dedication and logistic assets to achieve the desired objective. Among these advantages is the online launch of educational films on the university's platform which aims at the improvement of understanding by students, and the information provided during practical work. For this, we have made three videos on the implementation of shaped clasps, while fixing the duration of the films successively at 8min50, 5min05 and 3min30. The videos were evaluated by the entire class through a questionnaire distributed to students who were present in the practical work training session. The biostatistical analysis revealed the preference to be for the 8min50 video with an initial viewing percentage of 59.3%. At a second and another viewing, preference was successively in favor of the 5min05 video (54.5%) and that of 3min 30 (43.4%). Furthermore, the students’ favorite videos were those with a time interval of 10 to 20 minutes (46.9%) for upcoming educational materials.
知识的传递是一个关键的步骤,需要奉献精神和物流资产来实现预期的目标。这些优势之一是在学校的平台上在线推出旨在提高学生理解的教育影片,以及在实际工作中提供的信息。为此,我们制作了三个关于形扣实施的视频,并将影片的时长依次设定为8min50, 5min05, 3min30。这些视频是由全班同学通过向参加实际工作培训的学生分发问卷的方式来评估的。生物统计学分析显示,人们更喜欢8分钟50分钟的视频,初次观看率为59.3%。在第二次和第二次观看时,偏好依次为5min05(54.5%)和3min 30(43.4%)。此外,学生们最喜欢的视频是那些间隔10到20分钟的即将到来的教育材料(46.9%)。
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引用次数: 0
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International Journal of Medicine and Surgery
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