World Journal of Biological and Pharmaceutical Research最新文献

{"title":"Effects of D-allulose on di (2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP)-induced toxicity in rats","authors":"Shigeru Suna, Masaaki Tokuda","doi":"10.53346/wjbpr.2024.6.1.0076","DOIUrl":"https://doi.org/10.53346/wjbpr.2024.6.1.0076","url":null,"abstract":"Background: Oral exposure to high concentrations of DEHP and DBP causes testicular and hepatotoxicity in rodents. Phthalate metabolites such as mono (2-ethylhexyl) phthalate (MEHP) and mono-n-butyl phthalate (MBP) stimulate peroxisome proliferator-activated receptors and disrupts carbohydrate and lipid metabolism. The oxidative stress generated may be closely related to these toxicities. Method: To clarify the effects of the rare sugar D-allulose, a potent free radical scavenger, on testicular and hepatotoxicity induced by DEHP and DBP, rats were fed DEHP or DBP containing diet and D-allulose water. Result: Dietary exposure to DEHP and DBP induced a significant decrease in testicular weight and significant increase in liver weight. D-allulose treatment significantly inhibited the testicular weight loss. But D-allulose treatment did not significantly suppress the increase in liver weight. Plasma glucose levels were significantly lower in the DEHP- or DBP-only treated groups compared to controls, but were improved by D-allulose treatment. This suggests that D-allulose blocks DEHP- and DBP-induced glycemic suppression. Plasma lipid-related markers such as total cholesterol, high-density lipoprotein cholesterol, and triglycerides were lower than controls in all treatment groups on the DEHP and DBP diets, but showed a slight trend toward improvement with D-allulose. Conclusion: D-allulose reduced DEHP- and DBP-induced testicular toxicity and blood glucose suppression in rats, but did not improve liver hypertrophy. This effect may be due to the strong oxidant scavenging ability of D-allulose.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiulcer activity of the stem bark aqueous extract of Croton oligandrum (Euphorbiaceae) against Ethanol/HCl-induced gastric mucosal injury in rats","authors":"Christophe Mezui, Gustave Lebeau Ndji Otto, Lorraine Nkouendazem Ngueke, Joseph Fleurie Emakoua, Rosalie Armelle Ambassa Mbang, Paul Vernyuy Tan","doi":"10.53346/wjbpr.2023.5.2.0073","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.5.2.0073","url":null,"abstract":"Gastric ulcer is an alteration of the lining of the stomach with destruction of mucus-producing cells. Many factors are contributing to the development of peptic ulcer such as phygiological stress, high production of acid, non-steroidal anti-inflammatory drugs (NSAIDs) and alcohol consumption. Croton oligandrum is traditionally used to treat many diseases including gastric ulcers. This study aims to investigate the cytoprotective activity of Croton oligandrum. To assess the gastroprotective potential of Croton oligandrum ulcer models were established using ethanol and indomethacin. Sucralfate was used as reference anti-ulcer drugs. Rats were treated with Croton oligandrum before induction of gastric ulceration by ethanol/HCl or HCl-ethanol-Indomethacin. The area and ulcer index appearance of ulcers were quantified, and mucus was measured. Pretreatment with Croton oligandrum showed a remarkable decrease in ulcer area when compared with control groups. Croton oligandrum (50, 100 mg/kg and 200 mg/kg of body weight) exhibited gastroprotective activity and prevented both gastric lesions induced in rats.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139139406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphatidylethanol (PEth) in practice: A specific and proportional marker of alcohol consumption","authors":"H. Belhadj-Tahar, Nouredine Sadeg, Bruno Journe, Cherif Messaoudi, G. Malonga, Sara Morais, F. Brousse","doi":"10.53346/wjbpr.2023.5.2.0070","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.5.2.0070","url":null,"abstract":"Alcohol abuse causes more than three million deaths a year, or one in twenty, more than three-quarters of them men. Alcohol abuse accounts for over 5% of the global burden of disease. In this context, objective clinical and biochemical tests are essential to characterize drinking patterns, quantify the amount of ethanol ingested daily and enable effective management of these patients. We recently investigated the feasibility and benefits of measuring phosphatidylethanol (PEth) in daily medical practice for the management of alcohol dependence in the outpatient setting. We report the results of a quantification of palmitoyl-2-oleoyl-glycero-3-phosphoethanol (PEth 16:0/18:1) in comparison with biological indicators (SGOT, SGPT