{"title":"Museo Vasco de Historia de la Medicina y de la Ciencia","authors":"A. Erkoreka, Josu Hernando Pérez","doi":"10.19230/JONNPR.4180","DOIUrl":"https://doi.org/10.19230/JONNPR.4180","url":null,"abstract":"","PeriodicalId":265734,"journal":{"name":"Jounal of Negative and No Positive Results","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128140786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identificación y análisis de factores de riesgo psicosocial según la NOM-035-STPS-2018 en una universidad mexicana","authors":"Ernesto Cotonieto-Martínez","doi":"10.19230/JONNPR.3836","DOIUrl":"https://doi.org/10.19230/JONNPR.3836","url":null,"abstract":"","PeriodicalId":265734,"journal":{"name":"Jounal of Negative and No Positive Results","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114461995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristina Rodriguez Rada, Ángel Celada Rodríguez, Carmen Celada Roldán, M. L. T. Marcos, Mario Romero de Ávila, P. López
espanolLa “diabesidad” es un concepto en auge que hace referencia a los individuos con diabetes mellitus tipo 2 y obesidad. Ambos conceptos se encuentran intimamente relacionados.Se ha llevado a cabo una busqueda en Web Of Science para realizar una revision bibliografica con el objetivo de establecer la relacion existente entre la obesidad, la diabetes mellitus tipo 2 y los factores de riesgo cardiovascular.El tejido adiposo es una glandula endocrina capaz de secretar hormonas, citoquinas y sustancias vasoactivas. En los individuos obesos, este tejido adiposo se muestra disfuncional, secretando de forma inusual ciertas adipocinas como la leptina y adiponectina. Tanto es asi, que en individuos obesos sometidos a una cirugia bariatrica se ha visto como la relacion adiponectina/leptina se invierte. Ademas, en un ambiente obesogenico, el tejido adiposo muestra un fenotipo proinflamatorio, que ayuda a perpetuar el proceso de resistencia a la insulina y el consiguiente desarrollo de prediabetes y diabetes mellitus tipo 2.Es importante determinar nuevas dianas terapeuticas para la diabesidad, como el factor de transcripcion GPS2, que muestra una disminucion de sus niveles en sujetos obesos, lo cual predispone a un fenotipo pro-diabetico.Recientemente se ha demostrado que mi-483-5p se expresa en tejidos relevantes de diabetes y enfermedad cardiovascular, lo cual predice su potencial como biomarcador en sangre de dichas enfermedades.En conclusion, esta revision pretende recalcar la importancia de controlar los factores de riesgo cardiovascular, como la obesidad, para impedir el desarrollo posterior de una enfermedad estrechamente ligada a esta como es la diabetes tipo 2. English"Diabesity" is a booming concept that refers to individuals with type 2 diabetes mellitus and obesity. Both concepts are closely related.A search of Web Of Science was carried out to carry out a bibliographic review with the aim of establishing the relationship between obesity, type 2 diabetes mellitus and cardiovascular risk factors.Adipose tissue is an endocrine gland capable of secreting hormones, cytokines, and vasoactive substances. In obese individuals, this adipose tissue is dysfunctional, secreting certain adipokines such as leptin and adiponectin in an unusual way. So much so, that in obese individuals undergoing bariatric surgery, the adiponectin / leptin ratio has been