Pub Date : 2025-06-19DOI: 10.1016/j.chembiol.2025.05.001
Irene Molina , Ryan Mansell , Rui Liang , Benigno Crespo , Margarita Puente , Virginia Franco , Sara Viera , Isabel Camino , Anas Saadeddin , Peter Bellotti , Annie Leung , Sam Henning , Shan Sun , Mikayla Herring , Celia Lopez , Carmen Cuevas , Peter Pogány , Beatriz Urones , Leigh Baxt , Esther Fernández , Lydia Mata-Cantero
Spreading resistance to front-line treatments necessitate the search for new classes of antimalarials. Limitations of standard screening conditions lead us to develop an assay using culture media that more closely reflects nutrient levels in human serum to reveal new therapeutically relevant parasite pathways. Our approach was validated by testing 22k compounds followed by a full 750k compound screen and identified 29 chemotypes with higher activity in nutrient restricted media that were further characterized. Through a combination of chemo-genomics and innovative photocatalytic proximity labeling proteomics, we identified the target of two compounds as the CLAG3 component of the plasmodial surface anion channel (PSAC). Strikingly, every one of the other 29 chemotypes selected was also found to block PSAC activity, highlighting the importance of this nutrient channel for parasite survival under physiological conditions. The effect of PSAC inhibitors in the in vivo humanized mouse model was confirmed.
{"title":"The critical role of PSAC channel in malaria parasite survival is driven home by phenotypic screening under relevant nutrient levels","authors":"Irene Molina , Ryan Mansell , Rui Liang , Benigno Crespo , Margarita Puente , Virginia Franco , Sara Viera , Isabel Camino , Anas Saadeddin , Peter Bellotti , Annie Leung , Sam Henning , Shan Sun , Mikayla Herring , Celia Lopez , Carmen Cuevas , Peter Pogány , Beatriz Urones , Leigh Baxt , Esther Fernández , Lydia Mata-Cantero","doi":"10.1016/j.chembiol.2025.05.001","DOIUrl":"10.1016/j.chembiol.2025.05.001","url":null,"abstract":"<div><div>Spreading resistance to front-line treatments necessitate the search for new classes of antimalarials. Limitations of standard screening conditions lead us to develop an assay using culture media that more closely reflects nutrient levels in human serum to reveal new therapeutically relevant parasite pathways. Our approach was validated by testing 22k compounds followed by a full 750k compound screen and identified 29 chemotypes with higher activity in nutrient restricted media that were further characterized. Through a combination of chemo-genomics and innovative photocatalytic proximity labeling proteomics, we identified the target of two compounds as the CLAG3 component of the plasmodial surface anion channel (PSAC). Strikingly, every one of the other 29 chemotypes selected was also found to block PSAC activity, highlighting the importance of this nutrient channel for parasite survival under physiological conditions. The effect of PSAC inhibitors in the <em>in vivo</em> humanized mouse model was confirmed.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 6","pages":"Pages 826-838.e13"},"PeriodicalIF":6.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-19DOI: 10.1016/j.chembiol.2025.05.003
Siyuan Zou , Yihong Sun , Weixin Tang
CRISPR base editors (BEs) have introduced a new chapter in precise genome editing. The brief but fruitful history of BE development documents many case studies that not only lay the foundation of base-editing technology but are also instrumental to future protein engineering efforts. In this review, we summarize the development and engineering of various BEs with a focus on recent progress. These include traditional cytosine and adenine base editors (CBEs and ABEs), novel TadA-derived CBEs, transversion BEs, dual BEs, and CRISPR-free BEs. We discuss each aspect of the workflow and highlight the successes and challenges encountered in the engineering process.