GGT) on a group of volunteers followed as outpatients for alcohol problems. Methods: In this prospective study, a total population of 57 volunteers consulting a private addictology practice was recruited for PEth tests, 21 of which were complemented by biological tests including SGOT, SGPT GGT assays. A file was completed specifying the methods of alcohol use, the quantities consumed (AU) and the Alcohol Use Disorders Identification Test (AUDIT) score. Blood samples are collected in a 10 µL drop, using a medical device (VAMS from Neoteryx, USA), air-dried. The dry samples are extracted and reconstituted with methanol. The analyzes carried out by high pressure liquid chromatography coupled with high resolution mass spectrometry. Results and discussion: 57 volunteers (19 F and 38 M) aged between 20 and 70 were included. These volunteers had the Quantities consumed (AU/d) at 6.7 (0-20) and the Alcohol Use Disorders Identification Test (AUDIT) score at 17.8 (0-30). A strong positive correlation of 0.88 (n=57) was observed between PEth concentrations and levels of daily alcohol consumption. The usual biology, the \"hepatic assessment\" provides little or no information on the risks associated with alcohol consumption with correlation coefficient estimated at 0.28 for GGT, 0.09 for SGOT and 0.00 for SGPT. PEth degradation was 13% for samples stored at room temperature, compared with those stored at +4°C and -80°C. Conclusion: PEth is a specific and proportional marker of alcohol consumption. Measuring PEth enables us to accurately gauge the reality of alcohol consumption and adapt it to care and prevention contexts. This measurement of phosphatidylethanol (PEth) can be carried out as part of a consultation, at a distance from the analysis centers. Finally, the PEth, along with the interpretation tools described in this article, is an important help in the management of alcohol dependence.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139140429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of chemical thinning on the fruit parameters of ‘Majhoul’ date palm during fruit development","authors":"Mohamed Arba, Otmane ELLADI, Hicham OUACHOUO, Ahmed SABRI","doi":"10.53346/wjbpr.2023.5.2.0069","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.5.2.0069","url":null,"abstract":"The aim of this work was to study the effect of NAA (Naphthalene acetic acid) on the chemical thinning of ‘Majhoul’ date palm in order to use this operation as an alternative to manual thinning, which is a costly operation carried out by the farmers. Experiments were carried out on an adult plantation of ‘Majhoul’ cv in Tafilalet area. Thinning treatments used were T0 (control treated with water), T1 (application of 150 and 300 ppm NAA 30 and 60 days after pollination), T2 (application of 250 and 500 ppm NAA 30 and 60 days after pollination) and T3 (manual thinning performed by the farmer). These treatments were used on three flowering phases of this variety. Obtained results showed that for the early flowering phase, T2 NAA treatment increased fruit drop for 77% compared to the control. Thinning treatments T1, T2 and T3 yielded fruit with larger size (fruit mass of 17.26, 18.51 and 20.88 g respectively) than that of the control (13.67 g). The late flowering phase also gave fruit with larger size (fruit mass of 18.73 g and fruit length of 4.44 cm) than that of the other flowering phases (fruit mass of 17 g and fruit length of 4.34 cm for the other flowering phases).","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139197721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and its possible origin","authors":"None Vogt PR, None del Valle LD, None Fimia DR","doi":"10.53346/wjbpr.2023.5.1.0068","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.5.1.0068","url":null,"abstract":"The struggle between man and infectious diseases dates back to the very beginning of civilization, where the increase of infectious entities is closely associated with poor human actions and management of ecosystems. The objective of the present research was to outline the possible origin of the new coronavirus officialized as SARS-CoV-2 causing COVID-19. A series of aspects about the possible origin of the new pandemic are presented, broken down as follows: Where does this virus come from? probable theories about how this virus spread to humans, what do we know?, what don't we know?, and what can we do now?. It is concluded that this is a highly infectious entity with a high probability of zoonotic transmission, where bats and the mammal known as pangolin stand out as potential reservoirs, but the possibility of synthesizing this virus at laboratory level should not be ruled out, so we do not know if the virus will become endemic, recurrent year after year or finally be controlled; What we do know for sure is that the joint efforts of all human beings living on this planet are needed to win the battle against this new coronavirus.