reversed. Furthermore, in an obesogenic environment, adipose tissue displays a proinflammatory phenotype, which helps perpetuate the process of insulin resistance and the consequent development of prediabetes and type 2 diabetes mellitus.It is important to determine new therapeutic targets for diabesity, such as the GPS2 transcription factor, which shows a decrease in its levels in obese subjects, which predisposes to a pro-diabetic phenotype.Mi-483-5p has recently been shown to be expressed in relevant tissues of diabetes and cardiovascular disease, which predicts its potential as a blood biomarker for th
西班牙语“diabesidad”是一个新兴的概念，指的是2型糖尿病和肥胖患者。这两个概念是密切相关的。进行了一个搜索Web Of Science进行订正bibliografica目标是建立之间的关系肥胖症、2型糖尿病和心血管风险因素mellitus。脂肪组织是内分泌腺，能够分泌激素、细胞因子和血管活性物质。在肥胖个体中，这种脂肪组织功能失调，异常分泌某些脂肪因子，如瘦素和脂联素。在肥胖患者中，脂联素/瘦素的关系被认为是相反的。此外obesogenico紧张的气氛,脂肪组织显示了表型proinflamatorio进程,有助于维持胰岛素抵抗和糖尿病前期和ii型糖尿病的mellitus随之发展。因此，我们的目标是确定新的糖尿病治疗靶点，如转录因子GPS2，它在肥胖受试者中显示其水平下降，从而导致糖尿病前表型。最近的研究表明，mi-483-5p在糖尿病和心血管疾病的相关组织中表达，这预测了它作为这些疾病的血液生物标志物的潜力。结论,该订正旨在强调控制的重要性心血管风险因素,如肥胖、防止随后发展一种疾病密切相关的如2型糖尿病。= =地理= =根据美国人口普查，这个县的面积为。这两个概念密切相关。was A search of Web of Science的out to carry out A bibliographic review with the aim of建立the relationship between obesity, type 2 mellitus糖尿病和心血管风险因素。脂肪组织是一种内分泌腺，能够分泌激素、细胞因子和血管活性物质。In this adipose组织is dysfunctional个人obese, secreting某些adipokines如leptin and adiponectin In an不寻常的方式。因此，在接受减肥手术的肥胖个体中，脂联素/瘦素的比例已经逆转。此外，在致肥胖的环境中，脂肪组织表现出促炎表型，这有助于维持胰岛素抵抗过程和由此产生的糖尿病前部和2型糖尿病的发展。It is important to new / target for diabesity确定,如the GPS2 transcription factor, which节目a decrease in its水平in obese publication, which predisposes向pro-diabetic phenotype。Mi-483-5p惧得到日内瓦to be表示有关tissues糖尿病和心血管疾病,which predicts its潜力as a的biomarker这些疾病。在这一审查结论,以突破《控制心血管风险因素的重视,如obesity,防止疾病closely related to the development of a由斯德哥尔摩it,如type 2糖尿病。
{"title":"Análisis de la relación entre Diabetes Mellitus tipo 2 y la obesidad con los factores de riesgo cardiovascular","authors":"Cristina Rodriguez Rada, Ángel Celada Rodríguez, Carmen Celada Roldán, M. L. T. Marcos, Mario Romero de Ávila, P. López","doi":"10.19230/JONNPR.3817","DOIUrl":"https://doi.org/10.19230/JONNPR.3817","url":null,"abstract":"espanolLa “diabesidad” es un concepto en auge que hace referencia a los individuos con diabetes mellitus tipo 2 y obesidad. Ambos conceptos se encuentran intimamente relacionados.Se ha llevado a cabo una busqueda en Web Of Science para realizar una revision bibliografica con el objetivo de establecer la relacion existente entre la obesidad, la diabetes mellitus tipo 2 y los factores de riesgo cardiovascular.El tejido adiposo es una glandula endocrina capaz de secretar hormonas, citoquinas y sustancias vasoactivas. En los individuos obesos, este tejido adiposo se muestra disfuncional, secretando de forma inusual ciertas adipocinas como la leptina y adiponectina. Tanto es asi, que en individuos obesos sometidos a una cirugia bariatrica se ha visto como la relacion adiponectina/leptina se invierte. Ademas, en un ambiente obesogenico, el tejido adiposo muestra un fenotipo proinflamatorio, que ayuda a perpetuar el proceso de resistencia a la insulina y el consiguiente desarrollo de prediabetes y diabetes mellitus tipo 2.Es importante determinar nuevas dianas terapeuticas para la diabesidad, como el factor de transcripcion GPS2, que muestra una disminucion de sus niveles en sujetos