{"title":"Charting the development and engineering of CRISPR base editors: lessons and inspirations","authors":"Siyuan Zou , Yihong Sun , Weixin Tang","doi":"10.1016/j.chembiol.2025.05.003","DOIUrl":"10.1016/j.chembiol.2025.05.003","url":null,"abstract":"<div><div>CRISPR base editors (BEs) have introduced a new chapter in precise genome editing. The brief but fruitful history of BE development documents many case studies that not only lay the foundation of base-editing technology but are also instrumental to future protein engineering efforts. In this review, we summarize the development and engineering of various BEs with a focus on recent progress. These include traditional cytosine and adenine base editors (CBEs and ABEs), novel TadA-derived CBEs, transversion BEs, dual BEs, and CRISPR-free BEs. We discuss each aspect of the workflow and highlight the successes and challenges encountered in the engineering process.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 6","pages":"Pages 789-808"},"PeriodicalIF":6.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144219283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-19DOI: 10.1016/j.chembiol.2025.05.009
William Garland , Torben Heick Jensen
In the June 12th issue of Cell, Baluapuri et al.1 report that loss of the Integrator (INT) complex triggers cellular stress by unleashing aberrant transcription, resulting in production of immunogenic double-stranded RNA. Dissecting early and late consequences of INT depletion, the study exemplifies how transcriptional dysregulation can culminate in profound physiological outcomes.
{"title":"Integrator: A guardian against RNA-induced chaos","authors":"William Garland , Torben Heick Jensen","doi":"10.1016/j.chembiol.2025.05.009","DOIUrl":"10.1016/j.chembiol.2025.05.009","url":null,"abstract":"<div><div>In the June 12<sup>th</sup> issue of <em>Cell</em>, Baluapuri et al.<span><span><sup>1</sup></span></span> report that loss of the Integrator (INT) complex triggers cellular stress by unleashing aberrant transcription, resulting in production of immunogenic double-stranded RNA. Dissecting early and late consequences of INT depletion, the study exemplifies how transcriptional dysregulation can culminate in profound physiological outcomes.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 6","pages":"Pages 780-782"},"PeriodicalIF":6.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-19DOI: 10.1016/j.chembiol.2025.05.008
Bradley Laflamme , Christopher Blackman , Mackenzie Loranger , Richard Trilles , Kalina Doytchinova-Weil , Stephen S. Scully , J. Miles Blackburn , Anastasia L.G. Kanegesuku , Jennifer L. Roizen , Stephen Bengtson , Lauren E. Brown , John A. Porco , Keiko Yoshioka , Luke Whitesell , Rajagopal Subramaniam , Nicole Robbins , Leah E. Cowen
Fungal phytopathogens are responsible for major losses in agricultural yields annually. While the use of topical fungicides remains key to managing agricultural pathogens, the emergence of drug-resistant strains necessitates identifying additional treatment options. In this study, we performed an in vitro small molecule screen against the devastating cereal pathogen Fusarium graminearum, identifying CMLD009688 as a priority growth inhibitor. Chemical-genetic profiling and subsequent experiments with CMLD009688 revealed that this compound functions as a cationic amphiphilic drug (CAD) and perturbs vacuolar integrity in F. graminearum. CMLD009688 displayed synergy with strobilurin fungicides in limiting F. graminearum growth—likely through both compounds independently affecting vacuolar stability—and a combination treatment of CMLD009688 with the strobilurin pyraclostrobin strongly limited the virulence of both F. graminearum and Botrytis cinerea in distinct models of plant infection. Thus, our findings highlight that cationic amphiphilic molecules show immense promise in helping to protect crops from fungal diseases.
{"title":"A cationic amphiphilic drug synergizes with strobilurin fungicides to control fungal-borne plant diseases","authors":"Bradley Laflamme , Christopher Blackman , Mackenzie Loranger , Richard Trilles , Kalina Doytchinova-Weil , Stephen S. Scully , J. Miles Blackburn , Anastasia L.G. Kanegesuku , Jennifer L. Roizen , Stephen Bengtson , Lauren E. Brown , John A. Porco , Keiko Yoshioka , Luke Whitesell , Rajagopal Subramaniam , Nicole Robbins , Leah E. Cowen","doi":"10.1016/j.chembiol.2025.05.008","DOIUrl":"10.1016/j.chembiol.2025.05.008","url":null,"abstract":"<div><div>Fungal phytopathogens are responsible for major losses in agricultural yields annually. While the use of topical fungicides remains key to managing agricultural pathogens, the emergence of drug-resistant strains necessitates identifying additional treatment options. In this study, we performed an <em>in vitro</em> small molecule screen against the devastating cereal pathogen <em>Fusarium graminearum</em>, identifying <strong>CMLD009688</strong> as a priority growth inhibitor. Chemical-genetic profiling and subsequent experiments with <strong>CMLD009688</strong> revealed that this compound functions as a cationic amphiphilic drug (CAD) and perturbs vacuolar integrity in <em>F. graminearum</em>. <strong>CMLD009688</strong> displayed synergy with strobilurin fungicides in limiting <em>F. graminearum</em> growth—likely through both compounds independently affecting vacuolar stability—and a combination treatment of <strong>CMLD009688</strong> with the strobilurin pyraclostrobin strongly limited the virulence of both <em>F. graminearum</em> and <em>Botrytis cinerea</em> in distinct models of plant infection. Thus, our findings highlight that cationic amphiphilic molecules show immense promise in helping to protect crops from fungal diseases.