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MDCT appearances of pancreatic insulinoma as well as the other well differentiated endocrine tumors","authors":"None A Hilendarov, None Al Georgiev, None L Chervenkov, None N Sirakov","doi":"10.53346/wjbpr.2023.5.1.0064","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.5.1.0064","url":null,"abstract":"Introduction: Pancreatic endocrine tumors (PETs) are primarily well-differentiated tumors composed of cells that resemble normal islet cells but that arise from pancreatic ductal cells. They are classified as functioning or nonfunctioning according to their associated clinical symptoms; insulinomas, gastrinomas and glucagonomas are the most common function­ing PETs Case Report: A 36-years old man presented with a one-month history of fainting attacks and dizziness, symptoms of hypoglycemia such as hunger, sweating, palpitations, loss of consciousness and syncope. We tried abdominal enhanced spiral CT to localize the tumor, but that wasn’t successful. Therefore, we tried a new method of MD spiral CT scanning and localized the tumor. Discussion and Conclusion: Insulinomas are the commonest islet cell tumors of the pancreas, followed by gastrinomas. Preoperative localization is very helpful in planning the operation: it allows the surgeon to determine whether simple tumor resection or partial pancreatectomy is likely to be required.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136277087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tin hair analysis in poly symptomatic patients with Essure® implant","authors":"Hafid Belhadj-Tahar, Florent Brousse, Gilles Malonga, Sara Morais, Nouredine Sadeg","doi":"10.53346/wjbpr.2023.5.1.0065","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.5.1.0065","url":null,"abstract":"Objective: Essure® is a permanently implanted contraceptive device withdrawn from the market in 2018 because of adverse effects associated with this device, including gynecological disorders and extrapelvic symptoms. After surgical removal device, examination of uterine biopsies showed the frequent presence of tin resulting from implant degradation. In this context, the biological monitoring of tin metal in implanted patients becomes an issue of capital importance since hair is the best matrix to reveal long-term metallic exposure. Methods: The aim of this retrospective study was to compare hair chromium, nickel and tin levels in 10 Essure® implanted patients (aged 50±2 years old) presenting with adverse events, in particular psychosomatic manifestations, with 25 healthy non implanted volunteers’ group (aged 47± 4 years old). Hair chromium, nickel and tin analyses were performed on a 7800 ICP-MS inductively coupled plasma mass spectrometer. Results: For the group of healthy subjects, all tin concentrations in hair (25/25) were below the quantification limit of 0.1 µg/g, with 2 concentrations above the detection limit of 0.07 µg/g. Similarly, all nickel and chromium concentrations (25/25) were below the quantification limit, with 2 Cr concentrations and one Ni concentration above the detection limit of 0.1 µg/g. In the implanted group, subjects had mean hair concentrations of nickel and tin of 0.94+0.39 µg/g and 0.25 ± 0.17 µg/g respectively. All subjects (10/10) had chromium concentrations below the limit of quantification. For nickel and tin assays in hair above the quantification thresholds, there were positive correlations between (a) nickel or tin concentrations and the duration of device implantation (correlation coefficient of 0.79 for tin and 0.44 for nickel) and between (b) tin concentration and the multiplicity of extra-pelvic symptoms (correlation coefficient of 0.76), with (c) no correlation observed between nickel concentration and symptom multiplicity. Conclusion: Tin seems to be an important factor involved in the physio pathogenesis of extra pelvic symptoms in patients with the Essure® medical device. In this context, the hair tin analysis is a useful tool in the monitoring of patients with Essure® implants.