obesos, lo cual predispone a un fenotipo pro-diabetico.Recientemente se ha demostrado que mi-483-5p se expresa en tejidos relevantes de diabetes y enfermedad cardiovascular, lo cual predice su potencial como biomarcador en sangre de dichas enfermedades.En conclusion, esta revision pretende recalcar la importancia de controlar los factores de riesgo cardiovascular, como la obesidad, para impedir el desarrollo posterior de una enfermedad estrechamente ligada a esta como es la diabetes tipo 2. English\"Diabesity\" is a booming concept that refers to individuals with type 2 diabetes mellitus and obesity. Both concepts are closely related.A search of Web Of Science was carried out to carry out a bibliographic review with the aim of establishing the relationship between obesity, type 2 diabetes mellitus and cardiovascular risk factors.Adipose tissue is an endocrine gland capable of secreting hormones, cytokines, and vasoactive substances. In obese individuals, this adipose tissue is dysfunctional, secreting certain adipokines such as leptin and adiponectin in an unusual way. So much so, that in obese individuals undergoing bariatric surgery, the adiponectin / leptin ratio has been reversed. Furthermore, in an obesogenic environment, adipose tissue displays a proinflammatory phenotype, which helps perpetuate the process of insulin resistance and the consequent development of prediabetes and type 2 diabetes mellitus.It is important to determine new therapeutic targets for diabesity, such as the GPS2 transcription factor, which shows a decrease in its levels in obese subjects, which predisposes to a pro-diabetic phenotype.Mi-483-5p has recently been shown to be expressed in relevant tissues of diabetes and cardiovascular disease, which predicts its potential as a blood biomarker for th","PeriodicalId":265734,"journal":{"name":"Jounal of Negative and No Positive Results","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125832950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
espanolLa pandemia por COVID-19 y las serias repercusiones que esta teniendo han hecho que se agilice el desarrollo de un arma terapeutica fundamental para comenzar a erradicarla: las vacunas. Son un instrumento fundamental de prevencion primaria que se administrara inicialmente a los grupos mas vulnerables o con alto riesgo de exposicion, ampliando el abanico de administracion a otro tipo de poblacion en fases posteriores. Puede surgir controversia a la hora de vacunar a grupos ginecologicos especificos, como son las gestantes, mujeres lactantes o pacientes con cancer ginecologico. El proposito de este articulo es analizar la informacion disponible con respecto a la vacunacion en estos grupos. EnglishThe COVID-19 pandemic and its serious repercussions are accelerating the development of a fundamental therapeutic strategy to begin eradicating this illness: vaccines. They are a fundamental instrument of primary prevention that will be administer initially to vulnerable groups or those with high risk of exposure, expanding in later phases the administration to another populations. There can be controversy in vaccinating some specific gynecological groups, like pregnant women, lactating women or patients with gynecological cancer. The purpose of this article is to analyze the information available regarding vaccination in these concrete groups.