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 6","pages":"Pages 872-884.e7"},"PeriodicalIF":6.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-15DOI: 10.1016/j.chembiol.2025.04.004
Andreas Damianou , Hannah B.L. Jones , Athina Grigoriou , Mohammed A. Akbor , Edward Jenkins , Philip D. Charles , Iolanda Vendrell , Simon Davis , Benedikt M. Kessler
The growing interest in deubiquitinases (DUBs) as drug targets for modulating critical molecular pathways in disease is fueled by the discovery of their specific cellular roles. A crucial aspect of this fact is the identification of DUB substrates. While mass spectrometry-based proteomic methods can be used to study global changes in cellular ubiquitination following DUB activity perturbation, these datasets often include indirect and downstream ubiquitination events. To enrich for the direct substrates of DUB enzymes, we have developed a proximal-ubiquitome workflow that combines proximity labeling methodology (ascorbate peroxidase-2 [APEX2]) with subsequent ubiquitination enrichment based on the K-ε-GG motif. We applied this technology to identify altered ubiquitination events in the vicinity of the DUB ubiquitin-specific protease 30 (USP30) upon its inhibition. Our findings reveal ubiquitination events previously associated with USP30 on TOMM20 and FKBP8, as well as the candidate substrate LETM1, which is deubiquitinated in a USP30-dependent manner.
{"title":"Integrative proximal-ubiquitomics profiling for deubiquitinase substrate discovery applied to USP30","authors":"Andreas Damianou , Hannah B.L. Jones , Athina Grigoriou , Mohammed A. Akbor , Edward Jenkins , Philip D. Charles , Iolanda Vendrell , Simon Davis , Benedikt M. Kessler","doi":"10.1016/j.chembiol.2025.04.004","DOIUrl":"10.1016/j.chembiol.2025.04.004","url":null,"abstract":"<div><div>The growing interest in deubiquitinases (DUBs) as drug targets for modulating critical molecular pathways in disease is fueled by the discovery of their specific cellular roles. A crucial aspect of this fact is the identification of DUB substrates. While mass spectrometry-based proteomic methods can be used to study global changes in cellular ubiquitination following DUB activity perturbation, these datasets often include indirect and downstream ubiquitination events. To enrich for the direct substrates of DUB enzymes, we have developed a proximal-ubiquitome workflow that combines proximity labeling methodology (ascorbate peroxidase-2 [APEX2]) with subsequent ubiquitination enrichment based on the K-ε-GG motif. We applied this technology to identify altered ubiquitination events in the vicinity of the DUB ubiquitin-specific protease 30 (USP30) upon its inhibition. Our findings reveal ubiquitination events previously associated with USP30 on TOMM20 and FKBP8, as well as the candidate substrate LETM1, which is deubiquitinated in a USP30-dependent manner.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 5","pages":"Pages 736-751.e8"},"PeriodicalIF":6.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-15DOI: 10.1016/j.chembiol.2025.04.003
Mitchel L. Tepe , Yitan Chen , Allison Carso , Huiqing Zhou
Detection and quantification of tRNA chemical modifications are critical for understanding their regulatory functions in biology and diseases. However, tRNA-seq–based methods for modification mapping encountered challenges both experimentally (poor processivity of heavily modified tRNAs during reverse transcription or RT) and bioinformatically (frequent reads misalignment to highly similar tRNA genes). Here, we report “MapID-tRNA-seq” where we deployed an evolved reverse transcriptase (RT-1306) into tRNA-seq and developed “MapIDs” that reduce redundancy of the human tRNA genome and explicitly annotate genetic variances. RT-1306 generated robust mutations against m1A and m3C, and RT stops against multiple bulky roadblock modifications. MapID-assisted data processing enabled systematic exclusion of false-positive discoveries of modifications which arise from reads misalignment onto similar genes. We applied MapID-tRNA-seq into mapping m1A, m3C and expression levels of tRNAs in three mammary cell lines, which revealed cell-type dependent modification sites and potential translational regulation of the reduced mitochondrial activities in breast cancer.