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115185228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific new mucinous benign pancreatic cysts: A new pathological unit","authors":"A. Hilendarov, A. Georgiev, Lyubomir Chervenkov, N. V. Sirakov","doi":"10.53346/wjbpr.2023.5.1.0063","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.5.1.0063","url":null,"abstract":"Introduction: The cystic lesions of the pancreas consists of a range of pathologies which may be broadly divided into neoplastic, non- neo plastic cysts. Recently new non-neoplastic cystic lesions, called mucinous non-neoplastic cysts (MNCs), have been described. Materials and Methods: The imaging methods (ultrasound and CT) were used as well as invasive imaging methods under image control with a view of the histological verification of the diagnosis. Included cases of pancreatic cystic lesions are described, accidentally detected by ultrasound and CT scan and other diagnostic methods were made for different purpose. Results and Discussion: The finding usually was a cyst in the body of the pancreas, apparently communicating with the pancreatic duct. The Endoscopic Retrograde Cholangiopancreatography and laboratory tests of liver function, serum carcino embryonic antigen (CEA)and carbohydrate antigen C19 -9 were within normal limits. After the distal pancreatectomy in three of the patients the histological speciment showed a simple cyst, lined with mucinous epithelium. Conclusion: We recommend that patients diagnosed with 'benign' mucinous neoplasm are closely monitored due to the inability to completely confirm the benign nature of the lesions. Moreover, the existence of the MNC, as a truly unique cystic lesion, remains controversial.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128569353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verification of the peculiarities of the Anthophoridae Family (Insecta: Hymenoptera)","authors":"Carlos Henrique Marchiori","doi":"10.53346/wjbpr.2023.5.1.0059","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.5.1.0059","url":null,"abstract":"Solitary behavior is characterized by the independence of females in building and provisioning their nests. There is no cooperation, or division of labor, between females of the same generation, or between mother and daughters. Most of the time, the mother dies before her offspring emerges, with no intergenerational relationships. There is a great diversity of nesting habits among solitary bees. Several species of the Megachilidae, Anthophoridae, and Apidae families nest in hollow branches of plants or pre-existing holes in wood. Others nest in cavities on the ground or in ravines or in protected places and few build exposed nests. The objective of this manuscript is to know the peculiarities of the Anthophoridae Family. The study proposed here constitutes bibliographical research in national and international publications that address the Anthophoridae (Insecta: Hymenoptera: Apoidea) in the field of Entomology. The bibliographical research was carried out using the descriptors Hymenoptera, wasps, and bees in the virtual library in Entomology and in the digital library of theses and dissertations of Universidade de São Paulo (BDTD). Concerned with drawing a public profile of quality research in the area, we sought, a literature review in the main journals in the area classified by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). In order to complement this analysis with other types of documents such as books, scientific journals, and documents.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123088062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic characterization of pathogenic bacteria isolated from herbal mixtures (agbo) samples collected in Ibadan, Nigeria","authors":"IA Adesokan, I. A. Adesokan, B. A. Oseni","doi":"10.53346/wjbpr.2023.5.1.0062","DOIUrl":"https://doi.org/10.53346/wjbpr.2023.5.1.0062","url":null,"abstract":"Herbal mixtures called agbo are usually prepared by mixing different plant parts in water and/or alcohol. It is usually prepared by local women who have no education and knowledge of quality control measures. Therefore, the samples of agbo retailed by these women are commonly contaminated by spoilage and pathogenic organisms. The aim of the current study is to characterize microorganisms isolated from samples of agbo collected from different markets. The microbial load obtained for different samples of agbo ranged between 0 to 1.67x106 cfu/ml. The microorganisms isolated from the samples of agbo are E. coli, Salmonella typhi, Proteus vulgaris, Pseudomonads among others. Majority of the microbes isolated from agbo were resistant to antibiotic tested. Therefore, it could be concluded from this study that samples of agbo retailed in Ibadan are heavily contaminated by spoilage and pathogenic bacteria. Consumers are therefore advised to desist from taking agbo samples retailed in Ibadan.","PeriodicalId":267430,"journal":{"name":"World Journal of Biological and Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121331568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}