{"title":"Vacunación de COVID-19 en grupos ginecológicos y obstétricos especiales","authors":"María Antonia Buenaventura Rubio","doi":"10.19230/JONNPR.4187","DOIUrl":"https://doi.org/10.19230/JONNPR.4187","url":null,"abstract":"espanolLa pandemia por COVID-19 y las serias repercusiones que esta teniendo han hecho que se agilice el desarrollo de un arma terapeutica fundamental para comenzar a erradicarla: las vacunas. Son un instrumento fundamental de prevencion primaria que se administrara inicialmente a los grupos mas vulnerables o con alto riesgo de exposicion, ampliando el abanico de administracion a otro tipo de poblacion en fases posteriores. Puede surgir controversia a la hora de vacunar a grupos ginecologicos especificos, como son las gestantes, mujeres lactantes o pacientes con cancer ginecologico. El proposito de este articulo es analizar la informacion disponible con respecto a la vacunacion en estos grupos. EnglishThe COVID-19 pandemic and its serious repercussions are accelerating the development of a fundamental therapeutic strategy to begin eradicating this illness: vaccines. They are a fundamental instrument of primary prevention that will be administer initially to vulnerable groups or those with high risk of exposure, expanding in later phases the administration to another populations. There can be controversy in vaccinating some specific gynecological groups, like pregnant women, lactating women or patients with gynecological cancer. The purpose of this article is to analyze the information available regarding vaccination in these concrete groups.","PeriodicalId":265734,"journal":{"name":"Jounal of Negative and No Positive Results","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129256011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jimena Guadalupe Prado Peláez, Ivan Hernández Pacheco, Jesús Carlos Ruvalcaba Ledezma, M. Hernández
espanolObjetivo. Documentar las generalidades, prevencion y tratamiento de la infeccion por virus del papiloma humano. Material y metodos. Se recolecto informacion relevante, articulos de investigacion originales, ensayos clinicos, y revisiones en revistas indexadas, para conocer las generalidades del virus de papiloma humano, infecciones pro VPH y cancer cervicouterino y cuales son las medidas de prevencion. Resultados. Los virus del papiloma humano o papilomavirus son un grupo de virus de ADN que pertenece a la familia Papillomaviridae, no poseen envoltura, y tienen un diametro aproximado de 52-55 nm. Las particulas virales estan compuestas por una capside proteica, conformada en un 95% por la proteina L1 y en un 5% por la proteina L2, las cuales se ensamblan para formar capsomeros icosaedricos. Conclusiones. La importancia de la vacunacion reside en la prevencion primaria que se realiza frente a infecciones de VPH, sin embargo, esta accion va mas alla de solo prevenir la infeccion, es evitar una lesion que es precursora de CACU. La introduccion de la vacuna de VPH en el esquema de vacunacion mexicano, no solo impacta en la prevencion de CACU y la infeccion por VPH, tambien supone la proteccion del bolsillo de las familias, que de esta forma se evitaria un gasto catastrofico por CACU. Esto significaria resultados no positivos. EnglishAim. To document the generalities, prevention and treatment of human papillomavirus infection. Material and methods. Relevant information was collected, original research articles, clinical trials, and reviews in indexed journals, to know the generalities of the human papilloma virus, pro HPV infections and cervical cancer and what are the prevention measures. Results. Human papillomavirus or papillomavirus are a group of DNA viruses that belong to the Papillomaviridae family, without envelopes, and have a diameter of 52-55 nm. Viral particles are composed of a protein capsid, made up of 95% by the L1 protein and 5% by the L2 protein, which are assembled to form icosahedral capsomeres. Conclusions. The importance of vaccination resides in the primary prevention that is carried out against HPV infections, however, this action goes beyond just preventing infection, it is avoiding an injury that is a precursor to CACU. The introduction of the HPV vaccine into the Mexican vaccination scheme, not only impacts on the prevention of CACU and HPV infection, it also supposes the protection of the pocket of the families, which in this way would avoid a catastrophic expense for CACU. This would mean non-positive results.