{"title":"MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA","authors":"Mitchel L. Tepe , Yitan Chen , Allison Carso , Huiqing Zhou","doi":"10.1016/j.chembiol.2025.04.003","DOIUrl":"10.1016/j.chembiol.2025.04.003","url":null,"abstract":"<div><div>Detection and quantification of tRNA chemical modifications are critical for understanding their regulatory functions in biology and diseases. However, tRNA-seq–based methods for modification mapping encountered challenges both experimentally (poor processivity of heavily modified tRNAs during reverse transcription or RT) and bioinformatically (frequent reads misalignment to highly similar tRNA genes). Here, we report “MapID-tRNA-seq” where we deployed an evolved reverse transcriptase (RT-1306) into tRNA-seq and developed “MapIDs” that reduce redundancy of the human tRNA genome and explicitly annotate genetic variances. RT-1306 generated robust mutations against m<sup>1</sup>A and m<sup>3</sup>C, and RT stops against multiple bulky roadblock modifications. MapID-assisted data processing enabled systematic exclusion of false-positive discoveries of modifications which arise from reads misalignment onto similar genes. We applied MapID-tRNA-seq into mapping m<sup>1</sup>A, m<sup>3</sup>C and expression levels of tRNAs in three mammary cell lines, which revealed cell-type dependent modification sites and potential translational regulation of the reduced mitochondrial activities in breast cancer.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 5","pages":"Pages 752-766.e7"},"PeriodicalIF":6.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-15DOI: 10.1016/j.chembiol.2025.04.006
Maria M. Shchepinova , Rachel Richardson , Jack W. Houghton , Abigail R. Walker , Mohammed A. Safar , Daniel Conole , Aylin C. Hanyaloglu , Edward W. Tate
Cellular signaling by membrane G protein-coupled receptors (GPCRs) is governed by a complex and diverse array of mechanisms. The dynamics of a GPCR interactome, as it evolves over time and space in response to an agonist, provide a unique perspective on pleiotropic signaling decoding and functional selectivity at the cellular level. In this study, we utilized proximity-based APEX2 proteomics to investigate the interaction network of the luteinizing hormone receptor (LHR) on a minute-to-minute timescale. We developed an analytical approach that integrates quantitative multiplexed proteomics with temporal reference profiles, creating a platform to identify the proteomic environment of APEX2-tagged LHR at the nanometer scale. LHR activity is finely regulated spatially, leading to the identification of putative interactors, including the Ras-related GTPase RAP2B, which modulate both receptor signaling and post-endocytic trafficking. This work provides a valuable resource for spatiotemporal nanodomain mapping of LHR interactors across subcellular compartments.
{"title":"Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism","authors":"Maria M. Shchepinova , Rachel Richardson , Jack W. Houghton , Abigail R. Walker , Mohammed A. Safar , Daniel Conole , Aylin C. Hanyaloglu , Edward W. Tate","doi":"10.1016/j.chembiol.2025.04.006","DOIUrl":"10.1016/j.chembiol.2025.04.006","url":null,"abstract":"<div><div>Cellular signaling by membrane G protein-coupled receptors (GPCRs) is governed by a complex and diverse array of mechanisms. The dynamics of a GPCR interactome, as it evolves over time and space in response to an agonist, provide a unique perspective on pleiotropic signaling decoding and functional selectivity at the cellular level. In this study, we utilized proximity-based APEX2 proteomics to investigate the interaction network of the luteinizing hormone receptor (LHR) on a minute-to-minute timescale. We developed an analytical approach that integrates quantitative multiplexed proteomics with temporal reference profiles, creating a platform to identify the proteomic environment of APEX2-tagged LHR at the nanometer scale. LHR activity is finely regulated spatially, leading to the identification of putative interactors, including the Ras-related GTPase RAP2B, which modulate both receptor signaling and post-endocytic trafficking. This work provides a valuable resource for spatiotemporal nanodomain mapping of LHR interactors across subcellular compartments.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 5","pages":"Pages 722-735.e7"},"PeriodicalIF":6.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-15DOI: 10.1016/j.chembiol.2025.04.005
Xing Zhang , Kyong Tkhe Fam , Tingting Dai , Howard C. Hang
The composition of the microbiota in patients has been shown to correlate with cancer progression and response to therapy, highlighting unique opportunities to improve patient outcomes. In this review, we discuss the challenges and advancements in understanding the chemical mechanisms of specific microbiota species, pathways, and molecules involved in cancer progression and treatment. We also describe the modulation of cancer and immunotherapy by the microbiota, along with approaches for investigating microbiota enzymes and metabolites. Elucidating these specific microbiota mechanisms and molecules should offer new opportunities for developing enhanced diagnostics and therapeutics to improve outcomes for cancer patients. Nonetheless, many microbiota mechanisms remain to be determined and require innovative chemical genetic approaches.
{"title":"Microbiota mechanisms in cancer progression and therapy","authors":"Xing Zhang , Kyong Tkhe Fam , Tingting Dai , Howard C. Hang","doi":"10.1016/j.chembiol.2025.04.005","DOIUrl":"10.1016/j.chembiol.2025.04.005","url":null,"abstract":"<div><div>The composition of the microbiota in patients has been shown to correlate with cancer progression and response to therapy, highlighting unique opportunities to improve patient outcomes. In this review, we discuss the challenges and advancements in understanding the chemical mechanisms of specific microbiota species, pathways, and molecules involved in cancer progression and treatment. We also describe the modulation of cancer and immunotherapy by the microbiota, along with approaches for investigating microbiota enzymes and metabolites. Elucidating these specific microbiota mechanisms and molecules should offer new opportunities for developing enhanced diagnostics and therapeutics to improve outcomes for cancer patients. Nonetheless, many microbiota mechanisms remain to be determined and require innovative chemical genetic approaches.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 5","pages":"Pages 653-677"},"PeriodicalIF":6.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-15DOI: 10.1016/j.chembiol.2025.04.011
Marcus Conrad
In an interview with Dr. Mishtu Dey, the editor-in-chief of Cell Chemical Biology, Prof. Marcus Conrad, a new advisory board member and lead author of the paper entitled “N-acetyl-L-cysteine averts ferroptosis by fostering glutathione peroxidase 4,” shares his perspective on his research area, opportunities in the chemical biology field, and his plans to meaningfully contribute in this new position.
{"title":"Meet the Cell Chemical Biology author and newest advisory board member: Marcus Conrad","authors":"Marcus Conrad","doi":"10.1016/j.chembiol.2025.04.011","DOIUrl":"10.1016/j.chembiol.2025.04.011","url":null,"abstract":"<div><div>In an interview with Dr. Mishtu Dey, the editor-in-chief of <em>Cell Chemical Biology</em>, Prof. Marcus Conrad, a new advisory board member and lead author of the paper entitled “<span><span>N-acetyl-L-cysteine averts ferroptosis by fostering glutathione peroxidase 4</span><svg><path></path></svg></span>,” shares his perspective on his research area, opportunities in the chemical biology field, and his plans to meaningfully contribute in this new position.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 5","pages":"Pages 643-645"},"PeriodicalIF":6.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-15DOI: 10.1016/j.chembiol.2025.04.010
Xing Zhang, Kyong Fam, Tingting Dai, Howard Hang
In an interview with Dr. Mishtu Dey, the editor-in-chief of Cell Chemical Biology, the authors of the Review article entitled “Microbiota mechanisms in cancer progression and therapy” share their perspectives on their field and lives as scientists.
{"title":"Meet the authors: Xing Zhang, Kyong Fam, Tingting Dai, and Howard Hang","authors":"Xing Zhang, Kyong Fam, Tingting Dai, Howard Hang","doi":"10.1016/j.chembiol.2025.04.010","DOIUrl":"10.1016/j.chembiol.2025.04.010","url":null,"abstract":"<div><div>In an interview with Dr. Mishtu Dey, the editor-in-chief of <em>Cell Chemical Biology</em>, the authors of the Review article entitled “<span><span>Microbiota mechanisms in cancer progression and therapy</span><svg><path></path></svg></span>” share their perspectives on their field and lives as scientists.</div></div>","PeriodicalId":265,"journal":{"name":"Cell Chemical Biology","volume":"32 5","pages":"Pages 646-648"},"PeriodicalIF":6.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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