espanolObjetivo。记录人类乳头瘤病毒感染的一般情况、预防和治疗。材料和方法。我们收集了相关信息、原始研究文章、临床试验和索引期刊的评论，以了解人类乳头瘤病毒、hpv感染和宫颈癌的一般情况以及预防措施。结果。人类乳头瘤病毒或乳头瘤病毒是一组dna病毒，属于乳头瘤病毒科，无包膜，直径约为52-55纳米。病毒颗粒由蛋白质衣壳组成，其中95%由L1蛋白组成，5%由L2蛋白组成，它们结合在一起形成二十面体衣壳。结论。疫苗接种的重要性在于对hpv感染进行的初级预防，然而，这一行动不仅仅是预防感染，它还避免了作为CACU前体的损伤。在墨西哥疫苗接种计划中引入hpv疫苗，不仅影响了CACU和hpv感染的预防，还保护了家庭的口袋，从而避免了灾难性的CACU支出。这意味着没有积极的结果。EnglishAim。记录人类乳头瘤病毒感染的概括性、预防和治疗。他的父亲是一名律师，母亲是一名律师。收集相关信息、原始研究文章、临床试验和编入索引期刊的评论，了解人类乳头瘤病毒、HPV原感染和宫颈癌的概括性以及预防措施。结果。= =地理= =根据美国人口普查，这个县的面积为，其中土地面积为，其中土地面积为。病毒性particles are任of a protein capsid, made up of 95% by the升1 protein and by the protein二级5%,which are assembled to form icosahedral capsomeres。结论。疫苗接种的重要性在于预防HPV感染的初级预防，然而，这一行动不仅仅是预防感染，它还避免了作为CACU前体的伤害。将人乳头瘤病毒疫苗纳入墨西哥疫苗接种计划不仅对预防CACU和人乳头瘤病毒感染产生影响，而且还假定保护家庭的口袋，从而避免给CACU带来灾难性的费用。这将意味着非阳性结果。
{"title":"VPH: Generalidades, prevención y vacunación","authors":"Jimena Guadalupe Prado Peláez, Ivan Hernández Pacheco, Jesús Carlos Ruvalcaba Ledezma, M. Hernández","doi":"10.19230/JONNPR.3767","DOIUrl":"https://doi.org/10.19230/JONNPR.3767","url":null,"abstract":"espanolObjetivo. Documentar las generalidades, prevencion y tratamiento de la infeccion por virus del papiloma humano. Material y metodos. Se recolecto informacion relevante, articulos de investigacion originales, ensayos clinicos, y revisiones en revistas indexadas, para conocer las generalidades del virus de papiloma humano, infecciones pro VPH y cancer cervicouterino y cuales son las medidas de prevencion. Resultados. Los virus del papiloma humano o papilomavirus son un grupo de virus de ADN que pertenece a la familia Papillomaviridae, no poseen envoltura, y tienen un diametro aproximado de 52-55 nm. Las particulas virales estan compuestas por una capside proteica, conformada en un 95% por la proteina L1 y en un 5% por la proteina L2, las cuales se ensamblan para formar capsomeros icosaedricos. Conclusiones. La importancia de la vacunacion reside en la prevencion primaria que se realiza frente a infecciones de VPH, sin embargo, esta accion va mas alla de solo prevenir la infeccion, es evitar una lesion que es precursora de CACU. La introduccion de la vacuna de VPH en el esquema de vacunacion mexicano, no solo impacta en la prevencion de CACU y la infeccion por VPH, tambien supone la proteccion del bolsillo de las familias, que de esta forma se evitaria un gasto catastrofico por CACU. Esto significaria resultados no positivos. EnglishAim. To document the generalities, prevention and treatment of human papillomavirus infection. Material and methods. Relevant information was collected, original research articles, clinical trials, and reviews in indexed journals, to know the generalities of the human papilloma virus, pro HPV infections and cervical cancer and what are the prevention measures. Results. Human papillomavirus or papillomavirus are a group of DNA viruses that belong to the Papillomaviridae family, without envelopes, and have a diameter of 52-55 nm. Viral particles are composed of a protein capsid, made up of 95% by the L1 protein and 5% by the L2 protein, which are assembled to form icosahedral capsomeres. Conclusions. The importance of vaccination resides in the primary prevention that is carried out against HPV infections, however, this action goes beyond just preventing infection, it is avoiding an injury that is a precursor to CACU. The introduction of the HPV vaccine into the Mexican vaccination scheme, not only impacts on the prevention of CACU and HPV infection, it also supposes the protection of the pocket of the families, which in this way would avoid a catastrophic expense for CACU. This would mean non-positive results.","PeriodicalId":265734,"journal":{"name":"Jounal of Negative and No Positive Results","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116806966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：